WO2000053749A3 - Vascular adhesion molecules and modulation of their function - Google Patents

Vascular adhesion molecules and modulation of their function Download PDF

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Publication number
WO2000053749A3
WO2000053749A3 PCT/EP2000/002219 EP0002219W WO0053749A3 WO 2000053749 A3 WO2000053749 A3 WO 2000053749A3 EP 0002219 W EP0002219 W EP 0002219W WO 0053749 A3 WO0053749 A3 WO 0053749A3
Authority
WO
WIPO (PCT)
Prior art keywords
adhesion molecules
modulation
function
vascular adhesion
cram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/002219
Other languages
French (fr)
Other versions
WO2000053749A2 (en
Inventor
Beat Albert Imhof
Michel Aurrand-Lions
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RMF Dictagene SA
Original Assignee
RMF Dictagene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0200606A priority Critical patent/HU229376B1/en
Priority to DE60045681T priority patent/DE60045681D1/en
Priority to AU41051/00A priority patent/AU782139B2/en
Priority to CA2362896A priority patent/CA2362896C/en
Priority to BR0008915-0A priority patent/BR0008915A/en
Priority to AT00920497T priority patent/ATE500328T1/en
Priority to IL14531000A priority patent/IL145310A0/en
Priority to JP2000603370A priority patent/JP4836329B2/en
Priority to EP00920497A priority patent/EP1163337B1/en
Priority to EEP200100472A priority patent/EE05497B1/en
Priority to MXPA01009110A priority patent/MXPA01009110A/en
Priority to NZ514091A priority patent/NZ514091A/en
Application filed by RMF Dictagene SA filed Critical RMF Dictagene SA
Priority to HK02104558.4A priority patent/HK1044169B/en
Publication of WO2000053749A2 publication Critical patent/WO2000053749A2/en
Publication of WO2000053749A3 publication Critical patent/WO2000053749A3/en
Priority to IS6072A priority patent/IS2819B/en
Priority to NO20014417A priority patent/NO333085B1/en
Anticipated expiration legal-status Critical
Priority to AU2005202246A priority patent/AU2005202246B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention relates to new polypeptide in isolated form belonging to a subfamily of the human Immunoglobulin Superfamily, which polypeptide shows at least 70 % sequence homology with the amino acid sequence of the murine Confluency Regulated Adhesion Molecules 1 or 2 (CRAM-1 or CRAM-2) as depicted in the Figure upper and second row, respectively, and antibodies thereto as well as their use in treatment of inflammation and tumors.
PCT/EP2000/002219 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function Ceased WO2000053749A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
MXPA01009110A MXPA01009110A (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function.
AU41051/00A AU782139B2 (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function
CA2362896A CA2362896C (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function
BR0008915-0A BR0008915A (en) 1999-03-11 2000-03-13 Polypeptide in isolated form, antibodies, soluble polypeptide, poly- or oligonucleotide, and process for the specific identification of differently expressed DNA sequences
AT00920497T ATE500328T1 (en) 1999-03-11 2000-03-13 VASCULAR ADHESION MOLECULES AND MODULATION OF THEIR FUNCTION
IL14531000A IL145310A0 (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function
JP2000603370A JP4836329B2 (en) 1999-03-11 2000-03-13 Regulation of vascular adhesion molecules and their functions
EP00920497A EP1163337B1 (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function
EEP200100472A EE05497B1 (en) 1999-03-11 2000-03-13 A polypeptide, a soluble CRAM-1 polypeptide, a polynucleotide, and an antibody
HU0200606A HU229376B1 (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function
DE60045681T DE60045681D1 (en) 1999-03-11 2000-03-13 VASCULAR ADHESION MOLECULES AND MODULATION OF THEIR FUNCTION
NZ514091A NZ514091A (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function
HK02104558.4A HK1044169B (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function
IS6072A IS2819B (en) 1999-03-11 2001-09-10 Vascular adhesion molecules and formulation of their activity @
NO20014417A NO333085B1 (en) 1999-03-11 2001-09-11 Soluble CRAM-1 polypeptide antibody directed against CRAM-1 which modulates transendothelial migration of leukocytes, as well as its use for the preparation of drugs for inhibiting angiogenesis in tumors.
AU2005202246A AU2005202246B2 (en) 1999-03-11 2005-05-24 Vascular adhesion molecules and modulation of their function

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99200746 1999-03-11
EP99200746.8 1999-03-11

Publications (2)

Publication Number Publication Date
WO2000053749A2 WO2000053749A2 (en) 2000-09-14
WO2000053749A3 true WO2000053749A3 (en) 2000-12-14

Family

ID=8239973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/002219 Ceased WO2000053749A2 (en) 1999-03-11 2000-03-13 Vascular adhesion molecules and modulation of their function

Country Status (22)

Country Link
US (3) US7393651B2 (en)
EP (2) EP2292761A1 (en)
JP (2) JP4836329B2 (en)
CN (2) CN100469878C (en)
AT (1) ATE500328T1 (en)
AU (1) AU782139B2 (en)
BR (1) BR0008915A (en)
CA (1) CA2362896C (en)
CZ (1) CZ303128B6 (en)
DE (1) DE60045681D1 (en)
EE (1) EE05497B1 (en)
ES (1) ES2361905T3 (en)
HU (1) HU229376B1 (en)
IL (1) IL145310A0 (en)
IS (1) IS2819B (en)
MX (1) MXPA01009110A (en)
NO (1) NO333085B1 (en)
NZ (1) NZ514091A (en)
PL (1) PL207994B1 (en)
RU (1) RU2244748C2 (en)
WO (1) WO2000053749A2 (en)
ZA (1) ZA200107283B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8088386B2 (en) 1998-03-20 2012-01-03 Genentech, Inc. Treatment of complement-associated disorders
US8007798B2 (en) 1997-11-21 2011-08-30 Genentech, Inc. Treatment of complement-associated disorders
JP4836329B2 (en) * 1999-03-11 2011-12-14 メルク セローノ エス．エイ． Regulation of vascular adhesion molecules and their functions
GB0100750D0 (en) * 2001-01-11 2001-02-21 Inpharmatica Ltd Novel proteins
WO2003006673A2 (en) * 2001-07-11 2003-01-23 Texas Biotechnology Corporation A nucleic acid encoding a human junctional adhesion protein (jam3)
US7642341B2 (en) 2003-12-18 2010-01-05 Merck Serono S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
EP1533617A1 (en) * 2003-11-19 2005-05-25 RMF Dictagene S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer
SG10201804008UA (en) 2005-11-04 2018-06-28 Genentech Inc Use of complement pathway inhibitors to treat ocular diseases
RU2464030C2 (en) * 2006-05-26 2012-10-20 Регадо Байосайенсиз, Инк. Introduction of anticoagulative system reg1
CA2663243A1 (en) 2006-09-28 2008-04-03 Merck Serono S.A. Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use
TW201716437A (en) 2006-11-02 2017-05-16 建南德克公司 Humanized anti-factor D antibodies and uses thereof
FR2909092B1 (en) * 2006-11-24 2012-10-19 Pf Medicament NEW ANTI-PROLIFERATION ANTIBODIES
AR066660A1 (en) 2007-05-23 2009-09-02 Genentech Inc PREVENTION AND TREATMENT OF EYE CONDITIONS ASSOCIATED WITH THEIR COMPLEMENT
US8772257B2 (en) * 2007-08-06 2014-07-08 Noxxon Pharma Ag SDF-1 binding nucleic acids and the use thereof
CR20170001A (en) 2008-04-28 2017-08-10 Genentech Inc ANTI FACTOR D HUMANIZED ANTIBODIES
SG11201601044XA (en) 2013-08-12 2016-03-30 Genentech Inc Compositions and method for treating complement-associated conditions
AU2015253042A1 (en) 2014-05-01 2016-10-20 Genentech, Inc. Anti-factor D antibody variants and uses thereof
EP3368090A1 (en) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
US10407510B2 (en) 2015-10-30 2019-09-10 Genentech, Inc. Anti-factor D antibodies and conjugates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024897A1 (en) * 1996-12-04 1998-06-11 F.Hoffmann-La Roche Ag Junctional adhesion molecule (jam), a transmembrane protein of tight junctions
WO1998042739A2 (en) * 1997-03-21 1998-10-01 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053753A2 (en) * 1999-03-08 2000-09-14 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
US20030170864A1 (en) * 2000-05-30 2003-09-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6552198A (en) * 1997-03-14 1998-09-29 Human Genome Sciences, Inc. 28 human secreted proteins
DK1000149T3 (en) 1997-08-01 2007-09-10 Serono Genetics Inst Sa 5'-ESTs for secreted proteins identified from brain tissue
US20030092002A1 (en) 1997-09-17 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1002864A1 (en) 1998-11-10 2000-05-24 Universita' degli studi di Bologna HIgR and related V domain for the manufacture of a medicament for preventing or treating HSV-1, HSV-2 and BHV infections
CA2348757A1 (en) * 1998-12-16 2000-06-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP4836329B2 (en) * 1999-03-11 2011-12-14 メルク セローノ エス．エイ． Regulation of vascular adhesion molecules and their functions
US7642341B2 (en) 2003-12-18 2010-01-05 Merck Serono S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
EP1533617A1 (en) 2003-11-19 2005-05-25 RMF Dictagene S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024897A1 (en) * 1996-12-04 1998-06-11 F.Hoffmann-La Roche Ag Junctional adhesion molecule (jam), a transmembrane protein of tight junctions
WO1998042739A2 (en) * 1997-03-21 1998-10-01 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 1 October 1998 (1998-10-01), MARRA M.: "EST; Mouse mammary gland cDNA clone IMAGE:1447499", XP002144155 *
DATABASE EMBL 11 May 1999 (1999-05-11), MARRA M.: "EST; M. musculus cDNA clone IMAGE:1970215 similar to Junctional Adhesion Molecule", XP002144156 *
DATABASE EMBL 11 November 1999 (1999-11-11), HILLIER L.: "EST; H. sapiens cDNA clone IMAGE:2783568 similar to Junction Adhesion Molecule", XP002144157 *

Also Published As

Publication number Publication date
EP1163337A2 (en) 2001-12-19
ZA200107283B (en) 2002-12-24
NO20014417L (en) 2001-11-12
BR0008915A (en) 2002-04-09
RU2244748C2 (en) 2005-01-20
HUP0200606A2 (en) 2002-06-29
DE60045681D1 (en) 2011-04-14
US20080274970A1 (en) 2008-11-06
HU229376B1 (en) 2013-11-28
ES2361905T3 (en) 2011-06-24
AU4105100A (en) 2000-09-28
CA2362896C (en) 2012-07-31
IS2819B (en) 2012-12-15
US20100267649A1 (en) 2010-10-21
US7670826B2 (en) 2010-03-02
PL350417A1 (en) 2002-12-16
NO333085B1 (en) 2013-02-25
IS6072A (en) 2001-09-10
JP2010233572A (en) 2010-10-21
HK1044169A1 (en) 2002-10-11
JP4836329B2 (en) 2011-12-14
EE200100472A (en) 2002-12-16
JP2002537837A (en) 2002-11-12
CN1637019A (en) 2005-07-13
CZ20013267A3 (en) 2002-02-13
MXPA01009110A (en) 2002-08-20
CA2362896A1 (en) 2000-09-14
IL145310A0 (en) 2003-01-12
WO2000053749A2 (en) 2000-09-14
EE05497B1 (en) 2011-12-15
HUP0200606A3 (en) 2004-11-29
NO20014417D0 (en) 2001-09-11
CN1355843A (en) 2002-06-26
EP1163337B1 (en) 2011-03-02
ATE500328T1 (en) 2011-03-15
US7393651B2 (en) 2008-07-01
AU782139B2 (en) 2005-07-07
US8143056B2 (en) 2012-03-27
EP2292761A1 (en) 2011-03-09
PL207994B1 (en) 2011-02-28
CN100469878C (en) 2009-03-18
US20050266426A1 (en) 2005-12-01
NZ514091A (en) 2004-01-30
CZ303128B6 (en) 2012-04-18

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