WO2002000853A3 - Regulation de la protease de type caspase 1 humaine - Google Patents

Regulation de la protease de type caspase 1 humaine Download PDF

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Publication number
WO2002000853A3
WO2002000853A3 PCT/EP2001/007287 EP0107287W WO0200853A3 WO 2002000853 A3 WO2002000853 A3 WO 2002000853A3 EP 0107287 W EP0107287 W EP 0107287W WO 0200853 A3 WO0200853 A3 WO 0200853A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease
human caspase
regulation
reagents
caspase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007287
Other languages
English (en)
Other versions
WO2002000853A2 (fr
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001269095A priority Critical patent/AU2001269095A1/en
Priority to EP01947406A priority patent/EP1297154A2/fr
Priority to US10/311,954 priority patent/US20040132023A1/en
Publication of WO2002000853A2 publication Critical patent/WO2002000853A2/fr
Publication of WO2002000853A3 publication Critical patent/WO2002000853A3/fr
Anticipated expiration legal-status Critical
Priority to US11/357,125 priority patent/US7192732B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22036—Caspase-1 (3.4.22.36), i.e. interleukin-1-beta-convertase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des réactifs qui régulent l'activité de la protéase de type caspase 1 humaine et des réactifs qui se lient à des produits géniques de la protéase de type caspase 1 humaine. Ces réactifs peuvent être utilisés pour traiter une maladie allergique, l'asthme, le cancer et les maladies neurodégénératives.
PCT/EP2001/007287 2000-06-26 2001-06-26 Regulation de la protease de type caspase 1 humaine Ceased WO2002000853A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2001269095A AU2001269095A1 (en) 2000-06-26 2001-06-26 Regulation of human caspase-1-like protease
EP01947406A EP1297154A2 (fr) 2000-06-26 2001-06-26 Regulation de la protease de type caspase 1 humaine
US10/311,954 US20040132023A1 (en) 2000-06-26 2001-06-26 Regulation of human caspase-1-like protease
US11/357,125 US7192732B2 (en) 2000-06-26 2006-02-21 Regulation of human caspase-1-like protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21400900P 2000-06-26 2000-06-26
US60/214,009 2000-06-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10311954 A-371-Of-International 2001-06-26
US11/357,125 Continuation US7192732B2 (en) 2000-06-26 2006-02-21 Regulation of human caspase-1-like protease

Publications (2)

Publication Number Publication Date
WO2002000853A2 WO2002000853A2 (fr) 2002-01-03
WO2002000853A3 true WO2002000853A3 (fr) 2002-08-08

Family

ID=22797417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007287 Ceased WO2002000853A2 (fr) 2000-06-26 2001-06-26 Regulation de la protease de type caspase 1 humaine

Country Status (4)

Country Link
US (2) US20040132023A1 (fr)
EP (1) EP1297154A2 (fr)
AU (1) AU2001269095A1 (fr)
WO (1) WO2002000853A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1746167A1 (fr) * 2005-07-20 2007-01-24 Apoxis SA Méthode d'identification des components anti-inflammatoires.
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
DE102011118024A1 (de) * 2011-08-01 2013-02-07 Technische Universität Dresden Inhibitor der Expression der Pro-Caspase 1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858778A (en) * 1996-12-27 1999-01-12 Thomas Jefferson University SF caspase-1 and compositions for making and methods of using the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962301A (en) 1992-06-12 1999-10-05 Massachusetts Institute Of Technology Relatedness of human interleukin-1β convertase gene to a C. elegans cell death gene, inhibitory portions of these genes and uses therefor
AU5102993A (en) 1992-09-18 1994-04-12 Merck & Co., Inc. Dna encoding murine precursor interleukin 1beta converting enzyme
US5654146A (en) * 1995-05-31 1997-08-05 Incyte Pharmaceuticals, Inc. Human ice homolog
US5869315A (en) * 1995-12-18 1999-02-09 Basf Aktiengesellschaft Modified interleukin-1β converting enzyme with increased stability
CA2328457A1 (fr) * 1998-06-20 1999-12-29 Washington University Complexes peptidiques de permeation membranaire destines a l'imagerie medicale, au diagnostic et a la therapie pharmaceutique
WO2001098468A2 (fr) * 2000-06-16 2001-12-27 Incyte Genomics, Inc. Proteases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858778A (en) * 1996-12-27 1999-01-12 Thomas Jefferson University SF caspase-1 and compositions for making and methods of using the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 10 October 1998 (1998-10-10), ROBERT STRAUSBERG: "similar to gb:M87507 INTERLEUKIN-1 BETA CONVERTASE PRECURSOR (HUMAN)", XP002192390, retrieved from EBI Database accession no. AI189378 *
DATABASE EMBL [online] 28 October 1998 (1998-10-28), ROBERT STRAUSBERG: "similar to gb:M87507 INTERLEUKIN-1 BETA CONVERTASE", XP002192391, retrieved from EBI Database accession no. AI220630 *
DATABASE SWALL [online] 1 April 1993 (1993-04-01), THORNBERRY,N.A., ET AL.: "INTERLEUKIN-1 BETA CONVERTASE (IL-1BC) (EC 3.4.22.36)", XP002192392, retrieved from EBI Database accession no. P29466 *
See also references of EP1297154A2 *

Also Published As

Publication number Publication date
EP1297154A2 (fr) 2003-04-02
US7192732B2 (en) 2007-03-20
AU2001269095A1 (en) 2002-01-08
WO2002000853A2 (fr) 2002-01-03
US20060141552A1 (en) 2006-06-29
US20040132023A1 (en) 2004-07-08

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