WO2002072811A3 - Regulation de la proteine de type lyase prenylcysteine humaine - Google Patents

Regulation de la proteine de type lyase prenylcysteine humaine Download PDF

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Publication number
WO2002072811A3
WO2002072811A3 PCT/EP2002/002683 EP0202683W WO02072811A3 WO 2002072811 A3 WO2002072811 A3 WO 2002072811A3 EP 0202683 W EP0202683 W EP 0202683W WO 02072811 A3 WO02072811 A3 WO 02072811A3
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WO
WIPO (PCT)
Prior art keywords
protein
prenylcysteine lyase
human
human prenylcysteine
lyase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/002683
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English (en)
Other versions
WO2002072811A2 (fr
Inventor
Rainer H Koehler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002308251A priority Critical patent/AU2002308251A1/en
Publication of WO2002072811A2 publication Critical patent/WO2002072811A2/fr
Anticipated expiration legal-status Critical
Publication of WO2002072811A3 publication Critical patent/WO2002072811A3/fr
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90212—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des réactifs qui régulent une protéine de type lyase prénylcystéine humaine et des réactifs qui se lient à des produits géniques de la protéine de type lyase prénylcystéine humaine, ces réactifs pouvant jouer un rôle dans la prévention, l'atténuation ou la correction de dysfonctionnements ou de maladies, entre autres du cancer.
PCT/EP2002/002683 2001-03-13 2002-03-12 Regulation de la proteine de type lyase prenylcysteine humaine Ceased WO2002072811A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002308251A AU2002308251A1 (en) 2001-03-13 2002-03-12 Human prenylcysteine lyase-like protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27503401P 2001-03-13 2001-03-13
US60/275,034 2001-03-13

Publications (2)

Publication Number Publication Date
WO2002072811A2 WO2002072811A2 (fr) 2002-09-19
WO2002072811A3 true WO2002072811A3 (fr) 2004-07-15

Family

ID=23050623

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002683 Ceased WO2002072811A2 (fr) 2001-03-13 2002-03-12 Regulation de la proteine de type lyase prenylcysteine humaine

Country Status (2)

Country Link
AU (1) AU2002308251A1 (fr)
WO (1) WO2002072811A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998029545A1 (fr) * 1996-12-30 1998-07-09 Pharmacia & Upjohn Company NOUVELLES SEQUENCES DES PROTEINES p56 AFFECTANT LES CANAUX K-ATP
WO2000077037A2 (fr) * 1999-06-15 2000-12-21 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques les codant
EP1067182A2 (fr) * 1999-07-08 2001-01-10 Helix Research Institute Proteine secretoire ou proteine de membrane

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998029545A1 (fr) * 1996-12-30 1998-07-09 Pharmacia & Upjohn Company NOUVELLES SEQUENCES DES PROTEINES p56 AFFECTANT LES CANAUX K-ATP
WO2000077037A2 (fr) * 1999-06-15 2000-12-21 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques les codant
EP1067182A2 (fr) * 1999-07-08 2001-01-10 Helix Research Institute Proteine secretoire ou proteine de membrane

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TSCHANTZ WILLIAM R ET AL: "Cloning, expression, and cellular localization of a human prenylcysteine lyase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 50, 10 December 1999 (1999-12-10), pages 35802 - 35808, XP002222193, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2002308251A1 (en) 2002-09-24
WO2002072811A2 (fr) 2002-09-19

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