WO2003103563A2 - Inhalateur de poudre - Google Patents

Inhalateur de poudre Download PDF

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Publication number
WO2003103563A2
WO2003103563A2 PCT/IN2003/000215 IN0300215W WO03103563A2 WO 2003103563 A2 WO2003103563 A2 WO 2003103563A2 IN 0300215 W IN0300215 W IN 0300215W WO 03103563 A2 WO03103563 A2 WO 03103563A2
Authority
WO
WIPO (PCT)
Prior art keywords
powder
air inlet
inhaler
inlet hole
inlialer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2003/000215
Other languages
English (en)
Other versions
WO2003103563A3 (fr
Inventor
Satish Gokhale
Subhas Balaram Bhowmick
Kirti Wardhaman Ganorkar
Ashwin Bhujanga Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharmaceutical Industries Ltd
Original Assignee
Sun Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Ltd filed Critical Sun Pharmaceutical Industries Ltd
Priority to AU2003267809A priority Critical patent/AU2003267809A1/en
Publication of WO2003103563A2 publication Critical patent/WO2003103563A2/fr
Publication of WO2003103563A3 publication Critical patent/WO2003103563A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52—Details
    • B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5816—Opening or contents-removing devices added or incorporated during package manufacture for tearing a corner or other small portion next to the edge, e.g. a U-shaped portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/43—General characteristics of the apparatus making noise when used correctly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • This invention relates to a powder inhaler.
  • the site of administration of the powder medicament is the bronchial tubes and their ramifications in the lungs of the patient being treated including particularly, the bronchi and bronchioles, which are the primary sites of administration or also the nasal passage or nasal mucosa.
  • the powder dose of medicament reaches and is applied uniformly to as much of the surface of the bronchi and other parts of the lung as possible.
  • propellants to dispense metered doses of a powder medicament with the assistance of a propellant gas.
  • the propellant of choice is Freon, one of various nonflammable fluorocarbons.
  • use of this particular propellant has been the object of recently passed environmental laws, which severely restrict its use or even ban it outright.
  • fluorocarbons may actually aggravate the condition of patients suffering from asthma and acute or chronic bronchitis, thus creating a further reason to avoid this nearly universal propellant. While attempts have been made to substitute other propellant gases for the fluorocarbons, these attempts have experienced problems and have not met with uniform success.
  • Dry powder inlialers are known in the prior art. Many of the known inlialers, particularly of the cartridge type presently on the market are relatively large in size, are useful for delivery of multiple doses and, as a consequence of their expense, are intended for repeated use.
  • Dry powder inlialers which have been used in the past, dispense unit doses of medication from pre-filled capsules.
  • the capsule in order for such devices to function properly, the capsule must be correctly positioned in the device, which, when actuated, either punctures or pulls the capsules open.
  • Such devices are prone to incorrect dosing, particularly by children, the elderly, and patients with impaired motor function.
  • pieces of the gelatin capsule shell may be dispensed with the medication.
  • U.S. patent No. 4,265,236 discloses a tubular inhaler comprising a flexible tube, the ends of which normally are sealingly inserted into each other.
  • the seal of the inhaler disclosed may not be moisture-proof, hi this inhaler, the air pathway is linear and unidirectional, and there is no medicament recess where the medicament would be preferably located.
  • the housing of the inhaler has a compartment for storing the medicament, which is sealed from the airflow path by a tape covering the compartment outlet.
  • a tape covering the compartment outlet is sealed from the external environment by either a peel-off piece of lidding material or by sealing of the lower wall of the inhaler with the upper wall.
  • U.S. Patent No. 5,660,169 (Astra Alctiebolag) discloses a disposable breath-actuated inhaler comprising a housing forming an air flow path open at both ends, wherein one end forms an air inlet and one end forms an air outlet.
  • the housing further comprises a compartment for storing medicament, wherein the compartment is sealed from the airflow path by a tape covering the compartment outlet, wherein the inner end of the tape is attached to the lower part of the housing between the air inlet and the compartment.
  • the tape is bent backward away from the air outlet so as to extend through the air inlet.
  • the present invention provides a powder inhaler for administration of a unit dose of a medicament, said powder inhaler comprising:
  • the present invention discloses a inhaler which comprises powdered medicament, said inhaler being breath actuated or driven by a power source other than fluorocarbon propellants and which permits a patient to inliale through the mouth or nose, a medication in powder form for administration to the bronchia and lungs.
  • the inhaler of the invention is made up of walls enclosing at least one chamber comprising a medicament containing recess at one end and a channel extending from the medicament containing recess to the air outlet hole.
  • the inhaler has a lower wall, an upper wall and side walls. These may be formed by the sealing of the upper and lower walls or may be parts of a single one-piece body formed by moulding methods known to those skilled in the art.
  • the medicament containing recess and the channel leading to the air outlet hole form a single aerodynamically streamlined chamber.
  • the chamber has a medicament containing deep end and a shallow end extending to the air outlet hole.
  • the inhaler has two chambers wherein the first chamber is the medicament containing recess and the second chamber is the channel leading into the air outlet hole.
  • the obstruction may be in the form of a baffle between the two chambers placed at suitable angle, for example the medicament recess itself may be cup shaped and the walls of the cup may form an obstruction.
  • the baffle-type obstruction only partially segregates the two chambers and allows open space between them.
  • the obstruction may extend wall to wall to fully segregate the two chambers, in this case, the obstruction is in the form of a sieve and with breath actuation and/or air from the power source the aerosolized particles pass through this mesh-like or sieve-like obstruction.
  • the air inlet hole(s) may be designed so that they can be closed or sealed by a cap.
  • the air inlet hole(s) which is sealed by a cap may be further designed such that it/they can be connected to a power source other than a fluorocarbon, for example it may be connected to a can containing compressed air and having an actuation device. More simply it can be connected to a bulb which can be compressed by the patient to blow air for aerosolization of the powder medicament in coordination with the inhalation by the patient.
  • the upper wall of the body is preferably designed in shape and size to be suitable for convenience in holding by the patient.
  • the medicament containing recess and channel lead into an air outlet hole, over which the mouth of the patient is placed to receive the powder medication by inhalation.
  • the walls of the body comprising the medicament containing recess and the channel have scored formation therein adapted and arranged to modify the air passageway to cause changes in the direction of the airflow and the flow of the particles through the passageway.
  • the medicament containing recess and the channel may have scored formation on the lower walls, the upper walls or on both the upper and lower walls or on all the walls.
  • the chamber is so designed that air from air inlet leaves the curvilinear chamber in a centripetal direction under swirling motion.
  • the airflow at the upper part of the recess or air pathway is laminar whereas in the lower part, regions of turbulence are formed due to the scored formations.
  • the air inlet holes communicate with the curvilinear recess tangentially so that air enters the recess perpendicularly to the upper wall and will of its own accord, enter the curvilinear chamber tangentially and impact the medicament powder bed directly.
  • the significance of tangential entry of air into the curvilinear chamber is that this helps to ensure laminar air flow within the curvilinear medicament recess, which is advantageous in terms of providing easy aersolization and circulation of the particulate substance in a manner to give rise to turbulence of the particles of the medicament, h particular embodiments of the present invention, there is means for improving the incoming air flow so as to directly impact the medicament powder bed.
  • the air inlet hole may have a short tubular extension into the medicament containing recess, angled and designed to direct the stream of incoming air directly on to the medicament powder bed.
  • the diameter of the short tubular extension may be uniform or may be tapered.
  • the means for directing the air directly on to the powder bed may also include suitably designed airflow deflectors.
  • the air inlet hole(s) are smaller than the air outlet hole to prevent powder medicament particles from escaping.
  • the air inlet hole(s) are so disposed with respect to the air outlet hole that the powder medicament will not readily fall out of the recess, but is so disposed that ingress of air will aerosolize said powder medicament bed directly during inhalation and the aerosolized medicament powder will be agitated under turbulence and will be drawn into the breath of the user.
  • a moisture-proof peel-off piece of lidding material may be provided for blocking the air inlet hole(s) in their inoperative configuration, which can be manually peeled off so as to expose the air inlet holes for use.
  • the air inlet hole(s) may be designed so that they can be closed or sealed by cap(s). The cap may be a tight fit, screw on or twist off cap.
  • Figure 1 shows a side view of a powder inhaler having a single chamber wherein the means of sealing is achieved by sealing of the layers;
  • FIGS 8 and 9 explain the construction features of the powder inhaler of Figure 1;
  • FIGS 10 and 11 illustrate the operational features of the powder inhaler of Figure 1;
  • Figure 17 shows an alternative embodiment of the inhaler having two chambers and an obstruction between the chambers
  • Figure 20 and 21 show alternate embodiment of the inhaler of Figure 17 with the air inlet hole located between the upper wall and the lower wall of the powder inhaler;
  • Figure 22 shows an alternate embodiment of the powder inhaler with an upper curved wall and scored formation on the upper wall and lower wall.
  • tab 22 aerodynamically streamlined chamber containing medicament recess and a channel
  • FIG. 1 illustrates an embodiment of the inhaler having a single chamber.
  • the inhaler (10) has mainly a flat planar shape consisting of the lower wall (16) and an upper wall (14).
  • the medicament containing recess and the channel leading to the air outlet hole form a single aerodynamically streamlined chamber (22) which contains the medicament.
  • the chamber has a shallow end extending into the air outlet hole and a medicament containing deep end.
  • the lower wall (16) is covered and secured by the upper wall (14) which is flat in this embodiment.
  • a peel-off piece of lidding material (12) for example, a metal foil typically an aluminum foil is adhered to the top surface of the upper wall (14).
  • Figure 2 shows the bottom plan view of the inhaler of Figure 1.
  • the practical embodiment of the inhaler is in the form of a square or a rectangle having the medicament containing chamber (22) diagonally placed on the lower wall (16).
  • the two ends of the inhaler (10) form the operative feature of the invention.
  • the corner piece (20) constitutes the shallow end having the sucking and air outlet hole.
  • the air outlet hole is sealed as a result of the sealing between the lower wall and the upper wall.
  • the air inlets are sealed from the environment by the peel-off piece of lidding material, thus providing a moisture-proof environment within the chamber.
  • the wall of the aerodynamically streamlined chamber or the channel leading into the air outlet hole can have various configurations of the scored formations.
  • the scored formation acts to add turbulence to the medicament entrained in the air stream.
  • the formation may be in the form of protrusions or projections of various shapes, for example, spiral, single or multiple ribs, linear, helical, circular, cone, wedge, rectangular and the like.
  • the formation can also be in the form of depressions or dimples of various shapes, for example, spiral, linear, helical, circular, cone, wedge, rectangular and the like.
  • Figures 4 to 7 show different configurations of the scored formations of the wall of the aerodynamically streamlined chamber, particularly the formations (26 and 26a, 26b and 26c).
  • Figures 8 and 9 show the areas highlighted to demarcate the secured areas.
  • Figure 8 shows the demarcated areas between the peel-off piece of lidding material (12) and the upper wall (14).
  • the area (28) is the unsecured area between the lidding material and the upper wall lying above the air inlet hole (24).
  • the area (30) is the secured area between the upper wall (14) and the lower wall (16), and the remaining area of the upper wall that bears the air inlet hole (24) and lies above the aerodynamically streamlined chamber (22) is not secured.
  • Figure 12 is the side view of the inhaler in the operative configuration as seen in Figure 11.
  • the particulate medicament (36) is seen in the aerodynamically streamlined chamber (22).
  • a user sucks at the air outlet hole (34) causing intake of air tangentially to the aerodynamically streamlined chamber (22) through the air inlet hole (24).
  • the air stream impacts the medicament powder bed directly, causes agitation and turbulence of the medicament (36) which causes aerosolizing of the particles as seen in Figure 14 and the aerosolized particles are ejected in the direction (38) into the buccal cavity of the user [not seen].
  • the shape of the inhaler may be modified or may be different from that disclosed in the previous embodiments.
  • the inhaler may be cylindrical, capsule-shaped, rectangular, spoon-shaped, polygonal, cone shaped or funnel-shaped and the like.
  • Figure 18 shows an embodiment with a different shape of the inhaler.
  • FIG. 20 and 21 Yet another embodiment of the inlialer of the present invention is shown in Figures 20 and 21.
  • the air inlet hole is located between the lower wall and upper wall of the inhaler so that the air inlet pathway is formed between the sealed upper and lower walls of the inhaler
  • the air inlet hole (40) is in the shape of a tubular protrusion in the lower wall as shown in Figure 20.
  • the protrusion is broken off as shown in Figure 21, so that the air inlet hole is in its operative configuration (41) and air will flow in (42) through the air inlet hole.
  • the medicament containing recess is separated from the channel leading into the air outlet hole by an obstruction to the air flow path between the recess and the channel.
  • a single inlet hole or multiple air inlet holes can be provided for the inlialer of this embodiment.
  • the upper wall of the inhaler may be curved, hi this embodiment, typically both the lower wall as well as the upper wall may have scored formations.
  • the scored formation may be in various configurations as described before.
  • Figure 22 shows an embodiment of the inlialer with a curved upper wall and an aerodynamically streamlined chamber -containing medicament.
  • the upper wall and the lower wall of the chamber have spiral design of the scored formation, hi this embodiment, particularly, the upper and lower curved walls may not be sealed to each other but may be interlocked mechanically when placed against each other and opened by the user.
  • a dose of medicament may be placed in the recess at the time of does administration by the patient.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un inhalateur de poudre pour l'administration d'une dose unitaire d'un médicament. Cet inhalateur comprend : (A) des parois définissant au moins une chambre qui comporte une cavité contenant le médicament, à une extrémité, et un canal s'étendant depuis la cavité en direction d'un orifice de sortie d'air ; (B) un ou plusieurs orifice(s) d'entrée d'air se situant à proximité de la cavité contenant le médicament ; (C) un orifice de sortie d'air ; et (D) des moyens d'obturation des orifices d'entrée et de sortie d'air. L'emplacement du ou des orifice(s) d'entrée d'air par rapport à la cavité contenant le médicament permet, lorsque le patient inspire, au flux d'air de toucher directement le lit de poudre, d'entraîner les particules et de les transporter vers l'orifice de sortie d'air en vue de leur absorption par le patient.
PCT/IN2003/000215 2002-06-07 2003-06-06 Inhalateur de poudre Ceased WO2003103563A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003267809A AU2003267809A1 (en) 2002-06-07 2003-06-06 Powder inhaler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN509MU2002 2002-06-07
IN509/MUM/2002 2002-06-07

Publications (2)

Publication Number Publication Date
WO2003103563A2 true WO2003103563A2 (fr) 2003-12-18
WO2003103563A3 WO2003103563A3 (fr) 2004-07-15

Family

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Application Number Title Priority Date Filing Date
PCT/IN2003/000215 Ceased WO2003103563A2 (fr) 2002-06-07 2003-06-06 Inhalateur de poudre

Country Status (2)

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AU (1) AU2003267809A1 (fr)
WO (1) WO2003103563A2 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008087418A3 (fr) * 2007-01-17 2008-10-30 Philip Braithwaite Dispositif
WO2009102276A1 (fr) * 2008-02-12 2009-08-20 Astrazeneca Ab Inhalateur comprenant un socle pourvu de plusieurs cavités hermétiquement fermées contenant des médicaments
WO2009102275A1 (fr) * 2008-02-12 2009-08-20 Astrazeneca Ab Inhalateur comprenant un socle comportant au moins une cavité hermétiquement fermée contenant un médicament
WO2009102274A1 (fr) * 2008-02-12 2009-08-20 Astrazeneca Ab Inhalateur comportant une base possédant au moins une cavité fermée hermétiquement contenant un médicament
US8151793B2 (en) 2007-12-20 2012-04-10 Astrazeneca Ab Device and method for deaggregating powder
WO2014175815A1 (fr) * 2013-04-23 2014-10-30 Simplified Solutions Sweden Ab Inhalateur jetable pour substances sous forme de poudre
US8931476B2 (en) 2009-06-09 2015-01-13 Ivax Pharmaceuticals Ireland Inhaler
WO2015097034A1 (fr) * 2013-12-23 2015-07-02 Iconovo Ab Inhalateur à poudre sèche à dose unique
WO2015121276A1 (fr) * 2014-02-12 2015-08-20 Sanofi-Aventis Deutschland Gmbh Réservoir pour médicament liquide
US9211383B2 (en) 2009-07-01 2015-12-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
WO2015198121A1 (fr) * 2014-06-27 2015-12-30 Belforti Sergio Inhalateur à poudre
WO2016014586A1 (fr) * 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Désagglomérateur de médicament en poudre sèche
US9446209B2 (en) 2011-09-07 2016-09-20 Concentrx Pharmaceuticals, Inc. Dry powder inhalation device
US10456537B2 (en) 2017-03-28 2019-10-29 Concentrx Pharmaceuticals, Inc. Devices and methods for delivering dry powder medicaments
WO2022043336A1 (fr) 2020-08-25 2022-03-03 Vectura Delivery Devices Limited Inhalateur de poudre sèche monodose
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US9283337B2 (en) 2007-12-20 2016-03-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
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WO2009102275A1 (fr) * 2008-02-12 2009-08-20 Astrazeneca Ab Inhalateur comprenant un socle comportant au moins une cavité hermétiquement fermée contenant un médicament
US8397718B2 (en) 2008-02-12 2013-03-19 Astrazeneca Ab Inhaler comprising a base having at least one sealed cavity containing medicament
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WO2009102274A1 (fr) * 2008-02-12 2009-08-20 Astrazeneca Ab Inhalateur comportant une base possédant au moins une cavité fermée hermétiquement contenant un médicament
WO2009102276A1 (fr) * 2008-02-12 2009-08-20 Astrazeneca Ab Inhalateur comprenant un socle pourvu de plusieurs cavités hermétiquement fermées contenant des médicaments
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US11185647B2 (en) 2017-03-28 2021-11-30 Concentrx Pharmaceuticals, Inc. Devices and methods for delivering dry powder medicaments
US11911560B2 (en) 2017-03-28 2024-02-27 Concentrx Pharmaceuticals, Inc. Devices and methods for delivering dry powder medicaments
WO2022043336A1 (fr) 2020-08-25 2022-03-03 Vectura Delivery Devices Limited Inhalateur de poudre sèche monodose
US12673172B2 (en) 2020-08-25 2026-07-07 Vectura Delivery Devices Limited Unit dose dry powder inhaler with blister cavity including a bowl, channel and tube
WO2022234065A1 (fr) 2021-05-07 2022-11-10 Vectura Delivery Devices Limited Inhalateur de poudre sèche monodose

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