WO2000003747A3 - Utilisation odontologique de matieres nanostructurees a base d'apatite - Google Patents

Utilisation odontologique de matieres nanostructurees a base d'apatite Download PDF

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Publication number
WO2000003747A3
WO2000003747A3 PCT/IT1999/000224 IT9900224W WO0003747A3 WO 2000003747 A3 WO2000003747 A3 WO 2000003747A3 IT 9900224 W IT9900224 W IT 9900224W WO 0003747 A3 WO0003747 A3 WO 0003747A3
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WO
WIPO (PCT)
Prior art keywords
apatite
nanocrystalline
dentine
materials
remineralisation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT1999/000224
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English (en)
Other versions
WO2000003747A2 (fr
Inventor
Giovanni Dolci
Romano Mongiorgi
Carlo Prati
Giovanni Valdre
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Priority to CA002338021A priority Critical patent/CA2338021A1/fr
Priority to EP99936957A priority patent/EP1098623A2/fr
Priority to AU51919/99A priority patent/AU5191999A/en
Publication of WO2000003747A2 publication Critical patent/WO2000003747A2/fr
Publication of WO2000003747A3 publication Critical patent/WO2000003747A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/15—Compositions characterised by their physical properties
    • A61K6/17—Particle size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/52—Cleaning; Disinfecting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/74—Fillers comprising phosphorus-containing compounds
    • A61K6/75—Apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Biophysics (AREA)
  • Birds (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des matières nanocristallines biocompatibles à base d'apatite. Ces matières, qui présentent une surface spécifique élevée, sont caractérisées par des cristallites dont la taille moyenne varie entre 0,5 et 200 nm, et par de possibles déformations et/ou défauts. Ces matières sont en outre destinées à être utilisées dans les domaines de la chirurgie dentaire et de l'hygiène dentaire, en particulier pour produire des préparations, des solutions, des dentifrices, et des substances permettant de reminéraliser l'émail et la dentine, et pour traiter l'hyperesthésie dentinaire. Ces matières nanostructurées à base d'apatite présentent également des propriétés physiques et chimiques spécifiques, liées à leur nature nanocristalline et à la présence de possibles déformations et/ou défauts. Ainsi, elles affichent par exemple une réactivité chimique superficielle remarquable et une capacité hygrométrique satisfaisante, ce qui permet à ces matières de se recristalliser en raison du caractère métastable du système nanocristallin, et donc de pouvoir être utilisées pour reminéraliser l'émail et la dentine. La taille des grains est par ailleurs suffisante pour permettre à la fois une pénétration mécanique facile et profonde de ces matières à l'intérieur des tubules dentinaires, et une cimentation de la surface intérieure de ceux-ci par gonflement et réaction rapide avec les tissus naturels.
PCT/IT1999/000224 1998-07-17 1999-07-16 Utilisation odontologique de matieres nanostructurees a base d'apatite Ceased WO2000003747A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002338021A CA2338021A1 (fr) 1998-07-17 1999-07-16 Utilisation odontologique de matieres nanostructurees a base d'apatite
EP99936957A EP1098623A2 (fr) 1998-07-17 1999-07-16 Utilisation odontologique de matieres nanostructurees a base d'apatite
AU51919/99A AU5191999A (en) 1998-07-17 1999-07-16 Odontostomatologic use of apatite-based nanostructured materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM98A000476 1998-07-17
IT98RM000476A IT1299563B1 (it) 1998-07-17 1998-07-17 Uso odontostomatologico di materiali a base apatitica nanostrutturati

Publications (2)

Publication Number Publication Date
WO2000003747A2 WO2000003747A2 (fr) 2000-01-27
WO2000003747A3 true WO2000003747A3 (fr) 2000-05-11

Family

ID=11406050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1999/000224 Ceased WO2000003747A2 (fr) 1998-07-17 1999-07-16 Utilisation odontologique de matieres nanostructurees a base d'apatite

Country Status (5)

Country Link
EP (1) EP1098623A2 (fr)
AU (1) AU5191999A (fr)
CA (1) CA2338021A1 (fr)
IT (1) IT1299563B1 (fr)
WO (1) WO2000003747A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081161B2 (en) 2000-10-16 2006-07-25 University Of South Carolina Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using cement
US7090722B2 (en) 2004-05-17 2006-08-15 3M Innovative Properties Company Acid-reactive dental fillers, compositions, and methods
US7090721B2 (en) 2004-05-17 2006-08-15 3M Innovative Properties Company Use of nanoparticles to adjust refractive index of dental compositions
US7156911B2 (en) 2004-05-17 2007-01-02 3M Innovative Properties Company Dental compositions containing nanofillers and related methods
US7649029B2 (en) 2004-05-17 2010-01-19 3M Innovative Properties Company Dental compositions containing nanozirconia fillers

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19930335A1 (de) * 1999-07-02 2001-01-18 Henkel Kgaa Kompositmaterialien aus Calciumverbindungen und Proteinkomponenten
CN1106861C (zh) 2000-05-19 2003-04-30 清华大学 纳米相钙磷盐/胶原/聚乳酸骨复合多孔材料的制备方法
DE10028975B4 (de) * 2000-06-16 2005-06-30 Henkel Kgaa Zusammensetzungen zur Behandlung von Zahn- und/oder Knochengewebe
DE10063945A1 (de) * 2000-12-20 2002-07-04 Henkel Kgaa Remineralisierende Dental-Klebefolie
US6921544B2 (en) 2001-03-06 2005-07-26 Rutgers, The State University Magnesium-substituted hydroxyapatites
US20040101494A1 (en) 2002-11-26 2004-05-27 Scott Douglas Craig Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth
DE102004025030A1 (de) * 2004-05-18 2005-12-15 S&C Polymer Silicon- und Composite-Spezialitäten GmbH Nano-Apatit-Füllstoffe enthaltende härtbare Restaurationsmaterialien
WO2006083418A2 (fr) 2005-01-04 2006-08-10 Rutgers, The State University Hydroxyapatite de dimensions et de morphologie regulables
DE102005027813A1 (de) * 2005-06-15 2006-12-28 Henkel Kgaa Remineralisierende Mund- und Zahnpflege- und -reinigungsmittel
US8287914B2 (en) 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
CN101489925B (zh) 2006-05-30 2013-07-10 科斯威尔股份有限公司 用碳酸根置换的羟磷灰石的生物活性纳米粒子及其制备方法和包含其的组合物
EP2409677A4 (fr) * 2009-03-19 2013-02-13 Britesmilejapan Co Ltd Matériau de réparation de surface de dents
JP2013508262A (ja) 2009-10-26 2013-03-07 ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー 制御可能なサイズおよび形態を有するハイドロキシアパタイト
WO2012159645A1 (fr) 2011-05-26 2012-11-29 Coswell S.P.A. Produits de soins dentaires comportant des particules de fluor-hydroxyapatite à substitution de carbonate
EP2591825A1 (fr) * 2011-11-08 2013-05-15 PeGoMa B.V. Compositions pour le traitement de dents et utilisation
JP5973585B2 (ja) * 2011-11-08 2016-08-23 コスウェル・エス・ペー・アーＣｏｓｗｅｌｌ Ｓ．Ｐ．Ａ． ラクトフェリン機能化表面を有する生体模倣ヒドロキシアパタイト粒子を含有するデンタルケア製品
GB201202341D0 (en) * 2012-02-10 2012-03-28 Periproducts Ltd Multicomponent oral care compostion
EP2900200A2 (fr) 2012-08-13 2015-08-05 Matthew Scott Spaid Composition de blanchiment dentaire
EP3053570B1 (fr) * 2013-09-30 2018-11-21 Kuraray Noritake Dental Inc. Matériau d'étanchéité de tubule dentinaire de type à un constituant
ITMI20132003A1 (it) 2013-11-29 2015-05-30 Perfetti Van Melle Spa Prodotti di confetteria con calcio fosfato
WO2017178824A1 (fr) * 2016-04-14 2017-10-19 M B Lloyd Limited Formulation dentaire pour le traitement de la sensibilité des dents
RU2627624C1 (ru) * 2016-10-06 2017-08-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) Средство для реминерализации твердых тканей зубов
EP4212478A1 (fr) 2018-12-27 2023-07-19 Shiraishi Kogyo Kaisha, Ltd. Methode de production de particules d'hydroxyapatite
CN116251230B (zh) * 2023-01-30 2024-07-16 重庆大学 一种利用雾化法构建不稳定无定型磷酸钙团簇的仿生矿化牙釉质的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323632A1 (fr) * 1987-12-28 1989-07-12 Asahi Kogaku Kogyo Kabushiki Kaisha Composition pour la fabrication d'un matériau durcissable du type phosphate de calcium et procédé pour la production d'un tel matériau
IT1271874B (it) * 1994-03-07 1997-06-09 Massimo Minozzi Addizionamento di idrossiapatite, ca10(po4)6(oh)2, ultramicronizzata, h.a.u.m., diametro dei microcristalli: o,2 - 1,o micron, range 70% ai vari tipi di cemento canalare per l'otturazione definitiva dei canali radicolari del dente.
EP0786245A1 (fr) * 1996-01-24 1997-07-30 Sangi Co., Ltd. Compositions dentaires contenant de l'hydroxyapatite submicrométrique
WO1997041273A1 (fr) * 1996-04-30 1997-11-06 Flametal S.P.A. Procede de preparation de revetements d'hydroxyapatite
EP0832636A2 (fr) * 1996-09-30 1998-04-01 Degussa Aktiengesellschaft Matériau dentaire polymérisable et utilisation d'une charge d'apatite dans ce matériau dentaire
WO1998016268A2 (fr) * 1996-10-16 1998-04-23 Etex Corporation Procede de preparation de phosphate de calcium peu cristallin et technique d'utilisation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323632A1 (fr) * 1987-12-28 1989-07-12 Asahi Kogaku Kogyo Kabushiki Kaisha Composition pour la fabrication d'un matériau durcissable du type phosphate de calcium et procédé pour la production d'un tel matériau
IT1271874B (it) * 1994-03-07 1997-06-09 Massimo Minozzi Addizionamento di idrossiapatite, ca10(po4)6(oh)2, ultramicronizzata, h.a.u.m., diametro dei microcristalli: o,2 - 1,o micron, range 70% ai vari tipi di cemento canalare per l'otturazione definitiva dei canali radicolari del dente.
EP0786245A1 (fr) * 1996-01-24 1997-07-30 Sangi Co., Ltd. Compositions dentaires contenant de l'hydroxyapatite submicrométrique
WO1997041273A1 (fr) * 1996-04-30 1997-11-06 Flametal S.P.A. Procede de preparation de revetements d'hydroxyapatite
EP0832636A2 (fr) * 1996-09-30 1998-04-01 Degussa Aktiengesellschaft Matériau dentaire polymérisable et utilisation d'une charge d'apatite dans ce matériau dentaire
WO1998016268A2 (fr) * 1996-10-16 1998-04-23 Etex Corporation Procede de preparation de phosphate de calcium peu cristallin et technique d'utilisation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ATSUSHI N ET AL: "Synthesis and sintering behavior of hydroxyapatite by chemical process", COMPENDEX / EIX97353729434, 1997, XP002131868 *
DE GROOT ET AL: "Morphology and composition of nanograde calcium phosphate needle-like crystals formed by simple hydrothermal treatment", JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE, vol. 5, no. 6-7, July 1994 (1994-07-01), London, England, pages 326 - 331, XP002131869 *
WANG R Z ET AL: "Synthesis of nanophase hydroxyapatite/collagen", JOURNAL OF MATERIALS SCIENCE LETTERS, vol. 14, no. 7, 1 April 1995 (1995-04-01), London, England, XP002131870 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081161B2 (en) 2000-10-16 2006-07-25 University Of South Carolina Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using cement
US7527687B2 (en) 2000-10-16 2009-05-05 University Of South Carolina Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement
US7090722B2 (en) 2004-05-17 2006-08-15 3M Innovative Properties Company Acid-reactive dental fillers, compositions, and methods
US7090721B2 (en) 2004-05-17 2006-08-15 3M Innovative Properties Company Use of nanoparticles to adjust refractive index of dental compositions
US7156911B2 (en) 2004-05-17 2007-01-02 3M Innovative Properties Company Dental compositions containing nanofillers and related methods
US7361216B2 (en) 2004-05-17 2008-04-22 3M Innovative Properties Company Dental compositions containing nanofillers and related methods
US7649029B2 (en) 2004-05-17 2010-01-19 3M Innovative Properties Company Dental compositions containing nanozirconia fillers

Also Published As

Publication number Publication date
EP1098623A2 (fr) 2001-05-16
ITRM980476A0 (it) 1998-07-17
CA2338021A1 (fr) 2000-01-27
ITRM980476A1 (it) 2000-01-17
IT1299563B1 (it) 2000-03-16
WO2000003747A2 (fr) 2000-01-27
AU5191999A (en) 2000-02-07

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