WO1999038547A3 - Enhanced biocompatibility coatings for medical implants - Google Patents

Enhanced biocompatibility coatings for medical implants Download PDF

Info

Publication number
WO1999038547A3
WO1999038547A3 PCT/US1999/001766 US9901766W WO9938547A3 WO 1999038547 A3 WO1999038547 A3 WO 1999038547A3 US 9901766 W US9901766 W US 9901766W WO 9938547 A3 WO9938547 A3 WO 9938547A3
Authority
WO
WIPO (PCT)
Prior art keywords
coatings
medical implants
compound
anticlotting
enhanced biocompatibility
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/001766
Other languages
French (fr)
Other versions
WO1999038547A2 (en
Inventor
Michael Helmus
Michael J Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Priority to EP99904351A priority Critical patent/EP1051210A2/en
Priority to AU24765/99A priority patent/AU2476599A/en
Priority to JP2000529278A priority patent/JP2002501789A/en
Priority to BR9908533-0A priority patent/BR9908533A/en
Priority to CA002318736A priority patent/CA2318736A1/en
Publication of WO1999038547A2 publication Critical patent/WO1999038547A2/en
Publication of WO1999038547A3 publication Critical patent/WO1999038547A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Enhanced biocompatibility coatings for medical implants and acute exposure medical devices are disclosed in conjunction with methods for their production and use. The biocompatible coatings are particularly advantageous when used in conjunction with high surface area materials such as porous resins, fabrics and textiles and comprise ionically bound complexes of at least one anticlotting compound and at least one quaternary ammonium compound having greater than 0.15 and less than 40 IU of anticlotting compound per CM2. The coatings are produced by forming a solution of the complex having a concentration greater than 0.005 % and less than 1.5 % w/v which is applied to the surface and allowed to dry. The coatings reduce the propensity for thrombus deposition without impairing healing and tissue ingrowth into the device.
PCT/US1999/001766 1998-01-30 1999-01-28 Enhanced biocompatibility coatings for medical implants Ceased WO1999038547A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99904351A EP1051210A2 (en) 1998-01-30 1999-01-28 Enhanced biocompatibility coatings for medical implants
AU24765/99A AU2476599A (en) 1998-01-30 1999-01-28 Enhanced biocompatibility coatings for medical implants
JP2000529278A JP2002501789A (en) 1998-01-30 1999-01-28 Enhanced biocompatibility coatings for medical implants
BR9908533-0A BR9908533A (en) 1998-01-30 1999-01-28 Improved biocompatibility coating for medical implants and acute exposure medical devices, process for producing an improved biocompatibility coating, and medical implant or acute exposure medical device
CA002318736A CA2318736A1 (en) 1998-01-30 1999-01-28 Enhanced biocompatibility coatings for medical implants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1614798A 1998-01-30 1998-01-30
US09/016,147 1998-01-30

Publications (2)

Publication Number Publication Date
WO1999038547A2 WO1999038547A2 (en) 1999-08-05
WO1999038547A3 true WO1999038547A3 (en) 1999-09-23

Family

ID=21775639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/001766 Ceased WO1999038547A2 (en) 1998-01-30 1999-01-28 Enhanced biocompatibility coatings for medical implants

Country Status (6)

Country Link
EP (1) EP1051210A2 (en)
JP (1) JP2002501789A (en)
AU (1) AU2476599A (en)
BR (1) BR9908533A (en)
CA (1) CA2318736A1 (en)
WO (1) WO1999038547A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
CN121927145A (en) * 2026-03-30 2026-04-28 天津包钢稀土研究院有限责任公司 Rare earth-based anticoagulant coating for PVC pipeline and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005825A1 (en) * 1991-09-20 1993-04-01 Baxter International Inc. Processes for reducing the thrombogenicity of biomaterials
WO1993021860A1 (en) * 1992-05-07 1993-11-11 Intervascular, Inc. Non-thrombogenic vascular prosthesis
US5679400A (en) * 1993-04-26 1997-10-21 Medtronic, Inc. Intravascular stent and method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005825A1 (en) * 1991-09-20 1993-04-01 Baxter International Inc. Processes for reducing the thrombogenicity of biomaterials
WO1993021860A1 (en) * 1992-05-07 1993-11-11 Intervascular, Inc. Non-thrombogenic vascular prosthesis
US5679400A (en) * 1993-04-26 1997-10-21 Medtronic, Inc. Intravascular stent and method

Also Published As

Publication number Publication date
BR9908533A (en) 2000-11-28
CA2318736A1 (en) 1999-08-05
JP2002501789A (en) 2002-01-22
EP1051210A2 (en) 2000-11-15
AU2476599A (en) 1999-08-16
WO1999038547A2 (en) 1999-08-05

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