WO2001098518A3 - Biotransformation von biologisch aktiven verbindungen aus verschiedenen chemischen stoffklassen mittels der enzyme laccase und manganperoxidase - Google Patents

Biotransformation von biologisch aktiven verbindungen aus verschiedenen chemischen stoffklassen mittels der enzyme laccase und manganperoxidase Download PDF

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Publication number
WO2001098518A3
WO2001098518A3 PCT/EP2001/007152 EP0107152W WO0198518A3 WO 2001098518 A3 WO2001098518 A3 WO 2001098518A3 EP 0107152 W EP0107152 W EP 0107152W WO 0198518 A3 WO0198518 A3 WO 0198518A3
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Prior art keywords
active ingredients
functional groups
activity
enzymes
additional functional
Prior art date
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Ceased
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PCT/EP2001/007152
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English (en)
French (fr)
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WO2001098518A2 (de
Inventor
Wolf-Dieter Juelich
Frieder Schauer
Ulrike Lindequist
Elke Hammer
Annett Schaefer
Ulrike Jonas
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Ganomycin Gesellschaft fuer Biomedizinische Forschung mbH
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Ganomycin Gesellschaft fuer Biomedizinische Forschung mbH
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Application filed by Ganomycin Gesellschaft fuer Biomedizinische Forschung mbH filed Critical Ganomycin Gesellschaft fuer Biomedizinische Forschung mbH
Priority to EP01951629A priority Critical patent/EP1303631B9/de
Priority to JP2002504666A priority patent/JP2004501619A/ja
Priority to CA002413554A priority patent/CA2413554A1/en
Priority to DK01951629.3T priority patent/DK1303631T3/da
Priority to AU72506/01A priority patent/AU7250601A/en
Priority to DE50115493T priority patent/DE50115493D1/de
Priority to AT01951629T priority patent/ATE469232T1/de
Publication of WO2001098518A2 publication Critical patent/WO2001098518A2/de
Publication of WO2001098518A3 publication Critical patent/WO2001098518A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Verfahren zur Herstellung von biologisch aktiven Wirkstoffen, wobei ausgehend von Arznei- und Pflanzenschutzmitteln als Substrate, die als funktionelle Gruppe mindestens eine Amino- oder Hydroxylgruppe tragen, mittels einer durch Enzyme oder Mischungen mit enzymatischer Aktivität mit breitem Substratspektrum katalysierten ein-Elektronen-Reaktion Wirkstoffe mit zusätzlichen funktionellen Gruppen und modifiziertem Wirkungsspektrum und modifizierten Anwendungseigenschaften erhältlich werden, dadurch gekennzeichnet, dass als Enzyme radikalbildende Enzyme und/oder als Mischungen mit enzymatischer Aktivität Überstände ligninolytischer Pilze in wässriger Lösung eingesetzt werden, wobei als zusätzliche funktionelle Gruppen A) polyfunktionelle Synthone, die dem Wirkstoff ein verändertes Lösungsverhalten in wässrigen und lipophilen Systemen und eine hohe Grenzflächenaktivität verleihen, B) aromatische Moleküle, heteroaromatische Verbindungen, C) Heterozyklische Verbindungen, D) Wirkstoffe mit eigenständiger biologischer Wirksamkeit, E) Wirkstoffe, die eine eigenständige Wirkung und Tensideigenschaften in einem Molekül vereinen, einführbar sind, die mit den Ausgangstoffen kovalent verknüpfte Kopplungsprodukte mit verändertem Verteilungsverhalten ergeben, durch die polyfunktionale Interaktionen mit dem Zielorganismus ermöglicht werden.
PCT/EP2001/007152 2000-06-23 2001-06-23 Biotransformation von biologisch aktiven verbindungen aus verschiedenen chemischen stoffklassen mittels der enzyme laccase und manganperoxidase Ceased WO2001098518A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP01951629A EP1303631B9 (de) 2000-06-23 2001-06-23 Biotransformation von biologisch aktiven verbindungen aus verschiedenen chemischen stoffklassen mittels der enzyme laccase und manganperoxidase
JP2002504666A JP2004501619A (ja) 2000-06-23 2001-06-23 酵素ラッカーゼおよびマンガンペルオキシダーゼを用いる異なる種類の化学物質からの生物学的活性化合物の生体内変化
CA002413554A CA2413554A1 (en) 2000-06-23 2001-06-23 Biotransformation of biologically active compounds made of various classes of chemical substances by means of laccase and manganese peroxidase enzymes
DK01951629.3T DK1303631T3 (da) 2000-06-23 2001-06-23 Biotransformation af biologisk aktive forbindelser fra forskellige kemiske stofklasser ved hjælp af enzymerne laccase og manganperoxidase
AU72506/01A AU7250601A (en) 2000-06-23 2001-06-23 Biotransformation of biologically active compounds made of various classes of chemical substances by means of laccase and manganese peroxidase enzymes
DE50115493T DE50115493D1 (de) 2000-06-23 2001-06-23 Biotransformation von biologisch aktiven verbindungen aus verschiedenen chemischen stoffklassen mittels der enzyme laccase und manganperoxidase
AT01951629T ATE469232T1 (de) 2000-06-23 2001-06-23 Biotransformation von biologisch aktiven verbindungen aus verschiedenen chemischen stoffklassen mittels der enzyme laccase und manganperoxidase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10029671A DE10029671A1 (de) 2000-06-23 2000-06-23 Biotransformation von biologisch aktiven Verindungen aus verschiedenen chemischen Stoffklassen mittels der Enzyme Laccase und Manganperoxidase
DE10029671.8 2000-06-23

Publications (2)

Publication Number Publication Date
WO2001098518A2 WO2001098518A2 (de) 2001-12-27
WO2001098518A3 true WO2001098518A3 (de) 2002-06-20

Family

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PCT/EP2001/007152 Ceased WO2001098518A2 (de) 2000-06-23 2001-06-23 Biotransformation von biologisch aktiven verbindungen aus verschiedenen chemischen stoffklassen mittels der enzyme laccase und manganperoxidase

Country Status (11)

Country Link
US (1) US20030180893A1 (de)
EP (1) EP1303631B9 (de)
JP (1) JP2004501619A (de)
AT (1) ATE469232T1 (de)
AU (1) AU7250601A (de)
CA (1) CA2413554A1 (de)
DE (2) DE10029671A1 (de)
DK (1) DK1303631T3 (de)
ES (1) ES2346183T3 (de)
PT (1) PT1303631E (de)
WO (1) WO2001098518A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2407433A1 (de) * 2010-07-15 2012-01-18 Da Volterra Verfahren zur Deaktivierung von Antibiotika
ES2701238T3 (es) * 2014-12-16 2019-02-21 Luxembourg Inst Science & Tech List Método de degradación e inactivación de antibióticos en agua mediante enzimas inmovilizadas en soportes funcionalizados
EP3210596A1 (de) 2016-02-29 2017-08-30 G.L. Pharma GmbH Missbrauchsverhindernde pharmazeutische zusammensetzung
EP3210630A1 (de) 2016-02-29 2017-08-30 G.L. Pharma GmbH Missbrauch-abschreckende pharmazeutische zusammensetzungen
EP3231420A1 (de) * 2016-02-29 2017-10-18 G.L. Pharma GmbH Missbrauchsverhindernde pharmazeutische zusammensetzungen
CN111302499B (zh) * 2019-11-07 2022-04-08 桂林理工大学 一种快速催化降解己烯雌酚的方法
CN111567517B (zh) * 2020-05-14 2021-08-10 河北威远生物化工有限公司 一种新型水性农药悬浮剂及其制备方法
CN115612403B (zh) * 2021-07-14 2023-12-01 中国科学院天津工业生物技术研究所 自组装强黏附共聚物膜及镀膜方法与应用
CN114380802B (zh) * 2022-01-07 2023-11-17 贵州大学 一类含咔唑基咪唑盐类化合物及其制备方法和应用
CN114563494A (zh) * 2022-02-25 2022-05-31 浙江大学 固相萃取-真空离心浓缩-液相色谱串联质谱检测饮用水中卤代萘醌的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960945A2 (de) * 1998-05-26 1999-12-01 Unifar Kimya Sanayii ve Ticaret A.S Verfahren zur enzymatischen Herstellung von Betalaktamantibiotika mit Produktrückgewinnung bei pH 1 in Gegenwart von immobilisiertes Penicillinamidase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT978495B (it) * 1973-01-26 1974-09-20 Antonimi E Procedimento per condurre reazio ni enzimatiche mediante l uso di sistemi bifasici acquoso organici
US4478683A (en) * 1981-11-09 1984-10-23 Westvaco Corporation Enzymatic catalyzed biocide system
US6015683A (en) * 1992-07-15 2000-01-18 Clinical Diagnostic Systems, Inc. Dry analytical element for acetaminophen assay
US5389356A (en) * 1993-01-05 1995-02-14 Utah State University Foundation Compounds and methods for generating oxygen free radicals used in general oxidation and reduction reactions
US5695951A (en) * 1994-12-20 1997-12-09 Biopure Corporation Chlorination of cephalexin with chloroperoxidase from Rathayibacter biopuresis
US5597704A (en) * 1995-05-01 1997-01-28 Food Industry Research And Development Institute Bioconversion of cephalosporin C to glutaryl-7-aminocephalosporanic acid
DE19726241A1 (de) * 1997-06-20 1998-12-24 Call Krimhild Erweitertes enzymatisches Multikomponentensystem zur Behandlung von Abwässern, zur Herstellung von Holzverbundstoffen, zum Deinken von Altpapier, Colour stripping von Altpapier, zum Einsatz als Oxidationssystem bei der organischen Synthese und zum Einsatz bei der Kohleverflüssigung
US6232457B1 (en) * 1998-09-10 2001-05-15 The Regents Of The University Of California Recombinant vanadium haloperoxidases and their uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960945A2 (de) * 1998-05-26 1999-12-01 Unifar Kimya Sanayii ve Ticaret A.S Verfahren zur enzymatischen Herstellung von Betalaktamantibiotika mit Produktrückgewinnung bei pH 1 in Gegenwart von immobilisiertes Penicillinamidase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AGEMATU HITOSI ET AL: "Transformation of 7-(4-hydroxyphenylacetamido)cephalosporanic acid into a new cephalosporin antibiotic, 7-(1-oxaspiro(2.5)octa-6-oxo-4,7 -diene-2-carboxamido)cephalosporanic acid, by laccase.", BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 57, no. 8, 1993, pages 1387 - 1388, XP002183146, ISSN: 0916-8451 *
ANYANWUTAKU I ET AL: "Oxidative coupling of Mithramycin and Hydroquinone catalyzed by Copper Oxidases and Benzoquinone. Implications for the mechanism of action of aureolic acid antibiotics", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, no. 6, 1994, pages 543 - 551, XP001041413 *
BHALERAO UDAY T ET AL: "Laccase enzyme catalysed efficient synthesis of 3-substituted-1,2,4-triazolo(4,3-b)(4,1,2)-benzothiadiazine-8-ones.", TETRAHEDRON, vol. 50, no. 13, 1994, pages 4019 - 4024, XP002183145, ISSN: 0040-4020 *
EGGERT CLAUDIA ET AL: "Laccase-mediated formation of the phenoxazinone derivative, cinnabarinic acid.", FEBS LETTERS, vol. 376, no. 3, 1995, pages 202 - 206, XP002183621, ISSN: 0014-5793 *
OSIADACZ J ET AL: "On the use of Trametes versicolor laccase for the conversion of 4-methyl-3-hydroxyanthranilic acid to actinocin chromophore", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 72, no. 1-2, 11 June 1999 (1999-06-11), pages 141 - 149, XP004172894, ISSN: 0168-1656 *

Also Published As

Publication number Publication date
EP1303631B1 (de) 2010-05-26
ES2346183T3 (es) 2010-10-13
DK1303631T3 (da) 2010-09-06
US20030180893A1 (en) 2003-09-25
ATE469232T1 (de) 2010-06-15
EP1303631A2 (de) 2003-04-23
EP1303631B9 (de) 2010-09-08
PT1303631E (pt) 2010-07-15
JP2004501619A (ja) 2004-01-22
CA2413554A1 (en) 2001-12-27
WO2001098518A2 (de) 2001-12-27
DE50115493D1 (de) 2010-07-08
AU7250601A (en) 2002-01-02
DE10029671A1 (de) 2002-01-10

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