WO2000032152A3 - Compositions et methodes de regulation de la pathogenese bacterienne - Google Patents

Compositions et methodes de regulation de la pathogenese bacterienne Download PDF

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Publication number
WO2000032152A3
WO2000032152A3 PCT/US1999/028751 US9928751W WO0032152A3 WO 2000032152 A3 WO2000032152 A3 WO 2000032152A3 US 9928751 W US9928751 W US 9928751W WO 0032152 A3 WO0032152 A3 WO 0032152A3
Authority
WO
WIPO (PCT)
Prior art keywords
signaling molecule
compositions
methods
bacterial
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/028751
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English (en)
Other versions
WO2000032152A2 (fr
Inventor
Bonnie Bassler
Michael G Surette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Priority to EP99963011A priority Critical patent/EP1135144A4/fr
Priority to KR1020017006954A priority patent/KR20010093800A/ko
Priority to AU19338/00A priority patent/AU1933800A/en
Priority to JP2000584850A priority patent/JP2003526327A/ja
Priority to CA002351731A priority patent/CA2351731A1/fr
Publication of WO2000032152A2 publication Critical patent/WO2000032152A2/fr
Anticipated expiration legal-status Critical
Publication of WO2000032152A3 publication Critical patent/WO2000032152A3/fr
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention concerne une molécule de signalisation, purifiée, extracellulaire, d'origine bactérienne, appelée autoinducteur 2 dont la production est régulée par des modifications environnementales accompagnant le passage d'une existence libre à une existence colonisatrice ou pathogène dans un organisme hôte. La molécule de signalisation stimule des gènes de luminescence LuxQ et, apparemment, divers gènes en rapport avec la pathogenèse dans l'espèce bactérienne qui produit ladite molécule. Cette invention concerne également une nouvelle classe de gènes bactériens intervenant dans la biosynthèse de la molécule de signalisation.
PCT/US1999/028751 1998-12-02 1999-12-02 Compositions et methodes de regulation de la pathogenese bacterienne Ceased WO2000032152A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99963011A EP1135144A4 (fr) 1998-12-02 1999-12-02 Compositions et methodes de regulation de la pathogenese bacterienne
KR1020017006954A KR20010093800A (ko) 1998-12-02 1999-12-02 세균의 병원성을 조절하는 조성물 및 방법
AU19338/00A AU1933800A (en) 1998-12-02 1999-12-02 Compositions and methods for regulating bacterial pathogenesis
JP2000584850A JP2003526327A (ja) 1998-12-02 1999-12-02 細菌性疾患発症を調節する組成物および方法
CA002351731A CA2351731A1 (fr) 1998-12-02 1999-12-02 Compositions et methodes de regulation de la pathogenese bacterienne

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11057098P 1998-12-02 1998-12-02
US60/110,570 1998-12-02

Publications (2)

Publication Number Publication Date
WO2000032152A2 WO2000032152A2 (fr) 2000-06-08
WO2000032152A3 true WO2000032152A3 (fr) 2002-12-12

Family

ID=22333745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028751 Ceased WO2000032152A2 (fr) 1998-12-02 1999-12-02 Compositions et methodes de regulation de la pathogenese bacterienne

Country Status (6)

Country Link
EP (1) EP1135144A4 (fr)
JP (1) JP2003526327A (fr)
KR (1) KR20010093800A (fr)
AU (1) AU1933800A (fr)
CA (1) CA2351731A1 (fr)
WO (1) WO2000032152A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405050B2 (en) 2004-04-12 2008-07-29 The Trustees Of Princeton University Small RNAs and bacterial strains involved in quorum sensing
US7547726B2 (en) 2004-04-12 2009-06-16 The Trustees Of Princeton University AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7326542B2 (en) * 1998-12-02 2008-02-05 Princeton University Compositions and methods for regulating bacterial pathogenesis
AU2001259734A1 (en) 2000-05-10 2001-11-20 Princeton University Compounds and methods for regulating bacterial growth and pathogenesis
US6416785B1 (en) 2000-08-23 2002-07-09 Biolitec Ag Molecular probes for targeting of cell density-indicating compounds
WO2002088298A1 (fr) * 2001-04-27 2002-11-07 The Procter & Gamble Company Composes, compositions et procedes permettant de reguler des films biologiques
CA2443287A1 (fr) * 2001-05-21 2002-11-28 Quorex Pharmaceuticals, Inc. Methodes de regulation des bacteries
CA2455504A1 (fr) * 2001-08-24 2003-03-06 Quorex Pharmaceuticals, Inc. Agents antibacteriens bases sur une liaison toxoanion
US7208612B2 (en) 2001-08-24 2007-04-24 Princeton University Crystals of LuxP and complexes thereof
WO2005072274A2 (fr) * 2004-01-23 2005-08-11 The Trustees Of Princeton University Composes autoinducteurs-2 utilises comme agents immunomodulateurs
ATE470499T1 (de) 2004-09-01 2010-06-15 Hatch Ltd Verbundeinblasrohr
GB0620715D0 (en) 2006-10-18 2006-11-29 Univ Durham Ethanol production
US8846327B2 (en) 2007-10-17 2014-09-30 Kao Corporation Method of quantifying autoinducer-2
KR101222907B1 (ko) 2010-09-08 2013-01-16 고려대학교 산학협력단 여시니아 엔테로콜리티카 랜덤 지노믹 ｄｎａ 단편을 이용한 유전자 칩
CN106434843A (zh) * 2016-10-27 2017-02-22 江南大学 一种选择性分离培养b群链球菌的培养基及其制备方法
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
AU2021224588B2 (en) 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
EP4323362B1 (fr) 2021-04-16 2025-05-07 Gilead Sciences, Inc. Procédés de préparation de carbanucléosides à l'aide d'amides
AU2022328698B2 (en) 2021-08-18 2025-02-20 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
CN115820605A (zh) * 2022-10-12 2023-03-21 河南师范大学 一种体外合成群体感应信号分子ai-2的方法
CN117305155B (zh) * 2023-08-28 2024-07-05 江苏省家禽科学研究所 一种抑制沙门氏菌毒力因子的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593827A (en) * 1991-04-18 1997-01-14 The University Of Nottingham Autoinducer
US5612184A (en) * 1991-07-30 1997-03-18 Bio-Technical Resources L.P. Device for detecting mercury in water
US5658748A (en) * 1993-08-18 1997-08-19 Valio Oy Streptococcus thermophilus strains and their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593827A (en) * 1991-04-18 1997-01-14 The University Of Nottingham Autoinducer
US5612184A (en) * 1991-07-30 1997-03-18 Bio-Technical Resources L.P. Device for detecting mercury in water
US5658748A (en) * 1993-08-18 1997-08-19 Valio Oy Streptococcus thermophilus strains and their use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BASSLER ET AL.: "Multiple Signalling Systems Controlling Expression of Luminescence In Vibrio Harveyi; Sequence and Function of Genes Encoding A Second Sensory Pathway", MOLECULAR MICROBIOLOGY., vol. 13, no. 2, 1994, pages 273 - 286, XP002913784 *
EBERHARD ET AL.: "Structural Identification of Autoinducer of Photobacterium Fisheri Luciferase", BIOCHEMISTRY., vol. 20, no. 9, 1981, pages 2444 - 2449, XP002923426 *
MANCINI ET AL.: "Cloning and Expression of the Photobacterium Phosphoreum Luminescence System Demonstrates a Unique Lux Gene Organization", J. OF BIOLOGICAL CHEMISTRY., vol. 263, no. 28, 5 October 1998 (1998-10-05), pages 14308 - 14314, XP002923427 *
MARTIN ET AL.: "Identification of a Locus Controlling Expression of Luminescence Genes In Vibrio Harveyi", J. OF BACTERIOLOGY., vol. 171, no. 5, May 1989 (1989-05-01), pages 2406 - 2414, XP002923428 *
See also references of EP1135144A4 *
SHOWALTER ET AL.: "Cloning and Nucleotide Sequence of luxR, a Regulatory Gene Controlling Bioluminescence In Vibrio Harveyi", JOURNAL OF BACTERIOLOGY., vol. 172, no. 6, June 1990 (1990-06-01), pages 2946 - 2954, XP002923429 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405050B2 (en) 2004-04-12 2008-07-29 The Trustees Of Princeton University Small RNAs and bacterial strains involved in quorum sensing
US7547726B2 (en) 2004-04-12 2009-06-16 The Trustees Of Princeton University AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure

Also Published As

Publication number Publication date
AU1933800A (en) 2000-06-19
JP2003526327A (ja) 2003-09-09
CA2351731A1 (fr) 2000-06-08
KR20010093800A (ko) 2001-10-29
EP1135144A4 (fr) 2005-07-20
EP1135144A1 (fr) 2001-09-26
WO2000032152A2 (fr) 2000-06-08

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