WO2003010176A3 - Complexes acide nucleique-proteine - Google Patents
Complexes acide nucleique-proteine Download PDFInfo
- Publication number
- WO2003010176A3 WO2003010176A3 PCT/GB2002/003351 GB0203351W WO03010176A3 WO 2003010176 A3 WO2003010176 A3 WO 2003010176A3 GB 0203351 W GB0203351 W GB 0203351W WO 03010176 A3 WO03010176 A3 WO 03010176A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- nucleic acid
- acid complexes
- complexes
- assemble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Analytical Chemistry (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002317380A AU2002317380A1 (en) | 2001-07-24 | 2002-07-23 | Protein-nucleic acid complexes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0118031A GB0118031D0 (en) | 2001-07-24 | 2001-07-24 | Self assembled protein nucleic acid complexes and self assembled protein arrays |
| GB0118031.4 | 2001-07-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003010176A2 WO2003010176A2 (fr) | 2003-02-06 |
| WO2003010176A3 true WO2003010176A3 (fr) | 2003-12-31 |
Family
ID=9919095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2002/003351 Ceased WO2003010176A2 (fr) | 2001-07-24 | 2002-07-23 | Complexes acide nucleique-proteine |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002317380A1 (fr) |
| GB (1) | GB0118031D0 (fr) |
| WO (1) | WO2003010176A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11845979B2 (en) | 2020-06-02 | 2023-12-19 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004067742A1 (fr) * | 2003-01-31 | 2004-08-12 | Keio University | Molecules affectees clivables et procede de criblage utilisant lesdites molecules |
| US8148302B2 (en) * | 2005-10-19 | 2012-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | In situ assembling of protein microarrays |
| WO2010127186A1 (fr) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Produits de construction d'acide nucléique et leurs procédés d'utilisation |
| US20120270748A1 (en) * | 2009-12-07 | 2012-10-25 | Prognosys Biosciences, Inc. | Peptide display arrays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| ES2555106T3 (es) | 2010-04-05 | 2015-12-29 | Prognosys Biosciences, Inc. | Ensayos biológicos codificados espacialmente |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| EP2694709B1 (fr) | 2011-04-08 | 2016-09-14 | Prognosys Biosciences, Inc. | Constructions peptidiques et systèmes d'essai |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| GB2500243A (en) * | 2012-03-15 | 2013-09-18 | Isogenica Ltd | Identifying members of immobilised peptide libraries comprising protein-DNA complexes |
| EP3901280B1 (fr) | 2012-10-17 | 2025-03-12 | 10x Genomics Sweden AB | Procédés et produits pour optimiser la detection localisée ou spatiale de l'expression génique dans un échantillon de tissu |
| CA2907050C (fr) | 2013-03-15 | 2023-09-26 | Prognosys Biosciences, Inc. | Procedes de detection de liaison peptide/mhc/tcr |
| CN105473744B (zh) | 2013-06-25 | 2020-06-19 | 普罗格诺西斯生物科学公司 | 采用微流控装置的空间编码生物分析 |
| WO2015070037A2 (fr) | 2013-11-08 | 2015-05-14 | Prognosys Biosciences, Inc. | Conjugués de polynucléotides et procédés de détection d'analytes |
| FI3901281T3 (fi) | 2015-04-10 | 2023-01-31 | Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi | |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| EP3894592A2 (fr) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Génération de réseaux spatiaux avec des gradients |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| EP3976820A1 (fr) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Procédés de détection de l'hétérogénéité spatiale d'un échantillon biologique |
| EP4025711A2 (fr) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Amélioration de la spécificité de la liaison d'un analyte |
| WO2021091611A1 (fr) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Agents de capture d'analytes marqués spatialement pour le multiplexage d'analytes |
| ES2946357T3 (es) | 2019-12-23 | 2023-07-17 | 10X Genomics Inc | Métodos para el análisis espacial usando ligación con molde de ARN |
| CN115135984B (zh) | 2019-12-23 | 2025-12-23 | 10X基因组学有限公司 | 可逆固定试剂及其使用方法 |
| WO2021133842A1 (fr) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Compositions et méthodes d'utilisation d'échantillons biologiques fixés dans des dosages basés sur des compartiments |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US12129516B2 (en) | 2020-02-07 | 2024-10-29 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US12399123B1 (en) | 2020-02-14 | 2025-08-26 | 10X Genomics, Inc. | Spatial targeting of analytes |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
| EP4549582A3 (fr) | 2020-04-22 | 2025-06-18 | 10x Genomics, Inc. | Procédés d'analyse spatiale à l'aide d'une déplétion d'arn ciblée |
| US12416603B2 (en) | 2020-05-19 | 2025-09-16 | 10X Genomics, Inc. | Electrophoresis cassettes and instrumentation |
| ES2989052T3 (es) | 2020-05-22 | 2024-11-25 | 10X Genomics Inc | Medición espacio-temporal simultánea de la expresión génica y la actividad celular |
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| WO2021242834A1 (fr) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Procédé de réinitialisation d'un réseau |
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| EP4164796A4 (fr) | 2020-06-10 | 2024-03-06 | 10x Genomics, Inc. | Procédés de distribution de fluide |
| EP4165207B1 (fr) | 2020-06-10 | 2024-09-25 | 10X Genomics, Inc. | Methode pour determiner la position d'un analyte dans un echantillon biologique |
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| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
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| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| ES2993269T3 (en) | 2020-09-18 | 2024-12-26 | 10X Genomics Inc | Sample handling apparatus and image registration methods |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| EP4121555B1 (fr) | 2020-12-21 | 2026-02-25 | 10X Genomics, Inc. | Procédés pour capturer des sondes et/ou des codes à barres |
| ES2989523T3 (es) | 2021-02-19 | 2024-11-26 | 10X Genomics Inc | Método de uso de un dispositivo modular de soporte para ensayos |
| ES3008686T3 (en) | 2021-03-18 | 2025-03-24 | 10X Genomics Inc | Multiplex capture of gene and protein expression from a biological sample |
| WO2022221425A1 (fr) | 2021-04-14 | 2022-10-20 | 10X Genomics, Inc. | Procédés de mesure d'une mauvaise localisation d'un analyte |
| EP4320271B1 (fr) | 2021-05-06 | 2025-03-19 | 10X Genomics, Inc. | Procédés pour augmenter la résolution d'une analyse spatiale |
| EP4347879B1 (fr) | 2021-06-03 | 2025-02-19 | 10X Genomics, Inc. | Procédés, compositions, kits et systèmes pour améliorer la capture d'analytes pour une analyse spatiale |
| US12553805B2 (en) | 2021-08-02 | 2026-02-17 | 10X Genomics, Inc. | Methods of preserving a biological sample |
| WO2023034489A1 (fr) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Procédés, compositions et kits pour bloquer une sonde de capture sur un réseau spatial |
| EP4419707A1 (fr) | 2021-11-10 | 2024-08-28 | 10X Genomics, Inc. | Procédés, compositions et kits pour déterminer l'emplacement d'un analyte dans un échantillon biologique |
| WO2023102118A2 (fr) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Procédés, compositions et systèmes pour la détection améliorée d'analytes in situ et analyse spatiale |
| WO2023122033A1 (fr) | 2021-12-20 | 2023-06-29 | 10X Genomics, Inc. | Auto-test pour dispositif d'imagerie |
| EP4482979B1 (fr) | 2022-11-09 | 2025-10-01 | 10X Genomics, Inc. | Procédés, compositions et kits pour déterminer l'emplacement de plusieurs analytes dans un échantillon biologique |
| WO2025179207A1 (fr) * | 2024-02-21 | 2025-08-28 | Enterprise Science Fund, Llc | Synthèse de peptides artificiels |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995011922A1 (fr) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | Banques de presentation de peptides et d'anticorps in vitro |
| WO1998023781A1 (fr) * | 1996-11-26 | 1998-06-04 | Johns Hopkins University | Systeme de detection de ligands et procedes d'utilisation associes |
-
2001
- 2001-07-24 GB GB0118031A patent/GB0118031D0/en not_active Ceased
-
2002
- 2002-07-23 AU AU2002317380A patent/AU2002317380A1/en not_active Abandoned
- 2002-07-23 WO PCT/GB2002/003351 patent/WO2003010176A2/fr not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995011922A1 (fr) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | Banques de presentation de peptides et d'anticorps in vitro |
| WO1998023781A1 (fr) * | 1996-11-26 | 1998-06-04 | Johns Hopkins University | Systeme de detection de ligands et procedes d'utilisation associes |
Non-Patent Citations (5)
| Title |
|---|
| BRADBURY A: "Evolution of the display technologies", TRENDS IN BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 5, May 2000 (2000-05-01), pages 183 - 184, XP004195994, ISSN: 0167-7799 * |
| CEBE REGIS ET AL: "Size of the ligand complex between the N-terminal domain of the gene III coat protein and the non-infectious phage strongly influences the usefulness of in vitro selective infective phage technology", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 352, no. 3, 2000, pages 841 - 849, XP002211404, ISSN: 0264-6021 * |
| DOI N ET AL: "STABLE: protein-DNA fusion system for screening of combinatorial protein libraries in vitro", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 457, no. 2, 27 August 1999 (1999-08-27), pages 227 - 230, XP004260157, ISSN: 0014-5793 * |
| NILSSON MIKAEL T I ET AL: "Functional expression and affinity selection of single-chain Cro by phage display: Isolation of novel DNA-binding proteins.", PROTEIN ENGINEERING, vol. 13, no. 7, July 2000 (2000-07-01), pages 519 - 526, XP002233554, ISSN: 0269-2139 * |
| STRICKER N L ET AL: "USING THE LAC REPRESSOR SYSTEM TO IDENTIFY INTERACTING PROTCINS", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, vol. 303, 1999, pages 451 - 468, XP000943989, ISSN: 0076-6879 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11845979B2 (en) | 2020-06-02 | 2023-12-19 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003010176A2 (fr) | 2003-02-06 |
| GB0118031D0 (en) | 2001-09-19 |
| AU2002317380A1 (en) | 2003-02-17 |
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