WO2002000836A3 - Variants de spinigerine, un peptide antibacterien et antifongique derive de pseudacanthotermes spiniger, leur procede de preparation et les compositions les contenant - Google Patents

Variants de spinigerine, un peptide antibacterien et antifongique derive de pseudacanthotermes spiniger, leur procede de preparation et les compositions les contenant Download PDF

Info

Publication number
WO2002000836A3
WO2002000836A3 PCT/FR2001/002100 FR0102100W WO0200836A3 WO 2002000836 A3 WO2002000836 A3 WO 2002000836A3 FR 0102100 W FR0102100 W FR 0102100W WO 0200836 A3 WO0200836 A3 WO 0200836A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial
spinigerin
pseudacanthotermes
spiniger
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2001/002100
Other languages
English (en)
Other versions
WO2002000836A2 (fr
Inventor
Philippe Bulet
Jules Hoffmann
Mireille Lamberty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Entomed AB
Original Assignee
Centre National de la Recherche Scientifique
Entomed AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique, Entomed AB filed Critical Centre National de la Recherche Scientifique
Priority to AU2001270722A priority Critical patent/AU2001270722A1/en
Publication of WO2002000836A2 publication Critical patent/WO2002000836A2/fr
Publication of WO2002000836A3 publication Critical patent/WO2002000836A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)

Abstract

La présente invention a pour objet des peptides de formule: β1 ζ2 υ3 β4 β5 ζ6 σ7 υ8 β9 ζ10 ζ11 ζ12 ζ13 β14 υ15 ζ16 β17 ζ18 ζ19 β20 ζ21 ζ22 σ23 β24 ζ25 dans laquelle: β est un acide aminé basique, ζ est un acide aminé hydrophobe, υ est un acide aminé chargé négativement ou de nature polaire/large, σ est un acide aminé choisi parmi la glycine, la sérine, l'alanine ou la thréonine. L'invention concerne aussi des compositions antibactériennes ou antifongiques pour être utilisées chez l'homme, l'animal ou les plantes comprenant au moins desdits peptides.
PCT/FR2001/002100 2000-06-29 2001-06-29 Variants de spinigerine, un peptide antibacterien et antifongique derive de pseudacanthotermes spiniger, leur procede de preparation et les compositions les contenant Ceased WO2002000836A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001270722A AU2001270722A1 (en) 2000-06-29 2001-06-29 Spinigerin variants, an antibacterial and antifungal peptide derived from pseudacanthotermes spiniger, preparation method and compositions containing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR00/08436 2000-06-29
FR0008436A FR2810986B1 (fr) 2000-06-29 2000-06-29 Peptides antibacteriens et antifongiques, leur procede de preparation et les compositions les contenant

Publications (2)

Publication Number Publication Date
WO2002000836A2 WO2002000836A2 (fr) 2002-01-03
WO2002000836A3 true WO2002000836A3 (fr) 2002-08-29

Family

ID=8851898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/002100 Ceased WO2002000836A2 (fr) 2000-06-29 2001-06-29 Variants de spinigerine, un peptide antibacterien et antifongique derive de pseudacanthotermes spiniger, leur procede de preparation et les compositions les contenant

Country Status (3)

Country Link
AU (1) AU2001270722A1 (fr)
FR (1) FR2810986B1 (fr)
WO (1) WO2002000836A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005826A1 (fr) * 1987-02-06 1988-08-11 International Genetic Engineering, Inc. Polypeptides presentant une activite contre les bacteries gram-positives et gram-negatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005826A1 (fr) * 1987-02-06 1988-08-11 International Genetic Engineering, Inc. Polypeptides presentant une activite contre les bacteries gram-positives et gram-negatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LAMBERTY, M. ET AL.: "Insect Immunity - Constitutive Expression of a Cysteine-Rich Antifungal and a Linear Antibacterial Peptide in a Termite Insect", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 6, 9 February 2001 (2001-02-09), pages 4085 - 4092, XP002162835 *
LOWENBERGER, C. ET AL.: "Antimicrobial Activity Spectrum, cDNA Cloning, and mRNA Expression of a Newly Isolated Member of the Cecropin Family from Mosquito Vector Aedes aegypti", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 29, 16 July 1999 (1999-07-16), pages 20092 - 20097, XP002165176 *

Also Published As

Publication number Publication date
FR2810986B1 (fr) 2002-09-27
WO2002000836A2 (fr) 2002-01-03
AU2001270722A1 (en) 2002-01-08
FR2810986A1 (fr) 2002-01-04

Similar Documents

Publication Publication Date Title
PT1927597T (pt) Péptidos antibacterianos
PL372626A1 (en) Peptide derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions
WO2005040192A3 (fr) Peptides antimicrobiens de la cathelidicine humaine
WO1998020133A3 (fr) Proteines a concentration amelioree en acides amines essentiels
CA2158058A1 (fr) Peptides biologiquement actifs provenant de domaines fonctionnels de proteines bactericides et augmentant la permeabilite; leurs utilisations
WO2002022821A3 (fr) Peptides antimicrobiens et methodes d'utilisation
FR2792202B1 (fr) Extrait peptidique de lupin et composition pharmaceutique ou cosmetique ou nutraceutique comprenant un tel extrait
ATE368053T1 (de) Antimikrobielle peptide
MX9701946A (es) Solucion oftalmica transportadora.
AU3780901A (en) Pharmaceutical composition for muscular anabolism
DE69911579D1 (de) Antimikrobielle peptide
WO2005060683A3 (fr) Peptides de petite taille pour le traitement de la maladie d'alzheimer et d'autres troubles de fibrillogenese de la proteine beta-amyloide
AU2002240057A1 (en) Therapeutic peptides for demyelinating conditions
EP2270035A3 (fr) Peptides améliorant l'activité CEH, compositions pharmaceutiques comprenant ces peptides et leur utilisation dans le traitement de l'athérosclérose
WO2005006938A3 (fr) Implants medicaux antimicrobiens et utilisations associees
WO2009091860A3 (fr) Compositions et procédés pour la suppression des polynucléotides cibles de la famille aphididae
WO2003013599A3 (fr) Vaccin anti-coronavirus.
MXPA03002334A (es) Combinaciones de productos activos para la proteccion de pieles animales y de cuero.
WO2004005339A3 (fr) Peptides lineaires cationiques ayant des proprietes antibacteriennes et/ou antifongiwues
MXPA03001304A (es) Acidos amino(oxo)aceticos inhibidores de la proteina tirosina fosfatasa.
EP1602721B8 (fr) Phospholipase a sb 2 /sb d'origine moule koji
HUP0400737A3 (en) Use of l-carnitine for preparation of compositions for stabilizing the proteins
WO2001000784A3 (fr) COMPOSE PEPTIDIQUE DERIVE D'UNE ORF DECALEE DU GENE iCE
DK1425295T3 (da) Modificerede peptider og deres anvendelse til behandling af autoimmune sygdomme
NO20004168D0 (no) Diagnostisk peptidreagens samt sett for pÕvisning av rickettsiosis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: CONSTATATION DE LA PERTE D UN DROIT SCIENTIFIQUE A LA REGLE 69(1) CBE (OEB FORM 1205A DU 11.03.2003)

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP