WO2000025824A3 - Stabile zubereitungen mit hyperforin - Google Patents

Stabile zubereitungen mit hyperforin Download PDF

Info

Publication number
WO2000025824A3
WO2000025824A3 PCT/DE1999/003485 DE9903485W WO0025824A3 WO 2000025824 A3 WO2000025824 A3 WO 2000025824A3 DE 9903485 W DE9903485 W DE 9903485W WO 0025824 A3 WO0025824 A3 WO 0025824A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyperforin
stable preparations
stabilized
complexing agents
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1999/003485
Other languages
English (en)
French (fr)
Other versions
WO2000025824A2 (de
Inventor
Karl-Heinz Stumpf
Clemens Erdelmeier
Rainer Oschmann
Peter Christian Schmidt
Harald Christian Josef Orth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19903570A external-priority patent/DE19903570A1/de
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Priority to EP99960848A priority Critical patent/EP1126882B1/de
Priority to AU17707/00A priority patent/AU1770700A/en
Priority to DE59915118T priority patent/DE59915118D1/de
Priority to AT99960848T priority patent/ATE453410T1/de
Publication of WO2000025824A2 publication Critical patent/WO2000025824A2/de
Publication of WO2000025824A3 publication Critical patent/WO2000025824A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/86—Use of additives, e.g. for stabilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Beschrieben sind durch Komplexierungsmittel stabilisiertes Hyperforin sowie hyperforinhaltige Extrakte, Konzentrate und Arzneimittel, die mit Komplexierungsmitteln stabilisiert sind.
PCT/DE1999/003485 1998-11-04 1999-11-02 Stabile zubereitungen mit hyperforin Ceased WO2000025824A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99960848A EP1126882B1 (de) 1998-11-04 1999-11-02 Stabile zubereitungen mit hyperforin
AU17707/00A AU1770700A (en) 1998-11-04 1999-11-02 Stable preparations with hyperforin
DE59915118T DE59915118D1 (de) 1998-11-04 1999-11-02 Stabile zubereitungen mit hyperforin
AT99960848T ATE453410T1 (de) 1998-11-04 1999-11-02 Stabile zubereitungen mit hyperforin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19850844.1 1998-11-04
DE19850844 1998-11-04
DE19903570A DE19903570A1 (de) 1998-11-04 1999-01-29 Stabile Zubereitungen mit Hyperforin
DE19903570.9 1999-01-29

Publications (2)

Publication Number Publication Date
WO2000025824A2 WO2000025824A2 (de) 2000-05-11
WO2000025824A3 true WO2000025824A3 (de) 2000-08-03

Family

ID=26049945

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/003485 Ceased WO2000025824A2 (de) 1998-11-04 1999-11-02 Stabile zubereitungen mit hyperforin

Country Status (3)

Country Link
EP (1) EP1126882B1 (de)
AU (1) AU1770700A (de)
WO (1) WO2000025824A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT408835B8 (de) 2000-05-23 2002-07-25 Andreas Dipl Ing Dr Kubin Präparation von hypericin gebunden an polyvinylpyrrolidon (pvp) verschiedenen polymerisations- und vernetzungsgrades
JP2014091681A (ja) * 2012-11-01 2014-05-19 Pixy:Kk 皮膚外用剤及び包接複合体を含む組成物

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0599307A1 (de) * 1992-11-27 1994-06-01 Dr. Willmar Schwabe GmbH & Co. Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
WO1997013489A2 (de) * 1995-09-29 1997-04-17 Dr. Willmar Schwabe Gmbh & Co. Stabiler extrakt aus hypericum perforatum l., verfahren zu seiner herstellung und pharmazeutische zubereitungen
WO1997022354A2 (de) * 1995-12-18 1997-06-26 Dreluso Pharmazeutika Dr. Elten & Sohn Gmbh Anwendung eines medikaments und verwendung eines stoffgemischs zur herstellung eines medikaments
DE19619512C1 (de) * 1995-09-29 1997-07-31 Schwabe Willmar Gmbh & Co Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen
WO1998044936A2 (de) * 1997-04-08 1998-10-15 Dr. Willmar Schwabe Gmbh & Co. Stabiler extrakt aus hypericum perforatum l., verfahren zu seiner herstellung und pharmazeutische zubereitungen
WO1999041220A1 (de) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Stabile hyperforin-salze, verfahren zu ihrer herstellung und verwendung zur therapie der alzheimerschen krankheit
WO1999040905A2 (de) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Verwendung von hyperforin und hyperforinhaltigen extrakten zur behandlung und prophylaxe von demenzerkrankungen
WO1999064388A1 (en) * 1998-06-10 1999-12-16 Indena S.P.A. Hyperforin derivatives, the use thereof and formulations containing them

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0599307A1 (de) * 1992-11-27 1994-06-01 Dr. Willmar Schwabe GmbH & Co. Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
WO1997013489A2 (de) * 1995-09-29 1997-04-17 Dr. Willmar Schwabe Gmbh & Co. Stabiler extrakt aus hypericum perforatum l., verfahren zu seiner herstellung und pharmazeutische zubereitungen
DE19619512C1 (de) * 1995-09-29 1997-07-31 Schwabe Willmar Gmbh & Co Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen
WO1997022354A2 (de) * 1995-12-18 1997-06-26 Dreluso Pharmazeutika Dr. Elten & Sohn Gmbh Anwendung eines medikaments und verwendung eines stoffgemischs zur herstellung eines medikaments
WO1998044936A2 (de) * 1997-04-08 1998-10-15 Dr. Willmar Schwabe Gmbh & Co. Stabiler extrakt aus hypericum perforatum l., verfahren zu seiner herstellung und pharmazeutische zubereitungen
WO1999041220A1 (de) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Stabile hyperforin-salze, verfahren zu ihrer herstellung und verwendung zur therapie der alzheimerschen krankheit
WO1999040905A2 (de) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Verwendung von hyperforin und hyperforinhaltigen extrakten zur behandlung und prophylaxe von demenzerkrankungen
WO1999064388A1 (en) * 1998-06-10 1999-12-16 Indena S.P.A. Hyperforin derivatives, the use thereof and formulations containing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; ORTH H.C.J. ET AL: "Stability and stabilization of hyperforin.", XP002136363, retrieved from STN Database accession no. 2000007643 *
DRUGS MADE IN GERMANY, (1999) 42/4 (110-113). *

Also Published As

Publication number Publication date
EP1126882B1 (de) 2009-12-30
EP1126882A2 (de) 2001-08-29
WO2000025824A2 (de) 2000-05-11
AU1770700A (en) 2000-05-22

Similar Documents

Publication Publication Date Title
MXPA02002086A (es) Composiciones que contienen metal, preparaciones y usos.
AU5296593A (en) Concentrated mouthrinse for efficient delivery of antimicrobials
ZA991489B (en) Oxaliplatin solution formulations and the method of use thereof.
ZA200407868B (en) 17alpha-Alkyl-17beta-oxy-estratrienes, uses thereof and pharmaceutical preparations.
AP9801392A0 (en) Concentrated antibody preparation.
CA2333601A1 (en) Surfactant for use in external preparations for skin and external preparation for skin containing the same
AU2002333373A1 (en) Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
WO2002024613A3 (en) Resorcinol derivatives
HRP20040171A2 (en) Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
WO2001062223A3 (de) Kosmetische zubereitungen enthaltend pflanzenextrakte
WO2001072264A3 (de) Pro-liposomal verkapselte zubereitungen (iv)
WO2003053180A3 (de) Wirkstoffhaltige unterwäsche
EP1066824A3 (de) Reizmittel und anreizende Riechstoffzusammensetzung
DE69932182D1 (de) Präparationen, die virus-ähnliche partikel als immunpotentiatoren enthalten und durch die schleimhaut verabreicht werden.
CA2265791A1 (en) External preparations containing watercress extract
EP0599262A3 (de) Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung.
AU2094200A (en) Cosmetic or medical preparation for topical use
WO2003011241A8 (de) Verwendung von kreatinin und/oder kreatininderivaten in kosmetischen oder dermatologischen zubereitungen
WO1999021574A3 (en) Enhancement of morphogen activity
CA2402708A1 (en) Torasemide-containing pharmaceutical preparations
MD970269A (en) Clavulanates
WO1998031712A3 (en) Chitosan-conjugates with acidic chelate-complex forming agents
ZA966616B (en) Benzenesulphonamide derivatives, their preparation and their application in theraphy.
EP1018336A4 (de) Karzinostatika
WO2001030372A3 (de) Zubereitungen pharmazeutischer wirkstoffe

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref country code: AU

Ref document number: 2000 17707

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DK DM EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DK DM EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1999960848

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09830971

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999960848

Country of ref document: EP