WO2001040468A3 - Nouvelles molecules de la famille de proteines de type card et utilisations de ces dernieres - Google Patents

Nouvelles molecules de la famille de proteines de type card et utilisations de ces dernieres Download PDF

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Publication number
WO2001040468A3
WO2001040468A3 PCT/US2000/032716 US0032716W WO0140468A3 WO 2001040468 A3 WO2001040468 A3 WO 2001040468A3 US 0032716 W US0032716 W US 0032716W WO 0140468 A3 WO0140468 A3 WO 0140468A3
Authority
WO
WIPO (PCT)
Prior art keywords
card
nucleic acid
proteins
molecules
related protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/032716
Other languages
English (en)
Other versions
WO2001040468A2 (fr
Inventor
John Bertin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/507,513 external-priority patent/US6540202B1/en
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU18114/01A priority Critical patent/AU1811401A/en
Priority to EP00980916A priority patent/EP1238074A2/fr
Publication of WO2001040468A2 publication Critical patent/WO2001040468A2/fr
Publication of WO2001040468A3 publication Critical patent/WO2001040468A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne de nouveaux polypeptides CARD-9, CARD-10, ou CARD-11 ainsi que des protéines, et des molécules d'acide nucléique. Outre les protéines isolées CARD-9, CARD-10, ou CARD-11, l'invention concerne également des protéines hybrides et des peptides antigéniques CARD-9, CARD-10, ou CARD-11, ainsi que des anticorps anti-CARD-9, anti-CARD-10, ou anti-CARD-11. La présente invention concerne également des molécules d'acide nucléique CARD-9, CARD-10, ou CARD-11, des vecteurs d'expression de recombinaison contenant une molécule d'acide nucléique selon l'invention, des cellules hôtes dans lesquelles ont été introduits les vecteurs d'expression et des animaux transgéniques non humains dans lesquels un gène CARD-9, CARD-10, ou CARD-11 a été introduit ou interrompu. Des procédés de diagnostic, de criblage et de thérapie dans lesquels on utilise ces compositions sont également décrits.
PCT/US2000/032716 1999-12-01 2000-12-01 Nouvelles molecules de la famille de proteines de type card et utilisations de ces dernieres Ceased WO2001040468A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU18114/01A AU1811401A (en) 1999-12-01 2000-12-01 Novel molecules of the card-related protein family and uses thereof
EP00980916A EP1238074A2 (fr) 1999-12-01 2000-12-01 Molecules de la famille de proteines de type card et utilisations de ces dernieres

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US16878099P 1999-12-01 1999-12-01
US60/168,780 1999-12-03
US50753300A 2000-02-18 2000-02-18
US09/507,533 2000-02-18
US09/507,513 US6540202B1 (en) 1999-02-23 2000-02-18 Mold matrix pin with integral spacing means
US51390400A 2000-02-25 2000-02-25
US09/513,904 2000-02-25
US68579100A 2000-10-10 2000-10-10
US09/685,791 2000-10-10

Publications (2)

Publication Number Publication Date
WO2001040468A2 WO2001040468A2 (fr) 2001-06-07
WO2001040468A3 true WO2001040468A3 (fr) 2002-01-17

Family

ID=27538782

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032716 Ceased WO2001040468A2 (fr) 1999-12-01 2000-12-01 Nouvelles molecules de la famille de proteines de type card et utilisations de ces dernieres

Country Status (1)

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WO (1) WO2001040468A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085933A2 (fr) * 2000-05-09 2001-11-15 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Proteines interagissant avec la plakoglobine
US20040072228A1 (en) * 2002-08-02 2004-04-15 Phenomix Corporation Card11 NFkB activating polypeptides, nucleic acids, inbred and transgenic animals, and methods of use thereof
GB0428301D0 (en) * 2004-12-24 2005-01-26 Immunoclin Ltd Resistance genes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040102A1 (fr) * 1998-02-06 1999-08-12 Millennium Pharmaceuticals, Inc. Nouvelles molecules de la famille de proteines liees au card et leur utilisation
WO2000058473A2 (fr) * 1999-03-31 2000-10-05 Curagen Corporation Acides nucleiques comprenant des phases de lecture ouverte codant des polypeptides; «orfx»

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040102A1 (fr) * 1998-02-06 1999-08-12 Millennium Pharmaceuticals, Inc. Nouvelles molecules de la famille de proteines liees au card et leur utilisation
WO2000058473A2 (fr) * 1999-03-31 2000-10-05 Curagen Corporation Acides nucleiques comprenant des phases de lecture ouverte codant des polypeptides; «orfx»

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BERTIN JOHN ET AL: "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappaB.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 52, 29 December 2000 (2000-12-29), pages 41082 - 41086, XP002165362, ISSN: 0021-9258 *
DATABASE EMBL [online] 11 December 1998 (1998-12-11), ROBERT STRAUSBERG: "tb24e03.x1 NCI_CGAP_Kid12 Homo sapiens cDNA clone IMAGE:2055292 3'", XP002165363, retrieved from EBI Database accession no. AI307612 *
HOFMANN K ET AL: "The CARD domain: a new apoptotic signalling motif", TIBS TRENDS IN BIOCHEMICAL SCIENCES,EN,ELSEVIER PUBLICATION, CAMBRIDGE, vol. 22, no. 5, 1 May 1997 (1997-05-01), pages 155 - 156, XP004061753, ISSN: 0968-0004 *
SRINIVASULA SRINIVASA M ET AL: "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 25, 18 June 1999 (1999-06-18), pages 17946 - 17954, XP002165361, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2001040468A2 (fr) 2001-06-07

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