WO2001069256A3 - Sensorelement zur optischen detektion von chemischen oder biochemischen analyten - Google Patents

Sensorelement zur optischen detektion von chemischen oder biochemischen analyten Download PDF

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Publication number
WO2001069256A3
WO2001069256A3 PCT/DE2001/000672 DE0100672W WO0169256A3 WO 2001069256 A3 WO2001069256 A3 WO 2001069256A3 DE 0100672 W DE0100672 W DE 0100672W WO 0169256 A3 WO0169256 A3 WO 0169256A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor element
outer layer
samples
optically detecting
detecting chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2001/000672
Other languages
English (en)
French (fr)
Other versions
WO2001069256A2 (de
Inventor
Ralf Waldhaeusl
Norbert Danz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority to US10/221,588 priority Critical patent/US20030132406A1/en
Priority to EP01916889A priority patent/EP1264180A2/de
Priority to AU44071/01A priority patent/AU4407101A/en
Priority to JP2001568084A priority patent/JP2003531361A/ja
Publication of WO2001069256A2 publication Critical patent/WO2001069256A2/de
Publication of WO2001069256A3 publication Critical patent/WO2001069256A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Die Erfindung betrifft ein Sensorelement zur optischen Detektion von chemischen oder biochemischen Analyten, die in unterschiedlichen Proben enthalten sein können. Aufgabengemäß sollen ein möglichst kleines Probenvolumen erforderlich und die einzelnen Proben relativ dicht benachbart zueinander angeordnet werden können, und trotzdem eine hohe Messgenauigkeit erreicht werden. Am Sensorelement ist mindestens eine Grenzfläche ausgebildet, an der infolge von Totalreflexion ein evaneszentes Feld ausgebildet wird. Die Proben sind in voneinander getrennten Kavitäten aufgenommen und die Kavitäten innerhalb einer unmittelbar auf einem Substrat aufgebrachten strukturierten Deckschicht ausgebildet. Dabei ist die Schichtdicke der Deckschicht zumindest größer als die Eindringtiefe des evaneszenten Feldes. Die Deckschicht besteht aus einem fluorierten Polymer und verhindert einen Stoffaustausch der einzelnen Proben, die in den verschiedenen Kavitäten aufgenommen sind.
PCT/DE2001/000672 2000-03-13 2001-02-16 Sensorelement zur optischen detektion von chemischen oder biochemischen analyten Ceased WO2001069256A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/221,588 US20030132406A1 (en) 2000-03-13 2001-02-16 Sensor element for optically detecting chemical or biochemical analytes
EP01916889A EP1264180A2 (de) 2000-03-13 2001-02-16 Sensorelement zur optischen detektion von chemischen oder biochemischen analyten
AU44071/01A AU4407101A (en) 2000-03-13 2001-02-16 Sensor element for optically detecting chemical or biochemical analytes
JP2001568084A JP2003531361A (ja) 2000-03-13 2001-02-16 センサーエレメントおよびその製造方法並びに検体検出方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10012793.2 2000-03-13
DE10012793A DE10012793C2 (de) 2000-03-13 2000-03-13 Sensorelement zur optischen Detektion von chemischen oder biochemischen Analyten

Publications (2)

Publication Number Publication Date
WO2001069256A2 WO2001069256A2 (de) 2001-09-20
WO2001069256A3 true WO2001069256A3 (de) 2002-04-11

Family

ID=7634935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/000672 Ceased WO2001069256A2 (de) 2000-03-13 2001-02-16 Sensorelement zur optischen detektion von chemischen oder biochemischen analyten

Country Status (6)

Country Link
US (1) US20030132406A1 (de)
EP (1) EP1264180A2 (de)
JP (1) JP2003531361A (de)
AU (1) AU4407101A (de)
DE (1) DE10012793C2 (de)
WO (1) WO2001069256A2 (de)

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JP2002139418A (ja) * 2000-11-01 2002-05-17 Nikon Corp マイクロウエルプレート及びマイクロウエルプレートを備える蛍光検出装置
JP3668198B2 (ja) * 2002-02-18 2005-07-06 株式会社東芝 光導波路型マイクロプレート
US20050084909A1 (en) * 2003-08-29 2005-04-21 Kenichi Uchiyama Antigen measuring device and method thereof, an antibody chip package and a pallet
EP1728065A1 (de) * 2003-11-28 2006-12-06 Lumiscence A/S Untersuchungssystem zur untersuchung eines präparats; untereinheiten und einheiten dafür, sensor und mikroskop
DE102004027957A1 (de) * 2004-06-08 2005-12-29 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Untersuchung der Wechselwirkung von Biomolekülen
TWI247886B (en) * 2005-01-06 2006-01-21 Univ Nat Taiwan Improved linear wave-guide type surface plasmon resonance micro sensor
US8349605B1 (en) 2005-04-12 2013-01-08 Colorado State University Research Foundation Optical analyte sensor
WO2008028160A2 (en) * 2006-09-01 2008-03-06 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP4883398B2 (ja) * 2006-09-06 2012-02-22 独立行政法人産業技術総合研究所 エバネッセント波励起蛍光観察における背景光低減方法及び部材
SE531493C2 (sv) 2006-10-31 2009-04-28 Knut Johansen Sensor
JP4597175B2 (ja) * 2007-09-21 2010-12-15 株式会社日立ハイテクノロジーズ 標的物質を検出するための分析装置、又は分析方法、若しくはこれら分析装置及び分析方法に用いるデバイス
JP2011503536A (ja) * 2007-11-05 2011-01-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロエレクトロニクスセンサ
JP2010066212A (ja) * 2008-09-12 2010-03-25 Univ Of Tokyo 測定装置及び観察対象の測定方法
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
EP3460458B1 (de) 2010-02-19 2021-08-11 Pacific Biosciences of California, Inc. Verfahren zur nukleinsäuresequenzierung
EP2591355B1 (de) 2010-07-09 2016-09-07 Case Western Reserve University In-vitro-point-of-care-sensor und verwendungsverfahren dafür
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
JP6029899B2 (ja) * 2012-09-07 2016-11-24 日東電工株式会社 Ｓｐｒセンサセルおよびｓｐｒセンサ
EP2936222B1 (de) 2012-12-18 2019-07-03 Pacific Biosciences Of California, Inc. Eine optische analysevorrichtung
US20140311925A1 (en) * 2013-01-09 2014-10-23 Case Western Reserve University In vitro point-of-care sensor and method of use
US9624540B2 (en) 2013-02-22 2017-04-18 Pacific Biosciences Of California, Inc. Integrated illumination of optical analytical devices
TWI692633B (zh) 2014-08-27 2020-05-01 美商加州太平洋生物科學公司 整合式分析裝置之陣列
EP3271762B1 (de) 2015-03-16 2023-01-04 Pacific Biosciences of California, Inc. Analysesystem umfassend integrierte vorrichtungen und systeme zur optischen freiraumkopplung
EP3292220B1 (de) 2015-05-07 2022-07-13 Pacific Biosciences of California, Inc. Multiprozessor-pipeline-architektur
EP4425153A3 (de) 2015-06-12 2024-11-20 Pacific Biosciences Of California, Inc. Integrierte zielwellenleitervorrichtungen und systeme zur optischen kopplung
US12535420B2 (en) 2020-02-18 2026-01-27 Pacific Biosciences Of California, Inc. Highly multiplexed nucleic acid sequencing systems
KR20240006033A (ko) 2021-05-04 2024-01-12 퍼시픽 바이오사이언스 오브 캘리포니아, 인크. 축소된 규모의 단위 셀을 갖는 통합 분석 장치의 어레이

Citations (7)

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WO1994027137A2 (en) * 1993-05-18 1994-11-24 University Of Utah Research Foundation Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
WO1995003538A1 (en) * 1993-07-20 1995-02-02 Balzers Aktiengesellschaft Optical biosensor matrix
WO1996035940A1 (en) * 1995-05-12 1996-11-14 Novartis Ag Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
US5639671A (en) * 1989-09-18 1997-06-17 Biostar, Inc. Methods for optimizing of an optical assay device
WO1998021571A1 (en) * 1996-11-11 1998-05-22 Novartis Ag Use of biosensors to diagnose plant diseases
WO1999054736A1 (en) * 1998-04-21 1999-10-28 Beckman Coulter, Inc. Detection of very low quantities of analyte
EP0971226A1 (de) * 1998-07-06 2000-01-12 Suzuki Motor Corporation SPR Sensorzelle und diese verwendende Vorrichtung für Immunoassay

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US4913519A (en) * 1988-03-04 1990-04-03 Fiberchem Inc. Optical sensor for the detection of ice formation and other chemical species
GB8811919D0 (en) * 1988-05-20 1988-06-22 Amersham Int Plc Biological sensors
US5919712A (en) * 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
DE19732619C2 (de) * 1997-07-29 1999-08-19 Fraunhofer Ges Forschung Optische Detektoreinrichtung
NL1008934C2 (nl) * 1998-04-20 1999-10-21 Univ Twente Geïntegreerde optische lichtgeleider inrichting.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639671A (en) * 1989-09-18 1997-06-17 Biostar, Inc. Methods for optimizing of an optical assay device
WO1994027137A2 (en) * 1993-05-18 1994-11-24 University Of Utah Research Foundation Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
WO1995003538A1 (en) * 1993-07-20 1995-02-02 Balzers Aktiengesellschaft Optical biosensor matrix
WO1996035940A1 (en) * 1995-05-12 1996-11-14 Novartis Ag Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
WO1998021571A1 (en) * 1996-11-11 1998-05-22 Novartis Ag Use of biosensors to diagnose plant diseases
WO1999054736A1 (en) * 1998-04-21 1999-10-28 Beckman Coulter, Inc. Detection of very low quantities of analyte
EP0971226A1 (de) * 1998-07-06 2000-01-12 Suzuki Motor Corporation SPR Sensorzelle und diese verwendende Vorrichtung für Immunoassay

Also Published As

Publication number Publication date
JP2003531361A (ja) 2003-10-21
DE10012793C2 (de) 2002-01-24
DE10012793A1 (de) 2001-09-27
US20030132406A1 (en) 2003-07-17
WO2001069256A2 (de) 2001-09-20
AU4407101A (en) 2001-09-24
EP1264180A2 (de) 2002-12-11

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