WO2002004644A3 - Aspartyl-protease - Google Patents

Aspartyl-protease Download PDF

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Publication number
WO2002004644A3
WO2002004644A3 PCT/EP2001/007512 EP0107512W WO0204644A3 WO 2002004644 A3 WO2002004644 A3 WO 2002004644A3 EP 0107512 W EP0107512 W EP 0107512W WO 0204644 A3 WO0204644 A3 WO 0204644A3
Authority
WO
WIPO (PCT)
Prior art keywords
aspartyl
proteases
substances
peptides
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007512
Other languages
English (en)
Other versions
WO2002004644A2 (fr
Inventor
Christian Haass
Harald Steiner
Katja Fechteler
Marcus Kostka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to AU2001281926A priority Critical patent/AU2001281926A1/en
Publication of WO2002004644A2 publication Critical patent/WO2002004644A2/fr
Publication of WO2002004644A3 publication Critical patent/WO2002004644A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6413—Aspartic endopeptidases (3.4.23)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des protéines, des peptides ou des aspartyl-protéases comportant des motifs de consensus spécifiés et des acides nucléiques codant lesdites protéines, peptides ou aspartyl-protéases. L'invention concerne également le dépistage de substances capables d'inhiber lesdites aspartyl-protéases, des substances identifiables grâce audit procédé et enfin, des compositions pharmaceutiques comprenant lesdites substances.
PCT/EP2001/007512 2000-07-07 2001-06-30 Aspartyl-protease Ceased WO2002004644A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281926A AU2001281926A1 (en) 2000-07-07 2001-06-30 Aspartylprotease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10032709.5 2000-07-07
DE2000132709 DE10032709A1 (de) 2000-07-07 2000-07-07 Aspartyl-Protease

Publications (2)

Publication Number Publication Date
WO2002004644A2 WO2002004644A2 (fr) 2002-01-17
WO2002004644A3 true WO2002004644A3 (fr) 2002-05-10

Family

ID=7647909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007512 Ceased WO2002004644A2 (fr) 2000-07-07 2001-06-30 Aspartyl-protease

Country Status (3)

Country Link
AU (1) AU2001281926A1 (fr)
DE (1) DE10032709A1 (fr)
WO (1) WO2002004644A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026331A1 (fr) * 2002-09-17 2004-04-01 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Peptides inhibant les activites de clivage specifiques des presenilines

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034099A2 (fr) * 1995-04-28 1996-10-31 Hsc Research And Development Limited Partnership Sequences genetiques et proteines associees a la maladie d'alzheimer et leur utilisation
EP0778266A1 (fr) * 1995-12-05 1997-06-11 Bristol-Myers Squibb Company Dérivés de 5-amino-6-cyclohexyle-4-hydroxy-hexanamide comme inhibiteurs de la production de protéines béta-amyloides
WO1997041443A2 (fr) * 1996-04-26 1997-11-06 Smithkline Beecham Plc Nouveau traitement
WO1998015828A1 (fr) * 1996-10-07 1998-04-16 Scios Inc. METHODE D'IDENTIFICATION DES INHIBITEURS DIRECTS DE L'ENZYME η-SECRETASE PRODUISANT LE β-AMYLOIDE
WO2001004277A1 (fr) * 1999-07-12 2001-01-18 Trustees Of Dartmouth College Composes et procedes d'identification de composes qui inhibent une nouvelle classe d'aspartyl proteases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034099A2 (fr) * 1995-04-28 1996-10-31 Hsc Research And Development Limited Partnership Sequences genetiques et proteines associees a la maladie d'alzheimer et leur utilisation
EP0778266A1 (fr) * 1995-12-05 1997-06-11 Bristol-Myers Squibb Company Dérivés de 5-amino-6-cyclohexyle-4-hydroxy-hexanamide comme inhibiteurs de la production de protéines béta-amyloides
WO1997041443A2 (fr) * 1996-04-26 1997-11-06 Smithkline Beecham Plc Nouveau traitement
WO1998015828A1 (fr) * 1996-10-07 1998-04-16 Scios Inc. METHODE D'IDENTIFICATION DES INHIBITEURS DIRECTS DE L'ENZYME η-SECRETASE PRODUISANT LE β-AMYLOIDE
WO2001004277A1 (fr) * 1999-07-12 2001-01-18 Trustees Of Dartmouth College Composes et procedes d'identification de composes qui inhibent une nouvelle classe d'aspartyl proteases

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DE STROOPER BART: "Closing in on gamma-secretase", NATURE (LONDON), vol. 405, 8 June 2000 (2000-06-08), pages 627 - 628, XP002186844, ISSN: 0028-0836 *
ESLER WILLIAM P ET AL: "Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.", NATURE CELL BIOLOGY, vol. 2, no. 7, July 2000 (2000-07-01), pages 428 - 434, XP001042318, ISSN: 1465-7392 *
KIMBERLY W TAYLOR ET AL: "The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 5, 4 February 2000 (2000-02-04), pages 3173 - 3178, XP002186849, ISSN: 0021-9258 *
LAPOINTE CHRISTIAN F ET AL: "The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 2, 14 January 2000 (2000-01-14), pages 1502 - 1510, XP002186846, ISSN: 0021-9258 *
LEIMER UWE ET AL: "Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.", BIOCHEMISTRY, vol. 38, no. 41, 12 October 1999 (1999-10-12), pages 13602 - 13609, XP002186843, ISSN: 0006-2960 *
LI YUE-MING ET AL: "Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.", NATURE (LONDON), vol. 405, no. 6787, 8 June 2000 (2000-06-08), pages 689 - 694, XP002186845, ISSN: 0028-0836 *
STEINER HARALD ET AL: "Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.", NATURE CELL BIOLOGY, vol. 2, no. 11, November 2000 (2000-11-01), pages 848 - 851, XP001035005, ISSN: 1465-7392 *
WOLFE MICHAEL S ET AL: "Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.", BIOCHEMISTRY, vol. 38, no. 35, 31 August 1999 (1999-08-31), pages 11223 - 11230, XP002186847, ISSN: 0006-2960 *
WOLFE MICHAEL S ET AL: "Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.", NATURE (LONDON), vol. 398, no. 6727, 8 April 1999 (1999-04-08), pages 513 - 517, XP002186848, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
AU2001281926A1 (en) 2002-01-21
DE10032709A1 (de) 2002-01-24
WO2002004644A2 (fr) 2002-01-17

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