WO2002020437A3 - Composes de base contenant des amides tertiaires avec activite sur les recepteurs de tachykinine et compositions pharmaceutiques les contenant - Google Patents

Composes de base contenant des amides tertiaires avec activite sur les recepteurs de tachykinine et compositions pharmaceutiques les contenant Download PDF

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Publication number
WO2002020437A3
WO2002020437A3 PCT/EP2001/010419 EP0110419W WO0220437A3 WO 2002020437 A3 WO2002020437 A3 WO 2002020437A3 EP 0110419 W EP0110419 W EP 0110419W WO 0220437 A3 WO0220437 A3 WO 0220437A3
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WO
WIPO (PCT)
Prior art keywords
activity
pharmaceutical compositions
basic compounds
tertiary amides
tachykinin receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/010419
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English (en)
Other versions
WO2002020437A2 (fr
Inventor
Antonio Guidi
Franco Pasqui
Maria Altamura
Carlo Alberto Maggi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Menarini Ricerche SpA
Original Assignee
Menarini Ricerche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche SpA filed Critical Menarini Ricerche SpA
Priority to AU2002210495A priority Critical patent/AU2002210495A1/en
Publication of WO2002020437A2 publication Critical patent/WO2002020437A2/fr
Publication of WO2002020437A3 publication Critical patent/WO2002020437A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés possédant une structure de base constituée d'un groupe alcène ou aromatique auquel sont liés deux amides vicinaux substitués contenant au moins un atome d'azote avec des caractéristiques de base, ainsi que leurs sels pharmaceutiquement acceptables utiles dans le traitement de maladies qui nécessitent l'utilisation d'antagonistes de NK2.
PCT/EP2001/010419 2000-09-11 2001-09-10 Composes de base contenant des amides tertiaires avec activite sur les recepteurs de tachykinine et compositions pharmaceutiques les contenant Ceased WO2002020437A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002210495A AU2002210495A1 (en) 2000-09-11 2001-09-10 Basic compounds containing tertiary amides with activity on tachykinin receptors, and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000FI000190A IT1317104B1 (it) 2000-09-11 2000-09-11 Composti basici contenenti ammidi terziarie ad attivita' sui recettoridelle tachichinine e composizioni farmaceutiche che li contengono.
FIFI2000A000190 2000-09-11

Publications (2)

Publication Number Publication Date
WO2002020437A2 WO2002020437A2 (fr) 2002-03-14
WO2002020437A3 true WO2002020437A3 (fr) 2002-05-10

Family

ID=11441957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010419 Ceased WO2002020437A2 (fr) 2000-09-11 2001-09-10 Composes de base contenant des amides tertiaires avec activite sur les recepteurs de tachykinine et compositions pharmaceutiques les contenant

Country Status (3)

Country Link
AU (1) AU2002210495A1 (fr)
IT (1) IT1317104B1 (fr)
WO (1) WO2002020437A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004010A1 (en) * 2002-07-10 2006-01-05 Hiromu Habashita Ccr4 antagonist and medical use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995002608A1 (fr) * 1993-07-13 1995-01-26 Pierre Fabre Medicament Nouveaux ligands des recepteurs de la cholecystokinine et gastriniques, leur procede de fabrication et les compositions pharmaceutiques les contenant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995002608A1 (fr) * 1993-07-13 1995-01-26 Pierre Fabre Medicament Nouveaux ligands des recepteurs de la cholecystokinine et gastriniques, leur procede de fabrication et les compositions pharmaceutiques les contenant

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MALLIK, IPSITA ET AL: "Design and synthesis of new ligands for positioning two metal ions", XP002190146, retrieved from STN Database accession no. 125:195586 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NONOYAMA, KIYOKO ET AL: "Copper(II) and nickel(II) complexes of binucleating N,N'-disubstituted imidazole-4,5-dicarboxamides", XP002190147, retrieved from STN Database accession no. 121:25502 *
POLYHEDRON (1994), 13(6-7), 891-7 *
POTIER E ET AL: "NEW NK-1 TACHYKININ RECEPTOR ANTAGONISTS BASED ON ALICYCLIC AMINO ACIDS AS A TEMPLATE: STEREOSELECTIVE SYNTHESIS AND CHIRALITY INVESTIGATION BY NMR", PEPTIDES, ELMSFORD, US, vol. 23, 1994, pages 315 - 316, XP000651334, ISSN: 0196-9781 *
SORBYE K ET AL: "N,N-1,2-Benzenedisulfonylimide, a new cyclic leaving group for the stereoselective nucleophilic substitution of amines", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 9, no. 4, 27 February 1998 (1998-02-27), pages 681 - 689, XP004131238, ISSN: 0957-4166 *
SYNLETT (1996), (8), 734-736 *
WALPOLE C ET AL: "2-NITROPHENYLCARBAMOYL-(S)-PROLYL-(S)-3-(2-NAPHTHYL)ALANYL-N-BENZYL-N- METHYLAMIDE (SDZ NKT 343), A POTENT HUMAN NK1 TACHYKININ RECEPTOR ANTAGONIST WITH GOOD ORAL ANALGESIC ACTIVITY IN CHRONIC PAIN MODELS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 17, 13 August 1998 (1998-08-13), pages 3159 - 3173, XP000972902, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
AU2002210495A1 (en) 2002-03-22
ITFI20000190A0 (it) 2000-09-11
WO2002020437A2 (fr) 2002-03-14
ITFI20000190A1 (it) 2002-03-11
IT1317104B1 (it) 2003-05-26

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