WO2002052260A3 - Biocapteur et son procede de production - Google Patents

Biocapteur et son procede de production Download PDF

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Publication number
WO2002052260A3
WO2002052260A3 PCT/EP2001/015225 EP0115225W WO02052260A3 WO 2002052260 A3 WO2002052260 A3 WO 2002052260A3 EP 0115225 W EP0115225 W EP 0115225W WO 02052260 A3 WO02052260 A3 WO 02052260A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
biosensor
plasmon
protective layer
carrying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/015225
Other languages
German (de)
English (en)
Other versions
WO2002052260A2 (fr
WO2002052260A9 (fr
Inventor
Andreas Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2002237253A priority Critical patent/AU2002237253A1/en
Publication of WO2002052260A2 publication Critical patent/WO2002052260A2/fr
Publication of WO2002052260A9 publication Critical patent/WO2002052260A9/fr
Publication of WO2002052260A3 publication Critical patent/WO2002052260A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un biocapteur comprenant un support (1) (prisme de verre), une couche (2) porteuse de plasmons, constituée d'une couche métallique à électrons libres, en particulier de l'or ou de l'argent, ou d'une couche semi-conductrice, et une couche d'hydrogel (6) constituée d'un polymère, en particulier du dextrane auquel des récepteurs (7) peuvent se lier. Ce biocapteur comprend en outre une couche de protection (4) composée d'oxyde de silicium ou d'un oxyde métallique, ou une couche de protection (9) composée d'un polymère et étant physisorbée sur la couche (2) porteuse de plasmons. La couche d'hydrogel (6) peut être liée par l'intermédiaire d'un lieur (5, 10) ; par exemple, si la couche de protection (4) est composée d'oxyde de silicium, le lieur (5) peut être du silane. La couche de protection (4) présente une épaisseur inférieure à 10 nm, de préférence inférieure à 5 nm, et protège efficacement la couche active (2) porteuse de plasmons contre des impuretés perturbatrices sans que l'effet optique physique produit par la résonance plasmonique de surface n'ait lieu à l'extérieur de la zone mesurable, de sorte que la fonction de biocapteur est préservée.
PCT/EP2001/015225 2000-12-22 2001-12-21 Biocapteur et son procede de production Ceased WO2002052260A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002237253A AU2002237253A1 (en) 2000-12-22 2001-12-21 Biosensor and method of producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064146.6 2000-12-22
DE2000164146 DE10064146A1 (de) 2000-12-22 2000-12-22 Biosensor und verfahren zu seiner Herstellung

Publications (3)

Publication Number Publication Date
WO2002052260A2 WO2002052260A2 (fr) 2002-07-04
WO2002052260A9 WO2002052260A9 (fr) 2002-09-19
WO2002052260A3 true WO2002052260A3 (fr) 2002-11-14

Family

ID=7668367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/015225 Ceased WO2002052260A2 (fr) 2000-12-22 2001-12-21 Biocapteur et son procede de production

Country Status (3)

Country Link
AU (1) AU2002237253A1 (fr)
DE (1) DE10064146A1 (fr)
WO (1) WO2002052260A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004061211A (ja) * 2002-07-26 2004-02-26 Shimadzu Corp 蛍光検出方法及び装置
JP2006322939A (ja) * 2005-05-19 2006-11-30 Agilent Technol Inc 結合したリガンドを有するエバネッセント波センサー
WO2007061981A2 (fr) 2005-11-21 2007-05-31 Lumera Corporation Detecteur a resonance de plasmon en surface avec mecanisme de balayage d’angle entraine par actionneur
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US20080188010A1 (en) * 2007-02-01 2008-08-07 Fujifilm Corporation Biosensor substrate
JP5021408B2 (ja) * 2007-09-26 2012-09-05 富士フイルム株式会社 バイオセンサー
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
FR2946433B1 (fr) 2009-06-05 2013-07-12 Ecole Polytechnique Dgar Utilisation d'une couche de silicium amorphe et procede d'analyse

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007202A1 (fr) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Technique amelioree d'analyse et appareil prevu a cet effet
US4992385A (en) * 1986-07-24 1991-02-12 Ares-Serono Research And Development Limited Partnership Polymer-coated optical structures and methods of making and using the same
DE19805809A1 (de) * 1998-02-12 1999-09-02 Biotul Bio Instr Gmbh Bestimmung der Oberflächenplasmonen-Resonanz mit Hilfe von örtlich oder zeitlich modifizierten Schichten
EP0945721A2 (fr) * 1998-03-24 1999-09-29 Dai Nippon Printing Co., Ltd. Elément biocapteur pour des mesures de résonance plasmon de surface, et son procédé de fabrication
DE19817180A1 (de) * 1998-04-17 1999-10-21 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung
DE19853428A1 (de) * 1998-11-19 2000-05-25 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19818360C2 (de) * 1998-04-24 2000-05-31 Suisse Electronique Microtech Dextranbeschichtete Oberfläche

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992385A (en) * 1986-07-24 1991-02-12 Ares-Serono Research And Development Limited Partnership Polymer-coated optical structures and methods of making and using the same
WO1988007202A1 (fr) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Technique amelioree d'analyse et appareil prevu a cet effet
DE19805809A1 (de) * 1998-02-12 1999-09-02 Biotul Bio Instr Gmbh Bestimmung der Oberflächenplasmonen-Resonanz mit Hilfe von örtlich oder zeitlich modifizierten Schichten
EP0945721A2 (fr) * 1998-03-24 1999-09-29 Dai Nippon Printing Co., Ltd. Elément biocapteur pour des mesures de résonance plasmon de surface, et son procédé de fabrication
DE19817180A1 (de) * 1998-04-17 1999-10-21 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung
DE19853428A1 (de) * 1998-11-19 2000-05-25 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
WO2002052260A2 (fr) 2002-07-04
DE10064146A1 (de) 2002-07-04
AU2002237253A1 (en) 2002-07-08
WO2002052260A9 (fr) 2002-09-19

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