WO2002000928A3 - Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung - Google Patents

Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung Download PDF

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Publication number
WO2002000928A3
WO2002000928A3 PCT/EP2001/007537 EP0107537W WO0200928A3 WO 2002000928 A3 WO2002000928 A3 WO 2002000928A3 EP 0107537 W EP0107537 W EP 0107537W WO 0200928 A3 WO0200928 A3 WO 0200928A3
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WO
WIPO (PCT)
Prior art keywords
immune system
diagnosis
diseases associated
cytosine methylation
genes associated
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Ceased
Application number
PCT/EP2001/007537
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English (en)
French (fr)
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WO2002000928A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
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Epigenomics AG
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Epigenomics AG
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Priority claimed from DE10032529A external-priority patent/DE10032529A1/de
Application filed by Epigenomics AG filed Critical Epigenomics AG
Priority to EP01967115A priority Critical patent/EP1294951A2/de
Priority to AU2001287575A priority patent/AU2001287575A1/en
Publication of WO2002000928A2 publication Critical patent/WO2002000928A2/de
Publication of WO2002000928A3 publication Critical patent/WO2002000928A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft die chemisch modifizierte genomische Sequenzen von mit dem Immunsystem assoziierten Genen, gegen die Sequenz gerichtete Oligonukleotide und/oder PNA-Oligomere zur Detektion des Cytosin-Methylierungszustandes von mit dem Immunsystem assoziierten Genen sowie ein Verfahren zur Ermittlung von genetischen und/oder epigenetischen Parametern von mit dem Immunsystem assoziierten Genen.
PCT/EP2001/007537 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung Ceased WO2002000928A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01967115A EP1294951A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten
AU2001287575A AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10032529.7 2000-06-30
DE10043826 2000-09-01
DE10043826.1 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002000928A2 WO2002000928A2 (de) 2002-01-03
WO2002000928A3 true WO2002000928A3 (de) 2002-08-01

Family

ID=26006285

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 Ceased WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007472 Ceased WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007470 Ceased WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007540 Ceased WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007536 Ceased WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
PCT/EP2001/007538 Ceased WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 Ceased WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007537 Ceased WO2002000928A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung

Family Applications Before (7)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 Ceased WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007472 Ceased WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007470 Ceased WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007540 Ceased WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007536 Ceased WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
PCT/EP2001/007538 Ceased WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 Ceased WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells

Country Status (5)

Country Link
US (5) US20040023230A1 (de)
EP (9) EP1297182A2 (de)
JP (1) JP2004501666A (de)
AU (8) AU2001276371A1 (de)
WO (8) WO2002002807A2 (de)

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