WO2002017985A3 - Microneedle structure and production method therefor - Google Patents

Microneedle structure and production method therefor Download PDF

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Publication number
WO2002017985A3
WO2002017985A3 PCT/IL2001/000806 IL0100806W WO0217985A3 WO 2002017985 A3 WO2002017985 A3 WO 2002017985A3 IL 0100806 W IL0100806 W IL 0100806W WO 0217985 A3 WO0217985 A3 WO 0217985A3
Authority
WO
WIPO (PCT)
Prior art keywords
production method
method therefor
protective layer
etching process
microneedle structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2001/000806
Other languages
French (fr)
Other versions
WO2002017985A2 (en
Inventor
Yehoshua Yeshurun
Meir Hefetz
Boer Meint De
J W Berenschot
J G E Gardeniers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanopass Ltd
Original Assignee
Nanopass Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13813100A external-priority patent/IL138131A0/en
Priority to US10/362,835 priority Critical patent/US7648484B2/en
Priority to AU2001282489A priority patent/AU2001282489B2/en
Priority to JP2002522956A priority patent/JP4750347B2/en
Priority to AU8248901A priority patent/AU8248901A/en
Priority to CA002420859A priority patent/CA2420859C/en
Application filed by Nanopass Ltd filed Critical Nanopass Ltd
Priority to EP01961111.0A priority patent/EP1330274B1/en
Publication of WO2002017985A2 publication Critical patent/WO2002017985A2/en
Publication of WO2002017985A3 publication Critical patent/WO2002017985A3/en
Anticipated expiration legal-status Critical
Priority to US12/651,485 priority patent/US7850657B2/en
Priority to US12/958,437 priority patent/US8454844B2/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00436—Shaping materials, i.e. techniques for structuring the substrate or the layers on the substrate
    • B81C1/005—Bulk micromachining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0361—Tips, pillars

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Micromachines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A method for processing a wafer to form a plurality of hollow microneedles projecing from a substrate includes forming, by use of a dry etching process, a number of groups of recessed features, each including at least one slot deployed to form an open shape having an included area and at least one hole located within the included area. The internal surfaces of the holes and the slots are then coated with a protective layer. An anisotropic wet etching process is then performed in such a manner as to remove material from outside the included areas while leaving a projecting feature within each of the included areas. The protective layer is then removed to reveal the microneedles.
PCT/IL2001/000806 2000-08-28 2001-08-28 Microneedle structure and production method therefor Ceased WO2002017985A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP01961111.0A EP1330274B1 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
AU2001282489A AU2001282489B2 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
JP2002522956A JP4750347B2 (en) 2000-08-28 2001-08-28 Microneedle structure and manufacturing method thereof
AU8248901A AU8248901A (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
CA002420859A CA2420859C (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
US10/362,835 US7648484B2 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
US12/651,485 US7850657B2 (en) 2000-08-28 2010-01-04 Microneedle structure and production method therefor
US12/958,437 US8454844B2 (en) 2000-08-28 2010-12-02 Microneedle structure and production method therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL138131 2000-08-28
IL13813100A IL138131A0 (en) 2000-08-28 2000-08-28 Microneedle structure and production method therefor
US09/677,175 US6533949B1 (en) 2000-08-28 2000-10-02 Microneedle structure and production method therefor
US09/677,175 2000-10-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/677,175 Continuation-In-Part US6533949B1 (en) 2000-08-28 2000-10-02 Microneedle structure and production method therefor

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10362835 A-371-Of-International 2001-08-28
US12/651,485 Continuation US7850657B2 (en) 2000-08-28 2010-01-04 Microneedle structure and production method therefor

Publications (2)

Publication Number Publication Date
WO2002017985A2 WO2002017985A2 (en) 2002-03-07
WO2002017985A3 true WO2002017985A3 (en) 2003-01-09

Family

ID=26323975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/000806 Ceased WO2002017985A2 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor

Country Status (6)

Country Link
US (4) US6533949B1 (en)
EP (1) EP1330274B1 (en)
JP (1) JP4750347B2 (en)
AU (2) AU8248901A (en)
CA (1) CA2420859C (en)
WO (1) WO2002017985A2 (en)

Cited By (3)

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US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient

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US8454844B2 (en) 2013-06-04
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