WO2002024927A3 - Regulation of human adam-ts 1 precursor-like protein - Google Patents

Regulation of human adam-ts 1 precursor-like protein Download PDF

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Publication number
WO2002024927A3
WO2002024927A3 PCT/EP2001/010700 EP0110700W WO0224927A3 WO 2002024927 A3 WO2002024927 A3 WO 2002024927A3 EP 0110700 W EP0110700 W EP 0110700W WO 0224927 A3 WO0224927 A3 WO 0224927A3
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WIPO (PCT)
Prior art keywords
precursor
protein
human adam
regulation
reagents
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/010700
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French (fr)
Other versions
WO2002024927A2 (en
Inventor
Jiing-Ren Liou
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Bayer AG
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Bayer AG
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Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001289886A priority Critical patent/AU2001289886A1/en
Publication of WO2002024927A2 publication Critical patent/WO2002024927A2/en
Publication of WO2002024927A3 publication Critical patent/WO2002024927A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Reagents which regulate human ADAM-TS 1 precursor-like protein and reagents which bind to human ADAM-TS 1 precursor-like gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cardiovascular and liver disorders, and COPD.
PCT/EP2001/010700 2000-09-20 2001-09-17 Regulation of human adam-ts 1 precursor-like protein Ceased WO2002024927A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289886A AU2001289886A1 (en) 2000-09-20 2001-09-17 Regulation of human adam-ts 1 precursor-like protein

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23420100P 2000-09-20 2000-09-20
US60/234,201 2000-09-20
US30715801P 2001-07-24 2001-07-24
US60/307,158 2001-07-24

Publications (2)

Publication Number Publication Date
WO2002024927A2 WO2002024927A2 (en) 2002-03-28
WO2002024927A3 true WO2002024927A3 (en) 2002-11-07

Family

ID=26927667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010700 Ceased WO2002024927A2 (en) 2000-09-20 2001-09-17 Regulation of human adam-ts 1 precursor-like protein

Country Status (2)

Country Link
AU (1) AU2001289886A1 (en)
WO (1) WO2002024927A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683165B1 (en) 1999-04-13 2004-01-27 Genome Therapeutics Corporation Human gene relating to respiratory diseases and obesity
AU2002319703A1 (en) 2001-07-27 2003-02-17 Wyeth Aggrecanase molecules
AU2002351945A1 (en) * 2001-11-13 2003-05-26 Universite De Liege A new disintegrin and metalloproteinase with thrombospondin type i repeats polynucleotide and its encoded polypeptide
CN111272746A (en) * 2020-03-09 2020-06-12 中国水产科学研究院东海水产研究所 Method for determining total amount of free amino acids in aquatic product by colorimetric method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000555A1 (en) * 1996-07-03 1998-01-08 Prockop Darwin J Recombinant n-proteinase, and the production, methods and uses thereof
WO1999061656A2 (en) * 1998-05-29 1999-12-02 Wisconsin Alumni Research Foundation Agent and method for modulation of cell migration
WO2001059133A1 (en) * 2000-02-14 2001-08-16 Merck Patent Gmbh Larynx carcinoma-associated protein larcap-1
WO2001083782A2 (en) * 2000-05-04 2001-11-08 Sugen, Inc. Novel proteases
WO2002016564A2 (en) * 2000-08-22 2002-02-28 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000555A1 (en) * 1996-07-03 1998-01-08 Prockop Darwin J Recombinant n-proteinase, and the production, methods and uses thereof
WO1999061656A2 (en) * 1998-05-29 1999-12-02 Wisconsin Alumni Research Foundation Agent and method for modulation of cell migration
WO2001059133A1 (en) * 2000-02-14 2001-08-16 Merck Patent Gmbh Larynx carcinoma-associated protein larcap-1
WO2001083782A2 (en) * 2000-05-04 2001-11-08 Sugen, Inc. Novel proteases
WO2002016564A2 (en) * 2000-08-22 2002-02-28 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BOLZ^A^1 H ET AL: "Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family", BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1522, no. 3, 30 December 2001 (2001-12-30), pages 221 - 225, XP004331262, ISSN: 0167-4781 *
DATABASE EMBL [online] 14 December 2001 (2001-12-14), PLOWMAN G. ET AL., Database accession no. AX319856 *
DATABASE EMBL [online] 16 January 2001 (2001-01-16), DIAS NETO E. ET AL, Database accession no. BF823025 *
DATABASE EMBL [online] 2 December 1999 (1999-12-02), KIMBLE J.E. ET AL.: "WO9961656", Database accession no. AAY53900 *
DATABASE EMBL [online] 22 August 2000 (2000-08-22), FROHME M.: "Homo sapiens EST, clone 3.3-n2", XP002201628, Database accession no. AJ403134 *
DATABASE EMBL [online] 23 March 2002 (2002-03-23), WALKE W.D. ET AL., Database accession no. AX392451 *
DATABASE EMBL [online] 24 November 1998 (1998-11-24), COLIGE A.C.: "Homo sapiens mRNA for procollagen I-N proteinase", XP002201629, Database accession no. AJ003125 *
DATABASE EMBL [online] 6 May 1999 (1999-05-06), BIRREN B. ET AL.: "Homo sapiens, clone RP11-91A1", XP002201630, Database accession no. AC007484 *
DATABASE EMBL [online] 6 September 2001 (2001-09-06), DUECKER K. ET AL., Database accession no. AX211285 *
DATABASE EMBL [online] 8 January 1998 (1998-01-08), COLIGE A. ET AL.: "WO9800555", Database accession no. AAW47028 *
DIAS NETO EMMANUEL ET AL: "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 7, 28 March 2000 (2000-03-28), March 28, 2000, pages 3491 - 3496, XP002201627, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU2001289886A1 (en) 2002-04-02
WO2002024927A2 (en) 2002-03-28

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