WO2000032152A3 - Compositions and methods for regulating bacterial pathogenesis - Google Patents

Compositions and methods for regulating bacterial pathogenesis Download PDF

Info

Publication number
WO2000032152A3
WO2000032152A3 PCT/US1999/028751 US9928751W WO0032152A3 WO 2000032152 A3 WO2000032152 A3 WO 2000032152A3 US 9928751 W US9928751 W US 9928751W WO 0032152 A3 WO0032152 A3 WO 0032152A3
Authority
WO
WIPO (PCT)
Prior art keywords
signaling molecule
compositions
methods
bacterial
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/028751
Other languages
French (fr)
Other versions
WO2000032152A2 (en
Inventor
Bonnie Bassler
Michael G Surette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Priority to EP99963011A priority Critical patent/EP1135144A4/en
Priority to KR1020017006954A priority patent/KR20010093800A/en
Priority to AU19338/00A priority patent/AU1933800A/en
Priority to JP2000584850A priority patent/JP2003526327A/en
Priority to CA002351731A priority patent/CA2351731A1/en
Publication of WO2000032152A2 publication Critical patent/WO2000032152A2/en
Anticipated expiration legal-status Critical
Publication of WO2000032152A3 publication Critical patent/WO2000032152A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
PCT/US1999/028751 1998-12-02 1999-12-02 Compositions and methods for regulating bacterial pathogenesis Ceased WO2000032152A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99963011A EP1135144A4 (en) 1998-12-02 1999-12-02 COMPOSITIONS AND METHODS FOR REGULATING BACTERIAL PATHOGENESIS
KR1020017006954A KR20010093800A (en) 1998-12-02 1999-12-02 Compositions and Methods for Regulating Bacterial Pathogenesis
AU19338/00A AU1933800A (en) 1998-12-02 1999-12-02 Compositions and methods for regulating bacterial pathogenesis
JP2000584850A JP2003526327A (en) 1998-12-02 1999-12-02 Compositions and methods for modulating bacterial disease development
CA002351731A CA2351731A1 (en) 1998-12-02 1999-12-02 Compositions and methods for regulating bacterial pathogenesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11057098P 1998-12-02 1998-12-02
US60/110,570 1998-12-02

Publications (2)

Publication Number Publication Date
WO2000032152A2 WO2000032152A2 (en) 2000-06-08
WO2000032152A3 true WO2000032152A3 (en) 2002-12-12

Family

ID=22333745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028751 Ceased WO2000032152A2 (en) 1998-12-02 1999-12-02 Compositions and methods for regulating bacterial pathogenesis

Country Status (6)

Country Link
EP (1) EP1135144A4 (en)
JP (1) JP2003526327A (en)
KR (1) KR20010093800A (en)
AU (1) AU1933800A (en)
CA (1) CA2351731A1 (en)
WO (1) WO2000032152A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405050B2 (en) 2004-04-12 2008-07-29 The Trustees Of Princeton University Small RNAs and bacterial strains involved in quorum sensing
US7547726B2 (en) 2004-04-12 2009-06-16 The Trustees Of Princeton University AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7326542B2 (en) * 1998-12-02 2008-02-05 Princeton University Compositions and methods for regulating bacterial pathogenesis
AU2001259734A1 (en) 2000-05-10 2001-11-20 Princeton University Compounds and methods for regulating bacterial growth and pathogenesis
US6416785B1 (en) 2000-08-23 2002-07-09 Biolitec Ag Molecular probes for targeting of cell density-indicating compounds
WO2002088298A1 (en) * 2001-04-27 2002-11-07 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
CA2443287A1 (en) * 2001-05-21 2002-11-28 Quorex Pharmaceuticals, Inc. Methods for regulating bacteria
CA2455504A1 (en) * 2001-08-24 2003-03-06 Quorex Pharmaceuticals, Inc. Anti-bacterial agents based upon oxoanion binding
US7208612B2 (en) 2001-08-24 2007-04-24 Princeton University Crystals of LuxP and complexes thereof
WO2005072274A2 (en) * 2004-01-23 2005-08-11 The Trustees Of Princeton University Autoinducer-2 compounds as immunomodulatory agents
ATE470499T1 (en) 2004-09-01 2010-06-15 Hatch Ltd COMPOSITE BLOWING TUBE
GB0620715D0 (en) 2006-10-18 2006-11-29 Univ Durham Ethanol production
US8846327B2 (en) 2007-10-17 2014-09-30 Kao Corporation Method of quantifying autoinducer-2
KR101222907B1 (en) 2010-09-08 2013-01-16 고려대학교 산학협력단 DNA chip using random genomic DNA fragments of Yersinia enterocolitica
CN106434843A (en) * 2016-10-27 2017-02-22 江南大学 Culture medium for selectively separating and culturing group B streptococci and preparation method thereof
TWI775313B (en) 2020-02-18 2022-08-21 美商基利科學股份有限公司 Antiviral compounds
TWI794742B (en) 2020-02-18 2023-03-01 美商基利科學股份有限公司 Antiviral compounds
AU2021224588B2 (en) 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
EP4323362B1 (en) 2021-04-16 2025-05-07 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
AU2022328698B2 (en) 2021-08-18 2025-02-20 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
CN115820605A (en) * 2022-10-12 2023-03-21 河南师范大学 A method for synthesizing quorum sensing signal molecule AI-2 in vitro
CN117305155B (en) * 2023-08-28 2024-07-05 江苏省家禽科学研究所 Method for inhibiting salmonella virulence factors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593827A (en) * 1991-04-18 1997-01-14 The University Of Nottingham Autoinducer
US5612184A (en) * 1991-07-30 1997-03-18 Bio-Technical Resources L.P. Device for detecting mercury in water
US5658748A (en) * 1993-08-18 1997-08-19 Valio Oy Streptococcus thermophilus strains and their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593827A (en) * 1991-04-18 1997-01-14 The University Of Nottingham Autoinducer
US5612184A (en) * 1991-07-30 1997-03-18 Bio-Technical Resources L.P. Device for detecting mercury in water
US5658748A (en) * 1993-08-18 1997-08-19 Valio Oy Streptococcus thermophilus strains and their use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BASSLER ET AL.: "Multiple Signalling Systems Controlling Expression of Luminescence In Vibrio Harveyi; Sequence and Function of Genes Encoding A Second Sensory Pathway", MOLECULAR MICROBIOLOGY., vol. 13, no. 2, 1994, pages 273 - 286, XP002913784 *
EBERHARD ET AL.: "Structural Identification of Autoinducer of Photobacterium Fisheri Luciferase", BIOCHEMISTRY., vol. 20, no. 9, 1981, pages 2444 - 2449, XP002923426 *
MANCINI ET AL.: "Cloning and Expression of the Photobacterium Phosphoreum Luminescence System Demonstrates a Unique Lux Gene Organization", J. OF BIOLOGICAL CHEMISTRY., vol. 263, no. 28, 5 October 1998 (1998-10-05), pages 14308 - 14314, XP002923427 *
MARTIN ET AL.: "Identification of a Locus Controlling Expression of Luminescence Genes In Vibrio Harveyi", J. OF BACTERIOLOGY., vol. 171, no. 5, May 1989 (1989-05-01), pages 2406 - 2414, XP002923428 *
See also references of EP1135144A4 *
SHOWALTER ET AL.: "Cloning and Nucleotide Sequence of luxR, a Regulatory Gene Controlling Bioluminescence In Vibrio Harveyi", JOURNAL OF BACTERIOLOGY., vol. 172, no. 6, June 1990 (1990-06-01), pages 2946 - 2954, XP002923429 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405050B2 (en) 2004-04-12 2008-07-29 The Trustees Of Princeton University Small RNAs and bacterial strains involved in quorum sensing
US7547726B2 (en) 2004-04-12 2009-06-16 The Trustees Of Princeton University AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure

Also Published As

Publication number Publication date
AU1933800A (en) 2000-06-19
JP2003526327A (en) 2003-09-09
CA2351731A1 (en) 2000-06-08
KR20010093800A (en) 2001-10-29
EP1135144A4 (en) 2005-07-20
EP1135144A1 (en) 2001-09-26
WO2000032152A2 (en) 2000-06-08

Similar Documents

Publication Publication Date Title
WO2000032152A3 (en) Compositions and methods for regulating bacterial pathogenesis
MXPA04000622A (en) Pyrazolylcarboxanilides as fungicides.
BR0307432B1 (en) difluoromethylthiazolylcarboxanilides
MX9801531A (en) Novel phosphino derivatives.
ATE451022T1 (en) DRINK COMPOSITIONS CONTAINING ARABINOGALACTAN AND MINERAL ADDITIVES
MY147478A (en) Microbiologically stabilised beer
TNSN97098A1 (en) EXTRACTION OF ANTIOXIDANTS
DK1328577T3 (en) Process and compositions
WO2004101826A3 (en) Methods to identify compounds that modulate the autoinducer-2 dependent quorum sensing system in vibrio harveyi
EA202192916A1 (en) STRAIN METHYLOBACTERIUM SP. NOV., COMPOSITIONS CONTAINING IT AND THEIR USE AS A BIOSTIMULANT AND ENDOPHYTIC NITROGEN-FIXING BACTERIA
DE69905715D1 (en) METHOD AND COMPOSITIONS FOR IMPROVING THE AEROBIC STABILITY OF SILAGE
DE69938240D1 (en) NEW G-PROTEIN-COUPLED RECEPTOR
FR2861731B1 (en) NOVEL PHOSPHATE FIXATION PROTEIN, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USES THEREOF
EA200600778A1 (en) 1,3-DIMETHYLBUTYLKARBOXANILES TO COMBAT AGAINST UNDESIRABLE MICROORANISMS
PL373377A1 (en) Furancarboxamides
CA2425984A1 (en) 2-pyrimidinyloxy-n-aryl-benzylamine derivatives, their preparation processes and uses
PL346143A1 (en) Tan-1057 derivatives
DE50213015D1 (en) LIPASE VARIANTS
WO2006128089A3 (en) Compositions and methods for treating tissue
WO2020065097A3 (en) Vanilla composition
BR0016100B1 (en) drinking water enhancing agent.
PL373468A1 (en) Oxathiincarboxamides
UA83662C2 (en) Process fot the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives thereof
TW200504036A (en) Novel lactams and uses thereof
MXPA05012743A (en) Improved cleaning composition.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2351731

Country of ref document: CA

Ref country code: CA

Ref document number: 2351731

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/005448

Country of ref document: MX

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 584850

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1020017006954

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 19338/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1999963011

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 512709

Country of ref document: NZ

WWP Wipo information: published in national office

Ref document number: 1999963011

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1020017006954

Country of ref document: KR

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWW Wipo information: withdrawn in national office

Ref document number: 1020017006954

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1999963011

Country of ref document: EP