WO2002054076A3 - Sensor zur lumineszenz-optischen bestimmung eines analyten - Google Patents

Sensor zur lumineszenz-optischen bestimmung eines analyten Download PDF

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Publication number
WO2002054076A3
WO2002054076A3 PCT/EP2001/015186 EP0115186W WO02054076A3 WO 2002054076 A3 WO2002054076 A3 WO 2002054076A3 EP 0115186 W EP0115186 W EP 0115186W WO 02054076 A3 WO02054076 A3 WO 02054076A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor
analyte
luminophore
donor
test medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/015186
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English (en)
French (fr)
Other versions
WO2002054076A2 (de
Inventor
Ingo Klimant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Priority to EP01984880A priority Critical patent/EP1346220B1/de
Priority to JP2002554723A priority patent/JP3782780B2/ja
Priority to US10/465,935 priority patent/US7067320B2/en
Priority to AT01984880T priority patent/ATE440283T1/de
Priority to DE50115064T priority patent/DE50115064D1/de
Publication of WO2002054076A2 publication Critical patent/WO2002054076A2/de
Publication of WO2002054076A3 publication Critical patent/WO2002054076A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y10T436/175383—Ammonia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/204998—Inorganic carbon compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Die Erfindung betrifft einen optisch-chemischen Sensor, der nach dem FRET-Prinzip arbeitet und einen Probenmedium Analyt reagierenden Akzeptor (Chromophor oder Luminophor) sowie einen Donor (Luminophor) aufweist, dadurch gekennzeichnet, da? sich der Akzeptor und der Donor in voneinander getrennten chemischen Phasen befinden, wobei die den Donor enthaltende Phase für die Luminseszenzeigenschaften des Luminophors beeinflussende Komponenten des Probenmediums in wesentlichen impermeabel ist. Die Erfindung betrifft weiters ein Verfahren zur qualitativen und/oder quantitativen Bestimmung zumindest eines Analyten bzw. Einer Komponente eines gasförmigen oder flüssigen Me?mediums nach dem FRET-Prinzip, gekennzeichnet durch die Verwendung des erfindungsgemä?en Sensors.
PCT/EP2001/015186 2000-12-29 2001-12-21 Sensor zur lumineszenz-optischen bestimmung eines analyten Ceased WO2002054076A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01984880A EP1346220B1 (de) 2000-12-29 2001-12-21 Sensor zur lumineszenz-optischen bestimmung eines analyten
JP2002554723A JP3782780B2 (ja) 2000-12-29 2001-12-21 被検体の発光光学的測定のためのセンサー
US10/465,935 US7067320B2 (en) 2000-12-29 2001-12-21 Sensor for luminescense-optical determination of an analyte
AT01984880T ATE440283T1 (de) 2000-12-29 2001-12-21 Sensor zur lumineszenz-optischen bestimmung eines analyten
DE50115064T DE50115064D1 (de) 2000-12-29 2001-12-21 Sensor zur lumineszenz-optischen bestimmung eines analyten

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0216100A AT410601B (de) 2000-12-29 2000-12-29 Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet
ATA2161/2000 2000-12-29

Publications (2)

Publication Number Publication Date
WO2002054076A2 WO2002054076A2 (de) 2002-07-11
WO2002054076A3 true WO2002054076A3 (de) 2002-10-10

Family

ID=3690008

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2001/015185 Ceased WO2002054045A2 (de) 2000-12-29 2001-12-21 Reagens zur lumineszenz-optischen bestimmung eines analyten
PCT/EP2001/015186 Ceased WO2002054076A2 (de) 2000-12-29 2001-12-21 Sensor zur lumineszenz-optischen bestimmung eines analyten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/015185 Ceased WO2002054045A2 (de) 2000-12-29 2001-12-21 Reagens zur lumineszenz-optischen bestimmung eines analyten

Country Status (6)

Country Link
US (2) US7067320B2 (de)
EP (2) EP1346220B1 (de)
JP (2) JP3782780B2 (de)
AT (3) AT410601B (de)
DE (2) DE50111978D1 (de)
WO (2) WO2002054045A2 (de)

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AT410601B (de) * 2000-12-29 2003-06-25 Hoffmann La Roche Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet
US7229835B2 (en) * 2001-10-25 2007-06-12 The University Of Maryland, Baltimore County Amine detection method and materials
US8183052B2 (en) * 2004-08-19 2012-05-22 Blood Cell Storage, Inc. Methods and apparatus for sterility testing
US8497134B2 (en) 2004-08-19 2013-07-30 Blood Cell Storage, Inc. Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
JP5017113B2 (ja) 2004-08-19 2012-09-05 ブラッド セル ストレージ， インコーポレイテッド 蛍光ｐＨ検出システムおよび関連する方法
DE102006001642B4 (de) * 2006-01-11 2008-02-21 Sartorius Biotech Gmbh Sauerstoffsensor und Messverfahren
DE502006004313D1 (de) * 2006-08-07 2009-09-03 Bucher Ag Langenthal Nanopartikel eines Authentifizierungssystems
EP1964927A1 (de) * 2007-02-27 2008-09-03 F. Hoffmann-La Roche AG Chinone als Mediatoren für photometrische Teste
US8969027B2 (en) * 2008-03-03 2015-03-03 Kansas State University Research Foundation Protease assay
WO2009152492A1 (en) * 2008-06-13 2009-12-17 University Of Connecticut Nucleic acid materials for nonradiative energy transfer and methods of production and use
WO2010135319A1 (en) * 2009-05-18 2010-11-25 University Of Connecticut Nucleic acid-based photovoltaic cell
US9040307B2 (en) 2011-05-27 2015-05-26 Blood Cell Storage, Inc. Fluorescent pH detector system and related methods
US9228949B2 (en) 2011-09-06 2016-01-05 The Hong Kong University Of Science And Technology Aggregation-induced emission luminogens for metal ion detection
MX2014003415A (es) 2011-09-28 2014-04-10 Hoffmann La Roche Mediadores azo.
US8742370B2 (en) * 2012-03-21 2014-06-03 Bah Holdings Llc Gas sensor
EP2728343A1 (de) * 2012-11-06 2014-05-07 Technische Universität Graz Optische Sonde für die quantitative Bestimmung eines Analyten
EP3405585B1 (de) 2016-01-21 2021-03-03 Selux Diagnostics, Inc. Verfahren für schnelltest auf antimikrobielle suszeptibilität
US9834808B2 (en) 2016-01-21 2017-12-05 SeLux Diagnostics, Inc. Methods for rapid antibiotic susceptibility testing
EP4481375A3 (de) 2016-10-05 2025-04-02 F. Hoffmann-La Roche AG Nachweisreagenzien und elektrodenanordnungen für diagnostische multianalyttestelemente sowie verfahren zur verwendung davon
JP6923647B2 (ja) 2016-10-24 2021-08-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ バイオセンサの導電性エレメントの未補償抵抗の補正方法および装置とシステム
US12203124B2 (en) 2016-12-23 2025-01-21 SeLux Diagnostics, Inc. Methods for improved rapid antimicrobial susceptibility testing
DE102017128564A1 (de) 2017-12-01 2019-06-06 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe, optischer Sensor und Verfahren zur Herstellung einer Sensormembran
US12042281B2 (en) * 2019-07-17 2024-07-23 Terumo Cardiovascular Systems Corporation Fluorescent nanomaterial sensors and related methods
US20230295549A1 (en) 2020-08-20 2023-09-21 Danmarks Tekniske Universitet Methods, assembly and system for high-throughput, parallel monitoring of reaction systems
WO2022147171A1 (en) 2020-12-30 2022-07-07 Hawkeye Bio, Limited Pristine graphene based biosensor for biomarker detection and related core particles, materials compositions methods and systems

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US4557900A (en) * 1982-09-28 1985-12-10 Cardiovascular Devices, Inc. Optical sensor with beads
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5114676A (en) * 1988-08-04 1992-05-19 Avl Ag Optical sensor for determining at least one parameter in a liquid or gaseous sample
US5194393A (en) * 1989-11-21 1993-03-16 Bayar Aktiengesellschaft Optical biosensor and method of use
US5711915A (en) * 1992-03-18 1998-01-27 Bayer Aktiengesellschaft Optical solid-phase biosensor based on polyionic layers labelled with fluorescent dyes
WO1998000714A1 (en) * 1996-06-28 1998-01-08 Valtion Teknillinen Tutkimuskeskus Fluorescent energy transfer ligand interaction assay on a lipid film
US5942189A (en) * 1996-10-16 1999-08-24 Avl Medical Instruments Ag Luminescence-optical method and sensor layer for quantitative determination of at least one chemical component of a gaseous or liquid sample
US6348322B1 (en) * 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
WO2000043780A1 (en) * 1999-01-19 2000-07-27 Imperial Cancer Research Technology Limited Methods for detecting changes to cellular components
WO2002039083A2 (en) * 2000-11-08 2002-05-16 Science & Technology Corporation @ Unm Fluorescence and fret based assays for biomolecules on beads

Also Published As

Publication number Publication date
WO2002054076A2 (de) 2002-07-11
AT410601B (de) 2003-06-25
EP1346223A2 (de) 2003-09-24
US20040166024A1 (en) 2004-08-26
ATA21612000A (de) 2002-10-15
ATE352786T1 (de) 2007-02-15
JP2004517316A (ja) 2004-06-10
DE50111978D1 (de) 2007-03-15
WO2002054045A3 (de) 2003-03-20
EP1346220B1 (de) 2009-08-19
EP1346223B1 (de) 2007-01-24
US20040175836A1 (en) 2004-09-09
US7456023B2 (en) 2008-11-25
JP3740466B2 (ja) 2006-02-01
JP3782780B2 (ja) 2006-06-07
EP1346220A2 (de) 2003-09-24
WO2002054045A2 (de) 2002-07-11
JP2004517321A (ja) 2004-06-10
DE50115064D1 (de) 2009-10-01
ATE440283T1 (de) 2009-09-15
US7067320B2 (en) 2006-06-27

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