WO1999042139A3 - Hydroxyethylstärke-konjugate, verfahren zu ihrer herstellung und diese enthaltenden pharmazeutische mittel - Google Patents

Hydroxyethylstärke-konjugate, verfahren zu ihrer herstellung und diese enthaltenden pharmazeutische mittel Download PDF

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Publication number
WO1999042139A3
WO1999042139A3 PCT/EP1999/000853 EP9900853W WO9942139A3 WO 1999042139 A3 WO1999042139 A3 WO 1999042139A3 EP 9900853 W EP9900853 W EP 9900853W WO 9942139 A3 WO9942139 A3 WO 9942139A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
same
hydroxyethyl starch
pharmaceuticals containing
starch conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/000853
Other languages
English (en)
French (fr)
Other versions
WO1999042139A2 (de
Inventor
Peter Mareski
Johannes Platzek
Bernd Raduechel
Ulrich Niedballa
Hanns-Joachim Weinmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to AU28328/99A priority Critical patent/AU2832899A/en
Publication of WO1999042139A2 publication Critical patent/WO1999042139A2/de
Publication of WO1999042139A3 publication Critical patent/WO1999042139A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Die Erfindung betrifft neue Hydroxyethylstärke-Konjugate and ihre Verwendung in der medizinischen Diagnostik.
PCT/EP1999/000853 1998-02-20 1999-02-09 Hydroxyethylstärke-konjugate, verfahren zu ihrer herstellung und diese enthaltenden pharmazeutische mittel Ceased WO1999042139A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28328/99A AU2832899A (en) 1998-02-20 1999-02-09 Hydroxyethyl starch conjugate, method for the production thereof and pharmaceuticals containing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19808079.4 1998-02-20
DE19808079A DE19808079A1 (de) 1998-02-20 1998-02-20 Hydroxyethylstärke-Konjugate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel

Publications (2)

Publication Number Publication Date
WO1999042139A2 WO1999042139A2 (de) 1999-08-26
WO1999042139A3 true WO1999042139A3 (de) 1999-09-30

Family

ID=7858971

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/000853 Ceased WO1999042139A2 (de) 1998-02-20 1999-02-09 Hydroxyethylstärke-konjugate, verfahren zu ihrer herstellung und diese enthaltenden pharmazeutische mittel

Country Status (3)

Country Link
AU (1) AU2832899A (de)
DE (1) DE19808079A1 (de)
WO (1) WO1999042139A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
BR0314227A (pt) 2002-09-11 2005-10-25 Fresenius Kabi De Gmbh Derivados de amido de hidroxialquila
US7538092B2 (en) 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
JP5191729B2 (ja) 2004-03-11 2013-05-08 フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 還元的アミノ化によって製造される、ヒドロキシアルキルデンプンとタンパク質とのコンジュゲート
DE102007015282B4 (de) * 2007-03-29 2017-10-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Viskositätsregulator, Verfahren zu dessen Herstellung und dessen Verwendung
EP2070950A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
WO2012139030A1 (en) 2011-04-06 2012-10-11 Cedars-Sinai Medical Center Polymalic acid based nanoconjugates for imaging
CN102321185B (zh) * 2011-08-09 2012-12-19 武汉华科大生命科技有限公司 一种中分子量羟乙基淀粉的合成方法
RU2655810C2 (ru) * 2016-10-12 2018-05-29 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Средство, увеличивающее мозговой кровоток

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0250358A2 (de) * 1986-06-20 1987-12-23 Schering Aktiengesellschaft Komplexe Verbindungen
WO1989006979A1 (en) * 1988-01-26 1989-08-10 Cockbain, Julian, Roderick, Michaelson Paramagnetic compounds
EP0361960A2 (de) * 1988-09-29 1990-04-04 RANNEY, David F. Verfahren und Vorrichtung zur Bilderzeugung mittels magnetischer Resonanz
EP0391621A1 (de) * 1989-04-03 1990-10-10 Nippon Universal Pharmaceutical Co., Ltd., Iodierte Hydroxyethylstärke mit niedriger Viskosität und Verfahren zu ihrer Herstellung
US4986980A (en) * 1984-11-01 1991-01-22 Nycomed As Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents
WO1992007259A1 (en) * 1990-10-16 1992-04-30 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
WO1995005669A1 (en) * 1993-08-12 1995-02-23 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US5458870A (en) * 1991-08-05 1995-10-17 Mallinckrodt Medical, Inc. Compositions for magnetic resonance imaging using a manganese oxalate

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4986980A (en) * 1984-11-01 1991-01-22 Nycomed As Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
EP0250358A2 (de) * 1986-06-20 1987-12-23 Schering Aktiengesellschaft Komplexe Verbindungen
WO1989006979A1 (en) * 1988-01-26 1989-08-10 Cockbain, Julian, Roderick, Michaelson Paramagnetic compounds
EP0361960A2 (de) * 1988-09-29 1990-04-04 RANNEY, David F. Verfahren und Vorrichtung zur Bilderzeugung mittels magnetischer Resonanz
EP0391621A1 (de) * 1989-04-03 1990-10-10 Nippon Universal Pharmaceutical Co., Ltd., Iodierte Hydroxyethylstärke mit niedriger Viskosität und Verfahren zu ihrer Herstellung
WO1992007259A1 (en) * 1990-10-16 1992-04-30 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
US5458870A (en) * 1991-08-05 1995-10-17 Mallinckrodt Medical, Inc. Compositions for magnetic resonance imaging using a manganese oxalate
WO1995005669A1 (en) * 1993-08-12 1995-02-23 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RONGVED P ET AL: "WATER-SOLUBLE POLYSACCHARIDES AS CARRIERS OF PARAMAGNETIC CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING: SYNTHESIS AND RELAXATION PROPERTIES", CARBOHYDRATE RESEARCH, vol. 214, no. 2, 30 July 1991 (1991-07-30), pages 315 - 323, XP000217853, ISSN: 0008-6215 *

Also Published As

Publication number Publication date
AU2832899A (en) 1999-09-06
WO1999042139A2 (de) 1999-08-26
DE19808079A1 (de) 1999-08-26

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