WO2000052013A2 - Composes thiazolo-indolinoniques - Google Patents

Composes thiazolo-indolinoniques Download PDF

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Publication number
WO2000052013A2
WO2000052013A2 PCT/US2000/005192 US0005192W WO0052013A2 WO 2000052013 A2 WO2000052013 A2 WO 2000052013A2 US 0005192 W US0005192 W US 0005192W WO 0052013 A2 WO0052013 A2 WO 0052013A2
Authority
WO
WIPO (PCT)
Prior art keywords
compound
thiazolindolinone
methyl
indol
thiazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/005192
Other languages
English (en)
Other versions
WO2000052013A3 (fr
Inventor
Ambrish Vyas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US09/914,420 priority Critical patent/US6492398B1/en
Priority to JP2000602239A priority patent/JP2003532620A/ja
Priority to BR0008677-0A priority patent/BR0008677A/pt
Priority to CA002361580A priority patent/CA2361580A1/fr
Priority to EP00914762A priority patent/EP1159280A2/fr
Priority to MXPA01008910A priority patent/MXPA01008910A/es
Priority to KR1020017011094A priority patent/KR20020005606A/ko
Priority to HK02103309.8A priority patent/HK1041692A1/zh
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to IL14480800A priority patent/IL144808A0/xx
Priority to AU36110/00A priority patent/AU3611000A/en
Publication of WO2000052013A2 publication Critical patent/WO2000052013A2/fr
Publication of WO2000052013A3 publication Critical patent/WO2000052013A3/fr
Priority to NO20014262A priority patent/NO20014262L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Definitions

  • the invention also relates in another aspect to methods for preparing various forms of such thiazolindolinone compound.
  • the present invention provides a thiazolindolinone compound having various forms that are useful as cyclin dependent kinase inhibitors.
  • Useful formulations may include the active ingredient and excipients, diluents, or carriers, formed into tablets, capsules, sprays, mouthwashes, lozenges, troches, pastilles, lollipops, suspensions, powders and the like, for application to the mucosa of the oral cavity.
  • Acceptable daily dosages of the CDK2 inhibitor for preventing/reducing the severity of epithtelial cytotoxicity side effects induced by chemotherapy and/or radiation therapy may be from about 0.1 to about 1000 mg/day, and preferably from about 50 to about 200 mg/day.

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne des composés thiazolo-indoliques convenant comme inhibiteurs de la kinase dépendante des cyclines de type II. Ces composés permettent de prévenir ou de réduire la gravité des effets secondaires de cytotoxicité épithéliale (alopécie, syndrome plantaire-palmaire, inflammation de muqueuse, etc.) induits par une chimiothérapie et/ou une radiothérapie chez patient suivant un tel traitement.
PCT/US2000/005192 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques Ceased WO2000052013A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1020017011094A KR20020005606A (ko) 1999-03-04 2000-03-01 티아졸로인돌리논 화합물
BR0008677-0A BR0008677A (pt) 1999-03-04 2000-03-01 Composto de tiazolindolinona, composição farmacêutica, e, métodos papa preparar um composto de tiazolindolinona, e de prevenção/reduçao da severidade dos efeitos colaterais de citotoxicidade epitelial da quimioterapia e/ou terapia de radiação
CA002361580A CA2361580A1 (fr) 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques
EP00914762A EP1159280A2 (fr) 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques
MXPA01008910A MXPA01008910A (es) 1999-03-04 2000-03-01 Compuestos de tiazoloindolinona.
HK02103309.8A HK1041692A1 (zh) 1999-03-04 2000-03-01 噻唑並吲滿酮化合物
IL14480800A IL144808A0 (en) 1999-03-04 2000-03-01 Thiazoloindolinone compounds
US09/914,420 US6492398B1 (en) 1999-03-04 2000-03-01 Thiazoloindolinone compounds
JP2000602239A JP2003532620A (ja) 1999-03-04 2000-03-01 チアゾロインドリノン化合物
AU36110/00A AU3611000A (en) 1999-03-04 2000-03-01 Thiazoloindolinone compounds
NO20014262A NO20014262L (no) 1999-03-04 2001-09-03 Tiazoloindolinon-forbindelser

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9904930.6 1999-03-04
GBGB9904930.6A GB9904930D0 (en) 1999-03-04 1999-03-04 Thiazoloindolinone compounds

Publications (2)

Publication Number Publication Date
WO2000052013A2 true WO2000052013A2 (fr) 2000-09-08
WO2000052013A3 WO2000052013A3 (fr) 2000-12-28

Family

ID=10848912

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005192 Ceased WO2000052013A2 (fr) 1999-03-04 2000-03-01 Composes thiazolo-indolinoniques

Country Status (18)

Country Link
EP (1) EP1159280A2 (fr)
JP (1) JP2003532620A (fr)
KR (1) KR20020005606A (fr)
CN (1) CN1355807A (fr)
AU (1) AU3611000A (fr)
BR (1) BR0008677A (fr)
CA (1) CA2361580A1 (fr)
CZ (1) CZ20013187A3 (fr)
GB (1) GB9904930D0 (fr)
HK (1) HK1041692A1 (fr)
HU (1) HUP0200376A3 (fr)
IL (1) IL144808A0 (fr)
MX (1) MXPA01008910A (fr)
NO (1) NO20014262L (fr)
PL (1) PL351476A1 (fr)
TR (1) TR200102557T2 (fr)
WO (1) WO2000052013A2 (fr)
ZA (1) ZA200106826B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369086B1 (en) * 1997-09-05 2002-04-09 Smithkline Beecham Corporation Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors
RU2362556C2 (ru) * 2007-03-13 2009-07-27 Российская военно-медицинская академия им. С.М. Кирова ПРИМЕНЕНИЕ ГИДРОБРОМИДА 2-АМИНО-4-АЦЕТИЛТИАЗОЛО[5,4-b]ИНДОЛА ДЛЯ ПОВЫШЕНИЯ РАБОТОСПОСОБНОСТИ
RU2420282C2 (ru) * 2009-03-23 2011-06-10 Федеральное государственное образовательное учреждение высшего профессионального образования Военно-медицинская академия им. С.М. Кирова МОРФ Средство, защищающее от травматического токсикоза
WO2011125763A1 (fr) 2010-03-31 2011-10-13 小野薬品工業株式会社 Agent préventif et/ou remède pour le syndrome d'enflure douloureuse des mains et des pieds
US10583111B2 (en) 2017-12-13 2020-03-10 Onquality Pharmaceuticals China Ltd. Method for preventing or treating diseases associated with the inhibition of EGFR
US10987336B2 (en) 2018-04-16 2021-04-27 Onquality Pharmaceuticals China Ltd. Method of preventing or treating side effect of tumor therapy

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2584430A1 (fr) * 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Procede de preparation du pimecrolimus
UA103319C2 (en) * 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
JP4761000B1 (ja) * 2010-11-08 2011-08-31 小野薬品工業株式会社 手足症候群の予防および／または治療剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002511852A (ja) * 1997-05-07 2002-04-16 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての２−インドリノン誘導体
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369086B1 (en) * 1997-09-05 2002-04-09 Smithkline Beecham Corporation Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors
RU2362556C2 (ru) * 2007-03-13 2009-07-27 Российская военно-медицинская академия им. С.М. Кирова ПРИМЕНЕНИЕ ГИДРОБРОМИДА 2-АМИНО-4-АЦЕТИЛТИАЗОЛО[5,4-b]ИНДОЛА ДЛЯ ПОВЫШЕНИЯ РАБОТОСПОСОБНОСТИ
RU2420282C2 (ru) * 2009-03-23 2011-06-10 Федеральное государственное образовательное учреждение высшего профессионального образования Военно-медицинская академия им. С.М. Кирова МОРФ Средство, защищающее от травматического токсикоза
WO2011125763A1 (fr) 2010-03-31 2011-10-13 小野薬品工業株式会社 Agent préventif et/ou remède pour le syndrome d'enflure douloureuse des mains et des pieds
US8729056B2 (en) 2010-03-31 2014-05-20 Ono Pharmaceutical Co., Ltd. Preventive and/or therapeutic agent of hand-foot syndrome
US10583111B2 (en) 2017-12-13 2020-03-10 Onquality Pharmaceuticals China Ltd. Method for preventing or treating diseases associated with the inhibition of EGFR
US10987336B2 (en) 2018-04-16 2021-04-27 Onquality Pharmaceuticals China Ltd. Method of preventing or treating side effect of tumor therapy

Also Published As

Publication number Publication date
HUP0200376A2 (en) 2002-06-29
EP1159280A2 (fr) 2001-12-05
BR0008677A (pt) 2002-01-08
CN1355807A (zh) 2002-06-26
CA2361580A1 (fr) 2000-09-08
CZ20013187A3 (cs) 2002-02-13
NO20014262L (no) 2001-10-30
GB9904930D0 (en) 1999-04-28
NO20014262D0 (no) 2001-09-03
PL351476A1 (en) 2003-04-22
AU3611000A (en) 2000-09-21
TR200102557T2 (tr) 2007-01-22
ZA200106826B (en) 2003-02-25
MXPA01008910A (es) 2002-03-27
HUP0200376A3 (en) 2003-07-28
WO2000052013A3 (fr) 2000-12-28
IL144808A0 (en) 2002-06-30
HK1041692A1 (zh) 2002-07-19
KR20020005606A (ko) 2002-01-17
JP2003532620A (ja) 2003-11-05

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