WO2001020004A3 - Proteines phosphatase et proteines kinase - Google Patents

Proteines phosphatase et proteines kinase Download PDF

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Publication number
WO2001020004A3
WO2001020004A3 PCT/US2000/025515 US0025515W WO0120004A3 WO 2001020004 A3 WO2001020004 A3 WO 2001020004A3 US 0025515 W US0025515 W US 0025515W WO 0120004 A3 WO0120004 A3 WO 0120004A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein phosphatase
kinase proteins
pphkp
provides
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/025515
Other languages
English (en)
Other versions
WO2001020004A2 (fr
Inventor
Henry Yue
Y Tom Tang
Olga Bandman
Jennifer L Hillman
Mariah R Baughn
Yalda Azimzai
Dyung Aina M Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to JP2001523775A priority Critical patent/JP2003509053A/ja
Priority to CA002383927A priority patent/CA2383927A1/fr
Priority to EP00968368A priority patent/EP1212436A2/fr
Priority to AU78297/00A priority patent/AU7829700A/en
Publication of WO2001020004A2 publication Critical patent/WO2001020004A2/fr
Publication of WO2001020004A3 publication Critical patent/WO2001020004A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Cette invention porte sur des protéines phosphatase et sur des protéines kinase (PPHKP) humaines, ainsi que sur des polynucléotides qui identifient et codent PPHKP. L'invention porte également sur des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. L'invention porte aussi sur des procédés de diagnostic, traitement ou prévention de pathologies associées à l'expression de PPHKP.
PCT/US2000/025515 1999-09-15 2000-09-14 Proteines phosphatase et proteines kinase Ceased WO2001020004A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001523775A JP2003509053A (ja) 1999-09-15 2000-09-14 プロテインホスファターゼ及びプロテインキナーゼ
CA002383927A CA2383927A1 (fr) 1999-09-15 2000-09-14 Proteines phosphatase et proteines kinase
EP00968368A EP1212436A2 (fr) 1999-09-15 2000-09-14 Proteines phosphatase et proteines kinase
AU78297/00A AU7829700A (en) 1999-09-15 2000-09-14 Protein phosphatase and kinase proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15414199P 1999-09-15 1999-09-15
US60/154,141 1999-09-15

Publications (2)

Publication Number Publication Date
WO2001020004A2 WO2001020004A2 (fr) 2001-03-22
WO2001020004A3 true WO2001020004A3 (fr) 2001-10-18

Family

ID=22550173

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025515 Ceased WO2001020004A2 (fr) 1999-09-15 2000-09-14 Proteines phosphatase et proteines kinase

Country Status (5)

Country Link
EP (1) EP1212436A2 (fr)
JP (1) JP2003509053A (fr)
AU (1) AU7829700A (fr)
CA (1) CA2383927A1 (fr)
WO (1) WO2001020004A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377662A1 (fr) * 1999-08-13 2001-02-22 Sugen, Inc. Nouvelles phosphatases de proteines et diagnostic et traitement des troubles lies a la phosphatase
EP1259620A2 (fr) * 2000-02-29 2002-11-27 Millennium Pharmaceuticals, Inc. 2504, 15977 et 14760, nouveaux membres de la famille proteine kinase et leurs utilisations
WO2001073060A2 (fr) * 2000-03-24 2001-10-04 Millennium Pharmaceuticals, Inc. 18221, nouveau phosphatase a specificite double et ses utilisations
CA2405725A1 (fr) * 2000-04-10 2001-10-18 Merck Patent Gesellschaft Mit Beschraenkter Haftung Identification d'une nouvelle phosphatase a specificite double
US6461846B2 (en) * 2000-05-30 2002-10-08 Pe Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2002020732A2 (fr) * 2000-09-07 2002-03-14 Bayer Aktiengesellschaft Régulation d'enzyme humaine de type map kinase phosphatase
US6825021B2 (en) * 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
AU2001294744A1 (en) * 2000-09-26 2002-04-08 Ceptyr, Inc. Dsp-16 dual-specificity phosphatase
JP2004514434A (ja) * 2000-11-20 2004-05-20 ピーイー　コーポレーション　（エヌワイ） 単離ヒトホスファターゼタンパク質、ヒトホスファターゼタンパク質をコード化する核酸分子及びその使用
JP2005506040A (ja) 2000-12-20 2005-03-03 ブリストル−マイヤーズ　スクイブ　カンパニー 新規なヒトホスファターゼをコードしたポリヌクレオチド
EP1694701A2 (fr) * 2003-12-16 2006-08-30 Ares Trading S.A. Sous-unités de la phosphatase pp2a, leurs modulateurs et leur utilisation pour le traitement de troubles mentaux
GB2465907B (en) * 2007-08-10 2013-07-10 Agency Science Tech & Res VHZ for diagnosis and treatment of cancer
WO2010016806A1 (fr) * 2008-08-08 2010-02-11 Agency For Science, Technology And Research (A*Star) Vhz pour le diagnostic et le traitement de cancers
RU2425426C1 (ru) * 2010-02-24 2011-07-27 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" Способ моделирования синдрома меллори-вейса
JP6472075B2 (ja) * 2015-02-26 2019-02-20 学校法人順天堂 Ｇｉｓｔの予後又は治療抵抗性の診断

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009199A2 (fr) * 1997-08-20 1999-02-25 University Of Medicine And Dentistry Of New Jersey Facteur d'elongation-2 kinase(ef-2 kinase) et ses procedes d'utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009199A2 (fr) * 1997-08-20 1999-02-25 University Of Medicine And Dentistry Of New Jersey Facteur d'elongation-2 kinase(ef-2 kinase) et ses procedes d'utilisation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUHEN K L ET AL: "Mechanism of interferon action Sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 178, no. 1, 31 October 1996 (1996-10-31), pages 191 - 193, XP004043360, ISSN: 0378-1119 *
MARTELL K J ET AL: "HVH-5: A PROTEIN TYROSINE PHOSPHATASE ABUNDANT IN BRAIN THAT INACTIVATES MITOGEN-ACTIVATED PROTEIN KINASE", JOURNAL OF NEUROCHEMISTRY,US,NEW YORK, NY, vol. 65, no. 4, 1995, pages 1823 - 1833, XP000196676, ISSN: 0022-3042 *
STONE S R ET AL: "THE NUCLEOTIDE SEQUENCE OF THE COMPLEMENTARY DNA ENCODING THE HUMAN LUNG PROTEIN PHOSPHATASE 2A-ALPHA CATALYTIC SUBUNIT", NUCLEIC ACIDS RESEARCH, vol. 16, no. 23, 1988, pages 11365, XP002160654, ISSN: 0305-1048 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7579148B2 (en) 2001-06-08 2009-08-25 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases
US7604936B2 (en) 2002-04-24 2009-10-20 Xdx, Inc. Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases

Also Published As

Publication number Publication date
AU7829700A (en) 2001-04-17
EP1212436A2 (fr) 2002-06-12
JP2003509053A (ja) 2003-03-11
WO2001020004A2 (fr) 2001-03-22
CA2383927A1 (fr) 2001-03-22

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