WO2001013902A3 - Wirkstoffkombination enthaltend Clonidin und Pramipexol - Google Patents

Wirkstoffkombination enthaltend Clonidin und Pramipexol Download PDF

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Publication number
WO2001013902A3
WO2001013902A3 PCT/EP2000/007718 EP0007718W WO0113902A3 WO 2001013902 A3 WO2001013902 A3 WO 2001013902A3 EP 0007718 W EP0007718 W EP 0007718W WO 0113902 A3 WO0113902 A3 WO 0113902A3
Authority
WO
WIPO (PCT)
Prior art keywords
combination
active agents
pramipexol
containing clonidine
clonidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/007718
Other languages
English (en)
French (fr)
Other versions
WO2001013902A2 (de
Inventor
Hans-Michael Brecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MXPA02001138A priority Critical patent/MXPA02001138A/es
Priority to PL00353358A priority patent/PL353358A1/xx
Priority to AU64406/00A priority patent/AU6440600A/en
Priority to EP00951485A priority patent/EP1210081A2/de
Priority to BR0013353-1A priority patent/BR0013353A/pt
Priority to JP2001518040A priority patent/JP2003507420A/ja
Priority to IL14774100A priority patent/IL147741A0/xx
Priority to CA002376606A priority patent/CA2376606A1/en
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to KR1020027002149A priority patent/KR20020060163A/ko
Publication of WO2001013902A2 publication Critical patent/WO2001013902A2/de
Publication of WO2001013902A3 publication Critical patent/WO2001013902A3/de
Priority to NO20020793A priority patent/NO20020793L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die vorliegende Erfindung betrifft eine Wikstoffkombination bestehend aus Clonidin und Pramipexol zur Behandlung des Restless Leg Syndroms.
PCT/EP2000/007718 1999-08-19 2000-08-09 Wirkstoffkombination enthaltend clonidin und pramipexol Ceased WO2001013902A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IL14774100A IL147741A0 (en) 1999-08-19 2000-08-09 Combination of active agents, said combination containing clonidine
AU64406/00A AU6440600A (en) 1999-08-19 2000-08-09 Combination of active agents, said combination containing clonidine
EP00951485A EP1210081A2 (de) 1999-08-19 2000-08-09 Wirkstoffkombination enthaltend clonidin und pramipexol
BR0013353-1A BR0013353A (pt) 1999-08-19 2000-08-09 Combinação de substância ativa com clonidina
JP2001518040A JP2003507420A (ja) 1999-08-19 2000-08-09 作用物質の組成物、クロニジンを含む前記組成物
MXPA02001138A MXPA02001138A (es) 1999-08-19 2000-08-09 Combinacion de sustancias activas con clonidina.
PL00353358A PL353358A1 (en) 1999-08-19 2000-08-09 Combination of active agents, said combination containing clonidine and pramipexol
CA002376606A CA2376606A1 (en) 1999-08-19 2000-08-09 Active substance combination with clonidine
KR1020027002149A KR20020060163A (ko) 1999-08-19 2000-08-09 클로니딘 및 프라미펙솔을 함유하는 활성제의 배합물
NO20020793A NO20020793L (no) 1999-08-19 2002-02-18 Virkestoffkombinasjon med clonidin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19938825.3 1999-08-19
DE19938825A DE19938825A1 (de) 1999-08-19 1999-08-19 Wirkstoffkombination mit Clonidin

Publications (2)

Publication Number Publication Date
WO2001013902A2 WO2001013902A2 (de) 2001-03-01
WO2001013902A3 true WO2001013902A3 (de) 2001-08-23

Family

ID=7918574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007718 Ceased WO2001013902A2 (de) 1999-08-19 2000-08-09 Wirkstoffkombination enthaltend clonidin und pramipexol

Country Status (19)

Country Link
US (1) US20020010201A1 (de)
EP (1) EP1210081A2 (de)
JP (1) JP2003507420A (de)
KR (1) KR20020060163A (de)
AR (1) AR025330A1 (de)
AU (1) AU6440600A (de)
BR (1) BR0013353A (de)
CA (1) CA2376606A1 (de)
CO (1) CO5200840A1 (de)
CZ (1) CZ2002515A3 (de)
DE (1) DE19938825A1 (de)
IL (1) IL147741A0 (de)
MX (1) MXPA02001138A (de)
NO (1) NO20020793L (de)
PE (1) PE20010642A1 (de)
PL (1) PL353358A1 (de)
TR (1) TR200200449T2 (de)
UY (1) UY26293A1 (de)
WO (1) WO2001013902A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
EP1453505B1 (de) 2001-12-11 2010-09-08 University Of Virginia Patent Foundation Verwendung von pramipexol zur behandlung von amyotrophischer lateralsklerose
US20040048779A1 (en) * 2002-05-06 2004-03-11 Erwin Schollmayer Use of rotigotine for treating the restless leg syndrome
DE10220230A1 (de) * 2002-05-06 2003-11-27 Sanol Arznei Schwarz Gmbh Verwendung von Rotigotine zur Behandlung des Restless Leg Syndroms
AU2003262860A1 (en) 2002-08-30 2004-03-19 Kyowa Hakko Kogyo Co., Ltd. Adenosine a2a receptor antagonists for treating restless legs syndrome or related disorders
DK1426049T3 (da) * 2002-12-02 2005-08-22 Sanol Arznei Schwarz Gmbh Iontophoretisk tilförsel af rotigotin til behandling af Parkinsons sygdom
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
CN102160865A (zh) 2006-05-16 2011-08-24 诺普神经科学股份有限公司 R(+)和s(-)普拉克索的组合物以及使用该组合物的方法
WO2008009664A2 (en) * 2006-07-19 2008-01-24 Boehringer Ingelheim International Gmbh Treatment of pain
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US8519148B2 (en) 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
EP1987815A1 (de) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Im Mund-Nasen-Rachenraum verabreichbare pharmazeutische Zusammensetzungen enthaltend Dopaminagonisten zur Vorbeugung und/oder Behandlung von unruhigen Gliedmassen
EP2334185A4 (de) 2008-08-19 2011-09-21 Knopp Neurosciences Inc Zusammensetzungen und verfahren zur verwendung von (r)-pramipexol
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
CA2896055C (en) * 2012-12-28 2021-02-16 Noven Pharmaceuticals, Inc. Compositions and methods for transdermal delivery of amphetamine and clonidine
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
EP4578509A3 (de) 2013-07-12 2025-11-19 Areteia Therapeutics, Inc. Behandlung eines erhöhten spiegels von eosinophilen und/oder basophilen
HUE055850T2 (hu) 2013-08-13 2022-01-28 Knopp Biosciences Llc Készítmények és módszerek a krónikus urticaria (csalánkiütés) kezelésére
WO2015023786A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112842A (en) * 1989-11-09 1992-05-12 Boehringer Ingelheim Kg Transdermal administration of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole
DE4325491A1 (de) * 1993-07-29 1995-02-02 Boehringer Ingelheim Kg Verwendung von zentral wirksamen alpha-2-Agonisten zur Hemmung des Postaggressionsstoffwechsels
DE19701619A1 (de) * 1997-01-17 1998-07-23 Boehringer Ingelheim Pharma Verwendung von Pramipexol zur Behandlung des restless legs syndroms
US6001861A (en) * 1998-01-16 1999-12-14 Pharmacia & Upjohn Company Use of pramipexole in the treatment of restless legs syndrome
WO2000054773A1 (en) * 1999-03-12 2000-09-21 Nitromed, Inc. Dopamine agonists in combination with nitric oxide donors, compositions and methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112842A (en) * 1989-11-09 1992-05-12 Boehringer Ingelheim Kg Transdermal administration of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole
DE4325491A1 (de) * 1993-07-29 1995-02-02 Boehringer Ingelheim Kg Verwendung von zentral wirksamen alpha-2-Agonisten zur Hemmung des Postaggressionsstoffwechsels
DE19701619A1 (de) * 1997-01-17 1998-07-23 Boehringer Ingelheim Pharma Verwendung von Pramipexol zur Behandlung des restless legs syndroms
US6001861A (en) * 1998-01-16 1999-12-14 Pharmacia & Upjohn Company Use of pramipexole in the treatment of restless legs syndrome
WO2000054773A1 (en) * 1999-03-12 2000-09-21 Nitromed, Inc. Dopamine agonists in combination with nitric oxide donors, compositions and methods of use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLLADO-SEIDEL V. ET AL: "Aetiology and treatment of resless legs syndrome", CNS DRUGS, vol. 12, no. 1, July 1999 (1999-07-01), pages 9 - 20, XP000989833 *
DOOLEY M. ET AL: "Pramipexole. A review of its use in the management of early and advanced parkinson's disease", DRUGS&AGING, vol. 12, no. 6, June 1998 (1998-06-01), pages 495 - 514, XP000989824 *
ZOE A. ET AL: "High dose clonidine in a case of restless legs syndrome", THE ANNALS OF PHARMACOTHERAPY, vol. 28, August 1994 (1994-08-01), pages 878 - 881, XP000989816 *

Also Published As

Publication number Publication date
JP2003507420A (ja) 2003-02-25
KR20020060163A (ko) 2002-07-16
WO2001013902A2 (de) 2001-03-01
US20020010201A1 (en) 2002-01-24
EP1210081A2 (de) 2002-06-05
CO5200840A1 (es) 2002-09-27
CA2376606A1 (en) 2001-03-01
BR0013353A (pt) 2002-04-23
NO20020793D0 (no) 2002-02-18
TR200200449T2 (tr) 2002-08-21
PL353358A1 (en) 2003-11-17
DE19938825A1 (de) 2001-04-26
NO20020793L (no) 2002-02-18
CZ2002515A3 (cs) 2002-05-15
PE20010642A1 (es) 2001-06-08
UY26293A1 (es) 2001-04-30
IL147741A0 (en) 2002-08-14
MXPA02001138A (es) 2002-10-31
AU6440600A (en) 2001-03-19
AR025330A1 (es) 2002-11-20

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