WO2003042231A3 - Bispezifisches anti-cd28-antikörper-molekül - Google Patents

Bispezifisches anti-cd28-antikörper-molekül Download PDF

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Publication number
WO2003042231A3
WO2003042231A3 PCT/EP2002/012545 EP0212545W WO03042231A3 WO 2003042231 A3 WO2003042231 A3 WO 2003042231A3 EP 0212545 W EP0212545 W EP 0212545W WO 03042231 A3 WO03042231 A3 WO 03042231A3
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WO
WIPO (PCT)
Prior art keywords
antibody molecule
variable domain
bispecific anti
linked
binding site
Prior art date
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Ceased
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PCT/EP2002/012545
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English (en)
French (fr)
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WO2003042231A2 (de
Inventor
Gundram Jung
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Individual
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Priority to CA2505342A priority Critical patent/CA2505342C/en
Priority to US10/495,664 priority patent/US7538196B2/en
Priority to DE50210328T priority patent/DE50210328D1/de
Priority to EP02779543A priority patent/EP1444268B1/de
Priority to AU2002342896A priority patent/AU2002342896A1/en
Publication of WO2003042231A2 publication Critical patent/WO2003042231A2/de
Publication of WO2003042231A3 publication Critical patent/WO2003042231A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Ein erstes bispezifisches Antikörper-Molekül weist zumindest eine Bindestelle mit einer variablen Domäne einer leichten Kette (VL) und eine damit verbundene variable Domäne einer schweren Kette (VH) für den T-Zell-Rezeptor CD28 auf. Das Antikörper-Molekül weist ausserdem zumindest eine Bindestelle mit einer variablen Domäne einer schweren Kette (VH) und eine damit verbundene variable Domäne einer leichte Kette (VL) für ein Tumor-Antigen auf. Die variablen Domänen der schweren Ketten der beiden Spezifitäten sind miteinander durch einen Peptidlinker verbunden. Ein zweites bispezifisches Antikörper-Molekül ist bivalent für CD28 und zumindest monovalent für das Tumor-Antigen.
PCT/EP2002/012545 2001-11-12 2002-11-09 Bispezifisches anti-cd28-antikörper-molekül Ceased WO2003042231A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2505342A CA2505342C (en) 2001-11-12 2002-11-09 Bispecific antibody molecule
US10/495,664 US7538196B2 (en) 2001-11-12 2002-11-09 Bispecific antibody molecule
DE50210328T DE50210328D1 (de) 2001-11-12 2002-11-09 Bispezifisches anti-cd28 antikörper-molekül
EP02779543A EP1444268B1 (de) 2001-11-12 2002-11-09 Bispezifisches anti-cd28 antikörper-molekül
AU2002342896A AU2002342896A1 (en) 2001-11-12 2002-11-09 Bispecific anti-cd28 antibody molecule

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10156482A DE10156482A1 (de) 2001-11-12 2001-11-12 Bispezifisches Antikörper-Molekül
DE10156482.1 2001-11-12

Publications (2)

Publication Number Publication Date
WO2003042231A2 WO2003042231A2 (de) 2003-05-22
WO2003042231A3 true WO2003042231A3 (de) 2004-03-04

Family

ID=7706078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/012545 Ceased WO2003042231A2 (de) 2001-11-12 2002-11-09 Bispezifisches anti-cd28-antikörper-molekül

Country Status (8)

Country Link
US (1) US7538196B2 (de)
EP (1) EP1444268B1 (de)
AT (1) ATE364633T1 (de)
AU (1) AU2002342896A1 (de)
CA (1) CA2505342C (de)
DE (2) DE10156482A1 (de)
ES (1) ES2289156T3 (de)
WO (1) WO2003042231A2 (de)

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Publication number Priority date Publication date Assignee Title
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SCHOONJANS R ET AL: "Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives", JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO, US, vol. 165, no. 12, 15 December 2000 (2000-12-15), pages 7050 - 7057, XP002207879, ISSN: 0022-1767 *

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US9334331B2 (en) 2010-11-17 2016-05-10 Chugai Seiyaku Kabushiki Kaisha Bispecific antibodies

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EP1444268A2 (de) 2004-08-11
EP1444268B1 (de) 2007-06-13
WO2003042231A2 (de) 2003-05-22
ES2289156T3 (es) 2008-02-01
CA2505342A1 (en) 2003-05-22
CA2505342C (en) 2013-01-29
DE10156482A1 (de) 2003-05-28
US20050244416A1 (en) 2005-11-03
ATE364633T1 (de) 2007-07-15
DE50210328D1 (de) 2007-07-26
US7538196B2 (en) 2009-05-26

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