WO2002077254A3 - Verfahren zur gewinnung von wertstoffen aus organismen - Google Patents

Verfahren zur gewinnung von wertstoffen aus organismen Download PDF

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Publication number
WO2002077254A3
WO2002077254A3 PCT/EP2002/003252 EP0203252W WO02077254A3 WO 2002077254 A3 WO2002077254 A3 WO 2002077254A3 EP 0203252 W EP0203252 W EP 0203252W WO 02077254 A3 WO02077254 A3 WO 02077254A3
Authority
WO
WIPO (PCT)
Prior art keywords
products
organisms
useful products
useful
accumulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/003252
Other languages
English (en)
French (fr)
Other versions
WO2002077254A2 (de
Inventor
Hans Joerg Kunte
Erwin A Galinski
Katrin Grammann
Angela Volke
Thorsten Bestvater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bitop AG
Original Assignee
Bitop AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bitop AG filed Critical Bitop AG
Priority to EP02735162A priority Critical patent/EP1409707B1/de
Priority to DE50213171T priority patent/DE50213171D1/de
Publication of WO2002077254A2 publication Critical patent/WO2002077254A2/de
Publication of WO2002077254A3 publication Critical patent/WO2002077254A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Steroid Compounds (AREA)

Abstract

Es wird ein Verfahren beschrieben, das dazu geeignet ist, Wertstoffe, die normalerweise im Zellinnern zurückgehalten werden, in Organismen zu produzieren und aus diesen zu gewinnen, ohne daß die produzierenden Organismen zerstört werden. Dabei wird eine Überproduktion und Ausscheidung in das umgebende Medium ermöglicht. Insbesondere kann man durch dieses Verfahren hohe Konzentrationen des Wertstoffes in der Produktlösung erzielen und in großen Mengen die Endprodukte von Stoffwechselwegen gewinnen, die normalerweise durch Feed-Back-Hemmung in der Syntheseleistung limitiert wären. Das Verfahren ist dadurch gekennzeichnet, daß zelleigene Transportsysteme für die Akkumulation/Rückhaltung dieser Wertstoffe ausgeschaltet oder in ihrer Befähigung zur Akkumulation/Rückhaltung dieser Wertstoffe beeinträchtigt werden.
PCT/EP2002/003252 2001-03-23 2002-03-22 Verfahren zur gewinnung von wertstoffen aus organismen Ceased WO2002077254A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02735162A EP1409707B1 (de) 2001-03-23 2002-03-22 Verfahren zur gewinnung von wertstoffen aus organismen
DE50213171T DE50213171D1 (de) 2001-03-23 2002-03-22 Verfahren zur gewinnung von wertstoffen aus organismen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10114189.0 2001-03-23
DE10114189A DE10114189B4 (de) 2001-03-23 2001-03-23 Verfahren zur Gewinnung von Wertstoffen aus Organismen durch Beeinflussung/Beeinträchtigung der zelleigenen Transportsysteme für diese Wertstoffe bzw. durch Verwendung von Produktionsstämmen, denen besagte Transportsysteme fehlen

Publications (2)

Publication Number Publication Date
WO2002077254A2 WO2002077254A2 (de) 2002-10-03
WO2002077254A3 true WO2002077254A3 (de) 2002-12-19

Family

ID=7678662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/003252 Ceased WO2002077254A2 (de) 2001-03-23 2002-03-22 Verfahren zur gewinnung von wertstoffen aus organismen

Country Status (5)

Country Link
EP (1) EP1409707B1 (de)
AT (1) ATE419372T1 (de)
DE (2) DE10114189B4 (de)
ES (1) ES2321486T3 (de)
WO (1) WO2002077254A2 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2768048C (en) 2008-07-14 2020-07-07 Delaney Technologies Inc. Self-supporting pier for a retractable roof system for a large building structure
JP7132935B2 (ja) 2017-03-06 2022-09-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 適合溶質の使用
EP3608404A1 (de) * 2018-08-09 2020-02-12 Technische Universität München Verbessertes verfahren zur herstellung von chemischen verbindungen aus oxaloacetat durch mikroorganismen
EP4007561B8 (de) 2019-08-01 2025-10-08 SUSONITY Commercial GmbH Vorbeugung und reduktion von verhornungsstörungen und zugehörige kosmetische mittel
CN112646766B (zh) * 2020-12-30 2023-08-18 内蒙古伊品生物科技有限公司 一种改造基因bbd29_04920的产l-谷氨酸的重组菌株及其构建方法与应用
CN112342254B (zh) * 2021-01-08 2021-04-23 江苏省中国科学院植物研究所 一种发酵生产四氢甲基嘧啶羧酸的方法
EP4424809A1 (de) 2023-03-03 2024-09-04 FCC Aqualia, S.A. Verfahren zur umwandlung von methanhaltigen gasströmen in osmolyte unter verwendung einer bakterienkultur in einem taylor-fluss-bioreaktor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925615A1 (de) * 1999-06-04 2000-12-07 Erwin A Galinski Verfahren zur Produktion von Ectoinen (1,4,5,6-Tetrahydro-2-methyl-4-pyrimidin-carbonsäure und 1,4,5,6-Tetrahydro-2-methyl-5-hydroxy-4- pyrimidincarbonsäure) in nicht-halophilen Organismen unter Verwendung salzarmer Medien

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925615A1 (de) * 1999-06-04 2000-12-07 Erwin A Galinski Verfahren zur Produktion von Ectoinen (1,4,5,6-Tetrahydro-2-methyl-4-pyrimidin-carbonsäure und 1,4,5,6-Tetrahydro-2-methyl-5-hydroxy-4- pyrimidincarbonsäure) in nicht-halophilen Organismen unter Verwendung salzarmer Medien

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FORWARD JASON A ET AL: "TRAP transporters: A new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.", JOURNAL OF BACTERIOLOGY, vol. 179, no. 17, 1997, pages 5482 - 5493, XP002216029, ISSN: 0021-9193 *
GOUESBET GWENOLA ET AL: "Characterization of the Erwinia chrysanthemi osmoprotectant transporter gene ousA.", JOURNAL OF BACTERIOLOGY, vol. 178, no. 2, 1996, pages 447 - 455, XP002216028, ISSN: 0021-9193 *
GRAMMANN K ET AL: "Identification and characterization of an osmoregulated tetrahydropyrimidine transport system in Halomonas elongata.", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART A MOLECULAR & INTEGRATIVE, vol. 126A, no. Suppl. 1, July 2000 (2000-07-01), 21st Congress of the European Society for Comparative Physiology and Biochemistry;Liege, Belgium; July 24-28, 2000, July, 2000, pages S84, XP002216027, ISSN: 1095-6433 *
GRAMMANN KATRIN ET AL: "New type of osmoregulated solute transporter identified in halophilic members of the Bacteria domain: TRAP transporter TeaABC mediates uptake of ectoine and hydroxyectoine in Halomonas elongata DSM 2581T.", JOURNAL OF BACTERIOLOGY, vol. 184, no. 11, June 2002 (2002-06-01), June, 2002, pages 3078 - 3085, XP008009093, ISSN: 0021-9193 *
LOUIS P ET AL: "Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli.", MICROBIOLOGY (READING, ENGLAND) ENGLAND APR 1997, vol. 143 ( Pt 4), April 1997 (1997-04-01), pages 1141 - 1149, XP002216031, ISSN: 1350-0872 *
PETER H ET AL: "CORYNEBACTERIUM GLUTAMICUM IS EQUIPPED WITH FOUR SECONDARY CARRIERSFOR COMPATIBLE SOLUTES: IDENTIFICATION, SEQUENCING, AND CHARACTERIZATION OF THE PROLINE/ECTOINE UPTAKE SYSTEM, PROP, AND THE ECTOINE/PROLINE/GLYCINE BETAINE CARRIER, ECTP", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 180, no. 22, 1998, pages 6005 - 6012, XP000917352, ISSN: 0021-9193 *
RABUS RALF ET AL: "TRAP transporters: An ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters.", MICROBIOLOGY (READING), vol. 145, no. 12, December 1999 (1999-12-01), pages 3431 - 3445, XP002216030, ISSN: 1350-0872 *
SAUER T ET AL: "BACTERIAL MILKING: A NOVEL BIOPROCESS FOR PRODUCTION OF COMPATIBLE SOLUTES", BIOTECHNOLOGY AND BIOENGINEERING, INTERSCIENCE PUBLISHERS, LONDON, GB, vol. 57, no. 3, 1998, pages 306 - 313, XP000919323, ISSN: 0006-3592 *

Also Published As

Publication number Publication date
DE50213171D1 (de) 2009-02-12
EP1409707B1 (de) 2008-12-31
ATE419372T1 (de) 2009-01-15
DE10114189A1 (de) 2002-09-26
EP1409707A2 (de) 2004-04-21
DE10114189B4 (de) 2013-01-03
WO2002077254A2 (de) 2002-10-03
ES2321486T3 (es) 2009-06-08

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