WO2002102416A3 - Glycoconjugues antiviraux - Google Patents

Glycoconjugues antiviraux Download PDF

Info

Publication number
WO2002102416A3
WO2002102416A3 PCT/DE2002/002103 DE0202103W WO02102416A3 WO 2002102416 A3 WO2002102416 A3 WO 2002102416A3 DE 0202103 W DE0202103 W DE 0202103W WO 02102416 A3 WO02102416 A3 WO 02102416A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycoconjugates
bromoalkyl
glucosides
benzoyl
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2002/002103
Other languages
German (de)
English (en)
Other versions
WO2002102416A2 (fr
Inventor
Volker Kinzel
Jennifer Reed
Jost Reinhard
Manfred Wiessler
Von Stosch Andreas Graf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Steinbeis & Co fur Technologietransfer GmbH
Steinbeis & Co fur Techn GmbH
Original Assignee
Steinbeis & Co fur Technologietransfer GmbH
Steinbeis & Co fur Techn GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steinbeis & Co fur Technologietransfer GmbH, Steinbeis & Co fur Techn GmbH filed Critical Steinbeis & Co fur Technologietransfer GmbH
Priority to AU2002320870A priority Critical patent/AU2002320870A1/en
Priority to DE10292610T priority patent/DE10292610D2/de
Publication of WO2002102416A2 publication Critical patent/WO2002102416A2/fr
Publication of WO2002102416A3 publication Critical patent/WO2002102416A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne des bromoalkyl-β-D-glucosides protégés par un acétyle ou un benzoyle, et des glycoconjugués pouvant être synthétisés par transformation des bromoalkyl-β-D-glucosides protégés par un acétyle ou un benzoyle avec des structures de base isochinolindione. L'invention concerne également des procédés de fabrication destinés à la synthèse des bromoalkyl-β-D-glucosides protégés par un acétyle ou un benzoyle et desdits glycoconjugués, des agents pharmaceutiques contenant lesdits glycoconjugués, ainsi que l'utilisation desdits glycoconjugués dans la fabrication d'agents pharmaceutiques destinés au traitement de maladies virales, notamment des infections par VIH.
PCT/DE2002/002103 2001-06-18 2002-06-10 Glycoconjugues antiviraux Ceased WO2002102416A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002320870A AU2002320870A1 (en) 2001-06-18 2002-06-10 Antiviral glycoconjugates
DE10292610T DE10292610D2 (de) 2001-06-18 2002-06-10 Antivirale Glykokonjugate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10129256A DE10129256A1 (de) 2001-06-18 2001-06-18 Antivirale Glykokonjugate
DE10129256.2 2001-06-18

Publications (2)

Publication Number Publication Date
WO2002102416A2 WO2002102416A2 (fr) 2002-12-27
WO2002102416A3 true WO2002102416A3 (fr) 2003-08-21

Family

ID=7688526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/002103 Ceased WO2002102416A2 (fr) 2001-06-18 2002-06-10 Glycoconjugues antiviraux

Country Status (3)

Country Link
AU (1) AU2002320870A1 (fr)
DE (2) DE10129256A1 (fr)
WO (1) WO2002102416A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3765516A2 (fr) * 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Molécules multifonctionnelles et utilisations associées

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675392A (en) * 1982-06-23 1987-06-23 Svenska Sockerfabriks Ab Glycosides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3614000A1 (de) * 1986-04-25 1987-10-29 Boehringer Mannheim Gmbh Neue isochinolindione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675392A (en) * 1982-06-23 1987-06-23 Svenska Sockerfabriks Ab Glycosides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALLEN HJ, KISAILUS EC: "Glycoconjugates: Composition, structure and function", 1992, MARCEL DEKKER, NY, BASEL, XP008012971 *
ANDREAS GRAF V. STOSCH, VOLKER KINZEL, JENNIFER REED: "Extension of the polarity-dependent "Switch Phenomenon" of the gp120 binding domain as a target for antiviral chemotherapy", BIOCHEMISTRY, vol. 35, 1996, pages 411 - 417, XP001109565 *
PARFITT K: "Martindale. The complete drug reference", 1999, PHARMACEUTICAL PRESS, LONDON, XP002229588 *

Also Published As

Publication number Publication date
DE10292610D2 (de) 2004-07-29
WO2002102416A2 (fr) 2002-12-27
AU2002320870A1 (en) 2003-01-02
DE10129256A1 (de) 2003-01-02

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