WO1999042144A1 - Compositions de sterilisation a base de pentafluoropropane et d'oxyde d'ethylene - Google Patents

Compositions de sterilisation a base de pentafluoropropane et d'oxyde d'ethylene Download PDF

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Publication number
WO1999042144A1
WO1999042144A1 PCT/US1999/003510 US9903510W WO9942144A1 WO 1999042144 A1 WO1999042144 A1 WO 1999042144A1 US 9903510 W US9903510 W US 9903510W WO 9942144 A1 WO9942144 A1 WO 9942144A1
Authority
WO
WIPO (PCT)
Prior art keywords
ethylene oxide
pentafluoropropane
azeotrope
diluent
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/003510
Other languages
English (en)
Inventor
Barbara Ruth Decaire
Peter Brian Logsdon
Claude Carlisle Woltz, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Honeywell International Inc
Original Assignee
AlliedSignal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AlliedSignal Inc filed Critical AlliedSignal Inc
Priority to AU26863/99A priority Critical patent/AU2686399A/en
Publication of WO1999042144A1 publication Critical patent/WO1999042144A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/206—Ethylene oxide

Definitions

  • the invention relates to compositions of 1,1,1,3,3-pentafluoropropane and ethylene oxide.
  • the compositions of the invention are useful as sterilizing agents.
  • Sterilization with a germicidal agent plays an important role in sterilizing heat sensitive materials. Rapid growth in the use of sterile, disposable, medical devices is just one consequence of gaseous sterilization with such agents.
  • a sterilization chamber containing articles to be sterilized is evacuated and the articles are preconditioned at an optimal relative humidity, generally between about 20 and 70 percent.
  • the sterilizing gas is admitted at an appropriate pressure and temperature while contact is maintained between the sterilizing atmosphere and the articles to be sterilized. After an appropriate time period, the chamber is evacuated to remove the sterilant gas.
  • CFC-12 dichlorodifluoromethane
  • ethylene oxide ethylene oxide
  • carbon dioxide ethylene oxide
  • a candidate diluent preferably should be miscible with ethylene oxide in the liquid phase and should not be so highly volatile that it will segregate from the ethylene oxide to any great extent during vaporization.
  • Azeotrope-like mixtures are useful in this context because they do not fractionate by normal evaporation or distillation processes. Therefore, a need exists for an environmentally acceptable diluent that is compatible with the objects being sterilized, is chemically stable, is minimally segregating, and provides sufficient vapor pressure to deliver the liquid mixture to the sterilization chamber.
  • the invention provides sterilizing gas compositions and methods for using the compositions.
  • the invention provides a method for sterilizing articles comprising, consisting essentially o ⁇ or consisting of the step of exposing the articles to a mixture of ethylene oxide and 1,1,1,3,3-pentafluoropropane ("HFC- 245fa").
  • HFC- 245fa 1,1,1,3,3-pentafluoropropane
  • mixtures of ethylene oxide and HFC-245fe are provided, which mixtures comprise, consist essentially o ⁇ or consist of ethylene oxide and HFC-245fa.
  • mixtures of ethylene oxide and HFC-245fa is meant both nonazeotropic and azeotrope-like compositions of ethylene oxide and HFC-245fa.
  • the invention provides azeotrope-like and nonazeotropic compositions comprising from about 1 to about 99 weight percent ethylene oxide and from about 99 to about 1 weight percent HFC-245fa.
  • the invention provides azeotrope-like compositions comprising, consisting essentially of and consisting of effective amounts of ethylene oxide and HFC-245fa.
  • effective amounts is meant the amount of each component that, in combination with the other component, results in the formation of an azeotrope-like composition.
  • the invention comprises azeotrope-like compositions comprising from about 4 to about 50, preferably from about 10 to about 40, weight percent ethylene oxide and from about 96 to about 50, preferably from about 90 to about 60, weight percent HFC-245& having a vapor pressure of about 7.4 psia to about 8.6 psia at about 0° C.
  • nonazeotropic sterilant gas compositions comprising from about 96 to about 50 weight percent ethylene oxide and from about 4 to about 50 weight percent HFC-245fa are provided.
  • azeotrope-like compositions are compositions that behave like azeotropic mixtures. From fundamental principles, the thermodynamic state of a fluid is defined by pressure and temperature as well as liquid composition and vapor composition.
  • An azeotropic mixture is a system of two or more components in which the liquid composition and vapor composition are equal at the state pressure and temperature. In practice, this means that the components of an azeotropic mixture are constant boiling and cannot be separated during a phase change.
  • Azeotrope-like compositions behave like azeotropic mixtures, g_, or are constant boiling or essentially constant boiling.
  • the composition of the vapor formed during boiling or evaporation is identical, or substantially identical, to the original liquid composition.
  • the liquid composition changes, if at all, only to a minimal or negligible extent.
  • non-azeotrope-like compositions in which, during boiling or evaporation, the liquid composition changes to a substantial degree. All azeotrope-like compositions of the invention within the indicated ranges as well as certain compositions outside these ranges are azeotrope-like.
  • the azeotrope-like compositions of the invention may include additional components that do not form new azeotropic or azeotrope-like systems, or additional components that are not in the first distillation cut.
  • the first distillation cut is the first cut taken after the distillation column displays steady state operation under total reflux conditions.
  • One way to determine whether the addition of a component forms a new azeotropic or azeotrope-like system so as to be outside of this invention is to distill a sample of the composition with the component under conditions that would be expected to separate a nonazeotropic mixture into its separate components.
  • the additional component will fractionate from the azeotropic or azeotrope-like components. If the mixture is azeotrope-like, some finite amount of a first distillation cut will be obtained that contains all of the mixture components that is constant boiling or behaves as a single substance.
  • azeotrope-like compositions there is a range of compositions containing the same components in varying proportions that are azeotrope-like, or constant boiling. All such compositions are intended to be covered by the terms "azeotrope-like" and "constant boiling * '.
  • azeotrope-like As an example, it is well known that at differing pressures, the composition of a given azeotrope will vary at least slightly as does the boiling point of the composition. Thus, an azeotrope of A and B represents a unique type of relationship, but with a variable composition depending on temperature and/or pressure.
  • compositions containing the same components in varying proportions that are azeotrope-like there is a range of compositions containing the same components in varying proportions that are azeotrope-like. All such compositions are intended to be covered by the term azeotrope-like as used herein.
  • the components of the composition of the invention are known materials that are commercially available or may be prepared by known methods.
  • the components are of sufficiently high purity so as to avoid the introduction of adverse influences on the properties of the system.
  • HFC-245fa is not as good a flame suppressant as other ethylene oxide diluents. Therefore, in a most preferred embodiment, the invention provides azeotrope-like and nonazeotropic compositions comprising, consisting essentially o ⁇ and consisting of ethylene oxide and HFC-245fa and a flame suppressant effective amount ofat least one diluent.
  • a flame suppressant effective amount of diluent is an amount sufficient to increase the flame suppressing effect of the HFC-245fa.
  • an amount of from about 60 to about 90, preferably from about 66 to about 84, weight percent of diluent is used, based on the sum of the weight percentages of the ethylene oxide and HFC-245fa components.
  • Suitable diluents are any diluent other than HFC-245fa that is more volatile than the ethylene oxide/HFC-245fa blend.
  • Illustrative diluents include, without limitation, 1,1,2,2,2-pentafluoroethane ("HFC- 125”), cWorodifluoromethane (“HCFC- 22"), l,l,l,2-tetrafluoroethane ("HFC-134a”), l,l,2,2-tetrafluoroethane (“HFC- 134”), l,l,l,3,3,3-hexafluoropropane (HFC-236fa), 1,1,1,2,3,3,3-heptafluoropropane (HFC-227ea), nitrogen, carbon dioxide, and sulfur hexafluoride.
  • HFC- 125 1,1,2,2,2-pentafluoroethane
  • HCFC- 22 cWorodifluoromethane
  • HFC-134a l,l,l,2-tetrafluoroethane
  • HFC-134a l,l,2,2-tetrafluor
  • compositions containing the azeotrope-like composition and diluent should be greater than about 6 weight percent, preferably from about 8 to about 13 weight percent, more preferably from about 9 to about 11 weight percent, most preferably about 10 weight percent, ethylene oxide.
  • Preferred compositions containing these mole percents of ethylene oxide are shown on Table 1. The values on Table 1 are understood to be prefaced by the term "about".
  • the compositions of the invention are used as sterilizing gases in any manner well known in the art such as by exposing the article to be sterilized to the sterilizing gas under conditions and for a period of time necessary to achieve the desired degree of sterility.
  • the process is effected - 6 - by placing the article to be sterilized in a chamber, evacuating the chamber, Immidifying the chamber, and exposing the article to the sterilizing gas for an appropriate period of time.
  • the sterilant compositions of the invention may be used to sterilize a great many articles.
  • medical equipment and materials that may be sterilized include, without limitation, diagnostic endoscopes, syringes, test tubes, incubators, pacemakers, tubing, gloves, catheters, sheeting, needles, scalpels, dilators, pumps, and intraocular lenses.
  • the compositions may be used as a fumigant for items outside of the medical field including, without limitation, foodstuffs, furs, bedding, and paper goods.
  • the sterilant compositions are effective against all forms of life, particularly insects, bacteria, viruses, molds, fungi, and other microorganisms.
  • the compositions of the invention may be prepared using any effective mixing technique known to those ordinarily skilled in the art. For example, each compound may be pumped gravimetrically through a manifold into a sterilant container and the container rolled to intermix the compounds into a homogeneous composition. Alternatively, the compounds may be pumped into a mixing tank, recirculated in the tank until a fully homogeneous composition is formed, and then pumped from the mixing tank into a sterilant container.
  • compositions of the invention may be packaged in any storage containers of suitable design such as United States Department of Transportation ("DOT") Specifications 4BA 240, 4BA 300, 4BW 240, or other DOT specification cylinders or trailers of suitable working pressure.
  • DOT United States Department of Transportation
  • the compositions also may be packaged in American Society of Mechanical Engineers storage vessel.
  • the storage cylinders may be delivered to the use site holding the sterilant compositions at a pressure generally within the range of from about 70 to about 190 pounds per square inch absolute at 70° F.
  • the cylinders are then connected through a series of valves, control valves, vaporizers, and appropriate conduits to carry out the sterilization

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention concerne des compositions à effet azéotropique et non azéotropique à base de 1,1,1,3,3-pentafluoropropane et d'oxyde d'éthylène. Les compositions de l'invention s'utilisent comme agents de stérilisation.
PCT/US1999/003510 1998-02-19 1999-02-18 Compositions de sterilisation a base de pentafluoropropane et d'oxyde d'ethylene Ceased WO1999042144A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26863/99A AU2686399A (en) 1998-02-19 1999-02-18 Sterilizing compositions of pentafluoropropane and ethylene oxide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2622698A 1998-02-19 1998-02-19
US09/026,226 1998-02-19

Publications (1)

Publication Number Publication Date
WO1999042144A1 true WO1999042144A1 (fr) 1999-08-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/003510 Ceased WO1999042144A1 (fr) 1998-02-19 1999-02-18 Compositions de sterilisation a base de pentafluoropropane et d'oxyde d'ethylene

Country Status (2)

Country Link
AU (1) AU2686399A (fr)
WO (1) WO1999042144A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432357B1 (en) 1998-02-19 2002-08-13 Honeywell International Inc. Sterilizing gas compositions of ethylene oxide, pentafluoroethane and heptafluoropropane
WO2001051097A3 (fr) * 2000-01-10 2002-10-10 Honeywell Int Inc Procede d'utilisation de melanges contenant de l'oxyde d'ethylene non-inflammable destines a desinfecter par fumigation des microbes causant des degats au metal
WO2008101054A1 (fr) * 2007-02-16 2008-08-21 Honeywell International Inc. Compositions de fumigant azéotrope à l'iodure de méthyle

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2043586A1 (fr) * 1969-05-21 1971-02-19 Ici Ltd
US5039485A (en) * 1990-09-26 1991-08-13 Union Carbide Industrial Gases Technology Corporation Sterilization method
US5254309A (en) * 1992-07-21 1993-10-19 E. I. Du Pont De Nemours And Company Sterilant mixture and sterilization method
WO1995004022A1 (fr) * 1993-07-29 1995-02-09 Alliedsignal Inc. Procede de preparation de pentafluoropropane-1,1,1,3,3
WO1996001797A1 (fr) * 1994-07-11 1996-01-25 Alliedsignal Inc. Procede de fabrication de 1,1,1,3,3-pentafluoropropane
EP0738773A1 (fr) * 1995-04-20 1996-10-23 Elf Atochem S.A. Mélanges pseudo-azéotropiques à base de difluorométhane et de pentafluoroéthane, et leurs applications comme fluides frigorigènes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2043586A1 (fr) * 1969-05-21 1971-02-19 Ici Ltd
US5039485A (en) * 1990-09-26 1991-08-13 Union Carbide Industrial Gases Technology Corporation Sterilization method
US5254309A (en) * 1992-07-21 1993-10-19 E. I. Du Pont De Nemours And Company Sterilant mixture and sterilization method
WO1995004022A1 (fr) * 1993-07-29 1995-02-09 Alliedsignal Inc. Procede de preparation de pentafluoropropane-1,1,1,3,3
WO1996001797A1 (fr) * 1994-07-11 1996-01-25 Alliedsignal Inc. Procede de fabrication de 1,1,1,3,3-pentafluoropropane
EP0738773A1 (fr) * 1995-04-20 1996-10-23 Elf Atochem S.A. Mélanges pseudo-azéotropiques à base de difluorométhane et de pentafluoroéthane, et leurs applications comme fluides frigorigènes

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432357B1 (en) 1998-02-19 2002-08-13 Honeywell International Inc. Sterilizing gas compositions of ethylene oxide, pentafluoroethane and heptafluoropropane
WO2001051097A3 (fr) * 2000-01-10 2002-10-10 Honeywell Int Inc Procede d'utilisation de melanges contenant de l'oxyde d'ethylene non-inflammable destines a desinfecter par fumigation des microbes causant des degats au metal
US6605254B2 (en) * 2000-01-10 2003-08-12 Alliedsignal Inc. Method using ethylene oxide to fumigate corrosion promoting microbes
WO2008101054A1 (fr) * 2007-02-16 2008-08-21 Honeywell International Inc. Compositions de fumigant azéotrope à l'iodure de méthyle
US7544306B2 (en) 2007-02-16 2009-06-09 Honeywell International Inc. Azeotropic fumigant compositions of methyl iodide
US7695635B2 (en) 2007-02-16 2010-04-13 Honeywell International Inc Azeotrope-like compositions of 1-chloro-3,3,3-trifluoropropene and methyl iodide
EP2308298A1 (fr) * 2007-02-16 2011-04-13 Honeywell International Inc. Composition contenant de l'iodure de méthyle pour la fumigation
EP2316266A1 (fr) * 2007-02-16 2011-05-04 Honeywell International Inc. Composition contenant de l'iodure de méthyle pour la fumigation
EP2327303A1 (fr) * 2007-02-16 2011-06-01 Honeywell International Inc. Composition contenant de l'iodure de méthyle pour la fumigation

Also Published As

Publication number Publication date
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