WO2003018793A1 - Nouveau gene presentant une sequence de type facteur d'echange de nucleotides guanyliques - Google Patents

Nouveau gene presentant une sequence de type facteur d'echange de nucleotides guanyliques Download PDF

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Publication number
WO2003018793A1
WO2003018793A1 PCT/JP2002/008408 JP0208408W WO03018793A1 WO 2003018793 A1 WO2003018793 A1 WO 2003018793A1 JP 0208408 W JP0208408 W JP 0208408W WO 03018793 A1 WO03018793 A1 WO 03018793A1
Authority
WO
WIPO (PCT)
Prior art keywords
sequence
guanine nucleotide
nucleotide exchange
exchange factor
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008408
Other languages
English (en)
Japanese (ja)
Inventor
Shuichiro Inagaki
Yoshihiro Kawamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP2003523642A priority Critical patent/JP4219808B2/ja
Publication of WO2003018793A1 publication Critical patent/WO2003018793A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne un nouveau polypeptide présentant une séquence (SecL-1) de type facteur d'échange de nucléotides guanyliques humains et de souris et un gène codant ledit polypeptide ; un polypeptide de recombinaison faisant appel à la séquence d'ADN codant le polypeptide susmentionné et un procédé de production afférent ; un anticorps le reconnaissant spécifiquement et un procédé de production afférent ; un inhibiteur de prolifération cellulaire, un agent induisant l'apoptose et un remède contre les maladies du foie le contenant ; une méthode de criblage d'un composé qui régule spécifiquement la protéine susmentionnée à l'aide dudit polypeptide, etc.
PCT/JP2002/008408 2001-08-23 2002-08-21 Nouveau gene presentant une sequence de type facteur d'echange de nucleotides guanyliques Ceased WO2003018793A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003523642A JP4219808B2 (ja) 2001-08-23 2002-08-21 グアニンヌクレオチド交換因子様配列を有する新規遺伝子

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001253344 2001-08-23
JP2001-253344 2001-08-23

Publications (1)

Publication Number Publication Date
WO2003018793A1 true WO2003018793A1 (fr) 2003-03-06

Family

ID=19081693

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008408 Ceased WO2003018793A1 (fr) 2001-08-23 2002-08-21 Nouveau gene presentant une sequence de type facteur d'echange de nucleotides guanyliques

Country Status (2)

Country Link
JP (1) JP4219808B2 (fr)
WO (1) WO2003018793A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018126A1 (fr) * 1997-10-07 1999-04-15 Ono Pharmaceutical Co., Ltd. POLYPEPTIDE, ADNc LE CODANT ET LEUR UTILISATION
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001029221A2 (fr) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Nouvelles proteines et polynucleotides codant ces proteines
WO2001032676A1 (fr) * 1999-10-29 2001-05-10 Human Genome Sciences, Inc. 25 proteines secretes par l'homme
WO2001053453A2 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques de moelle osseuse et polypeptides associes
WO2001059063A2 (fr) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018126A1 (fr) * 1997-10-07 1999-04-15 Ono Pharmaceutical Co., Ltd. POLYPEPTIDE, ADNc LE CODANT ET LEUR UTILISATION
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001029221A2 (fr) * 1999-10-20 2001-04-26 Zymogenetics, Inc. Nouvelles proteines et polynucleotides codant ces proteines
WO2001032676A1 (fr) * 1999-10-29 2001-05-10 Human Genome Sciences, Inc. 25 proteines secretes par l'homme
WO2001053453A2 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques de moelle osseuse et polypeptides associes
WO2001059063A2 (fr) * 2000-01-31 2001-08-16 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ACHSTETTER T. ET AL.: "SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast golgi apparatus", J. BIOL. CHEM., vol. 263, no. 24, 1988, pages 11711 - 11717, XP002040610 *
AKIRA TOGAWA ET AL.: "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors", J. BIOL. CHEM., vol. 274, no. 18, 1999, pages 12308 - 12315, XP002966803 *
MORINAGA N. ET AL.: "Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor", PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 12926 - 12931, XP002966802 *

Also Published As

Publication number Publication date
JP4219808B2 (ja) 2009-02-04
JPWO2003018793A1 (ja) 2004-12-09

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