WO2001040802A3 - Nouvelle proteine - Google Patents

Nouvelle proteine Download PDF

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Publication number
WO2001040802A3
WO2001040802A3 PCT/GB2000/004606 GB0004606W WO0140802A3 WO 2001040802 A3 WO2001040802 A3 WO 2001040802A3 GB 0004606 W GB0004606 W GB 0004606W WO 0140802 A3 WO0140802 A3 WO 0140802A3
Authority
WO
WIPO (PCT)
Prior art keywords
ltrgw1
bltr
leukotrienes
binding
leukotriene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/004606
Other languages
English (en)
Other versions
WO2001040802A2 (fr
Inventor
Diane Joan Cousens
Diane Michele Ignar
Philippe Sanseau
Filippo Volpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9928539.7A external-priority patent/GB9928539D0/en
Priority claimed from GB0012699A external-priority patent/GB0012699D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to AU15407/01A priority Critical patent/AU1540701A/en
Priority to US10/130,845 priority patent/US20030171545A1/en
Priority to EP00977773A priority patent/EP1240523A2/fr
Publication of WO2001040802A2 publication Critical patent/WO2001040802A2/fr
Publication of WO2001040802A3 publication Critical patent/WO2001040802A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une méthode d'identification d'un composé qui module l'activité du récepteur du leucotriène du type B4 (LTRGW1). Cette méthode consiste à mettre ce composé en contact avec un polypeptide LTRGW1 contenant i) la séquence d'acide aminé de SEQ ID #2, ii) une variante de (i) qui est capable de se lier à des leucotriènes; ou iii) un fragment de (i) ou de (ii) qui est capable de se lier à des leucotriènes. En outre, on a pu déterminer que LTRGW1 stimule la réponse du récepteur du leucotriène B4 (BLTR) à LTB4. Par conséquent, LTRGW1 peut être utilisé dans des méthodes d'identification de composés qui modulent l'activité du récepteur BLTR.
PCT/GB2000/004606 1999-12-02 2000-12-01 Nouvelle proteine Ceased WO2001040802A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU15407/01A AU1540701A (en) 1999-12-02 2000-12-01 Novel protein
US10/130,845 US20030171545A1 (en) 1999-12-02 2000-12-01 Novel Protein
EP00977773A EP1240523A2 (fr) 1999-12-02 2000-12-01 Polypeptides du type bltr utilises dans la detection des modulateurs de bltr

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9928539.7A GB9928539D0 (en) 1999-12-02 1999-12-02 Novel protein
GB9928539.7 1999-12-02
GB0012699.5 2000-05-24
GB0012699A GB0012699D0 (en) 2000-05-24 2000-05-24 Novel protein

Publications (2)

Publication Number Publication Date
WO2001040802A2 WO2001040802A2 (fr) 2001-06-07
WO2001040802A3 true WO2001040802A3 (fr) 2002-02-21

Family

ID=26244346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004606 Ceased WO2001040802A2 (fr) 1999-12-02 2000-12-01 Nouvelle proteine

Country Status (4)

Country Link
US (1) US20030171545A1 (fr)
EP (1) EP1240523A2 (fr)
AU (1) AU1540701A (fr)
WO (1) WO2001040802A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3930201A (en) * 2000-03-17 2001-09-24 Bayer Aktiengesellschaft Regulation of human leukotriene B4-like G protein-coupled receptor
AU2002359362A1 (en) * 2001-11-07 2003-05-19 Millennium Pharmaceuticals, Inc. Methods and compositions for treating hematological disorders using 232, 2059, 10630, 12848, 13875, 14395, 14618, 17692 or 58874
WO2004106938A2 (fr) * 2003-06-02 2004-12-09 Bayer Healthcare Ag Agents de diagnostic et de therapie pour des maladies associees au p2y recepteur purique 7 couple a une proteine g (p2y7)
US8906632B2 (en) * 2007-03-23 2014-12-09 Korea University Research & Business Foundation Use of inhibitors of leukotriene B4 receptor BLT2 for treating asthma

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042484A1 (fr) * 1998-02-20 1999-08-26 Smithkline Beecham Corporation Fishboy, un recepteur couple a la proteine g
WO2000029423A1 (fr) * 1998-11-12 2000-05-25 Merck & Co., Inc. Recepteur couple a la proteine g ressemblant au recepteur b4 de la leukotriene
WO2001019985A1 (fr) * 1999-09-10 2001-03-22 Meiji Seika Kaisha, Ltd. Nouveaux recepteurs et genes codant pour ces memes recepteurs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465212B1 (en) * 1999-09-20 2002-10-15 Schering Corporation Leukotriene receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042484A1 (fr) * 1998-02-20 1999-08-26 Smithkline Beecham Corporation Fishboy, un recepteur couple a la proteine g
WO2000029423A1 (fr) * 1998-11-12 2000-05-25 Merck & Co., Inc. Recepteur couple a la proteine g ressemblant au recepteur b4 de la leukotriene
WO2001019985A1 (fr) * 1999-09-10 2001-03-22 Meiji Seika Kaisha, Ltd. Nouveaux recepteurs et genes codant pour ces memes recepteurs

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 11 September 2000 (2000-09-11), LIU, Q. ET AL.: "Novel human polynucleotide encoding a G-protein coupled receptor, HG07, the agonist or antagonist of HG07 useful for treating disorders involving multiple sclerosis, or arhtritis", XP002170532 *
DATABASE EMBL 25 February 2000 (2000-02-25), ELSHOURBAGY, N ET AL.: "A new G-protein coupled receptor, Fishboy used to treat, e.g. benign prostatic hypertrophy", XP002170530 *
DATABASE EMBL 5 June 2001 (2001-06-05), KATO, K. ET AL.: "Human leukotriene B4 receptor used in screening modifiers of its ligand binding for use in treatment of leukotriene B4-associated diseases", XP002170531 *
JACKSON R H ET AL: "COMPARISON OF ANTAGONIST AND AGONIST BINDING TO THE LEUKOTRIENE B-4 RECEPTOR ON INTACT HUMAN POLYMORPHONUCLEAR NEUTROPHILS PMN", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 262, no. 1, 1992, pages 80 - 89, XP001011803, ISSN: 0022-3565 *
WIELAND THOMAS ET AL: "Measurement of receptor-stimulated guanosine 5'-O-(gamma-thio)triphosphate binding by G proteins.", METHODS IN ENZYMOLOGY, vol. 237, 1994, 1994 Academic Press, Inc.; Academic Press Ltd. 1250 Sixth Ave., San Diego, California 92101, USA; 14 Belgrave Square, 24-28 Oval Road, London NW1 70X, England, UK, pages 3 - 13, XP000197101, ISBN: 0-12-182138-2 *

Also Published As

Publication number Publication date
AU1540701A (en) 2001-06-12
US20030171545A1 (en) 2003-09-11
EP1240523A2 (fr) 2002-09-18
WO2001040802A2 (fr) 2001-06-07

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