WO2000004868A3 - Banques de polyhydroxamates et leurs analogues - Google Patents

Banques de polyhydroxamates et leurs analogues Download PDF

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Publication number
WO2000004868A3
WO2000004868A3 PCT/US1999/016848 US9916848W WO0004868A3 WO 2000004868 A3 WO2000004868 A3 WO 2000004868A3 US 9916848 W US9916848 W US 9916848W WO 0004868 A3 WO0004868 A3 WO 0004868A3
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WO
WIPO (PCT)
Prior art keywords
polyhydroxamate
matrix
analog
polyhydroxamates
bound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/016848
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English (en)
Other versions
WO2000004868A2 (fr
Inventor
Garland R Marshall
Leonard O Rosik
Otto F Schall
Urszula J Slomczynska
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METAPHORE Inc
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METAPHORE Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by METAPHORE Inc filed Critical METAPHORE Inc
Priority to JP2000560861A priority Critical patent/JP2002521319A/ja
Priority to EP99937465A priority patent/EP1098659A4/fr
Priority to AU52295/99A priority patent/AU5229599A/en
Priority to CA002337756A priority patent/CA2337756A1/fr
Publication of WO2000004868A2 publication Critical patent/WO2000004868A2/fr
Publication of WO2000004868A3 publication Critical patent/WO2000004868A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

L'invention concerne un procédé de synthèse de polyhydroxamates voulus et d'analogues de polyhydroxamates. Le procédé consiste à lier un premier composant du polyhydroxamate voulu ou d'un analogue de polyhydroxamate à une matrice de support dans des conditions effectives pour former un premier intermédiaire lié à la matrice de ce polyhydroxamate voulu ou de son analogue; à étendre ce premier intermédiaire lié à la matrice au moyen de réactifs dans des conditions de réaction effectives pour former un ou plusieurs intermédiaires supplémentaires liés à la matrice de ce polyhydroxamate voulu ou de son analogue, ce qui permet de former un précurseur lié à la matrice du polyhydroxamate voulu ou de l'analogue de polyhydroxamate. On retire les groupes protecteurs utilisés lors de la synthèse du précurseur et on enlève de la matrice de support le précurseur lié à la matrice, ce qui permet d'effectuer une synthèse du polyhydroxamate voulu ou de l'analogue de polyhydroxamate. L'invention concerne également des procédés de production, de criblage et de sélection de banques de polyhydroxamates candidats, des banques et des polyhydroxamates d'analogues de polyhydroxamates, de leurs intermédiaires, ainsi que des procédés d'utilisation de ces composés et de leurs compositions.
PCT/US1999/016848 1998-07-23 1999-07-23 Banques de polyhydroxamates et leurs analogues Ceased WO2000004868A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000560861A JP2002521319A (ja) 1998-07-23 1999-07-23 ポリヒドロキサメートおよびそのアナログのライブラリー
EP99937465A EP1098659A4 (fr) 1998-07-23 1999-07-23 Banques de polyhydroxamates et leurs analogues
AU52295/99A AU5229599A (en) 1998-07-23 1999-07-23 Libraries of polyhydroxamates and their analogs
CA002337756A CA2337756A1 (fr) 1998-07-23 1999-07-23 Banques de polyhydroxamates et leurs analogues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9388398P 1998-07-23 1998-07-23
US60/093,883 1998-07-23

Publications (2)

Publication Number Publication Date
WO2000004868A2 WO2000004868A2 (fr) 2000-02-03
WO2000004868A3 true WO2000004868A3 (fr) 2000-05-04

Family

ID=22241527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/016848 Ceased WO2000004868A2 (fr) 1998-07-23 1999-07-23 Banques de polyhydroxamates et leurs analogues

Country Status (5)

Country Link
EP (1) EP1098659A4 (fr)
JP (1) JP2002521319A (fr)
AU (1) AU5229599A (fr)
CA (1) CA2337756A1 (fr)
WO (1) WO2000004868A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916799B2 (en) 1997-11-03 2005-07-12 Duke University Substituted porphyrins
US7470677B2 (en) 1993-10-15 2008-12-30 Aeolus Pharmaceuticals, Inc. Oxidant scavengers
US7485721B2 (en) 2002-06-07 2009-02-03 Duke University Substituted porphyrins

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
AU4338502A (en) * 2000-10-23 2002-06-24 Genetics Inst Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures
EP1439842A4 (fr) 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
US20040236519A1 (en) * 2001-06-08 2004-11-25 Marshall Garland R. Libraries of confomationally constrained peptides, chiral azacrowns, and peptidomimetics and methods of making the same
CN102105146A (zh) 2008-05-23 2011-06-22 国立犹太保健医院 用于治疗与暴露于烷化物质有关的损伤的方法
US9334716B2 (en) 2012-04-12 2016-05-10 Halliburton Energy Services, Inc. Treatment fluids comprising a hydroxypyridinecarboxylic acid and methods for use thereof
EP3131585B1 (fr) * 2014-03-19 2020-07-15 Universität Zürich Agents de chélation bifonctionnels polydentés dans le diagnostic et la thérapie radionucléide
KR102727918B1 (ko) * 2018-04-10 2024-11-11 사노피-아벤티스 도이칠란트 게엠베하 캡핑을 사용한 릭시세나티드 합성
CN110270133A (zh) * 2019-07-30 2019-09-24 深圳市百迈生命科学有限公司 一种基于pe筛板偶联化学基团的整体柱板制备方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987253A (en) * 1988-09-19 1991-01-22 University Of Florida Method for the synthesis of desferrioxamine B and analogs thereof
WO1996026223A1 (fr) * 1995-02-24 1996-08-29 British Biotech Pharmaceuticals Limited Synthese de derives d'acide hydroxamique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322961A (en) * 1992-12-09 1994-06-21 University Of Florida Analogs of desferrioxamine B and method for synthesis thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987253A (en) * 1988-09-19 1991-01-22 University Of Florida Method for the synthesis of desferrioxamine B and analogs thereof
WO1996026223A1 (fr) * 1995-02-24 1996-08-29 British Biotech Pharmaceuticals Limited Synthese de derives d'acide hydroxamique

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BERGERON ET AL.: "Structural Alterations in Desferrioxamine Compatible with Iron Clearance in Animals", J. MED. CHEM.,, vol. 35, no. 25, 1992, pages 4739 - 4744, XP002925124 *
BERGERON ET AL.: "Synthesis and Biological Evaluation of Hydroxamate-Based Iron Chelators", J. MED. CHEM.,, vol. 34, no. 11, 1991, pages 3182 - 3187, XP002925122 *
DIONIS ET AL.: "Synthesis and Analytical Characterization of a Major Desferrioxamine B Metabolite", J. ORG. CHEM.,, vol. 54, no. 23, 1989, pages 5623 - 5627, XP002925123 *
FURKA ET AL.: "General Method for Rapid Synthesis of Multicomponent Mixtures", INT. J. PEPTIDE PROTEIN RES.,, vol. 37, 1991, pages 487 - 493, XP002925121 *
GOLEBIOASKI ET AL.: "Solid Supported Synthesis of Hydroxamic Acids", TET. LETT.,, vol. 39, no. 21, 21 May 1998 (1998-05-21), pages 3397 - 3400, XP002925120 *
GORDON ET AL.: "Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies and Future Directions", J. MED. CHEM.,, vol. 37, no. 10, 13 May 1994 (1994-05-13), pages 1385 - 1401, XP002925118 *
NGU ET AL.: "A New and Efficient Solid Phase Synthesis of Hydroxamic Acids", J. ORG. CHEM.,, vol. 62, no. 21, 17 October 1997 (1997-10-17), pages 7088 - 7089, XP002925119 *
See also references of EP1098659A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470677B2 (en) 1993-10-15 2008-12-30 Aeolus Pharmaceuticals, Inc. Oxidant scavengers
US6916799B2 (en) 1997-11-03 2005-07-12 Duke University Substituted porphyrins
US7485721B2 (en) 2002-06-07 2009-02-03 Duke University Substituted porphyrins

Also Published As

Publication number Publication date
EP1098659A2 (fr) 2001-05-16
WO2000004868A2 (fr) 2000-02-03
CA2337756A1 (fr) 2000-02-03
JP2002521319A (ja) 2002-07-16
EP1098659A4 (fr) 2004-11-24
AU5229599A (en) 2000-02-14

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