WO2002000928A3 - Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung - Google Patents

Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung Download PDF

Info

Publication number
WO2002000928A3
WO2002000928A3 PCT/EP2001/007537 EP0107537W WO0200928A3 WO 2002000928 A3 WO2002000928 A3 WO 2002000928A3 EP 0107537 W EP0107537 W EP 0107537W WO 0200928 A3 WO0200928 A3 WO 0200928A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune system
diagnosis
diseases associated
cytosine methylation
genes associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007537
Other languages
English (en)
French (fr)
Other versions
WO2002000928A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10032529A external-priority patent/DE10032529A1/de
Application filed by Epigenomics AG filed Critical Epigenomics AG
Priority to EP01967115A priority Critical patent/EP1294951A2/de
Priority to AU2001287575A priority patent/AU2001287575A1/en
Publication of WO2002000928A2 publication Critical patent/WO2002000928A2/de
Publication of WO2002000928A3 publication Critical patent/WO2002000928A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Die vorliegende Erfindung betrifft die chemisch modifizierte genomische Sequenzen von mit dem Immunsystem assoziierten Genen, gegen die Sequenz gerichtete Oligonukleotide und/oder PNA-Oligomere zur Detektion des Cytosin-Methylierungszustandes von mit dem Immunsystem assoziierten Genen sowie ein Verfahren zur Ermittlung von genetischen und/oder epigenetischen Parametern von mit dem Immunsystem assoziierten Genen.
PCT/EP2001/007537 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung Ceased WO2002000928A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01967115A EP1294951A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten
AU2001287575A AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10032529.7 2000-06-30
DE10043826.1 2000-09-01
DE10043826 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002000928A2 WO2002000928A2 (de) 2002-01-03
WO2002000928A3 true WO2002000928A3 (de) 2002-08-01

Family

ID=26006285

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 Ceased WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007472 Ceased WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007470 Ceased WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007537 Ceased WO2002000928A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung
PCT/EP2001/007540 Ceased WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007538 Ceased WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 Ceased WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007536 Ceased WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 Ceased WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007472 Ceased WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007470 Ceased WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/EP2001/007540 Ceased WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007538 Ceased WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 Ceased WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007536 Ceased WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status

Country Status (5)

Country Link
US (5) US20040023230A1 (de)
EP (9) EP1297182A2 (de)
JP (1) JP2004501666A (de)
AU (8) AU2001277521A1 (de)
WO (8) WO2002002807A2 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921467B2 (en) 1996-07-15 2005-07-26 Semitool, Inc. Processing tools, components of processing tools, and method of making and using same for electrochemical processing of microelectronic workpieces
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
CA2277925A1 (en) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US6565729B2 (en) 1998-03-20 2003-05-20 Semitool, Inc. Method for electrochemically depositing metal on a semiconductor workpiece
US6497801B1 (en) 1998-07-10 2002-12-24 Semitool Inc Electroplating apparatus with segmented anode array
TW527444B (en) 1999-04-13 2003-04-11 Semitool Inc System for electrochemically processing a workpiece
US7438788B2 (en) 1999-04-13 2008-10-21 Semitool, Inc. Apparatus and methods for electrochemical processing of microelectronic workpieces
US7020537B2 (en) 1999-04-13 2006-03-28 Semitool, Inc. Tuning electrodes used in a reactor for electrochemically processing a microelectronic workpiece
US7585398B2 (en) 1999-04-13 2009-09-08 Semitool, Inc. Chambers, systems, and methods for electrochemically processing microfeature workpieces
US7351314B2 (en) 2003-12-05 2008-04-01 Semitool, Inc. Chambers, systems, and methods for electrochemically processing microfeature workpieces
US7189318B2 (en) 1999-04-13 2007-03-13 Semitool, Inc. Tuning electrodes used in a reactor for electrochemically processing a microelectronic workpiece
US6916412B2 (en) 1999-04-13 2005-07-12 Semitool, Inc. Adaptable electrochemical processing chamber
US7264698B2 (en) 1999-04-13 2007-09-04 Semitool, Inc. Apparatus and methods for electrochemical processing of microelectronic workpieces
US6566078B1 (en) 1999-10-28 2003-05-20 Agensys, Inc. 36P6D5: secreted tumor antigen
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) * 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
WO2001077375A2 (en) 2000-04-06 2001-10-18 Epigenomics Ag Diagnosis of diseases associated with gene regulation
AU2001281311A1 (en) * 2000-07-10 2002-01-21 Epigenx Pharmaceutical, Inc. Detecting methylated cytosine in polynucleotides
JP2002034575A (ja) * 2000-07-28 2002-02-05 Shiseido Co Ltd ヒトＩＩ型５α−レダクターゼのプロモーター遺伝子およびその用途
EP1724355A3 (de) 2000-08-30 2007-05-23 North Carolina State University Transgene Pflanzen, die molekulare Decoys enthalten, die den Proteininhalt ändern
DE10054974A1 (de) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnose von mit Cdk4 assoziierten Krankheiten
JP2004533807A (ja) 2000-11-07 2004-11-11 ノース・キャロライナ・ステイト・ユニヴァーシティ プトレッシン−ｎ−メチルトランスフェラーゼプロモーター
DE10061338A1 (de) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnose von mit Angiogenese assoziierten Krankheiten
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
EP1410304A2 (de) * 2001-03-26 2004-04-21 Epigenomics AG Verfahren zur epigenetischen merkmalauswahl
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
CA2449920A1 (en) 2001-06-08 2002-12-19 Vector Tobacco Ltd. Modifying nicotine and nitrosamine levels in tobacco
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
DE10128508A1 (de) 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
AU2002343330A1 (en) 2001-08-31 2003-03-10 Semitool, Inc. Apparatus and methods for electrochemical processing of microelectronic workpieces
US7432050B2 (en) 2001-10-05 2008-10-07 Case Western Reserve University Methods and compositions for detecting colon cancers
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
US20030211522A1 (en) * 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
WO2003064701A2 (en) * 2002-01-30 2003-08-07 Epigenomics Ag Method for the analysis of cytosine methylation patterns
EP1340818A1 (de) * 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
IL163740A0 (en) * 2002-03-07 2005-12-18 Univ Johns Hopkins Genomic screen for epigenetically silenced genes associated with cancer
US7569553B2 (en) 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
WO2004005476A2 (en) * 2002-07-03 2004-01-15 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
EP1554407B1 (de) 2002-10-01 2009-07-29 Epigenomics AG Verfahren für die behandlung von proliferativen erkrankungen von brustzellen
EP1567669B1 (de) * 2002-12-02 2010-03-24 Illumina Cambridge Limited Bestimmung der methylierung von nukleinsäuresequenzen
AU2003303963A1 (en) * 2002-12-20 2004-10-25 Bioseek, Inc. Drug target
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
US7403568B2 (en) 2003-08-13 2008-07-22 Apple Inc. Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using temporal filtering
US7430335B2 (en) 2003-08-13 2008-09-30 Apple Inc Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using spatial filtering
US8062849B2 (en) * 2003-10-28 2011-11-22 The Johns Hopkins University Quantitative multiplex methylation-specific PCR
ES2801379T3 (es) 2003-12-01 2021-01-11 Epigenomics Ag Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el desarrollo de trastornos proliferativos de células de próstata
EP1561821B1 (de) 2003-12-11 2011-02-16 Epigenomics AG Marker zur Prognose der Reaktion auf Therapie bzw. der Überlebensrate von Brustkrebspatienten
EP2290073A3 (de) 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
US20090298054A1 (en) * 2004-07-18 2009-12-03 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
US20080171318A1 (en) * 2004-09-30 2008-07-17 Epigenomics Ag Epigenetic Methods and Nucleic Acids for the Detection of Lung Cell Proliferative Disorders
EP2302055B1 (de) 2004-11-12 2014-08-27 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNAa-inhibitorischen Molekülen verbunden sind
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
EP1693468A1 (de) 2005-02-16 2006-08-23 Epigenomics AG Verfahren zur Bestimmung des Methylierungsmusters einer Polynukleinsäure
EP1748080A3 (de) * 2005-03-11 2007-04-11 Epiontis GmbH Spezifische DNS zur epigenetischer Charakterisierung von Zellen und Geweben
US8298762B2 (en) 2005-03-11 2012-10-30 Epiontis Gmbh Specific DNAS for Epigenetic Characterisation of cells and tissues
WO2006113770A1 (en) 2005-04-15 2006-10-26 Epigenomics Ag A method for providing dna fragments derived from a remote sample
WO2006111586A2 (es) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Procedimiento para la determinación in vitro del grado de metilación del promotor de line-1
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
JP2009514555A (ja) 2005-11-08 2009-04-09 ユークリッド ダイアグノスティックス リミテッド ライアビリティー カンパニー 癌評価の遺伝子関連ＣｐＧアイランドのメチル化アッセイのための材料と方法
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
WO2007095032A2 (en) * 2006-02-09 2007-08-23 Novartis Ag Mutations and polymorphisms of ptk2b
US20070238115A1 (en) * 2006-02-27 2007-10-11 Dwinell Michael B Method of Diagnosing and Treating Colon Cancer
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
CA2652975A1 (en) 2006-05-31 2007-12-13 Orion Genomics Llc Gene methylation in cancer diagnosis
EP2044221B1 (de) * 2006-07-21 2015-07-22 Epigenomics AG Verfahren und kit zur analyse der methylierung in kolorektalen proliferativen zellerkrankungen
US20090131348A1 (en) * 2006-09-19 2009-05-21 Emmanuel Labourier Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008073915A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
ES2733069T3 (es) 2007-01-18 2019-11-27 Molecor Tecnologia Sl Sistema para la fabricación de zócalos integrados en tuberías de plástico de orientación biaxial
US20090075265A1 (en) 2007-02-02 2009-03-19 Orion Genomics Llc Gene methylation in thyroid cancer diagnosis
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
WO2009111643A2 (en) * 2008-03-06 2009-09-11 Asuragen, Inc. Microrna markers for recurrence of colorectal cancer
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
WO2010048337A2 (en) 2008-10-22 2010-04-29 Illumina, Inc. Preservation of information related to genomic dna methylation
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
WO2010091296A2 (en) * 2009-02-06 2010-08-12 The Regents Of The University Of California Emx2 in cancer diagnosis and prognosis
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
WO2010144634A1 (en) * 2009-06-09 2010-12-16 Banner Sun Health Research Institute Method and system to detect, diagnose, and monitor the progression of alzheimer's disease
WO2011051414A1 (en) * 2009-10-28 2011-05-05 Signature Diagnostics Ag Method for the prognosis of ovarian carcinoma
US9394570B2 (en) * 2010-04-21 2016-07-19 The Chinese University Of Hong Kong Marker for colon cancer and method for detecting colon cancer
CN103118854B (zh) 2010-09-06 2015-11-25 莫勒科尔科技有限公司 具有集成垫圈的双轴向定向塑料管套接件制造设备及其工艺
KR101865433B1 (ko) * 2010-10-22 2018-07-13 큐알엔에이, 인크. 알파-l 이두로니다아제 (idua)에 대한 자연 안티센스 전사체의 저해에 의한 idua 관련된 질환의 치료
WO2012162139A1 (en) 2011-05-20 2012-11-29 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
NZ621638A (en) * 2011-08-25 2016-03-31 Clinical Genomics Pty Ltd Dna methylation in colorectal and breast cancer diagnostic methods
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013131083A1 (en) * 2012-03-02 2013-09-06 Winthrop-University Hospital METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES
US10865446B2 (en) 2012-11-02 2020-12-15 The Johns Hopkins University DNA methylation biomarkers of post-partum depression risk
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
ES2527724B1 (es) * 2013-05-29 2015-11-10 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz Método para predecir la respuesta al tratamiento con radioterapia combinada con quimioterapia basada en cisplatino
CN120700143A (zh) 2014-03-31 2025-09-26 梅奥医学教育和研究基金会 检测结直肠赘生物
US9840742B2 (en) * 2014-06-16 2017-12-12 JBS Science Inc. Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
US20180230539A1 (en) * 2015-07-21 2018-08-16 Indiana University Research And Technology Corporation Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels
CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
JP7481804B2 (ja) 2016-04-14 2024-05-13 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 高度膵異形成の検出
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CN105734152B (zh) * 2016-04-20 2019-02-26 苏州吉诺瑞生物科技有限公司 检测人srpk2基因的表达水平的特异引物对及其应用
EP3507298B1 (de) * 2016-09-02 2023-08-30 Mayo Foundation for Medical Education and Research Erkennung eines leberzellkarzinoms
CA3041821A1 (en) * 2016-10-26 2018-05-03 Brown University A method to measure myeloid suppressor cells for diagnosis and prognosis of cancer
JP7356349B2 (ja) 2017-02-28 2023-10-04 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 前立腺癌検出
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
WO2019105090A1 (zh) * 2017-12-01 2019-06-06 博尔诚（北京）科技有限公司 用于检测食道癌的组合物及其用途
CR20200260A (es) 2017-12-15 2020-08-01 Bayer Animal Health Gmbh Composiciones inmunoestimulantes
EP3740589A4 (de) 2018-01-17 2021-11-03 The Regents of the University of California Auf phänotypischem alter und dna-methylierung basierte biomarker für lebenserwartung und morbidität
CN108977457B (zh) * 2018-08-31 2021-04-02 长江大学 一种黄鳝抗菌肽的制备方法
WO2020076983A1 (en) 2018-10-10 2020-04-16 The Regents Of The University Of California Dna methylation based biomarkers for life expectancy and morbidity
JP7320067B2 (ja) 2019-01-18 2023-08-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 保存された遺伝子座に基づく、哺乳動物に関するｄｎａメチル化測定
PE20212081A1 (es) * 2019-04-11 2021-10-28 Suntory Holdings Ltd Planta de stevia con baja formacion de polen
DE102020111423B4 (de) 2020-04-27 2022-03-03 Precision For Medicine Gmbh MYH11/NDE1 Region als epigenetischer Marker für die Identifizierung von Endothel-Vorläuferzellen (EPCs)
EP4168593A4 (de) * 2020-06-23 2024-11-27 The Regents of the University of Colorado, a body corporate Verfahren zur diagnose von atemwegspathogenen und vorhersage von covid-19-bezogenen ergebnissen
EP3945135A1 (de) * 2020-07-27 2022-02-02 Les Laboratoires Servier Biomarker zur diagnose und überwachung von lungenkrebs
CN116057185A (zh) 2020-08-15 2023-05-02 雷杰纳荣制药公司 治疗具有编码降钙素受体(calcr)的变体核酸分子的受试者的肥胖症
US20250210133A1 (en) 2022-03-15 2025-06-26 Genknowme S.A. Method Determining the Difference Between the Biological Age and the Chronological Age of a Subject
EP4728518A1 (de) 2023-06-15 2026-04-22 Genknowme S.A. Computerimplementiertes verfahren zur bestimmung eines wertes der allostatischen last eines menschen

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999011824A1 (en) * 1997-09-05 1999-03-11 The General Hospital Corporation An alpha-2 macroglobulin diagnostic test
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke
WO1999029898A2 (de) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5804407A (en) * 1993-11-04 1998-09-08 University Technologies International, Inc. Method of expressing genes in mammalian cells
US5756668A (en) * 1994-11-15 1998-05-26 The Johns Hopkins University School Of Medicine Hypermethylated in cancer polypeptide, HIC-1
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US20040048254A1 (en) * 2000-03-15 2004-03-11 Alexander Olek Diagnosis of diseases associated with tumor supressor genes and oncogenes
WO2001077375A2 (en) * 2000-04-06 2001-10-18 Epigenomics Ag Diagnosis of diseases associated with gene regulation
DE10128508A1 (de) * 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
WO2003004696A2 (en) * 2001-07-02 2003-01-16 Epigenomics Ag A distributed system for epigenetic based prediction of complex phenotypes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999011824A1 (en) * 1997-09-05 1999-03-11 The General Hospital Corporation An alpha-2 macroglobulin diagnostic test
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke
WO1999029898A2 (de) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] NCBI; 25 June 1997 (1997-06-25), MATTHIJS G ET AL: "H. sapiens gene for alpha-2-macroglobulin, exon 1", XP002184886, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ Database accession no. Z11711 *
DATABASE GENBANK [online] NCBI; 3 June 1999 (1999-06-03), MUZNY D ET AL: "Homo sapiens 12p13 BAC RPCI11-436I9", XP002184885, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ accession no. AC007436 *
DOW D J ET AL: "alpha-2 macroglobulin polymorphism and ALzheimer disease risk in the UK", NATURE GENETICS, vol. 22, 1 May 1999 (1999-05-01), pages 16 - 17, XP002184883 *
GRIGG G AND CLARK S: "Sequencing 5-methylcytosine residues in genomic DNA", BIOESSAYS, CAMBRIDGE, GB, vol. 16, no. 6, June 1994 (1994-06-01), pages 431 - 436, XP002106411, ISSN: 0265-9247 *
MATTHIJS G ET AL: "Structure of the human alpha-2 macroglobulin gene and its promoter.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 184, no. 2, 30 April 1992 (1992-04-30), pages 596 - 603, XP001038418 *
ONNO M ET AL: "CpG methylation patterns in the 5' part of nonclassical HLA-G gene in peripheral blood CD34+ cells and CD+ lymphocytes", TISSUE ANTIGENS, vol. 49, no. 4, April 1997 (1997-04-01), pages 356 - 364, XP001038213 *
POLLER W ET AL: "Cloning of the human alpha-2 macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiol site.", HUMAN GENETICS, vol. 88, no. 3, January 1992 (1992-01-01), pages 313 - 319, XP001038079 *
ULBRECHT M ET AL: "The HLA-E gene encodes two differentially regulated transcripts and acell surface protein.", JOURNAL OF IMMUNOLOGY, vol. 149, no. 9, 1 November 1992 (1992-11-01), pages 2945 - 2953, XP002185558 *

Also Published As

Publication number Publication date
EP1294948A2 (de) 2003-03-26
US20080026396A1 (en) 2008-01-31
WO2002002808A2 (en) 2002-01-10
AU2001289617A1 (en) 2002-01-08
US20040023230A1 (en) 2004-02-05
AU2001287576A1 (en) 2002-01-08
WO2002002807A8 (en) 2002-05-30
WO2002002809A3 (en) 2003-01-30
WO2002000927A2 (en) 2002-01-03
WO2002002806A2 (en) 2002-01-10
EP1294951A2 (de) 2003-03-26
WO2002000928A2 (de) 2002-01-03
WO2002000926A3 (en) 2002-11-21
EP1297185A2 (de) 2003-04-02
WO2002002806A3 (en) 2002-05-16
WO2002000927A3 (en) 2002-07-18
JP2004501666A (ja) 2004-01-22
US20030143606A1 (en) 2003-07-31
AU2001283916A1 (en) 2002-01-14
EP1676927A2 (de) 2006-07-05
WO2002002808A3 (en) 2003-09-04
EP1355932A2 (de) 2003-10-29
WO2002002807A2 (en) 2002-01-10
AU2001279707A1 (en) 2002-01-14
WO2002000926A8 (en) 2002-07-18
AU2001287575A1 (en) 2002-01-08
EP1297182A2 (de) 2003-04-02
AU2001276371A1 (en) 2002-01-14
EP1294950A2 (de) 2003-03-26
EP1356099A2 (de) 2003-10-29
AU2001283915A1 (en) 2002-01-08
EP1676927A3 (de) 2006-12-06
WO2002002809A2 (en) 2002-01-10
WO2002000926A2 (en) 2002-01-03
US20080145839A1 (en) 2008-06-19
WO2002000927A8 (en) 2002-03-21
WO2002000705A2 (en) 2002-01-03
WO2002000705A3 (en) 2003-08-14
US20040115630A1 (en) 2004-06-17
WO2002002807A3 (en) 2002-08-08
AU2001277521A1 (en) 2002-01-14
EP1294947A2 (de) 2003-03-26

Similar Documents

Publication Publication Date Title
WO2002000928A3 (de) Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung
WO2001081622A8 (en) Diagnosis of diseases associated with dna repair
WO2001068912A3 (de) Diagnosis of diseases associated with tumor suppressor genes and oncogenes
WO2001047944A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
EP0859061A3 (de) Nachweis von Mais-Pilzpathogenen durch Anwendung der polymerase Kettenreaktion
WO2002046454A3 (de) Diagnose von mit angiogenese assoziierten krankheiten durch bestimmung der methylierung von mit angiogenese assoziierten genen
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2002036814A3 (de) Diagnose von mit cdk4 assoziierten krankheiten durch bestimmung des methylierungszustandes des cdk4
WO2002012554A3 (de) Diagnose von mit cd24 assoziierten krankheiten
WO2002006523A3 (en) Method for detecting pre-disposition to hepatotoxicity
WO2002036604A3 (de) Diagnose von mit humos assoziierten krankheiten
WO2001048245A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001040521A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2002103041A3 (en) Method and nucleic acids for the differentiation of prostate and renal carcinomas
WO2001051670A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2000029622A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001038586A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001047942A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2001967115

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10311455

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001967115

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP