WO2002000928A3 - Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung - Google Patents

Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung Download PDF

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Publication number
WO2002000928A3
WO2002000928A3 PCT/EP2001/007537 EP0107537W WO0200928A3 WO 2002000928 A3 WO2002000928 A3 WO 2002000928A3 EP 0107537 W EP0107537 W EP 0107537W WO 0200928 A3 WO0200928 A3 WO 0200928A3
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WO
WIPO (PCT)
Prior art keywords
immune system
diagnosis
diseases associated
cytosine methylation
genes associated
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Ceased
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PCT/EP2001/007537
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English (en)
French (fr)
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WO2002000928A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
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Epigenomics AG
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Epigenomics AG
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Priority claimed from DE10032529A external-priority patent/DE10032529A1/de
Application filed by Epigenomics AG filed Critical Epigenomics AG
Priority to EP01967115A priority Critical patent/EP1294951A2/de
Priority to AU2001287575A priority patent/AU2001287575A1/en
Publication of WO2002000928A2 publication Critical patent/WO2002000928A2/de
Publication of WO2002000928A3 publication Critical patent/WO2002000928A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft die chemisch modifizierte genomische Sequenzen von mit dem Immunsystem assoziierten Genen, gegen die Sequenz gerichtete Oligonukleotide und/oder PNA-Oligomere zur Detektion des Cytosin-Methylierungszustandes von mit dem Immunsystem assoziierten Genen sowie ein Verfahren zur Ermittlung von genetischen und/oder epigenetischen Parametern von mit dem Immunsystem assoziierten Genen.
PCT/EP2001/007537 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung Ceased WO2002000928A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01967115A EP1294951A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten
AU2001287575A AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10032529.7 2000-06-30
DE10043826.1 2000-09-01
DE10043826 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002000928A2 WO2002000928A2 (de) 2002-01-03
WO2002000928A3 true WO2002000928A3 (de) 2002-08-01

Family

ID=26006285

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 Ceased WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007470 Ceased WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007472 Ceased WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007538 Ceased WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 Ceased WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007540 Ceased WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007536 Ceased WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
PCT/EP2001/007537 Ceased WO2002000928A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung

Family Applications Before (7)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 Ceased WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007470 Ceased WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007472 Ceased WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007538 Ceased WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 Ceased WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007540 Ceased WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007536 Ceased WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status

Country Status (5)

Country Link
US (5) US20040023230A1 (de)
EP (9) EP1294947A2 (de)
JP (1) JP2004501666A (de)
AU (8) AU2001276371A1 (de)
WO (8) WO2002002807A2 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921467B2 (en) 1996-07-15 2005-07-26 Semitool, Inc. Processing tools, components of processing tools, and method of making and using same for electrochemical processing of microelectronic workpieces
WO2000061498A2 (en) 1999-04-13 2000-10-19 Semitool, Inc. System for electrochemically processing a workpiece
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
DE69837996T2 (de) 1997-01-14 2008-02-28 Human Genome Sciences, Inc. Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US6565729B2 (en) 1998-03-20 2003-05-20 Semitool, Inc. Method for electrochemically depositing metal on a semiconductor workpiece
US6497801B1 (en) 1998-07-10 2002-12-24 Semitool Inc Electroplating apparatus with segmented anode array
US7189318B2 (en) 1999-04-13 2007-03-13 Semitool, Inc. Tuning electrodes used in a reactor for electrochemically processing a microelectronic workpiece
US6916412B2 (en) 1999-04-13 2005-07-12 Semitool, Inc. Adaptable electrochemical processing chamber
US7020537B2 (en) 1999-04-13 2006-03-28 Semitool, Inc. Tuning electrodes used in a reactor for electrochemically processing a microelectronic workpiece
US7438788B2 (en) 1999-04-13 2008-10-21 Semitool, Inc. Apparatus and methods for electrochemical processing of microelectronic workpieces
US7585398B2 (en) 1999-04-13 2009-09-08 Semitool, Inc. Chambers, systems, and methods for electrochemically processing microfeature workpieces
US7264698B2 (en) 1999-04-13 2007-09-04 Semitool, Inc. Apparatus and methods for electrochemical processing of microelectronic workpieces
US7351314B2 (en) 2003-12-05 2008-04-01 Semitool, Inc. Chambers, systems, and methods for electrochemically processing microfeature workpieces
AU775272B2 (en) 1999-10-28 2004-07-29 Agensys, Inc. 36P6D5: secreted tumor antigen
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
WO2001077377A2 (en) 2000-04-06 2001-10-18 Epigenomics Ag Diagnosis of diseases associated with dna replication by assessing dna methylation
AU2001281311A1 (en) * 2000-07-10 2002-01-21 Epigenx Pharmaceutical, Inc. Detecting methylated cytosine in polynucleotides
JP2002034575A (ja) * 2000-07-28 2002-02-05 Shiseido Co Ltd ヒトＩＩ型５α−レダクターゼのプロモーター遺伝子およびその用途
CN1330753C (zh) 2000-08-30 2007-08-08 北卡罗莱纳州立大学 含有可改变蛋白含量的分子诱导物的转基因植物
DE10054974A1 (de) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnose von mit Cdk4 assoziierten Krankheiten
WO2002038588A2 (en) 2000-11-07 2002-05-16 North Carolina State University Putrescine-n-methyltransferase promoter
DE10061338A1 (de) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnose von mit Angiogenese assoziierten Krankheiten
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
WO2002077895A2 (en) * 2001-03-26 2002-10-03 Epigenomics Ag Method for epigenetic feature selection
EP2280030A3 (de) 2001-04-10 2011-06-15 Agensys, Inc. Nukleinsäuren und zugehörige Proteine für die Behandlung und den Nachweis von Krebs
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
EP1406518A4 (de) 2001-06-08 2006-03-29 Vector Tobacco Ltd Modifikation von nicotin- und nitrosaminkonzentrationen in tabak
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
DE10128508A1 (de) 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
JP2005501180A (ja) 2001-08-31 2005-01-13 セミトゥール・インコーポレイテッド 超小型電子ワークピースの電気化学処理のための装置及び方法
WO2003031932A2 (en) 2001-10-05 2003-04-17 Case Western Reserve University Methods and compositions for detecting colon cancers
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
JP2005514956A (ja) * 2002-01-18 2005-05-26 ジェンザイム・コーポレーション 胎児ｄｎａの検出および対立遺伝子の定量化のための方法
AU2003212878A1 (en) * 2002-01-30 2003-09-02 Epigenomics Ag Identification of cell differentiation states based on methylation patterns
EP1340818A1 (de) * 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
CA2478592A1 (en) 2002-03-07 2003-09-18 The Johns Hopkins University School Of Medicine Genomic screen for epigenetically silenced genes associated with cancer
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
JP2005532067A (ja) * 2002-07-03 2005-10-27 コーリー ファーマシューティカル グループ，インコーポレイテッド 刺激性免疫応答用の核酸組成物
US7576066B2 (en) 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
CA2500255A1 (en) * 2002-10-01 2004-04-29 Epigenomics Ag Method and nucleic acids for the treatment of breast cell proliferative disorders
US20060094016A1 (en) * 2002-12-02 2006-05-04 Niall Gormley Determination of methylation of nucleic acid sequences
AU2003303963A1 (en) * 2002-12-20 2004-10-25 Bioseek, Inc. Drug target
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
US7430335B2 (en) 2003-08-13 2008-09-30 Apple Inc Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using spatial filtering
US7403568B2 (en) 2003-08-13 2008-07-22 Apple Inc. Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using temporal filtering
US8062849B2 (en) 2003-10-28 2011-11-22 The Johns Hopkins University Quantitative multiplex methylation-specific PCR
EP3269826B1 (de) * 2003-12-01 2020-03-11 Epigenomics AG Verfahren und nukleinsäuren zur analyse der genexpression, die mit der entwicklung von prostatazellproliferationserkrankungen assoziiert ist
EP1561821B1 (de) 2003-12-11 2011-02-16 Epigenomics AG Marker zur Prognose der Reaktion auf Therapie bzw. der Überlebensrate von Brustkrebspatienten
EP2290073A3 (de) 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
EP1961827A3 (de) * 2004-07-18 2008-09-17 Epigenomics AG Epigenetische Verfahren und Nukleinsäuren für den Nachweis von proliferativen Erkrankungen von Mammazellen
US20080171318A1 (en) * 2004-09-30 2008-07-17 Epigenomics Ag Epigenetic Methods and Nucleic Acids for the Detection of Lung Cell Proliferative Disorders
CA2857878A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
EP1863924A2 (de) 2005-03-11 2007-12-12 Epiontis GmbH Spezifische dnas zur epigenetischen charakterisierung von zellen und geweben
EP1748080A3 (de) * 2005-03-11 2007-04-11 Epiontis GmbH Spezifische DNS zur epigenetischer Charakterisierung von Zellen und Geweben
WO2006113770A1 (en) 2005-04-15 2006-10-26 Epigenomics Ag A method for providing dna fragments derived from a remote sample
WO2006111586A2 (es) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Procedimiento para la determinación in vitro del grado de metilación del promotor de line-1
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
EP1951911A2 (de) 2005-11-08 2008-08-06 Euclid Diagnostics LLC Materialien und verfahren zur prüfung auf methylierung von mit genen assoziierten cpg-inseln bei der diagnostizierung von krebs
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
WO2007095032A2 (en) * 2006-02-09 2007-08-23 Novartis Ag Mutations and polymorphisms of ptk2b
US20070238115A1 (en) * 2006-02-27 2007-10-11 Dwinell Michael B Method of Diagnosing and Treating Colon Cancer
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
AU2007254983A1 (en) 2006-05-31 2007-12-13 Orion Genomics Llc Gene methylation in cancer diagnosis
ES2546182T3 (es) * 2006-07-21 2015-09-21 Epigenomics Ag Métodos y kits para análisis de metilación en trastornos proliferativos celulares colorrectales
WO2008036765A2 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
CN101622348A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
US7959429B2 (en) 2007-01-18 2011-06-14 Molecor Tecnologia, S.L. System for manufacturing integrated sockets in biaxially oriented plastic pipes
EP2115161A4 (de) 2007-02-02 2010-12-15 Orion Genomics Llc Genmethylierung bei der krebsdiagnose
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
EP2198050A1 (de) 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
US20090233297A1 (en) * 2008-03-06 2009-09-17 Elizabeth Mambo Microrna markers for recurrence of colorectal cancer
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US8541207B2 (en) * 2008-10-22 2013-09-24 Illumina, Inc. Preservation of information related to genomic DNA methylation
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
CA2751688A1 (en) * 2009-02-06 2010-08-12 Biao He Emx2 in cancer diagnosis and prognosis
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
JP2012529659A (ja) * 2009-06-09 2012-11-22 バナー・サン・ヘルス・リサーチ・インスティテュート アルツハイマー病の進行を検出、診断、およびモニターするための方法およびシステム
US20130143210A1 (en) * 2009-10-28 2013-06-06 Fabian Model Method for the prognosis of ovarian carcinoma
US9394570B2 (en) * 2010-04-21 2016-07-19 The Chinese University Of Hong Kong Marker for colon cancer and method for detecting colon cancer
HUE027655T2 (en) 2010-09-06 2016-11-28 Molecor Tecnologia Sl Manufacturing tool and manufacturing process for producing biaxially oriented plastic boreholes with integrated seal
JP6049623B2 (ja) * 2010-10-22 2016-12-21 カッパーアールエヌエー，インコーポレイテッド α‐Ｌ‐イズロニダーゼ（ＩＤＵＡ）への天然アンチセンス転写物の阻害によるＩＤＵＡ関連疾患の治療
US10435743B2 (en) 2011-05-20 2019-10-08 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
US10526642B2 (en) 2011-08-25 2020-01-07 Commonwealth Scientific And Industrial Research Organisation DNA methylation in colorectal and breast cancer diagnostic methods
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013131083A1 (en) * 2012-03-02 2013-09-06 Winthrop-University Hospital METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES
EP2914752B1 (de) 2012-11-02 2022-03-09 The Johns Hopkins University Dna-methylierungsbiomarker für postnatale depression
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
ES2527724B1 (es) * 2013-05-29 2015-11-10 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz Método para predecir la respuesta al tratamiento con radioterapia combinada con quimioterapia basada en cisplatino
CN106460046A (zh) 2014-03-31 2017-02-22 梅奥医学教育和研究基金会 检测结直肠赘生物
US9840742B2 (en) * 2014-06-16 2017-12-12 JBS Science Inc. Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
US20180230539A1 (en) * 2015-07-21 2018-08-16 Indiana University Research And Technology Corporation Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels
KR20250172724A (ko) 2015-08-31 2025-12-09 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 위 신생물 검출 방법
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
US11078543B2 (en) 2016-04-14 2021-08-03 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
CN105734152B (zh) * 2016-04-20 2019-02-26 苏州吉诺瑞生物科技有限公司 检测人srpk2基因的表达水平的特异引物对及其应用
ES2956257T3 (es) * 2016-09-02 2023-12-18 Mayo Found Medical Education & Res Detección de carcinoma hepatocelular
CA3041821A1 (en) * 2016-10-26 2018-05-03 Brown University A method to measure myeloid suppressor cells for diagnosis and prognosis of cancer
CN110431241B (zh) 2017-02-28 2024-04-19 梅约医学教育与研究基金会 检测前列腺癌
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
JP6924335B2 (ja) * 2017-12-01 2021-08-25 バイオチェーン（ペキン）サイエンス アンド テクノロジー、インコーポレイテッドＢｉｏｃｈａｉｎ （Ｂｅｉｊｉｎｇ） Ｓｃｉｅｎｃｅ ＆ Ｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 食道癌を検出するための組成物及びその使用
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WO2020209266A1 (ja) * 2019-04-11 2020-10-15 サントリーホールディングス株式会社 花粉形成能の低いステビア植物
DE102020111423B4 (de) 2020-04-27 2022-03-03 Precision For Medicine Gmbh MYH11/NDE1 Region als epigenetischer Marker für die Identifizierung von Endothel-Vorläuferzellen (EPCs)
CA3184128A1 (en) * 2020-06-23 2021-12-30 Kathleen Barnes Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes
EP3945135A1 (de) * 2020-07-27 2022-02-02 Les Laboratoires Servier Biomarker zur diagnose und überwachung von lungenkrebs
KR20230051519A (ko) 2020-08-15 2023-04-18 리제너론 파마슈티칼스 인코포레이티드 칼시토닌 수용체 (calcr)를 인코딩하는 변이체 핵산 분자를 갖는 대상체에서 비만의 치료
WO2023175019A1 (en) 2022-03-15 2023-09-21 Genknowme S.A. Method determining the difference between the biological age and the chronological age of a subject
WO2024256726A1 (en) 2023-06-15 2024-12-19 Genknowme S.A. Computer implemented method determining a value of allostatic load of a human being

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999011824A1 (en) * 1997-09-05 1999-03-11 The General Hospital Corporation An alpha-2 macroglobulin diagnostic test
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke
WO1999029898A2 (de) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
DE69433180T2 (de) * 1993-10-26 2004-06-24 Affymetrix, Inc., Santa Clara Felder von nukleinsaeuresonden auf biologischen chips
US5804407A (en) * 1993-11-04 1998-09-08 University Technologies International, Inc. Method of expressing genes in mammalian cells
US5756668A (en) * 1994-11-15 1998-05-26 The Johns Hopkins University School Of Medicine Hypermethylated in cancer polypeptide, HIC-1
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
WO1998056952A1 (en) * 1997-06-09 1998-12-17 University Of Southern California A cancer diagnostic method based upon dna methylation differences
WO2001068912A2 (de) * 2000-03-15 2001-09-20 Epigenomics Ag Diagnosis of diseases associated with tumor suppressor genes and oncogenes
WO2001077377A2 (en) * 2000-04-06 2001-10-18 Epigenomics Ag Diagnosis of diseases associated with dna replication by assessing dna methylation
DE10128508A1 (de) * 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
WO2003004696A2 (en) * 2001-07-02 2003-01-16 Epigenomics Ag A distributed system for epigenetic based prediction of complex phenotypes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999011824A1 (en) * 1997-09-05 1999-03-11 The General Hospital Corporation An alpha-2 macroglobulin diagnostic test
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke
WO1999029898A2 (de) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] NCBI; 25 June 1997 (1997-06-25), MATTHIJS G ET AL: "H. sapiens gene for alpha-2-macroglobulin, exon 1", XP002184886, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ Database accession no. Z11711 *
DATABASE GENBANK [online] NCBI; 3 June 1999 (1999-06-03), MUZNY D ET AL: "Homo sapiens 12p13 BAC RPCI11-436I9", XP002184885, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ accession no. AC007436 *
DOW D J ET AL: "alpha-2 macroglobulin polymorphism and ALzheimer disease risk in the UK", NATURE GENETICS, vol. 22, 1 May 1999 (1999-05-01), pages 16 - 17, XP002184883 *
GRIGG G AND CLARK S: "Sequencing 5-methylcytosine residues in genomic DNA", BIOESSAYS, CAMBRIDGE, GB, vol. 16, no. 6, June 1994 (1994-06-01), pages 431 - 436, XP002106411, ISSN: 0265-9247 *
MATTHIJS G ET AL: "Structure of the human alpha-2 macroglobulin gene and its promoter.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 184, no. 2, 30 April 1992 (1992-04-30), pages 596 - 603, XP001038418 *
ONNO M ET AL: "CpG methylation patterns in the 5' part of nonclassical HLA-G gene in peripheral blood CD34+ cells and CD+ lymphocytes", TISSUE ANTIGENS, vol. 49, no. 4, April 1997 (1997-04-01), pages 356 - 364, XP001038213 *
POLLER W ET AL: "Cloning of the human alpha-2 macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiol site.", HUMAN GENETICS, vol. 88, no. 3, January 1992 (1992-01-01), pages 313 - 319, XP001038079 *
ULBRECHT M ET AL: "The HLA-E gene encodes two differentially regulated transcripts and acell surface protein.", JOURNAL OF IMMUNOLOGY, vol. 149, no. 9, 1 November 1992 (1992-11-01), pages 2945 - 2953, XP002185558 *

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