WO2001069261A3 - Proteines, genes et leur utilisation dans le diagnostic et le traitement de la demence vasculaire - Google Patents

Proteines, genes et leur utilisation dans le diagnostic et le traitement de la demence vasculaire Download PDF

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Publication number
WO2001069261A3
WO2001069261A3 PCT/GB2001/001106 GB0101106W WO0169261A3 WO 2001069261 A3 WO2001069261 A3 WO 2001069261A3 GB 0101106 W GB0101106 W GB 0101106W WO 0169261 A3 WO0169261 A3 WO 0169261A3
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WO
WIPO (PCT)
Prior art keywords
vascular dementia
treatment
vpis
diagnosis
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/001106
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English (en)
Other versions
WO2001069261A2 (fr
Inventor
Herath Mudiyanselage At Herath
Rajesh Bhikhu Parekh
Christian Rohlff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Glycosciences (UK) Ltd
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Oxford Glycosciences (UK) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0006285A external-priority patent/GB0006285D0/en
Priority claimed from GB0028734A external-priority patent/GB0028734D0/en
Application filed by Oxford Glycosciences (UK) Ltd filed Critical Oxford Glycosciences (UK) Ltd
Priority to EP01911898A priority Critical patent/EP1264183A2/fr
Priority to AU2001240820A priority patent/AU2001240820A1/en
Publication of WO2001069261A2 publication Critical patent/WO2001069261A2/fr
Publication of WO2001069261A3 publication Critical patent/WO2001069261A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00—Electrophoretic profiling, e.g. for proteome analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

La présente invention concerne des méthodes et des compositions convenant dans le criblage, le diagnostic et le pronostic de la démence vasculaire, ainsi que pour la surveillance de l'efficacité d'un traitement de la démence vasculaire, l'identification de patients susceptibles de réagir à un traitement thérapeutique particulier et le développement de médicaments. L'invention concerne également les caractéristiques associées à la démence vasculaire (VF), détectables par électrophorèse bidimensionnelle du liquide céphalo-rachidien, du sérum ou du plasma. L'invention concerne en outre des isoformes de protéines associées à la démence vasculaire (VPI), pouvant être détectées dans le liquide céphalo-rachidien, le sérum ou le plasma, ainsi que des préparations contenant des VPI isolées, des anticorps immunospécifiques pour ces VPI et des kits contenant les éléments susmentionnés.
PCT/GB2001/001106 2000-03-15 2001-03-14 Proteines, genes et leur utilisation dans le diagnostic et le traitement de la demence vasculaire Ceased WO2001069261A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01911898A EP1264183A2 (fr) 2000-03-15 2001-03-14 Le diagnostic et le traitement de la demence vasculaire
AU2001240820A AU2001240820A1 (en) 2000-03-15 2001-03-14 Proteins, genes and their use for diagnosis and treatment of vascular dementia

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0006285.1 2000-03-15
GB0006285A GB0006285D0 (en) 2000-03-15 2000-03-15 Proteins and their use for diagnosis and treatment of vascular dementia
GB0028734A GB0028734D0 (en) 2000-11-24 2000-11-24 Markers for vascular dementia
GB0028734.2 2000-11-24
US72439100A 2000-11-28 2000-11-28
US09/724,391 2000-11-28

Publications (2)

Publication Number Publication Date
WO2001069261A2 WO2001069261A2 (fr) 2001-09-20
WO2001069261A3 true WO2001069261A3 (fr) 2002-05-16

Family

ID=27255598

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001106 Ceased WO2001069261A2 (fr) 2000-03-15 2001-03-14 Proteines, genes et leur utilisation dans le diagnostic et le traitement de la demence vasculaire

Country Status (3)

Country Link
EP (1) EP1264183A2 (fr)
AU (1) AU2001240820A1 (fr)
WO (1) WO2001069261A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1368647A2 (fr) * 2000-12-29 2003-12-10 Oxford GlycoSciences (UK) Limited Proteines, genes et leur utilisation pour le diagnostic et le traitement de la reponse vasculaire
US7052849B2 (en) 2001-11-23 2006-05-30 Syn X Pharma, Inc. Protein biopolymer markers predictive of insulin resistance
US20030100012A1 (en) * 2001-11-23 2003-05-29 George Jackowski Plasma protease C1 biopolymer markers predictive of alzheimers disease
WO2004001421A2 (fr) * 2002-06-21 2003-12-31 Innogenetics N.V. Procede de diagnostic et diagnostic differentiel des maladies neurologiques
EP3654038B8 (fr) * 2017-07-13 2024-11-06 Mcbi Inc. Biomarqueur pour troubles de type déficience cognitive et méthode de dépistage des troubles de type déficience cognitive à l'aide dudit biomarqueur
CN111773204B (zh) * 2019-04-03 2023-01-24 上海市浦东新区浦南医院 二氯乙酸钠在制备治疗血管性痴呆药物中的用途

Citations (8)

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Publication number Priority date Publication date Assignee Title
WO1995002045A2 (fr) * 1993-07-09 1995-01-19 Celltech Limited Antagonistes de gelatinase utilises dans le traitement de cancer
WO1995030433A1 (fr) * 1994-05-09 1995-11-16 Research Development Foundation Nouvelle proteine endotheliale du cerveau et procedes d'utilisation de cette proteine
WO1995035373A2 (fr) * 1994-06-10 1995-12-28 La Jolla Cancer Research Foundation Molecules d'acide nucleique codant la contactine humaine
WO1996037776A1 (fr) * 1995-05-26 1996-11-28 Sugen, Inc. Ligands fonctionnels de la contactine molecule de reconnaissance des cellules axonales
EP0796913A2 (fr) * 1996-03-19 1997-09-24 Otsuka Pharmaceutical Co., Ltd. Protéine stimulant la dissociation du GDP, protéine d'assemblage de nucléosome spécifique au cerveau, enzyme de conjugaison d'ubiquitine spécifique aux muscles du squelette, protéine de prolifération de cellule, phosphatidylinositolkinase, protéines apparentés à nel
WO1998027226A2 (fr) * 1996-12-16 1998-06-25 Nova Molecular, Inc. Procede d'etablissement d'un pronostic pour un patient atteint d'une maladie neurologique
WO2000070099A2 (fr) * 1999-05-19 2000-11-23 Mitokor Expression genique differente dans des regions specifiques du cerveau, dans des maladies neurodegeneratives
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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995002045A2 (fr) * 1993-07-09 1995-01-19 Celltech Limited Antagonistes de gelatinase utilises dans le traitement de cancer
WO1995030433A1 (fr) * 1994-05-09 1995-11-16 Research Development Foundation Nouvelle proteine endotheliale du cerveau et procedes d'utilisation de cette proteine
WO1995035373A2 (fr) * 1994-06-10 1995-12-28 La Jolla Cancer Research Foundation Molecules d'acide nucleique codant la contactine humaine
WO1996037776A1 (fr) * 1995-05-26 1996-11-28 Sugen, Inc. Ligands fonctionnels de la contactine molecule de reconnaissance des cellules axonales
EP0796913A2 (fr) * 1996-03-19 1997-09-24 Otsuka Pharmaceutical Co., Ltd. Protéine stimulant la dissociation du GDP, protéine d'assemblage de nucléosome spécifique au cerveau, enzyme de conjugaison d'ubiquitine spécifique aux muscles du squelette, protéine de prolifération de cellule, phosphatidylinositolkinase, protéines apparentés à nel
WO1998027226A2 (fr) * 1996-12-16 1998-06-25 Nova Molecular, Inc. Procede d'etablissement d'un pronostic pour un patient atteint d'une maladie neurologique
WO2000070099A2 (fr) * 1999-05-19 2000-11-23 Mitokor Expression genique differente dans des regions specifiques du cerveau, dans des maladies neurodegeneratives
WO2001026671A1 (fr) * 1999-10-12 2001-04-19 Smithkline Beecham Corporation Procedes de traitement au moyen d'inhibiteurs doubles de metalloproteinase-2 matricielle et de metalloproteinase-9 matricielle

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Also Published As

Publication number Publication date
WO2001069261A2 (fr) 2001-09-20
AU2001240820A1 (en) 2001-09-24
EP1264183A2 (fr) 2002-12-11

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