WO2001068698A3 - Nichtselektiver kationenkanal - Google Patents

Nichtselektiver kationenkanal Download PDF

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Publication number
WO2001068698A3
WO2001068698A3 PCT/EP2001/002837 EP0102837W WO0168698A3 WO 2001068698 A3 WO2001068698 A3 WO 2001068698A3 EP 0102837 W EP0102837 W EP 0102837W WO 0168698 A3 WO0168698 A3 WO 0168698A3
Authority
WO
WIPO (PCT)
Prior art keywords
otrpc4
activators
modulators
blocking agents
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/002837
Other languages
English (en)
French (fr)
Other versions
WO2001068698A2 (de
Inventor
Guenter Schultz
Timothy Plant
Rainer Strotmann
Christian Harteneck
Karin Nunnenmacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of WO2001068698A2 publication Critical patent/WO2001068698A2/de
Publication of WO2001068698A3 publication Critical patent/WO2001068698A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft Nukleinsäuren, die für den nicht-selektiven Kationenkanal OTRPC4 kodieren, sowie Polypeptide, die durch besagte Nukleinsäuren kodiert werden. Weiterhin betrifft die Erfindung Wirte bzw. Wirtszellen, die besagtes Polypeptid exprimieren und Verfahren zum Auffinden von Blocker, Aktivator sowie Modulatoren besagter OTRPC4-Kationenkanäle. Die Erfindung umfasst Blocker, Aktivatoren und Modulatoren besagter OTRPC4-Kationenkanäle sowie pharmazeutische Zusammensetzungen enthaltend besagte Blocker, Aktivatoren und Modulatoren. Ausserdem betrifft die Erfindung nicht humane Säuger, die entweder OTRPC4 als Transgen, inaktiviertes Gen (knock-out) oder modifiziertes Gen (knock-in) enthalten.
PCT/EP2001/002837 2000-03-17 2001-03-14 Nichtselektiver kationenkanal Ceased WO2001068698A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10013296A DE10013296A1 (de) 2000-03-17 2000-03-17 Neuer nichtselektiver Kationenkanal
DE10013296.0 2000-03-17

Publications (2)

Publication Number Publication Date
WO2001068698A2 WO2001068698A2 (de) 2001-09-20
WO2001068698A3 true WO2001068698A3 (de) 2002-06-20

Family

ID=7635294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/002837 Ceased WO2001068698A2 (de) 2000-03-17 2001-03-14 Nichtselektiver kationenkanal

Country Status (2)

Country Link
DE (1) DE10013296A1 (de)
WO (1) WO2001068698A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1497328A2 (de) * 2002-04-16 2005-01-19 Bayer HealthCare AG Regulierung des human transient receptor potential channel

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032766A1 (en) * 1998-12-01 2000-06-08 Glaxo Group Limited Human vanilloid receptors and their uses
WO2001034805A2 (en) * 1999-11-12 2001-05-17 Abbott Laboratories Human vanilloid receptor gene
WO2001046258A2 (en) * 1999-12-23 2001-06-28 Incyte Genomics, Inc. Transporters and ion channels
WO2001053348A2 (en) * 2000-01-21 2001-07-26 Bristol-Myers Squibb Company Human polypeptides related to the vanilloid and trp families of cation channel proteins and nucleic acids encoding them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032766A1 (en) * 1998-12-01 2000-06-08 Glaxo Group Limited Human vanilloid receptors and their uses
WO2001034805A2 (en) * 1999-11-12 2001-05-17 Abbott Laboratories Human vanilloid receptor gene
WO2001046258A2 (en) * 1999-12-23 2001-06-28 Incyte Genomics, Inc. Transporters and ion channels
WO2001053348A2 (en) * 2000-01-21 2001-07-26 Bristol-Myers Squibb Company Human polypeptides related to the vanilloid and trp families of cation channel proteins and nucleic acids encoding them

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CATERINA ET AL: "A capsaicin-receptor homologue with a high threshold for noxious heat", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 398, 1 April 1999 (1999-04-01), pages 436 - 441, XP002105951, ISSN: 0028-0836 *
CATERINA M J ET AL: "THE CAPSAICIN RECEPTOR: A HEAT-ACTIVATED ION CHANNEL IN THE PAIN PATHWAY", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 389, 23 October 1997 (1997-10-23), pages 816 - 824, XP002075020, ISSN: 0028-0836 *
DATABASE EBI 1 November 2000 (2000-11-01), LIEDTKE, W. B. ET AL.: "Homo sapiens vanilloid receptor-related osmotically activated channel (VROAC) mRNA, complete cds", XP002182929 *
DATABASE EBI 12 September 2000 (2000-09-12), DELANY, N. S. ET AL.: "Human vanilloid receptor 3 coding sequence", XP002182928 *
DATABASE EBI 3 September 1999 (1999-09-03), SUZUKI, M.: "Mus musculus mRNA for ion channel, complete cds", XP002182927 *
LIEDTKE, W. ET AL.: "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor", CELL, vol. 103, October 2000 (2000-10-01), pages 525 - 535, XP002182926 *

Also Published As

Publication number Publication date
WO2001068698A2 (de) 2001-09-20
DE10013296A1 (de) 2001-09-20

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