WO2002066596A3 - Vorrichtung und verfahren zur untersuchung von ionenkanälen in membranen - Google Patents

Vorrichtung und verfahren zur untersuchung von ionenkanälen in membranen Download PDF

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Publication number
WO2002066596A3
WO2002066596A3 PCT/EP2002/000078 EP0200078W WO02066596A3 WO 2002066596 A3 WO2002066596 A3 WO 2002066596A3 EP 0200078 W EP0200078 W EP 0200078W WO 02066596 A3 WO02066596 A3 WO 02066596A3
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WO
WIPO (PCT)
Prior art keywords
membranes
ion channels
analyzing ion
analyzing
biochip
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Ceased
Application number
PCT/EP2002/000078
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English (en)
French (fr)
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WO2002066596A2 (de
Inventor
Niels Fertig
Jan Behrends
Robert Blick
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Priority to US10/466,018 priority Critical patent/US20050009171A1/en
Priority to CA002434214A priority patent/CA2434214A1/en
Priority to EP02718011A priority patent/EP1349916A2/de
Publication of WO2002066596A2 publication Critical patent/WO2002066596A2/de
Publication of WO2002066596A3 publication Critical patent/WO2002066596A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

Die Erfindung betrifft Vorrichtungen und Verfahren zur Untersuchung von Ionenkanälen in Membranen. Die Erfindung zeichnet sich aus durch einen Biochip mit einem Substrat, in welchem in Form einer MxN Matrix Öffnungen zur Aufnahme einer wenigstens einen Ionenkanal (I) umfassenden Zellmembran oder einer künstrlichen Lipidmembran (Me) vorgesehen sind, wobei M ≥ 1 und ≥ 1.
PCT/EP2002/000078 2001-01-08 2002-01-07 Vorrichtung und verfahren zur untersuchung von ionenkanälen in membranen Ceased WO2002066596A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/466,018 US20050009171A1 (en) 2001-01-08 2002-01-07 Device and method for analyzing ion channels in membranes
CA002434214A CA2434214A1 (en) 2001-01-08 2002-01-07 Device and method for analyzing ion channels in membranes
EP02718011A EP1349916A2 (de) 2001-01-08 2002-01-07 Vorrichtung und verfahren zur untersuchung von ionenkanälen in membranen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01100458.7 2001-01-08
EP01100458A EP1225216A1 (de) 2001-01-08 2001-01-08 Vorrichtung zur Untersuchung von Ionenkanälen in Membranen

Publications (2)

Publication Number Publication Date
WO2002066596A2 WO2002066596A2 (de) 2002-08-29
WO2002066596A3 true WO2002066596A3 (de) 2003-03-27

Family

ID=8176169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000078 Ceased WO2002066596A2 (de) 2001-01-08 2002-01-07 Vorrichtung und verfahren zur untersuchung von ionenkanälen in membranen

Country Status (4)

Country Link
US (1) US20050009171A1 (de)
EP (2) EP1225216A1 (de)
CA (1) CA2434214A1 (de)
WO (1) WO2002066596A2 (de)

Cited By (4)

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US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US7201836B2 (en) 1997-12-17 2007-04-10 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US9146221B2 (en) 2001-03-24 2015-09-29 Aviva Biosciences Corporation High-density ion transport measurement biochip devices and methods

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WO2002024862A2 (en) * 2000-09-19 2002-03-28 Cytion S.A. Sample positioning and analysis system
CA2468424A1 (en) * 2001-11-27 2003-06-05 Cecilia Farre A method for combined parallel agent delivery and electroporation for cell structures and use thereof
AU2003205132A1 (en) * 2002-02-12 2003-09-04 Celectricon AB Systems and methods for rapidly changing the solution environment around sensors
GB2398635A (en) 2003-02-21 2004-08-25 Sophion Bioscience As A substrate providing a cell gigaseal for a patch clamp
EP1801586B1 (de) * 2002-08-21 2010-10-13 Cellectricon Ab System zur Gewinnung und Erhaltung hochresistenter Verschlüsse bei Patch-Clamp-Aufzeichnungen
JP4386835B2 (ja) * 2002-08-21 2009-12-16 セレクトリコン アーベー パッチクランプ記録において高抵抗固着を獲得して維持するシステム及び方法
WO2004036202A1 (en) 2002-10-16 2004-04-29 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
US7075161B2 (en) * 2003-10-23 2006-07-11 Agilent Technologies, Inc. Apparatus and method for making a low capacitance artificial nanopore
WO2006138160A2 (en) * 2005-06-16 2006-12-28 The Regents Of The University Of California Amyloid beta protein channel structure and uses thereof indentifying potential drug molecules for neurodegenerative diseases
DE102006002462A1 (de) * 2006-01-18 2007-07-19 Evotec Technologies Gmbh Elektrischer Feldkäfig und zugehöriges Betriebsverfahren
KR20080012605A (ko) * 2006-08-04 2008-02-12 삼성에스디아이 주식회사 탄성 에너지 장벽을 이용한 생체막 소자
WO2008112713A1 (en) * 2007-03-13 2008-09-18 Nanoink, Inc. Nanolithography with use of viewports
US8092739B2 (en) * 2008-11-25 2012-01-10 Wisconsin Alumni Research Foundation Retro-percussive technique for creating nanoscale holes
US8623496B2 (en) * 2009-11-06 2014-01-07 Wisconsin Alumni Research Foundation Laser drilling technique for creating nanoscale holes
DE102011008206A1 (de) * 2011-01-10 2012-07-12 Albert-Ludwigs-Universität Freiburg Mikrostrukturvorrichtung zur Messung an molekularen Membranen und ein Verfahren zur Herstellung dieser Mikrostrukturvorrichtung
US9086401B2 (en) * 2013-03-06 2015-07-21 Wisconsin Alumni Research Foundation Radio-frequency ion channel antenna
DE102013016994A1 (de) 2013-10-14 2015-04-16 Arthur Singer Verfahren und Vorrichtung zur Charakterisierung der Dynamik ionisch-elektrischen Zellverhaltens
DE202013009075U1 (de) 2013-10-14 2014-09-15 Arthur Singer Vorrichtung zur Charakterisierung der Dynamik ionisch-elektrischen Zellverhaltens
DE102017130518B4 (de) 2017-12-19 2024-04-18 ChanPharm GmbH Messgerät, Messverfahren, Hochdurchsatz-Testgerät und Messkit für elektrophysiologische Messungen, insbesondere an Zellaggregaten
DE102019129042A1 (de) 2019-10-28 2021-04-29 ChanPharm GmbH Elektrophysiologisches Messgerät und Messverfahren zur Erfassung mindestens eines elektrischen Messwerts an einer biologischen Zellprobe
CN112811386A (zh) * 2020-12-30 2021-05-18 哈尔滨工业大学（深圳） 3d微电极的制备方法
DE102023209046A1 (de) 2023-09-18 2025-03-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Vorrichtung mit nanopipetten-array zum durchführen von elektrophysiologischen messungen und verfahren zum herstellen dieser vorrichtung

Citations (7)

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WO1994025862A1 (en) * 1993-05-04 1994-11-10 Washington State University Research Foundation Biosensor substrate for mounting bilayer lipid membrane containing a receptor
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US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
DE19841337C1 (de) * 1998-05-27 1999-09-23 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle

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WO1994025862A1 (en) * 1993-05-04 1994-11-10 Washington State University Research Foundation Biosensor substrate for mounting bilayer lipid membrane containing a receptor
WO1995016206A1 (en) * 1993-12-06 1995-06-15 Biosystems Technology Corporation Composition and method for detection of analytes
WO1999031503A1 (de) * 1997-12-17 1999-06-24 Horst Vogel Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
DE19827957A1 (de) * 1998-05-27 1999-12-09 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur Messung eines Zellpotentiales
WO1999066329A1 (en) * 1998-06-12 1999-12-23 Cenes Limited High throughput screen
WO2000025121A1 (en) * 1998-10-27 2000-05-04 President And Fellows Of Harvard College Biological ion channels in nanofabricated detectors
DE19936302A1 (de) * 1999-08-02 2001-02-15 Niels Fertig Vorrichtungen und Verfahren zur Untersuchung von Ionenkanälen in Membranen

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7201836B2 (en) 1997-12-17 2007-04-10 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US7387715B2 (en) 1997-12-17 2008-06-17 Molecular Devices Corporation Sample positioning and analysis system
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US9146221B2 (en) 2001-03-24 2015-09-29 Aviva Biosciences Corporation High-density ion transport measurement biochip devices and methods

Also Published As

Publication number Publication date
EP1225216A1 (de) 2002-07-24
CA2434214A1 (en) 2002-08-29
EP1349916A2 (de) 2003-10-08
WO2002066596A2 (de) 2002-08-29
US20050009171A1 (en) 2005-01-13

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