WO2002000638A3 - Nouveaux phthalides substitues, leur procede de preparation et compositions pharmaceutiques les contenant - Google Patents

Nouveaux phthalides substitues, leur procede de preparation et compositions pharmaceutiques les contenant Download PDF

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Publication number
WO2002000638A3
WO2002000638A3 PCT/IB2001/001535 IB0101535W WO0200638A3 WO 2002000638 A3 WO2002000638 A3 WO 2002000638A3 IB 0101535 W IB0101535 W IB 0101535W WO 0200638 A3 WO0200638 A3 WO 0200638A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
substituted phthalides
convulsive drugs
convulsive
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/001535
Other languages
English (en)
Other versions
WO2002000638A2 (fr
WO2002000638A8 (fr
Inventor
Zongru Guo
Fengming Chu
Juntian Zhang
Guangzhong Yang
Bailing Xu
Xinyi Niu
Zhihong Ren
Pierre Lestage
Pierre Renard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Materia Medica, CAMS&PUMC
Les Laboratoires Servier SAS
Original Assignee
Institute of Materia Medica, CAMS&PUMC
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SK106-2003A priority Critical patent/SK1062003A3/sk
Priority to BR0112043-3A priority patent/BR0112043A/pt
Priority to JP2002505386A priority patent/JP2004501909A/ja
Priority to EP01958282A priority patent/EP1320528A2/fr
Priority to CNB018120687A priority patent/CN100402515C/zh
Priority to AU2001280004A priority patent/AU2001280004A1/en
Priority to EA200300044A priority patent/EA200300044A1/ru
Priority to US10/312,650 priority patent/US6689808B2/en
Priority to MXPA02012569A priority patent/MXPA02012569A/es
Application filed by Institute of Materia Medica, CAMS&PUMC, Les Laboratoires Servier SAS filed Critical Institute of Materia Medica, CAMS&PUMC
Priority to CA002413752A priority patent/CA2413752A1/fr
Priority to HU0301567A priority patent/HUP0301567A3/hu
Priority to NZ523174A priority patent/NZ523174A/en
Publication of WO2002000638A2 publication Critical patent/WO2002000638A2/fr
Publication of WO2002000638A3 publication Critical patent/WO2002000638A3/fr
Priority to NO20026154A priority patent/NO20026154L/no
Anticipated expiration legal-status Critical
Publication of WO2002000638A8 publication Critical patent/WO2002000638A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I): dans laquelle R1 représente un alkyle ou un groupe uréido, R2 représente un groupe alkyle ou un atome d'hydrogène, ou R1 et R2 forment ensemble un cycle à 5 ou 6 éléments, R3 signifie un groupe CN, NO¿2?, NRaR'a, NRaSO2R'a, NRaCZR5 ou CZNRaR'a, R?4¿ signifie un atome d'hydrogène ou un groupe R3.
PCT/IB2001/001535 2000-06-28 2001-06-27 Nouveaux phthalides substitues, leur procede de preparation et compositions pharmaceutiques les contenant Ceased WO2002000638A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
MXPA02012569A MXPA02012569A (es) 2000-06-28 2001-06-27 Ftalidas substituidas novedosas, un procedimiento para su preparacion y las composiciones farmaceuticas que contienen a las mismas.
JP2002505386A JP2004501909A (ja) 2000-06-28 2001-06-27 抗けいれん薬としての置換フタリド類
CA002413752A CA2413752A1 (fr) 2000-06-28 2001-06-27 Nouveaux phthalides substitues, leur procede de preparation et compositions pharmaceutiques les contenant
CNB018120687A CN100402515C (zh) 2000-06-28 2001-06-27 用作抗惊厥药的取代2-苯并[c]呋喃酮
AU2001280004A AU2001280004A1 (en) 2000-06-28 2001-06-27 Substituted phthalides as anti-convulsive drugs
EA200300044A EA200300044A1 (ru) 2000-06-28 2001-06-27 Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
US10/312,650 US6689808B2 (en) 2000-06-28 2001-06-27 Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them
SK106-2003A SK1062003A3 (en) 2000-06-28 2001-06-27 Substituted phthalides as anti-convulsive drugs
EP01958282A EP1320528A2 (fr) 2000-06-28 2001-06-27 Substituierte phthalide als antikonvulsive medikamente
BR0112043-3A BR0112043A (pt) 2000-06-28 2001-06-27 Ftalidas substituìdas, processo para sua preparação e composições farmacêuticas contendo-as
HU0301567A HUP0301567A3 (en) 2000-06-28 2001-06-27 Substituted phthalides as anti-convulsive drugs
NZ523174A NZ523174A (en) 2000-06-28 2001-06-27 New substituted phthalides, a process for their preparation and pharmaceutical compositions containing them
NO20026154A NO20026154L (no) 2000-06-28 2002-12-20 Nye substituerte ftalider, fremgangsmåte for deres fremstilling og farmasöytiske sammensetninger inneholdende dem

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN00119329.5 2000-06-28
CNB001193295A CN1182127C (zh) 2000-06-28 2000-06-28 新的取代的2-苯并[c]呋喃酮化合物,其制备方法以及包含它们的药物组合物

Publications (3)

Publication Number Publication Date
WO2002000638A2 WO2002000638A2 (fr) 2002-01-03
WO2002000638A3 true WO2002000638A3 (fr) 2002-05-23
WO2002000638A8 WO2002000638A8 (fr) 2003-08-28

Family

ID=4587601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001535 Ceased WO2002000638A2 (fr) 2000-06-28 2001-06-27 Nouveaux phthalides substitues, leur procede de preparation et compositions pharmaceutiques les contenant

Country Status (19)

Country Link
US (1) US6689808B2 (fr)
EP (1) EP1320528A2 (fr)
JP (1) JP2004501909A (fr)
KR (1) KR20030024710A (fr)
CN (2) CN1182127C (fr)
AR (1) AR030239A1 (fr)
AU (1) AU2001280004A1 (fr)
BR (1) BR0112043A (fr)
CA (1) CA2413752A1 (fr)
CZ (1) CZ2003245A3 (fr)
EA (1) EA200300044A1 (fr)
HU (1) HUP0301567A3 (fr)
MX (1) MXPA02012569A (fr)
NO (1) NO20026154L (fr)
NZ (1) NZ523174A (fr)
PL (1) PL359373A1 (fr)
SK (1) SK1062003A3 (fr)
WO (1) WO2002000638A2 (fr)
ZA (1) ZA200210004B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7691420B2 (en) 2003-09-23 2010-04-06 Dsm Ip Assets B.V. Compositions for the treatment and prevention of diabetes mellitus
US8242168B2 (en) 2003-05-14 2012-08-14 Dsm Ip Assets B.V. Use of phthalide derivatives for the treatment of type 2 diabetes mellitus

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1605336A (zh) * 2003-10-10 2005-04-13 中国医学科学院药物研究所 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用
EP1757286B1 (fr) * 2004-06-18 2017-09-06 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Utilisation de l-n-butylphthalide pour la prevention ou le traitement de la maladie d'alzheimer
CN102125548A (zh) * 2010-01-13 2011-07-20 石药集团恩必普药业有限公司 丁苯酞及其衍生物在制备治疗帕金森病的药物中的应用
CN102260233A (zh) * 2011-05-04 2011-11-30 武汉科技大学 3-丁基-1(3h)-异苯并呋喃酮衍生物及其制备方法
CN105367526B (zh) * 2015-10-14 2017-07-28 济南诚汇双达化工有限公司 一种高纯度正丁基苯酞的制备方法
CN108727352B (zh) * 2017-04-14 2021-04-23 四川大学 一类哌啶烷氨甲酰基苯酞类化合物、其制备方法和用途
EP3845524B1 (fr) * 2018-03-19 2022-08-31 Henan Genuine Biotech Co., Ltd. Composés d'acide benzoïque, procédé de préparation associé et utilisations correspondantes
CN108752300B (zh) * 2018-05-16 2022-03-25 中国科学院昆明植物研究所 苄烯叉苯肽类化合物及其药物组合物和其应用
CN109111415B (zh) * 2018-10-25 2022-08-23 安徽中医药大学 一类石斛生物碱衍生物、制备方法和医药用途
CN112010827A (zh) * 2019-05-28 2020-12-01 四川大学 一类苄胺基苯酞类化合物、其制备方法和用途
CN112010837B (zh) * 2019-05-28 2021-12-17 四川大学 一类吡啶甲胺基苯酞类化合物、其制备方法和用途
CN110452203B (zh) * 2019-08-29 2021-04-13 忻州师范学院 一种1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的制备方法
CN112794831B (zh) * 2021-04-06 2021-07-27 北京理工大学 3-(3′-羟基丁基)异苯并呋喃-1(3h)-酮衍生物及其组合物、制备方法和用途
CN121405653A (zh) * 2024-07-26 2026-01-27 中国海洋大学 一种基于丁基苯酞结构的芳香烷胺类铁死亡抑制剂及其制备方法和应用
WO2026032440A1 (fr) * 2024-08-09 2026-02-12 千乘镜像(北京)科技有限公司 Composé tricyclique, son procédé de préparation et son utilisation
CN119176789B (zh) * 2024-09-14 2025-11-07 中国药科大学 一种具有神经保护功能的含脒基新型iNOS抑制剂及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151964A2 (fr) * 1984-02-02 1985-08-21 Laboratorio Farmaceutico C.T. s.r.l. Dérivés d'alpha-amino-gammabutyrolactone, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4855320A (en) * 1986-05-05 1989-08-08 Dr. Willmar Schwabe Gmbh & Company 5-arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them
EP0341081A2 (fr) * 1988-05-06 1989-11-08 Ono Pharmaceutical Co., Ltd. Dérivés amino-acides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW270133B (fr) * 1993-09-17 1996-02-11 Ciba Geigy
DE19618854A1 (de) * 1996-05-10 1997-11-13 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151964A2 (fr) * 1984-02-02 1985-08-21 Laboratorio Farmaceutico C.T. s.r.l. Dérivés d'alpha-amino-gammabutyrolactone, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4855320A (en) * 1986-05-05 1989-08-08 Dr. Willmar Schwabe Gmbh & Company 5-arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them
EP0341081A2 (fr) * 1988-05-06 1989-11-08 Ono Pharmaceutical Co., Ltd. Dérivés amino-acides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8242168B2 (en) 2003-05-14 2012-08-14 Dsm Ip Assets B.V. Use of phthalide derivatives for the treatment of type 2 diabetes mellitus
US7691420B2 (en) 2003-09-23 2010-04-06 Dsm Ip Assets B.V. Compositions for the treatment and prevention of diabetes mellitus

Also Published As

Publication number Publication date
CA2413752A1 (fr) 2002-01-03
CN1330069A (zh) 2002-01-09
NZ523174A (en) 2004-06-25
HUP0301567A2 (hu) 2003-09-29
CN1440398A (zh) 2003-09-03
AU2001280004A1 (en) 2002-01-08
HUP0301567A3 (en) 2005-08-29
NO20026154D0 (no) 2002-12-20
US6689808B2 (en) 2004-02-10
US20030220393A1 (en) 2003-11-27
CN1182127C (zh) 2004-12-29
KR20030024710A (ko) 2003-03-26
MXPA02012569A (es) 2004-05-17
ZA200210004B (en) 2003-12-10
CZ2003245A3 (cs) 2003-05-14
PL359373A1 (en) 2004-08-23
EP1320528A2 (fr) 2003-06-25
EA200300044A1 (ru) 2003-06-26
BR0112043A (pt) 2003-10-28
WO2002000638A2 (fr) 2002-01-03
NO20026154L (no) 2003-02-20
CN100402515C (zh) 2008-07-16
SK1062003A3 (en) 2003-05-02
WO2002000638A8 (fr) 2003-08-28
JP2004501909A (ja) 2004-01-22
AR030239A1 (es) 2003-08-13

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