WO2004001103A3 - Silk biomaterials and methods of use thereof - Google Patents

Silk biomaterials and methods of use thereof Download PDF

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Publication number
WO2004001103A3
WO2004001103A3 PCT/US2003/019893 US0319893W WO2004001103A3 WO 2004001103 A3 WO2004001103 A3 WO 2004001103A3 US 0319893 W US0319893 W US 0319893W WO 2004001103 A3 WO2004001103 A3 WO 2004001103A3
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WO
WIPO (PCT)
Prior art keywords
biomaterials
silk
processed
methods
avoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/019893
Other languages
French (fr)
Other versions
WO2004001103A2 (en
Inventor
David L Kaplan
Hyoung-Joon Jin
Gregory Rutledge
Sergei Fridrikh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Tufts University
Original Assignee
Massachusetts Institute of Technology
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology, Tufts University filed Critical Massachusetts Institute of Technology
Priority to AU2003253690A priority Critical patent/AU2003253690A1/en
Publication of WO2004001103A2 publication Critical patent/WO2004001103A2/en
Publication of WO2004001103A3 publication Critical patent/WO2004001103A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D1/00—Treatment of filament-forming or like material
    • D01D1/02—Preparation of spinning solutions
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • D01F4/02—Monocomponent artificial filaments or the like of proteins; Manufacture thereof from fibroin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Textile Engineering (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Mechanical Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides an all-aqueaous process for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (EPO)(a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the processed avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
PCT/US2003/019893 2002-06-24 2003-06-24 Silk biomaterials and methods of use thereof Ceased WO2004001103A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003253690A AU2003253690A1 (en) 2002-06-24 2003-06-24 Silk biomaterials and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39092902P 2002-06-24 2002-06-24
US60/390,929 2002-06-24

Publications (2)

Publication Number Publication Date
WO2004001103A2 WO2004001103A2 (en) 2003-12-31
WO2004001103A3 true WO2004001103A3 (en) 2004-04-08

Family

ID=30000648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/019893 Ceased WO2004001103A2 (en) 2002-06-24 2003-06-24 Silk biomaterials and methods of use thereof

Country Status (2)

Country Link
AU (1) AU2003253690A1 (en)
WO (1) WO2004001103A2 (en)

Cited By (8)

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Publication number Priority date Publication date Assignee Title
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
US9012784B2 (en) 2008-10-07 2015-04-21 Mc10, Inc. Extremely stretchable electronics
US9159635B2 (en) 2011-05-27 2015-10-13 Mc10, Inc. Flexible electronic structure
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
US9289132B2 (en) 2008-10-07 2016-03-22 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US9450043B2 (en) 2004-06-04 2016-09-20 The Board Of Trustees Of The University Of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
US9554484B2 (en) 2012-03-30 2017-01-24 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces

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CA2562415C (en) 2003-04-10 2015-10-27 Tufts University Concentrated aqueous silk fibroin solutions free of organic solvents and uses thereof
JP2008502739A (en) 2004-06-11 2008-01-31 トラスティーズ オブ タフツ カレッジ Silk-based drug delivery system
CN100382772C (en) * 2005-09-28 2008-04-23 南通大学 Preparation method of medical nerve graft containing silk fibroin
CN100404081C (en) * 2006-06-09 2008-07-23 浙江大学 A mesh tissue engineering scaffold
JP5896743B2 (en) 2008-10-09 2016-03-30 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ Modified silk film containing glycerol
WO2011041727A1 (en) 2009-10-01 2011-04-07 Mc10, Inc. Protective cases with integrated electronics
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
EP2513953B1 (en) 2009-12-16 2017-10-18 The Board of Trustees of the University of Illionis Electrophysiology using conformal electronics
JP5751728B2 (en) 2010-03-17 2015-07-22 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ Embedded biomedical devices on bioabsorbable substrates
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
JP2013542181A (en) 2010-09-03 2013-11-21 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ Plasmon nanoparticle-doped silk material
CA2815285C (en) 2010-10-19 2019-12-31 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
WO2013105997A2 (en) 2011-02-23 2013-07-18 Allergan, Inc. Compositions and improved soft tissue replacement methods
US9765934B2 (en) 2011-05-16 2017-09-19 The Board Of Trustees Of The University Of Illinois Thermally managed LED arrays assembled by printing
US20140370094A1 (en) 2011-11-08 2014-12-18 Tufts University Silk-based scaffold platform for engineering tissue constructs
BR112014011188B1 (en) 2011-11-09 2020-05-19 Trustees Of Tufts College injectable composition for use in the repair or augmentation of tissue in an individual and delivery device comprising said composition
AU2012335122B2 (en) 2011-11-09 2016-09-22 Trustees Of Tufts College Injectable silk fibroin foams and uses thereof
CN104472023B (en) 2011-12-01 2018-03-27 伊利诺伊大学评议会 Transient devices designed to undergo programmable transitions
WO2013102193A1 (en) 2011-12-29 2013-07-04 Trustees Of Tufts College Functionalization of biomaterials to control regeneration and inflammation responses
EP2814527A1 (en) 2012-02-16 2014-12-24 Allergan, Inc. Compositions and improved soft tissue replacement methods
WO2013123272A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Compositions and improved soft tissue replacement methods
EP2814526B1 (en) 2012-02-16 2016-11-02 Allergan, Inc. Compositions and improved soft tissue replacement methods
WO2013123270A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Compositions and improved soft tissue replacement methods
EP2841108A4 (en) 2012-04-25 2015-11-25 Tufts College SILK MICROSPHERES AND SURFACE LUBRICATION METHODS
CN103083224A (en) * 2013-02-06 2013-05-08 东华大学 Method for preparing dexamethasone slow-release medicine carrier
EP3304430A4 (en) 2015-06-01 2019-03-06 The Board of Trustees of the University of Illionis MINIATURIZED ELECTRONIC SYSTEMS HAVING WIRELESS POWER CAPACITIES AND NEAR FIELD COMMUNICATION
KR20180034342A (en) 2015-06-01 2018-04-04 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 Alternative UV detection method
WO2017112012A2 (en) * 2015-09-17 2017-06-29 Jerez Roberto Velozzi Load-bearing composite panels, materials, products, and processes to make and use same
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
US10857262B2 (en) 2016-10-31 2020-12-08 Sofregen Medical, Inc. Compositions comprising low molecular weight silk fibroin fragments and plasticizers
AU2019247655A1 (en) 2018-04-03 2020-10-01 Vaxess Technologies, Inc. Microneedle comprising silk fibroin applied to a dissolvable base
EP4045124A4 (en) 2019-10-15 2024-01-24 Sofregen Medical, Inc. DELIVERY DEVICES FOR ADMINISTRATION AND METHODS OF DELIVERY OF COMPOSITIONS
WO2023250117A2 (en) 2022-06-24 2023-12-28 Vaxess Technologies, Inc. Applicator for medicament patch
KR20260021782A (en) 2023-06-23 2026-02-13 백세스 테크놀로지스, 인코포레이티드 Applicator for drug patches
EP4605004A1 (en) * 2023-06-29 2025-08-27 Serigen Mediproducts Pvt. Ltd A non-adherent absorbent article

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US4820418A (en) * 1987-02-03 1989-04-11 Agency Of Industrial Science & Technology Water-alcohol separating membrane and method for separation of water and alcohol by the use thereof
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Title
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9450043B2 (en) 2004-06-04 2016-09-20 The Board Of Trustees Of The University Of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US9012784B2 (en) 2008-10-07 2015-04-21 Mc10, Inc. Extremely stretchable electronics
US9289132B2 (en) 2008-10-07 2016-03-22 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US9159635B2 (en) 2011-05-27 2015-10-13 Mc10, Inc. Flexible electronic structure
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
US9554484B2 (en) 2012-03-30 2017-01-24 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer

Also Published As

Publication number Publication date
WO2004001103A2 (en) 2003-12-31
AU2003253690A1 (en) 2004-01-06
AU2003253690A8 (en) 2004-01-06

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