WO1999044495A1 - Dispositif permettant de determiner la teneur en sucre dans le sang - Google Patents

Dispositif permettant de determiner la teneur en sucre dans le sang Download PDF

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Publication number
WO1999044495A1
WO1999044495A1 PCT/SE1999/000294 SE9900294W WO9944495A1 WO 1999044495 A1 WO1999044495 A1 WO 1999044495A1 SE 9900294 W SE9900294 W SE 9900294W WO 9944495 A1 WO9944495 A1 WO 9944495A1
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WO
WIPO (PCT)
Prior art keywords
blood sugar
contact surfaces
electric contact
sugar content
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE1999/000294
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English (en)
Inventor
John-Jacob Engellau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CONARMA AB
Original Assignee
CONARMA AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CONARMA AB filed Critical CONARMA AB
Priority to AU27558/99A priority Critical patent/AU2755899A/en
Publication of WO1999044495A1 publication Critical patent/WO1999044495A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves

Definitions

  • the present invention relates to a device and a method for the determination of blood sugar content.
  • Diabetes is a chronic metabolic disorder characterised by insufficient production of the hormone insulin. Diabetes causes fluctuations in the patient's blood sugar content. Serious complications, such as vascular changes which can lead to amputation, blindness and heart and kidney disease, may arise as a consequence of diabetes. The diabetic's loss of or reduced insulin production can be compensated for by means of existing insulin preparations. However, the patient's ability to "feel" his current blood sugar content is also reduced.
  • diabetics are obliged to use measuring methods which are carried out by means of a blood test and the addition of chemical reagents.
  • a biophysical parameter can be determined using either an invasive ("bloody”) or a non-invasive ("blood- less”) technique.
  • a measuring device especially for the determination of blood sugar content, is previously known from US-A-5 , 502 , 396. This known measuring device is based on the step of arranging a sample on the sensor forming part of the measuring device. This patent specification thus describes a device for invasive determination of the blood sugar content .
  • a device for non-invasive determination of the constituents of blood is known from WO 97/15227. According to that specification, data representative of the patient's ECG are used for determining the blood sugar content .
  • US-A-5, 119, 819 shows a device for non-invasive determination of changes in blood sugar content. With the aid of the device, acoustic speeds are measured in the tissue, which are then related to values of blood sugar content .
  • GB-2,033,575 describes a device for non-invasive determination of the capillary blood flow rate, in which is provided a means, which is adapted to be held against the patient's body surface, for applying alternating current.
  • Current is carried, at the depth of the capillary bed, along a path between two spaced-apart points.
  • the resulting voltage drop which is measured along at least part of the length of the current path, is said to pro- vide an indication of the capillary blood flow rate.
  • a further object of the invention is to provide a method of non- invasive blood sugar content determination.
  • the absorption capacity and electrical conductivity of blood in a certain tissue portion varies depending on the concentration of glucose in the blood flowing through the tissue portion.
  • This variation can be recorded, amplified, and read non-invasively, without direct access to the blood, in a device compris- ing a measuring part and a sensor part electrically connected thereto.
  • the user places, for example, his finger in the sensor part, whereby an open electric circuit is closed.
  • the reading is carried out spontaneously by means of the sensor part and can take place in most everyday situations.
  • This enables the diabetic to continuously record his current blood sugar conten . Having this knowledge enables the diabetic to adjust his diabetes therapy to minimise blood sugar content fluctuations.
  • IDDM patients Insulin-Dependent-Diabetes-Mellitus
  • ions e.g. sodium ions
  • the invention is based on the insight that blood sugar molecules have a dielectric effect on, inter alia, sodium ions.
  • the electrical impedance of a tissue with a high capillary blood flow rate varies with blood sugar content within certain frequency ranges .
  • closing an open electric circuit by placing a body part with a high capillary blood flow rate between two poles is the equi- valent of placing an impedance between the poles.
  • the magnitude of this impedance varies with the blood sugar content in the body part within certain frequency ranges for an applied electric field. Examples of body parts with a high capillary blood flow rate include the fingertips, toes, and earlobes .
  • this impedance variation can be integrated with a calibration process based on two or more programmable blood sugar values, determined by means of conventional measuring methods.
  • the impedance is determined at only one or a few frequencies, which enables very fast and simple measuring.
  • the molecular composition of the capillary blood is constant in all respects other than the blood sugar concentration. If the number of electrolytes in the blood varies between measurements, it may thus affect the measuring result. Consequently, according to a second method, the impedance is instead determined at a plurality of frequencies in a broad frequency spectrum. This determination is somewhat more time-consuming, but affords the possibility of compensating for changes in the composition of the blood between measurements.
  • Sodium chloride (NaCl) is a particularly important component in the electrolytic balance of blood.
  • Fig. 1 is a schematic view of a measuring device according to the invention, showing a measuring part and a sensor part connected thereto
  • Fig. 2 is a schematic view of the measuring part included in the device according to Fig. 1.
  • the measuring part 1 shown in Fig. 1 comprises a current supply means 11, an electric circuit 12, a memory medium 13, a microcomputer 14, and means 15 for inputting information to and reading information from the memory medium 13 as well as for reading measurement data.
  • the measuring part 1 is electrically connected to the sensor part 2, which comprises two opposing and spaced-apart electric contact surfaces 21, 22 with a first and a second electric potential.
  • an electric current e.g. of a magnitude of 10 mA
  • the impedance between the poles is proportional to the blood sugar content in the blood flowing through the human tissue.
  • the relationship between the impedance and the blood sugar content can be described by the formula:
  • Vg Ki x Z
  • Vg the blood sugar concentration
  • the calibration coefficient of the individual is obtained by means of the measuring device through at least two consecutive measurements at known blood sugar contents of the individual. These values, from a blood sugar determination of the capillary blood in a chemical blood sugar meter, are input as reference values to the memory medium 13 in connection with the respective cali- bration measurements. In connection with the calibration, the blood sugar values should have a minimum difference of 10mmol/1.
  • the voltage drop across the mass of tissue (the fingertip) placed between the poles is proportional to the blood sugar content of the blood flowing through the capillaries within a specific measurement range, e.g. 2-17 mmol/1.
  • the current measurement value is stated with, for example, one decimal and is expressed in, for example, mmol/1.
  • the electric contact surfaces 21, 22 are located at a fixed distance from each other, which is determined by the individual who is going to use the measuring device.
  • Measurement range blood sugar 2-17 mmol/1.
  • Accuracy 0.1 ⁇ 0.05 mmol/1
  • Measurement time 1-2 seconds
  • Calibration difference minimum 10 mmol/1
  • Calibration values two or more.
  • Measuring part microcomputer, electric circuit, display, keypad for calibration, batteries and fault indicator. Dimensions: height 20 x width 8 x depth 4 (cm) Display: LCD
  • Connecting cord with measuring part (for fingertip)
  • Sensor part diameter 10-25 mm (20 different dimensions)
  • Depth 20 mm, conical with a flat bottom.
  • the current supply means 11 comprises a multi-frequency generator, which generates a broad frequency spectrum within the frequency range of 0.1-2000 MHz.
  • An electric field is generated between the contact surfaces 21, 22 (the poles) .
  • electrical impedance is determined with the aid of the means 15 for at least a part of the frequency components generated by the multi-frequency generator.
  • This impedance spectrum is compared in the microcomputer 14 with spectra included in a spectrum library stored in the memory medium 13.
  • This spectrum library has been created by determining impedance spectra for known blood sugar concentrations of the patient, the loads being obtained by means of conventional methods.
  • the part of the spectrum which contains the "blood sugar signal” is identified and other parts of the spectrum are utilised to compensate for changes in the composition of the blood between measurements. Subsequently, a value for the blood sugar content of the blood is calculated.
  • the measuring instrument generates a warning signal if the microcomputer 14 detects signals for which it cannot compensate. These signals may represent external interference sources such as the patient ' s medicine intake.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un dispositif et des procédés permettant de déterminer la teneur en sucre dans le sang. Le dispositif comprend une partie mesure (1), et une partie détecteur (2) dont les surfaces de contact (21, 22) électriques peuvent être reliées avec l'un ou l'autre côté d'un morceau de tissu humain possédant une vitesse de flux sanguin capillaire élevée, pour déterminer de manière non invasive la teneur en sucre dans le sang.
PCT/SE1999/000294 1998-03-02 1999-03-02 Dispositif permettant de determiner la teneur en sucre dans le sang Ceased WO1999044495A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU27558/99A AU2755899A (en) 1998-03-02 1999-03-02 A device for the determination of blood sugar

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9800629-9 1998-03-02
SE9800629A SE512047C2 (sv) 1998-03-02 1998-03-02 Mätanordning, särskilt för blodsockerbestämning

Publications (1)

Publication Number Publication Date
WO1999044495A1 true WO1999044495A1 (fr) 1999-09-10

Family

ID=20410352

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1999/000294 Ceased WO1999044495A1 (fr) 1998-03-02 1999-03-02 Dispositif permettant de determiner la teneur en sucre dans le sang

Country Status (3)

Country Link
AU (1) AU2755899A (fr)
SE (1) SE512047C2 (fr)
WO (1) WO1999044495A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7184810B2 (en) 2002-09-04 2007-02-27 Solianis Holding Ag Method and a device for measuring glucose
US7315767B2 (en) 2001-03-06 2008-01-01 Solianis Holding Ag Impedance spectroscopy based systems and methods
CN100427025C (zh) * 2003-04-10 2008-10-22 宇东科技股份有限公司 一种测量血糖浓度的方法
US7534208B2 (en) 2002-09-24 2009-05-19 Max Link Device for the measurement of glucose concentrations
EP1656065A4 (fr) * 2003-08-19 2010-03-03 Ad Integrity Applications Ltd Procede pour controler le taux de glucose
US7693561B2 (en) 2001-03-06 2010-04-06 Solianis Holding Ag Method and device for determining the concentration of a substance in body liquid
US8197406B2 (en) 2003-12-02 2012-06-12 Biovotion Ag Device and method for measuring a property of living tissue
US9247905B2 (en) 2009-04-17 2016-02-02 Biovotion Ag Wide band field response measurement for glucose determination
US9713447B2 (en) 2005-11-10 2017-07-25 Biovotion Ag Device for determining the glucose level in body tissue

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2033575A (en) * 1978-05-24 1980-05-21 Rolfe P Investigating substances in a patient's bloodstream
US5119819A (en) * 1990-05-02 1992-06-09 Miles Inc. Method and apparatus for non-invasive monitoring of blood glucose
WO1997015227A1 (fr) * 1995-10-26 1997-05-01 Medtronic, Inc. Surveillance continue des constituants sanguins lies au diabete
WO1997023159A1 (fr) * 1995-12-22 1997-07-03 Cme Telemetrix Inc. Cavite integrante permettant d'effectuer des mesures dans des echantillons dispersant la lumiere

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2033575A (en) * 1978-05-24 1980-05-21 Rolfe P Investigating substances in a patient's bloodstream
US5119819A (en) * 1990-05-02 1992-06-09 Miles Inc. Method and apparatus for non-invasive monitoring of blood glucose
WO1997015227A1 (fr) * 1995-10-26 1997-05-01 Medtronic, Inc. Surveillance continue des constituants sanguins lies au diabete
WO1997023159A1 (fr) * 1995-12-22 1997-07-03 Cme Telemetrix Inc. Cavite integrante permettant d'effectuer des mesures dans des echantillons dispersant la lumiere

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7315767B2 (en) 2001-03-06 2008-01-01 Solianis Holding Ag Impedance spectroscopy based systems and methods
US7693561B2 (en) 2001-03-06 2010-04-06 Solianis Holding Ag Method and device for determining the concentration of a substance in body liquid
US7184810B2 (en) 2002-09-04 2007-02-27 Solianis Holding Ag Method and a device for measuring glucose
US7534208B2 (en) 2002-09-24 2009-05-19 Max Link Device for the measurement of glucose concentrations
CN100427025C (zh) * 2003-04-10 2008-10-22 宇东科技股份有限公司 一种测量血糖浓度的方法
EP1656065A4 (fr) * 2003-08-19 2010-03-03 Ad Integrity Applications Ltd Procede pour controler le taux de glucose
US8197406B2 (en) 2003-12-02 2012-06-12 Biovotion Ag Device and method for measuring a property of living tissue
US9713447B2 (en) 2005-11-10 2017-07-25 Biovotion Ag Device for determining the glucose level in body tissue
US9247905B2 (en) 2009-04-17 2016-02-02 Biovotion Ag Wide band field response measurement for glucose determination

Also Published As

Publication number Publication date
SE9800629L (sv) 1999-09-03
SE9800629D0 (sv) 1998-03-02
AU2755899A (en) 1999-09-20
SE512047C2 (sv) 2000-01-17

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