WO2003010176A3 - Complexes acide nucleique-proteine - Google Patents

Complexes acide nucleique-proteine Download PDF

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Publication number
WO2003010176A3
WO2003010176A3 PCT/GB2002/003351 GB0203351W WO03010176A3 WO 2003010176 A3 WO2003010176 A3 WO 2003010176A3 GB 0203351 W GB0203351 W GB 0203351W WO 03010176 A3 WO03010176 A3 WO 03010176A3
Authority
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WIPO (PCT)
Prior art keywords
protein
nucleic acid
acid complexes
complexes
assemble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2002/003351
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English (en)
Other versions
WO2003010176A2 (fr
Inventor
Mikhail Soloviev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Glycosciences UK Ltd
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Oxford Glycosciences UK Ltd
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Filing date
Publication date
Application filed by Oxford Glycosciences UK Ltd filed Critical Oxford Glycosciences UK Ltd
Priority to AU2002317380A priority Critical patent/AU2002317380A1/en
Publication of WO2003010176A2 publication Critical patent/WO2003010176A2/fr
Publication of WO2003010176A3 publication Critical patent/WO2003010176A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1062Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1075Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des techniques de production de protéines de recombinaison qui s'auto-assemblent en complexes avec des acides nucléiques en solution ou sur des supports et des complexes acide nucléique-protéine produits selon cette technique, par exemple dans une structure de jeu ordonné d'échantillon.
PCT/GB2002/003351 2001-07-24 2002-07-23 Complexes acide nucleique-proteine Ceased WO2003010176A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002317380A AU2002317380A1 (en) 2001-07-24 2002-07-23 Protein-nucleic acid complexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0118031A GB0118031D0 (en) 2001-07-24 2001-07-24 Self assembled protein nucleic acid complexes and self assembled protein arrays
GB0118031.4 2001-07-24

Publications (2)

Publication Number Publication Date
WO2003010176A2 WO2003010176A2 (fr) 2003-02-06
WO2003010176A3 true WO2003010176A3 (fr) 2003-12-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/003351 Ceased WO2003010176A2 (fr) 2001-07-24 2002-07-23 Complexes acide nucleique-proteine

Country Status (3)

Country Link
AU (1) AU2002317380A1 (fr)
GB (1) GB0118031D0 (fr)
WO (1) WO2003010176A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11845979B2 (en) 2020-06-02 2023-12-19 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067742A1 (fr) * 2003-01-31 2004-08-12 Keio University Molecules affectees clivables et procede de criblage utilisant lesdites molecules
US8148302B2 (en) * 2005-10-19 2012-04-03 The United States Of America As Represented By The Department Of Health And Human Services In situ assembling of protein microarrays
WO2010127186A1 (fr) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Produits de construction d'acide nucléique et leurs procédés d'utilisation
US20120270748A1 (en) * 2009-12-07 2012-10-25 Prognosys Biosciences, Inc. Peptide display arrays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
ES2555106T3 (es) 2010-04-05 2015-12-29 Prognosys Biosciences, Inc. Ensayos biológicos codificados espacialmente
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
EP2694709B1 (fr) 2011-04-08 2016-09-14 Prognosys Biosciences, Inc. Constructions peptidiques et systèmes d'essai
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
GB2500243A (en) * 2012-03-15 2013-09-18 Isogenica Ltd Identifying members of immobilised peptide libraries comprising protein-DNA complexes
EP3901280B1 (fr) 2012-10-17 2025-03-12 10x Genomics Sweden AB Procédés et produits pour optimiser la detection localisée ou spatiale de l'expression génique dans un échantillon de tissu
CA2907050C (fr) 2013-03-15 2023-09-26 Prognosys Biosciences, Inc. Procedes de detection de liaison peptide/mhc/tcr
CN105473744B (zh) 2013-06-25 2020-06-19 普罗格诺西斯生物科学公司 采用微流控装置的空间编码生物分析
WO2015070037A2 (fr) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Conjugués de polynucléotides et procédés de détection d'analytes
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
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WO2025179207A1 (fr) * 2024-02-21 2025-08-28 Enterprise Science Fund, Llc Synthèse de peptides artificiels

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011922A1 (fr) * 1993-10-29 1995-05-04 Affymax Technologies N.V. Banques de presentation de peptides et d'anticorps in vitro
WO1998023781A1 (fr) * 1996-11-26 1998-06-04 Johns Hopkins University Systeme de detection de ligands et procedes d'utilisation associes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011922A1 (fr) * 1993-10-29 1995-05-04 Affymax Technologies N.V. Banques de presentation de peptides et d'anticorps in vitro
WO1998023781A1 (fr) * 1996-11-26 1998-06-04 Johns Hopkins University Systeme de detection de ligands et procedes d'utilisation associes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BRADBURY A: "Evolution of the display technologies", TRENDS IN BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 5, May 2000 (2000-05-01), pages 183 - 184, XP004195994, ISSN: 0167-7799 *
CEBE REGIS ET AL: "Size of the ligand complex between the N-terminal domain of the gene III coat protein and the non-infectious phage strongly influences the usefulness of in vitro selective infective phage technology", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 352, no. 3, 2000, pages 841 - 849, XP002211404, ISSN: 0264-6021 *
DOI N ET AL: "STABLE: protein-DNA fusion system for screening of combinatorial protein libraries in vitro", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 457, no. 2, 27 August 1999 (1999-08-27), pages 227 - 230, XP004260157, ISSN: 0014-5793 *
NILSSON MIKAEL T I ET AL: "Functional expression and affinity selection of single-chain Cro by phage display: Isolation of novel DNA-binding proteins.", PROTEIN ENGINEERING, vol. 13, no. 7, July 2000 (2000-07-01), pages 519 - 526, XP002233554, ISSN: 0269-2139 *
STRICKER N L ET AL: "USING THE LAC REPRESSOR SYSTEM TO IDENTIFY INTERACTING PROTCINS", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, vol. 303, 1999, pages 451 - 468, XP000943989, ISSN: 0076-6879 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11845979B2 (en) 2020-06-02 2023-12-19 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors

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Publication number Publication date
WO2003010176A2 (fr) 2003-02-06
GB0118031D0 (en) 2001-09-19
AU2002317380A1 (en) 2003-02-17

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