WO2001040468A3 - Molecules of the card-related protein family and uses thereof - Google Patents

Molecules of the card-related protein family and uses thereof Download PDF

Info

Publication number
WO2001040468A3
WO2001040468A3 PCT/US2000/032716 US0032716W WO0140468A3 WO 2001040468 A3 WO2001040468 A3 WO 2001040468A3 US 0032716 W US0032716 W US 0032716W WO 0140468 A3 WO0140468 A3 WO 0140468A3
Authority
WO
WIPO (PCT)
Prior art keywords
card
nucleic acid
proteins
molecules
related protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/032716
Other languages
French (fr)
Other versions
WO2001040468A2 (en
Inventor
John Bertin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/507,513 external-priority patent/US6540202B1/en
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU18114/01A priority Critical patent/AU1811401A/en
Priority to EP00980916A priority patent/EP1238074A2/en
Publication of WO2001040468A2 publication Critical patent/WO2001040468A2/en
Publication of WO2001040468A3 publication Critical patent/WO2001040468A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10, or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US2000/032716 1999-12-01 2000-12-01 Molecules of the card-related protein family and uses thereof Ceased WO2001040468A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU18114/01A AU1811401A (en) 1999-12-01 2000-12-01 Novel molecules of the card-related protein family and uses thereof
EP00980916A EP1238074A2 (en) 1999-12-01 2000-12-01 Molecules of the card-related protein family and uses thereof

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US16878099P 1999-12-01 1999-12-01
US60/168,780 1999-12-03
US50753300A 2000-02-18 2000-02-18
US09/507,533 2000-02-18
US09/507,513 US6540202B1 (en) 1999-02-23 2000-02-18 Mold matrix pin with integral spacing means
US51390400A 2000-02-25 2000-02-25
US09/513,904 2000-02-25
US68579100A 2000-10-10 2000-10-10
US09/685,791 2000-10-10

Publications (2)

Publication Number Publication Date
WO2001040468A2 WO2001040468A2 (en) 2001-06-07
WO2001040468A3 true WO2001040468A3 (en) 2002-01-17

Family

ID=27538782

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032716 Ceased WO2001040468A2 (en) 1999-12-01 2000-12-01 Molecules of the card-related protein family and uses thereof

Country Status (1)

Country Link
WO (1) WO2001040468A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085933A2 (en) * 2000-05-09 2001-11-15 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Plakoglobin interacting proteins
US20040072228A1 (en) * 2002-08-02 2004-04-15 Phenomix Corporation Card11 NFkB activating polypeptides, nucleic acids, inbred and transgenic animals, and methods of use thereof
GB0428301D0 (en) * 2004-12-24 2005-01-26 Immunoclin Ltd Resistance genes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040102A1 (en) * 1998-02-06 1999-08-12 Millennium Pharmaceuticals, Inc. Novel molecules of the card-related protein family and uses thereof
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040102A1 (en) * 1998-02-06 1999-08-12 Millennium Pharmaceuticals, Inc. Novel molecules of the card-related protein family and uses thereof
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BERTIN JOHN ET AL: "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappaB.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 52, 29 December 2000 (2000-12-29), pages 41082 - 41086, XP002165362, ISSN: 0021-9258 *
DATABASE EMBL [online] 11 December 1998 (1998-12-11), ROBERT STRAUSBERG: "tb24e03.x1 NCI_CGAP_Kid12 Homo sapiens cDNA clone IMAGE:2055292 3'", XP002165363, retrieved from EBI Database accession no. AI307612 *
HOFMANN K ET AL: "The CARD domain: a new apoptotic signalling motif", TIBS TRENDS IN BIOCHEMICAL SCIENCES,EN,ELSEVIER PUBLICATION, CAMBRIDGE, vol. 22, no. 5, 1 May 1997 (1997-05-01), pages 155 - 156, XP004061753, ISSN: 0968-0004 *
SRINIVASULA SRINIVASA M ET AL: "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 25, 18 June 1999 (1999-06-18), pages 17946 - 17954, XP002165361, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2001040468A2 (en) 2001-06-07

Similar Documents

Publication Publication Date Title
WO1999066025A3 (en) Mtbx protein and nucleic acid molecules and uses therefor
WO2002070652A3 (en) Novel molecules of the card-related protein family and uses thereof
WO2002008279A3 (en) B7-h2 molecules, novel members of the b7 family and uses thereof
EP1009752A4 (en) Novel molecules of the tango-77 related protein family and uses thereof
WO2002044354A3 (en) Molecules of the card-related protein family and uses thereof
WO2000052047A3 (en) Human dickkopf-related protein and nucleic acid molecules and uses therefor
WO2001000826A3 (en) Novel molecules of the card-related protein family and uses thereof
AU3217100A (en) Methods of use of a novel lysyl oxidase-related protein
WO2000019988A8 (en) NOVEL Th2-SPECIFIC MOLECULES AND USES THEREOF
WO2000046236A3 (en) Novel rgs-containing molecules and uses thereof
WO2001061005A3 (en) Molecules of the pyrin domain protein family and uses thereof
WO2001009328A8 (en) 15571, a novel gpcr-like molecule of the secretin-like family and uses thereof
WO2000012544A3 (en) Novel irap-bp polypeptide and nucleic acid molecules and uses therefor
WO2001030971A3 (en) Novel molecules and the card-related protein family and uses thereof
WO2001018216A3 (en) 26176, a novel calpain protease and uses thereof
WO2002061049A3 (en) Novel molecules of the pyrin/nbs/lrr protein family and uses thereof
WO2000008045A3 (en) Novel molecules of the tango-93-related protein family and uses thereof
WO1999054437A3 (en) Novel molecules of the t125-related protein family and uses thereof
WO2002085939A8 (en) Novel molecules of the card-related protein family and uses thereof
WO2003029434A3 (en) Novel molecules of the hkid-1-related protein family and uses thereof
WO2001077151A3 (en) Fdrg proteins and nucleic acid molecules and uses therefor
WO2001059065A3 (en) Novel molecules of the card-related protein family and uses thereof
WO2002038767A3 (en) G protein-coupled receptor protein and nucleic acid molecules and uses therefor
WO1999062943A3 (en) Novel molecules of the aip-related protein family and uses thereof
WO2001040468A3 (en) Molecules of the card-related protein family and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000980916

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000980916

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000980916

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP