WO2003020703A1 - Cyclic amine compound - Google Patents

Cyclic amine compound Download PDF

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Publication number
WO2003020703A1
WO2003020703A1 PCT/JP2002/008650 JP0208650W WO03020703A1 WO 2003020703 A1 WO2003020703 A1 WO 2003020703A1 JP 0208650 W JP0208650 W JP 0208650W WO 03020703 A1 WO03020703 A1 WO 03020703A1
Authority
WO
WIPO (PCT)
Prior art keywords
cyclic amine
amine compound
represents hydrogen
compound
nr4co
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008650
Other languages
English (en)
French (fr)
Inventor
Tatsuhiko Kodama
Masahiro Tamura
Toshiaki Oda
Yukiyoshi Yamazaki
Masahiro Nishikawa
Shunji Takemura
Takeshi Doi
Yoshinori Kyotani
Masao Ohkuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/941,684 external-priority patent/US6395753B1/en
Priority claimed from US10/107,180 external-priority patent/US6605620B1/en
Priority to KR10-2004-7002264A priority Critical patent/KR20040030114A/ko
Priority to AU2002328576A priority patent/AU2002328576B8/en
Priority to CA2461963A priority patent/CA2461963C/en
Priority to NZ531498A priority patent/NZ531498A/en
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP2003524974A priority patent/JP4276070B2/ja
Priority to HK05106102.7A priority patent/HK1073312B/xx
Priority to EP02762881A priority patent/EP1422219A4/en
Priority to HU0401733A priority patent/HUP0401733A3/hu
Publication of WO2003020703A1 publication Critical patent/WO2003020703A1/ja
Priority to NO20040877A priority patent/NO327074B1/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PCT/JP2002/008650 2001-08-30 2002-08-28 Cyclic amine compound Ceased WO2003020703A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
HU0401733A HUP0401733A3 (en) 2001-08-30 2002-08-28 Cyclic amine-derivatives and pharmaceutical compositions containing them
EP02762881A EP1422219A4 (en) 2001-08-30 2002-08-28 CYCLIC AMINE COMPOUND
AU2002328576A AU2002328576B8 (en) 2001-08-30 2002-08-28 Cyclic amine compound
CA2461963A CA2461963C (en) 2001-08-30 2002-08-28 Cyclic amine compounds
NZ531498A NZ531498A (en) 2001-08-30 2002-08-28 Cyclic amine compounds and pharmaceutical composition containing the same
KR10-2004-7002264A KR20040030114A (ko) 2001-08-30 2002-08-28 환상 아민 화합물
JP2003524974A JP4276070B2 (ja) 2001-08-30 2002-08-28 環状アミン化合物
HK05106102.7A HK1073312B (en) 2001-08-30 2002-08-28 Cyclic amine compound
NO20040877A NO327074B1 (no) 2001-08-30 2004-02-25 Cyklisk aminforbindelse, slike forbindelser for bruk som medikament, farmasoytiske blandinger inneholdende slike samt anvendelse av disse for fremstilling av medisin for behandling av sykdommer.

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US09/941,684 US6395753B1 (en) 2001-08-30 2001-08-30 Cyclic amine compounds and pharmaceutical composition containing the same
US09/941,684 2001-08-30
US09/983,928 US6498169B1 (en) 2001-08-30 2001-10-26 Cyclic amine compounds and pharmaceutical composition containing the same
US09/983,928 2001-10-26
US10/107,180 US6605620B1 (en) 2001-08-30 2002-03-28 Cyclic amine compounds and pharmaceutical composition containing the same
US10/107,180 2002-03-28
US10/191,534 US6867221B2 (en) 2001-08-30 2002-07-10 Cyclic amine compounds and pharmaceutical composition containing the same
US10/191,534 2002-07-10

Publications (1)

Publication Number Publication Date
WO2003020703A1 true WO2003020703A1 (en) 2003-03-13

Family

ID=27493564

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008650 Ceased WO2003020703A1 (en) 2001-08-30 2002-08-28 Cyclic amine compound

Country Status (10)

Country Link
US (1) US6867221B2 (ja)
EP (1) EP1422219A4 (ja)
CN (1) CN100406441C (ja)
AU (1) AU2002328576B8 (ja)
CA (1) CA2461963C (ja)
HU (1) HUP0401733A3 (ja)
NO (1) NO327074B1 (ja)
NZ (1) NZ531498A (ja)
TW (1) TWI254706B (ja)
WO (1) WO2003020703A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005034953A1 (ja) * 2003-10-10 2005-04-21 Kowa Co., Ltd. 血管新生抑制薬
WO2006022374A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. ２－フェニルピリジン誘導体
WO2006030925A1 (ja) * 2004-09-13 2006-03-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
WO2006082834A1 (ja) * 2005-02-02 2006-08-10 Kowa Co., Ltd. ケラチノサイト増殖に起因する疾患の予防・治療剤
WO2008044337A1 (en) 2006-10-13 2008-04-17 Kowa Co., Ltd. γ-GLOBIN INDUCER
WO2010080864A1 (en) 2009-01-12 2010-07-15 Array Biopharma Inc. Piperidine-containing compounds and use thereof
US7910741B2 (en) 2003-03-14 2011-03-22 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
US8003642B2 (en) 2006-03-10 2011-08-23 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
US9241942B2 (en) 2007-06-08 2016-01-26 Mannkind Corporation IRE-1α inhibitors

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY134200A (en) * 2002-04-12 2007-11-30 Kowa Co Method for treating cancer
WO2004052859A1 (ja) * 2002-12-06 2004-06-24 Kowa Co., Ltd. エリスロポエチン産生促進剤
US20100022517A1 (en) * 2006-12-18 2010-01-28 Richards Lori A Ophthalmic formulation of rho kinase inhibitor compound
US8071779B2 (en) 2006-12-18 2011-12-06 Inspire Pharmaceuticals, Inc. Cytoskeletal active rho kinase inhibitor compounds, composition and use
SG11201401891RA (en) 2011-11-03 2014-05-29 Theravance Inc Rod -like hepatitis c virus inhibitors containing the fragement {2- [4- (bi phenyl - 4 - yl) - 1h - imidazo - 2 - yl] pyrrolidine - 1 - carbonlymethyl} amine
GB201708652D0 (en) * 2017-05-31 2017-07-12 Mission Therapeutics Ltd Novel compounds and uses

Citations (4)

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Publication number Priority date Publication date Assignee Title
FR1575591A (ja) * 1967-02-21 1969-07-25
JPH0971564A (ja) * 1995-07-06 1997-03-18 Japan Tobacco Inc ベンズアミドオキシム誘導体及びその医薬用途
EP0774257A2 (en) * 1995-11-20 1997-05-21 Kowa Co. Ltd. Use of piperazine and homopiperazine compounds for the inhibition of cellular adhesion and infiltration
US6395753B1 (en) * 2001-08-30 2002-05-28 Kowa Co., Ltd. Cyclic amine compounds and pharmaceutical composition containing the same

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CN1216921A (zh) 1996-04-30 1999-05-19 赫彻斯特马里恩鲁斯公司 用2,6－二烷基－4－甲硅烷基－苯酚诱导血管细胞粘着分子－1和治疗慢性炎症疾病的方法
JP3577183B2 (ja) 1996-06-17 2004-10-13 花王株式会社 動脈硬化症予防・治療剤
WO1998016497A1 (en) * 1996-10-11 1998-04-23 Kowa Co., Ltd. Novel diamide compounds and drugs containing the same
JPH10147568A (ja) 1996-11-19 1998-06-02 Mitsui Chem Inc ナフタレン誘導体およびそれを有効成分として含有する医薬品
JPH10182550A (ja) 1996-12-25 1998-07-07 Mitsui Chem Inc ヒドロキシ安息香酸誘導体およびそれを有効成分として含有する医薬品
JPH1193282A (ja) * 1997-09-19 1999-04-06 Ronbikku Japan:Kk 建築部材間のシール装置
JP4139453B2 (ja) 1997-09-24 2008-08-27 興和株式会社 細胞接着阻害剤
JP2000086641A (ja) 1998-09-11 2000-03-28 Kyorin Pharmaceut Co Ltd ２−置換ベンゾチアゾール誘導体及びその製造法
JP2000319277A (ja) 1999-05-11 2000-11-21 Ono Pharmaceut Co Ltd 縮合ピラジン化合物およびその化合物を有効成分とする薬剤
CA2373942A1 (en) * 1999-05-18 2000-11-23 Teijin Limited Remedies or prophylactis for diseases in association with chemokines
CA2378499A1 (en) * 1999-08-04 2001-02-15 Teijin Limited Cyclic amine ccr3 antagonists
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
WO2002020477A1 (en) 2000-09-07 2002-03-14 Kowa Co., Ltd. Apoptosis inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1575591A (ja) * 1967-02-21 1969-07-25
JPH0971564A (ja) * 1995-07-06 1997-03-18 Japan Tobacco Inc ベンズアミドオキシム誘導体及びその医薬用途
EP0774257A2 (en) * 1995-11-20 1997-05-21 Kowa Co. Ltd. Use of piperazine and homopiperazine compounds for the inhibition of cellular adhesion and infiltration
US6395753B1 (en) * 2001-08-30 2002-05-28 Kowa Co., Ltd. Cyclic amine compounds and pharmaceutical composition containing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1422219A4 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910741B2 (en) 2003-03-14 2011-03-22 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
WO2005034953A1 (ja) * 2003-10-10 2005-04-21 Kowa Co., Ltd. 血管新生抑制薬
JPWO2005034953A1 (ja) * 2003-10-10 2007-11-22 興和株式会社 血管新生抑制薬
JP4634303B2 (ja) * 2003-10-10 2011-02-16 興和株式会社 血管新生抑制薬
US7820700B2 (en) 2004-08-27 2010-10-26 Astellas Pharma Inc. 2-phenylpyridine derivative
WO2006022374A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. ２－フェニルピリジン誘導体
JP4894517B2 (ja) * 2004-08-27 2012-03-14 アステラス製薬株式会社 ２−フェニルピリジン誘導体
US8410276B2 (en) 2004-09-13 2013-04-02 Ono Pharmaceutical Co., Ltd. Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
WO2006030925A1 (ja) * 2004-09-13 2006-03-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
EP1790637A4 (en) * 2004-09-13 2010-03-24 Ono Pharmaceutical Co NITROGENIC HETEROCYCLIC DERIVATIVE AND THIS MEDICAMENT CONTAINING ACTIVE SUBSTANCE
RU2409565C2 (ru) * 2004-09-13 2011-01-20 Оно Фармасьютикал Ко., Лтд. Азотистые гетероциклические производные и лекарственные средства, содержащие их в качестве активного ингредиента
US8604207B2 (en) 2004-09-13 2013-12-10 Ono Pharmaceutical Co., Ltd. Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
JP4894518B2 (ja) * 2004-09-13 2012-03-14 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
US8143404B2 (en) 2004-09-13 2012-03-27 Ono Pharmaceutical Co., Ltd Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient
EP2546234A1 (en) * 2004-09-13 2013-01-16 Ono Pharmaceutical Co., Ltd. Nitrogeneous heterocyclic derivative and medicine containing the same as an active ingredient
JPWO2006082834A1 (ja) * 2005-02-02 2008-06-26 興和株式会社 ケラチノサイト増殖に起因する疾患の予防・治療剤
WO2006082834A1 (ja) * 2005-02-02 2006-08-10 Kowa Co., Ltd. ケラチノサイト増殖に起因する疾患の予防・治療剤
US8003642B2 (en) 2006-03-10 2011-08-23 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
WO2008044337A1 (en) 2006-10-13 2008-04-17 Kowa Co., Ltd. γ-GLOBIN INDUCER
US9241942B2 (en) 2007-06-08 2016-01-26 Mannkind Corporation IRE-1α inhibitors
US9546149B2 (en) 2007-06-08 2017-01-17 Mannkind Corporation IRE-1α inhibitors
US9981901B2 (en) 2007-06-08 2018-05-29 Fosun Orinove Pharmatech, Inc. IRE-1α inhibitors
WO2010080864A1 (en) 2009-01-12 2010-07-15 Array Biopharma Inc. Piperidine-containing compounds and use thereof
US8809538B2 (en) 2009-01-12 2014-08-19 Array Biopharma Inc. Piperidine-containing compounds and use thereof

Also Published As

Publication number Publication date
NO327074B1 (no) 2009-04-14
HUP0401733A3 (en) 2009-06-29
CA2461963C (en) 2010-08-17
NZ531498A (en) 2005-07-29
TWI254706B (en) 2006-05-11
US20040010147A1 (en) 2004-01-15
EP1422219A4 (en) 2005-08-17
AU2002328576B2 (en) 2008-04-03
NO20040877L (no) 2004-02-25
CN100406441C (zh) 2008-07-30
CN1604893A (zh) 2005-04-06
US6867221B2 (en) 2005-03-15
HUP0401733A2 (hu) 2004-12-28
EP1422219A1 (en) 2004-05-26
AU2002328576B8 (en) 2008-05-15
CA2461963A1 (en) 2003-03-13

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