WO2004004865A1 - Appareil et procede de filtration d'echantillons biologiques - Google Patents

Appareil et procede de filtration d'echantillons biologiques Download PDF

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Publication number
WO2004004865A1
WO2004004865A1 PCT/CA2003/000983 CA0300983W WO2004004865A1 WO 2004004865 A1 WO2004004865 A1 WO 2004004865A1 CA 0300983 W CA0300983 W CA 0300983W WO 2004004865 A1 WO2004004865 A1 WO 2004004865A1
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WO
WIPO (PCT)
Prior art keywords
sample
holder
end portion
filtrate
connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2003/000983
Other languages
English (en)
Inventor
Ann Afthimiadis
Donald William Mccormack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ST JOSEPH'S HEALTHCARE
St Joseph's Healthcare Hamilton
Original Assignee
ST JOSEPH'S HEALTHCARE
St Joseph's Healthcare Hamilton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ST JOSEPH'S HEALTHCARE, St Joseph's Healthcare Hamilton filed Critical ST JOSEPH'S HEALTHCARE
Priority to EP03737805A priority Critical patent/EP1517735B1/fr
Priority to JP2004518316A priority patent/JP4423351B2/ja
Priority to AT03737805T priority patent/ATE456969T1/de
Priority to DE60331188T priority patent/DE60331188D1/de
Priority to NZ537438A priority patent/NZ537438A/en
Priority to AU2003245776A priority patent/AU2003245776B2/en
Publication of WO2004004865A1 publication Critical patent/WO2004004865A1/fr
Priority to ZA2004/10405A priority patent/ZA200410405B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/563—Joints or fittings; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2201/00—Details relating to filtering apparatus
    • B01D2201/02—Filtering elements having a conical form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/043—Hinged closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Definitions

  • the present invention relates to a system of retrieving and analysing biological samples that improves the accuracy and reproducibility of results obtained from analysis of mucoid and/or suspension samples.
  • the present invention provides means of promoting standardization of sample collection and analysis between clinical studies and between clinical centres. More particularly, this invention relates to a two vial interconnected filtration system, that allows samples to pass from a sample tube to a filtrate tube, through standardized filters and to be treated with standardized reagents for analysis.
  • Sputum is defined as the expectorated lower respiratory secretions and is composed of fluid and cellular components including eosinophils, neutrophils, lymphocytes, macrophages, and epithelial cells. Analysis of the cells present in sputum is the best, presently known way to characterise the severity and type of inflammation present. This information in conjunction with other clinical parameters may be used to determine specific courses of treatment.
  • Increases in certain types of cells may indicate an infection or an inflammation that would be more sensitive to one course of treatment as opposed to another.
  • the size, number and type of cells found in the filtrate vary depending on the size and type of filter used. Incorrect filter pore size may result in selective cell loss and incorrect cell differentials. Incorrect filter mesh type and size may result in cell loss due to absorption of small samples. Improper placement of the filter may allow the filtrate to become contaminated by debris. Contaminates or debris may cause problems in analysis by varying the results that are produced, or by clogging apertures of automated cell counters. In addition to this, each time that a sample is handled and transferred from one vessel to another there will be loss of sample volume and content causing errors in the analysis and the final results of the experiment. Selection of the filter type and size necessary for removal of undesirable contaminants and debris is an important component that contributes to reproducible and valid results.
  • Samples may be collected at various points during a course of treatment and comparison of measurements such as cell counts and/or fluid phase indices may be analysed to determine effect of treatment. Clinical treatment may then be adjusted accordingly. Lack of standardized tests complicate comparison of analysis results of different samples, which may make it impossible to make an absolute clinical diagnostic decision, and to monitor treatment. It would not be definitive if variations in results were due to erroneous procedures or to actual change as a result of treatment.
  • a system developed with a standardized collection and filtration procedure could eliminate many errors in the handling, examination and measurement of a sample.
  • a system in which a sample could be collected in a sample holder, transported to the lab and then filtered through an internal filtration conduit into a second receiving vial, would be a desirable contribution to science.
  • samples are being collected in one collection vessel or sample holder.
  • the sample is then transported to a lab.
  • the sample is then poured from this vessel onto filters of varying sizes depending on the protocol in use.
  • the filtered sample, or filtrate is then received in a second receiving vessel, or filtrate holder. Transfers of a sample from vessel to vessel many times will cause loss of volume and cell yield.
  • a device is used for collecting a sample, filtering the sample through a filter with a standardized mesh size, and receiving the filtered sample directly into another connected vessel.
  • a device capable of performing these steps in a closed system will provide a solution to many of the aforementioned problems.
  • the steps of collection, filtration, collection of filtrate and analysis, could be conducted within one system and would eliminate transfer of sample. This may reduce chances of sample volume being lost, wrong filter sizes or types being used or improper filter positioning, thus preventing debris from passing through into the filtrate causing contamination.
  • This system will use a standardized filter type and pore size, or have various filters available within a kit for specific purposes.
  • the collected samples could be treated with reagents, in the collection vial or sample holder if desired. Treating the sample in the collection vial may therefore eliminates transfer steps and reduces sample loss. Use of a standardised system having standard filters, reagents, and apparatuses, would therefore allow all technicians to use the same protocol and result in comparable data and thus be reproducible and valid.
  • the collection or sample holder may be sealed from human contact from the point of collection. Both the receiving or collection vials may have reagents placed in it prior to collection or processing.
  • a device that could reduce the number of errors in processing a sample, increase the validity, reproducibility and simplify a process would be of great interest to pharmaceutical companies, hospitals, and research laboratories. There could be a decrease in the number of man- hours necessary and a reduction in the amount of reagents and equipment used for analysis, therefore a reduction in costs.
  • an apparatus for collection of a mucoid or suspension sample for filtration which comprises a sample holder, a filtrate holder, and a connection conduit containing a filter, which can be connected between the sample and filtrate holders.
  • the suspension sample passes from the sample holder through the filter, which collects contaminants such as debris, and passes to the filtrate holder as filtrate.
  • the sample holder has an entry end portion for collecting the mucoid or suspension sample, and an exit end portion.
  • a diaphragm, or a valve, or a perforated disc mechanism seals the exit end.
  • a diaphragm rupturing device When the sample holder is connected with the connection conduit, a diaphragm rupturing device then ruptures the diaphragm of the sample holder, thus allowing the suspension sample to flow freely from the sample holder to the filter that is contained within the connection conduit.
  • the suspension sample passes through the filter, purifying the sample by removal of contaminates such as debris.
  • the filtrate is then received in the filtrate holder, which may be removed, sealed and taken to a lab for analysis and processes demanded by the tests that are being performed.
  • the sample and filtrate holders of the filtration system may be inscribed with graduated markings for easy determination of the volume of sample contained therein, thus allowing direct calculation of concentration.
  • the diaphragm rupturing device is a male shaped protrusion.
  • the diaphragm of the sample holder is aligned with the male shaped protrusion such that the diaphragm rests on top of the male shaped protrusion.
  • the male shaped protrusion ruptures the diaphragm of the exit end portion of the sample holder when the sample holder and the rupturing device are pushed together, thus forcing the protrusion to puncture the diaphragm.
  • the diaphragm rupturing device is mounted on a support member, which is mounted within the connection conduit.
  • connection conduit When the sample holder is connected to the connection conduit, and pressure is applied, the diaphragm is forced against the male shaped protrusion. As the support member moves closer relative to the connection conduit, in the direction of the applied force, the diaphragm is moved to one side, permitting the sample to flow into the connection conduit.
  • the support member is illustrated in the preferred embodiment as fixed in the connection conduit, in another embodiment it could be a mounted on a moveable support member.
  • the male shaped protrusion defines a pathway or conduit through which the suspension sample flows from the sample holder.
  • the pathway is a hollow channel through the male shaped protrusion, and connects the sample holder to an interior chamber in the connection conduit, located between the diaphragm rupturing device and the filter, within the connection conduit.
  • the diaphragm rupturing device could be a variety of members that could cause a rupture or tear in a diaphragm, and is not limited to a male shaped protrusion.
  • the suspension sample could flow directly from the ruptured diaphragm into the connection conduit without the aid of a channel, if desired.
  • a diaphragm and a rupturing device is only one method for connecting the sample holder to the filter and the filtrate holder.
  • Other possible means of connection may include a selfsealing elastomeric end, through which a syringe type connector may be inserted, such as the type used for drug vials.
  • Another embodiment may use perforated rotatable disks, such that the perforations on each disk will allow a sample to flow through only when the perforations are aligned with one another. When the perforations are not aligned with one another, the perforations are sealed by the opposing disk.
  • connection conduit may also support an inlet, which passes from the outside of the connection conduit to the interior chamber of the connection conduit.
  • the inlet allows introduction of solutions from outside the filtration system. This would be desirable, to allow introduction of filter wetting solutions, and reagents or the like, without opening the filtration system to the environment, thus preventing risk of spillage, contamination of the sample, or exposure of the technician to infectious agents.
  • the interior chamber is defined by the walls of the connection conduit, the diaphragm rupturing device and support member, and a filter. Once the diaphragm is ruptured, the suspension sample flows from the sample holder, through the male shaped protrusion channel, into the interior chamber and onto the filter, where it is filtered and collected in the filtrate holder.
  • Figure 1 is a perspective illustration of the sample collection device partially exploded;
  • Figure 2 is a vertical section of a first component, the sample holder, of the 15 sample collection device;
  • Figure 3 is a vertical section of a second component, the filtrate holder, of the sample collection device
  • Figure 4 is a vertical section of a third component, the connection conduit, of the sample collection device
  • Figure 5 is a exploded vertical side elevation of the three filter components of the sample collection device
  • Figure 6 is a vertical section of some components of the sample holder, 5 shown partially assembled, at a first assembly stage;
  • Figure 7 is a vertical section corresponding to Fig 6 of all the components showing the collector vial partially inserted into the connection conduit, at a second assembly stage;
  • Figure 8 is a vertical section corresponding to Fig 7 showing the collection vial fully inserted into the connection conduit, at a third assembly stage;
  • Figure 9 is an exploded side elevation of the three filter components and 15 portions of the sample holder, the connector conduit and the filtrate holder. DESCRIPTION OF THE INVENTION
  • the invention is illustrated in a preferred embodiment, in the form of a device in which sputum aspirate or other biological suspension samples may be sampled in a three part sampling and filtration system (1 0), as illustrated in Figures through 9.
  • the filtration system (10) includes a collection or sample holder (12).
  • the collection or sample holder (12) for collection of a biological sample has an entry end portion (14) and an exit end portion(16).
  • the entry end portion (14) for collecting a suspension sample is closeable and has outer threads (1 8) allowing cap, stopper, or other closure (20) with attachments such as inner threads (not shown) to be attached to the entry end portion (14) in a well known manner.
  • the exit end portion (16) of the sample holder (12) defines an opening (22) which is temporarily closed, for example in this case, being rupturably sealed with diaphragm (24).
  • the sample holder (12) is inscribed with graduated markings, (not shown) for easy determination of sample volume.
  • Diaphragm (24) is mounted on a hinge flap (28), and is normally bonded to ledge (26), (Fig 2), until engaged by the rupture device, described below.
  • the receiving or filtrate holder (30) of the illustrated embodiment is generally made of the same material as the sample holder (1 2), and is closed at one end, in this case the lower end, as illustrated.
  • the filtrate holder (30) has an open ended receiving end portion (32) with attachments such as outer threads (34), and is closeable after collection of the filtrate with a cap, stopper, or other closure (36) which may have interior threads (not shown).
  • the filtrate holder (30) may also be inscribed with graduated markings for easy determination of volume of filtrate received.
  • connection conduit (38) of the illustrated embodiment has a sample receiving end portion (40) for connection with the exit end portion (16) of the sample holder (12).
  • the sample holder (12) has a circumference at its exit end portion (16), which is smaller than the interior circumference of the sample receiving end portion (40) of the connection conduit (38). This permits the exit end (16) of sample holder (12), to make a telescopic sliding fit into the receiving end (40) of connection conduit (38).
  • the connection conduit (38) has a lower attachment end (42), which is threaded on its interior and is adapted to be attached to the open or receiving end (32) of filtrate holder 30.
  • connection conduit (38) is shaped to receive a diaphragm rupturing device (44) on support member (46).
  • the diaphragm rupturing device (44) defines a pathway (48) through which the suspension sample will flow, from the sample holder (12) after the diaphragm (14) on the exit end portion (16) of the sample holder (12) is ruptured.
  • Vacuum release hole (50) passes through wall (52) of the connection conduit (38). Vacuum release hole (50) allows equalization of pressure, which thereby permits the sample to flow after diaphragm (24) is ruptured.
  • connection conduit (38) illustrate only one method of connection. It should be noted that the method of connection is not restricted to the telescopic sliding fit described. Other forms on interconnection are possible.
  • the diaphragm rupturing device (44), as illustrated in the preferred embodiment, (Figs. 5 and 9), is a male shaped tubular protrusion(54). This is formed by defining an angled edge (56), at the free end of protrusion (54).
  • the male shaped protrusion (54) ruptures the diaphragm (24) of the exit end portion (16) of the sample holder (12) when pressure is applied, forcing the sample holder (12) into the connection conduit (38).
  • edge (56) of male shaped protrusion (54) presses against and ruptures the diaphragm (24), thereby swinging the diaphragm 24 inwardly (Fig. 8) about its hinge flap 28, to one side of sample holder (12).
  • the rupture device (44) could be mounted on some form of slide (not shown), which would be manually slidable relative to connection conduit (38).
  • some form of slide not shown
  • pressure would be applied on the diaphragm (24) by a male shaped protrusion (54) which is moved relative to the axis of connection conduit (38).
  • the male shaped tubular protrusion (54) defines a pathway or channel (58) through which the suspension sample flows from the sample holder (12), into connection conduit (38).
  • the pathway (58) extends through the male shaped protrusion (54), and connects the sample holder (12) to connection conduit (38).
  • connection conduit (38) there is also received a filter support (60).
  • Filter support (60) is cylindrical in exterior shape and makes a snug pressure fit within the attachment end (42) of connection conduit (38).
  • Filter support (60) defines an interior filter support wall (62) of generally frusto- conical shape in section, wider at its upper end and tapering to its lower end.
  • a drainage tube (64) extends downwardly from its lower end.
  • Connection conduit (38) defines at its lower end a flange (66), which functions to retain filter support (60) in position within connection conduit (38).
  • the invention is not restricted to any particular shapes however. Filters, and filter supports could be of any functional shape. The filters could simply be flat discs in some cases, resting on any suitable frame work (not shown) allowing flow of filtrate from the filter.
  • a plurality of drain holes (70) are provided around male tubular protrusion (54). These ensure that any liquid which might collect around the outside of male protrusion (54), can drain through such holes (70) and flow down through the filter media (68).
  • the air inlet (50), which passes from the outside of the connection conduit (38) to the interior also allows introduction of solutions from outside the filtration system. This would be desirable, to allow introduction of filter wetting solutions, reagents or the like, without opening the sample collection system (1 0) to the environment. This will prevent risk of spillage, contamination of the sample or exposure of the technician to infectious agents.
  • sample holder (12) is formed with an exterior guide ridge (72), and connection conduit (38) is formed with a complementary guide groove (74).
  • connection conduit (38) is formed with a complementary guide groove (74).
  • the support (46) of the rupture device (44) has a guide block (76) 10 formed thereon, and guide block (76) also fits into guide groove (74) of connection conduit (38). This ensures that the rupture device (44) is in a preset orientation, when pressed into connection conduit (38), which corresponds with the desired orientation of sample holder (12).
  • filtrate holder (30) many methods may be used for capping and sealing the filtrate holder (30), such as a threaded cap, stopper, or other closure for example.
  • a physician, technician, nurse, or the like collects a biological 20 sample or a series of samples in a series of sample holders (1 2), from the subject source or different subject sources, into the entry end portion (14) of the sample holder (12).
  • the exit end portion (16) of the sample holder (12) is still sealed by the rupturable diaphragm (24) and may be covered by a protective means (not shown) to prevent accidental rupture of the diaphragm (24).
  • the entry end portion (14) of the sample holder (12) is then capped or sealed by a sealing means, such as cap.stopper, or other closure (20) and the sample holder (12) is transported for testing (As shown in Fig. 2). If desirable, reagents may be added to the collected sample in the sample holder (12).
  • the exit end portion (16) of the sample holder(12) is attached to the sample receiving end portion(40) of the connection conduit(38) by threads or some other convenient connection means.
  • the sample holder (12) is then slid into the connection conduit (38) and gradually pressed further into telescopic engagement. This will bring male protrusion (54) into contact with diaphragm (24)(See Figs. 6 and 7).
  • a solution may be introduced through the hole (50), in this embodiment by means of injection, or may be introduced through a resealable injection port (not shown) of a type well known in the art, for wetting the filter and! or mixing with the sample before filtration.
  • connection conduit (38) Further relative movement between sample holder (12) and connection conduit (38) will rupture diaphragm (24)(Fig. 8). Once the diaphragm (24) is ruptured, the sample flows from the sample holder (12), through the male shaped tubular protrusion (54), and flows into the connection conduit (38), and onto the filter media (68). There it is filtered and drains though drain tube (64) and flows into the filtrate holder (30).
  • the filtrate holder (30) as illustrated in this embodiment, will already have been attached to the connection conduit (38) by threads (34).
  • the filtrate holder (30) may then be removed from the connection conduit (38) and capped, or otherwise closed, and sealed for storage, transport or for testing procedures such as cell counts and centrifugation (Fig. 3).
  • any debris or contaminates that are larger than the pores (not shown) or mesh size (not shown) of the filter media (68) are removed.
  • sample holder (12) and the connection conduit (38), together with entire 15 filter assembly and filter media (68) may be discarded, or the parts may be sterilized for future use with a replacement filter.
  • a closeable cap, stopper, or other closure (not shown), or other form of seal, protects the purified sample or filtrate from becoming contaminated, or lost due to spillage, and also protects technicians and the like from exposure.
  • the closure may be removed when testing of the purified sample begins.
  • the filtrate holder(30) may be sterilized for future use or discarded.
  • a sterile pack (not shown) would contain the sample holder (12), the connection conduit (38), containing the filter support (60), filter media (68) and rupture device (44) already locked in place, and a filtrate holder (30), and suitable cap, stopper, or other closures or other seals, and dosage sized containers of reagents, filter wetting fluids and the like, and possibly gloves for handling the entire system, and a face mask.
  • a kit, in pack form would ensure that as far as possible all samples were taken in the same manner, and were all handled under sterile conditions, and were all filtered to the same degree.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un appareil et un procédé de collecte et de filtration d'un échantillon comprenant un porte-échantillon (12), un support récepteur de filtrat (30) et un conduit de connexion (38) avec une extrémité de réception d'échantillon et une extrémité de réception de filtrat et contenant un filtre (68). Le porte-échantillon (12) comporte une portion d'extrémité d'entrée (14) et une portion d'extrémité de sortie (16), avec un diaphragme (24) fermant normalement la portion de sortie. Le support récepteur de filtrat (30) comporte une portion d'extrémité de réception à fermeture (32) destinée à recevoir l'échantillon filtré. Le conduit de connexion (38) comprend un dispositif de rupture (44) permettant de perforer le diaphragme (24) sur la portion d'extrémité de sortie du porte-échantillon (12). Lorsque le porte-échantillon est inséré dans le conduit de connexion, le dispositif de rupture du diaphragme perfore le diaphragme, permettant la filtration de l'échantillon par le filtre disposé dans le conduit de connexion, le filtrat étant collecté dans le support récepteur de filtrat. L'invention concerne aussi un procédé de collecte d'échantillon biologique, de filtration de cet échantillon et de maintien du filtrat dans le support récepteur.
PCT/CA2003/000983 2002-07-03 2003-06-27 Appareil et procede de filtration d'echantillons biologiques Ceased WO2004004865A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP03737805A EP1517735B1 (fr) 2002-07-03 2003-06-27 Appareil et procede de filtration d'echantillons biologiques
JP2004518316A JP4423351B2 (ja) 2002-07-03 2003-06-27 生物学的サンプルを濾過する装置及び方法
AT03737805T ATE456969T1 (de) 2002-07-03 2003-06-27 Vorrichtung und verfahren zum filtrieren biologischer proben
DE60331188T DE60331188D1 (de) 2002-07-03 2003-06-27 Vorrichtung und verfahren zum filtrieren biologischer proben
NZ537438A NZ537438A (en) 2002-07-03 2003-06-27 Apparatus and method for filtering biological samples
AU2003245776A AU2003245776B2 (en) 2002-07-03 2003-06-27 Apparatus and method for filtering biological samples
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006132041A1 (fr) * 2005-06-08 2006-12-14 Nipro Corporation Recipient pour prelevement d’echantillons en phase liquide
EP1867972A4 (fr) * 2005-03-14 2009-04-08 Nipro Corp Récipient d échantillonnage de liquide
CN102782472A (zh) * 2009-10-02 2012-11-14 生命科技公司 样品制备装置和方法
CZ307454B6 (cs) * 2016-12-22 2018-09-05 Univerzita PalackĂ©ho v Olomouci Zařízení pro usnadnění manipulace s rozpouštědly, směsmi a vzorky na nosičích, sada pro manipulaci s nimi a použití zařízení a/nebo sady

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951762B2 (en) * 1998-12-23 2005-10-04 Zuk Jr Peter Apparatus comprising a disposable device and reusable instrument for synthesizing chemical compounds, and for testing chemical compounds for solubility
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060111620A1 (en) * 2004-11-23 2006-05-25 Squilla John R Providing medical services at a kiosk
TWI247084B (en) * 2004-12-17 2006-01-11 Ind Tech Res Inst Filter column module
GB2422794B (en) * 2005-02-05 2009-04-22 Diasys Europ Ltd Filtration device for biological samples
US7854343B2 (en) * 2005-03-10 2010-12-21 Labcyte Inc. Fluid containers with reservoirs in their closures and methods of use
EP1946410A2 (fr) * 2005-10-17 2008-07-23 Advanced Technology Materials, Inc. Raccord et procede de jonction de receptacles
GB2433219A (en) * 2005-12-16 2007-06-20 Diasys Europ Ltd A filtering device
WO2007137257A2 (fr) 2006-05-22 2007-11-29 3M Innovative Properties Company Système et procédé de préparation d'échantillons
US8567609B2 (en) * 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2008038653A1 (fr) * 2006-09-27 2008-04-03 Shin Corporation procédé de traitement d'échantillon et trousse d'essai
US7964098B2 (en) * 2007-02-06 2011-06-21 Alpha-Tec Systems, Inc. Apparatus and method for filtering biological samples
BRMU8700248Y1 (pt) * 2007-02-12 2016-12-20 José Carlos Lapenna disposição construtiva aplicada em coletor de amostra para fins de exame parasitológico de fezes
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
JP5479319B2 (ja) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
WO2009074177A1 (fr) * 2007-12-12 2009-06-18 Tecan Trading Ag Processeur d'échantillons médico-légaux
EP2567692B1 (fr) 2008-02-27 2016-04-06 Biomet Biologics, LLC Utilisation d'un dispositif pour obtenir des solutions riches en antagoniste de récepteur d'interleukine-1
WO2009111338A1 (fr) 2008-02-29 2009-09-11 Biomet Manufacturing Corp. Système et procédé pour la séparation d'une matière
WO2010093840A1 (fr) * 2009-02-11 2010-08-19 M Biosciences, Inc. Dispositifs et procédés de formation d'une couche de sang ou de suspensions cellulaires
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) * 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US20130071944A1 (en) * 2009-10-05 2013-03-21 Battelle Memorial Institute Sample preparation disposable devices and sample collection and preparation methods using same
US8585905B2 (en) * 2010-02-26 2013-11-19 Waters Technologies Corporation Devices, kits and methods for performing chemical processing
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
DE102010023229A1 (de) * 2010-06-09 2011-12-15 Otto Berners Vorrichtung und Verfahren für einen Transport und die Aufbereitung von Zellmaterial
CN107202727B (zh) * 2010-07-14 2020-12-22 恰根有限公司 用于分离和/或纯化生物分子的装置
EP2593768B1 (fr) * 2010-07-14 2024-06-19 Qiagen GmbH Nouveau dispositif de stockage, de collecte ou d'isolement
US10173219B2 (en) * 2011-02-07 2019-01-08 1Cryobio Ag Breakable vessel for sample storage
EP3682970A1 (fr) * 2011-03-24 2020-07-22 Boehringer Ingelheim Microparts GmbH Dispositif de séparation d'un résidu surnageant dans un échantillon liquide
JP6096665B2 (ja) * 2011-09-20 2017-03-15 富士紡ホールディングス株式会社 試薬容器
CN102539214A (zh) * 2012-02-23 2012-07-04 杭州遂真生物技术有限公司 一种样品处理用的组合试管及样品处理方法
CN102564796A (zh) * 2012-02-24 2012-07-11 万华普曼生物工程有限公司 一种粪便采集器
US8322539B1 (en) * 2012-03-02 2012-12-04 Scientific Plastic Products, Inc. Filter vial
AU2013267772B2 (en) 2012-05-30 2017-03-02 Lifecell Corporation Device for harvesting, processing, and transferring adipose tissue
US20130345596A1 (en) * 2012-06-25 2013-12-26 David S. Zimmon Apparatus and methods for removing and collecting biopsy specimens from biopsy devices with fixation and preparation for histopathological processing or other analysis
US11090338B2 (en) 2012-07-13 2021-08-17 Lifecell Corporation Methods for improved treatment of adipose tissue
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
EP3075841B1 (fr) 2012-09-06 2021-03-10 GID BIO, Inc. Appareil de traitement de tissus et procédé de traitement de tissu adipeux
JP2014098661A (ja) * 2012-11-15 2014-05-29 Olympus Corp 標本作製デバイス
AU2013347980B2 (en) 2012-11-20 2017-09-28 The Trustees Of Columbia University In The City Of New York Medical apparatus and method for collecting biological samples
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
EP3004866B1 (fr) * 2013-05-24 2019-11-06 Premier Biotech, Inc. Dispositif de test de fluide buccal à multiples stades
US20160123856A1 (en) * 2013-06-12 2016-05-05 Oasis Diagnostics Corporation Rna/prtein/dna preferential fluid sample collection system and methods
US10302535B2 (en) * 2013-09-12 2019-05-28 CellectGen, Inc. Biofluid collection and filtration device
WO2015070712A1 (fr) * 2013-11-14 2015-05-21 Abon Biopharm (Hangzhou) Co., Ltd. Dispositif et procédé d'utilisation du dispositif
EP3137139A1 (fr) 2014-05-02 2017-03-08 Lifecell Corporation Capteur d'injection avec mécanisme de rétroaction
US20170259260A1 (en) * 2014-09-12 2017-09-14 Vib Vzw Biological sampling and storage container
US20160114317A1 (en) * 2014-10-27 2016-04-28 Moishe Bodner Device and system for sampling and analyzing a liquid specimen
FI20155107A (fi) * 2015-02-19 2016-08-20 Thermo Fisher Scientific Oy Näyteastia
EP3258979A1 (fr) 2015-02-19 2017-12-27 Lifecell Corporation Dispositif de traitement de tissu, et systèmes et procédés associés
GB2535998A (en) * 2015-02-27 2016-09-07 Intelligent Fingerprinting Ltd A device for receiving and analysing a sample
US10421069B2 (en) * 2015-07-06 2019-09-24 Hans-Werner Heinrich Multifunctional system for particle separation
EP3633027A1 (fr) 2015-10-21 2020-04-08 LifeCell Corporation Procédés de gestion de tubes
AU2016342012A1 (en) 2015-10-21 2018-05-10 Lifecell Corporation Systems and methods for medical device control
WO2017100798A1 (fr) 2015-12-11 2017-06-15 Siemens Healthcare Diagnostics Inc. Contenant d'échantillon et procédé de séparation de sérum ou plasma et de sang total
EP3393390A1 (fr) 2015-12-22 2018-10-31 LifeCell Corporation Dispositif de remplissage de seringue pour transfert de graisse
BR112019003871A2 (pt) 2016-08-30 2019-07-16 Lifecell Corp sistemas e métodos para controle de dispositivo médico
EP3538865A4 (fr) 2016-11-14 2019-12-25 Siemens Healthcare Diagnostics Inc. Dispositif de préparation d'échantillon
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
US10974248B2 (en) * 2018-03-14 2021-04-13 MTC Bio Inc. Adapter for laboratory cell strainer
DE102019121342B4 (de) * 2018-08-15 2021-03-18 Mann+Hummel Gmbh Filterelement für den Einsatz als Partikelfilter in einem Kühlkreislauf eines elektrochemischen Energiewandlers und Verwendung des Filterelements in einer Anordnung mit einem elektrochemischen Energiewandler und einem Kühlkreislauf
US12128334B2 (en) * 2018-09-05 2024-10-29 Kin Mun Chin Filter press with threadably advanced filtrate receiving plunger
EP3846939B1 (fr) 2018-09-05 2023-05-03 Hero Scientific Ltd Détection de particules
US11992844B2 (en) 2018-11-13 2024-05-28 Becton, Dickinson And Company Dried reagent strainers and methods for making and using the same
KR102522436B1 (ko) * 2019-06-25 2023-04-17 (주)메디젠휴먼케어 액체 생검용 수집장치
IT201900016112A1 (it) * 2019-09-11 2021-03-11 Copan Italia Spa Tappo a rilascio, contenitore dotato di tappo e metodo di rilascio associato
EP4027894A4 (fr) * 2019-10-31 2023-09-13 Orasecure LLC Dispositif et procédé de collecte de fluide oral, de salive et d'expectorations
US20210196246A1 (en) * 2019-12-30 2021-07-01 Northeastern University Suction Based Saliva Treatment and Collector Device
EP4118412A1 (fr) 2020-03-11 2023-01-18 Hero Scientific Ltd Dispositifs de test
KR200496916Y1 (ko) * 2020-10-19 2023-06-01 임동선 타액 수집 키트
CA3202405A1 (fr) 2021-01-06 2022-07-14 Zvi Feldman Dispositifs d'echantillonnage a filtration
IT202100001025A1 (it) * 2021-01-21 2022-07-21 Comedical S R L Dispositivo di raccolta di un campione salivare
EP4323114A1 (fr) * 2021-04-14 2024-02-21 Quantoom Biosciences France SAS Unité de réaction tubulaire
WO2022265856A1 (fr) * 2021-06-17 2022-12-22 Becton, Dickinson And Company Dispositifs réactifs pour du colorant séché et leurs procédés de fabrication et d'utilisation
US12050052B1 (en) 2021-08-06 2024-07-30 Babson Diagnostics, Inc. Refrigerated carrier device for biological samples
EP4505185A1 (fr) 2022-04-06 2025-02-12 Babson Diagnostics, Inc. Chargeur automatisé de centrifugeuse
NL2032490B1 (en) * 2022-07-14 2024-01-25 Daklapack Europe B V Specimen collection device for home sampling and transport.
EP4554721A1 (fr) 2022-07-14 2025-05-21 Daklapack Europe B.V. Dispositif de collecte d'échantillon pour échantillonnage et transport domestiques
DE102023102184A1 (de) * 2023-01-30 2024-08-01 The smart period blood GmbH Adapter zum Überführen und Aufbereiten einer Menstruationsausscheidungen enthaltenden Probe in ein verschließbares Probengefäß
CN117288553B (zh) * 2023-11-24 2024-01-26 烟台至公生物医药科技有限公司 一种用于便携式质谱仪的样品快速滤过型净化装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788483A (en) * 1972-05-26 1974-01-29 W Conway Apparatus for filtration
US4678559A (en) * 1984-07-23 1987-07-07 Andreas Szabados Test specimen container for pasty specimen material
DE3722562A1 (de) * 1987-07-08 1989-01-19 Andreas Szabados Ringfoermiger filterkoerper
US5322800A (en) * 1991-06-26 1994-06-21 The United States Of America As Represented By The Secretary Of The Interior Method and device for safely preserving aqueous field samples using acid or base
US5556544A (en) * 1995-09-08 1996-09-17 Didier; Emmanuel R. Concentrator & filter
US5882943A (en) * 1996-07-31 1999-03-16 Aldeen; William Erick Filtration apparatus, kit and method for processing parasite samples
WO2001084113A1 (fr) * 2000-04-28 2001-11-08 Schlueter Gert Procede et dispositif de filtration d'un echantillon liquide notamment pour obtenir des preparations medicinales

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2110237A (en) * 1936-03-06 1938-03-08 Swift & Co Sediment tester
US2584397A (en) * 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another
US2775350A (en) * 1953-12-28 1956-12-25 Hugh A Jones Filters
US3300051A (en) * 1963-09-26 1967-01-24 Internat Equipment Co Filter tube for use in a centrifuge
US3539300A (en) * 1967-10-23 1970-11-10 Schering Corp Body fluid collector and separator having improved flow rate
US3615222A (en) * 1968-09-04 1971-10-26 New England Nuclear Corp Method and apparatus for measuring the amount of a component in a biological fluid
US3583627A (en) * 1969-09-04 1971-06-08 Onslow H Wilson Apparatus for the concentration of macromolecules and subcellular particles from dilute solutions
US3682321A (en) * 1970-03-02 1972-08-08 Volu Sol Chem And Mfg Co Inc Throw-away filter assembly
US3661265A (en) * 1970-07-27 1972-05-09 Contemporary Research And Dev Serum separator type container
US3701434A (en) * 1971-03-15 1972-10-31 Hugh C Moore Test tube system for separating blood into serum and red cells
US3955423A (en) * 1972-09-18 1976-05-11 Marvin Padover Liquid sampling method
US3932277A (en) * 1974-03-29 1976-01-13 Bio-Logics Products, Inc. Method and apparatus for separating blood fractions
US3977555A (en) * 1974-05-07 1976-08-31 Pharmaco, Inc. Protective safety cap for medicament vial
US3939822A (en) * 1974-08-14 1976-02-24 Jack Markowitz Disposable blood collection and filtering device
US3969250A (en) * 1975-03-10 1976-07-13 Farr Andrew F Apparatus for preparing liquid samples for analysis in automatic analyzers
US4035294A (en) * 1975-05-23 1977-07-12 Denver Chemical Manufacturing Company Pressure differential filtering device and method
US4131549A (en) * 1977-05-16 1978-12-26 Ferrara Louis T Serum separation device
US4146153A (en) * 1977-07-07 1979-03-27 Knight Development Corporation Sterile dispensing device
US4353868A (en) * 1981-05-29 1982-10-12 Sherwood Medical Industries Inc. Specimen collecting device
US4464254A (en) * 1982-06-03 1984-08-07 Porex Technologies, Corp. Device for separating serum from blood sample
JPS6077768A (ja) * 1983-10-06 1985-05-02 テルモ株式会社 液体濾過装置
US4783318A (en) * 1987-10-02 1988-11-08 The State Of Minnesota Apparatus for environmental leaching testing
US4891134A (en) * 1988-01-25 1990-01-02 Abbott Laboratories Sample filtration device
JPH0755498Y2 (ja) * 1988-07-13 1995-12-20 川澄化学工業株式会社 輸血及び血液検査用の被検血液採取器具
US5429803A (en) * 1991-04-18 1995-07-04 Lamina, Inc. Liquid specimen container and attachable testing modules
JP2523938B2 (ja) * 1989-09-18 1996-08-14 テルモ株式会社 血小板純化用フィルタ―
JPH0774772B2 (ja) * 1990-12-31 1995-08-09 エイ． レビン ロバート 血液サンプリング組立体、ターゲット細胞の採取方法およびターゲット成分の採取方法
US5501841A (en) * 1991-11-14 1996-03-26 Artchem, Inc. Connection-type treatment system for micro solution and method of treatment
JPH07110329A (ja) * 1993-08-20 1995-04-25 Dainippon Printing Co Ltd 便内潜血検出装置
US5976824A (en) * 1993-11-24 1999-11-02 Abbott Laboratories Method and apparatus for collecting a cell sample from a liquid specimen
US5582696A (en) * 1994-05-31 1996-12-10 Health Craft International, Inc. Glucose level monitoring apparatus
US5603900A (en) * 1995-05-19 1997-02-18 Millipore Investment Holdings Limited Vacuum filter device
US5786227A (en) * 1995-06-07 1998-07-28 Biex, Inc. Fluid collection kit and method
US5786228A (en) * 1995-06-07 1998-07-28 Biex, Inc. Fluid collection kit and method
US6221655B1 (en) * 1998-08-01 2001-04-24 Cytosignal Spin filter assembly for isolation and analysis
WO2001032828A2 (fr) * 1999-10-29 2001-05-10 Pall Corporation Traitement de fluide biologique

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788483A (en) * 1972-05-26 1974-01-29 W Conway Apparatus for filtration
US4678559A (en) * 1984-07-23 1987-07-07 Andreas Szabados Test specimen container for pasty specimen material
DE3722562A1 (de) * 1987-07-08 1989-01-19 Andreas Szabados Ringfoermiger filterkoerper
US5322800A (en) * 1991-06-26 1994-06-21 The United States Of America As Represented By The Secretary Of The Interior Method and device for safely preserving aqueous field samples using acid or base
US5556544A (en) * 1995-09-08 1996-09-17 Didier; Emmanuel R. Concentrator & filter
US5882943A (en) * 1996-07-31 1999-03-16 Aldeen; William Erick Filtration apparatus, kit and method for processing parasite samples
WO2001084113A1 (fr) * 2000-04-28 2001-11-08 Schlueter Gert Procede et dispositif de filtration d'un echantillon liquide notamment pour obtenir des preparations medicinales

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1867972A4 (fr) * 2005-03-14 2009-04-08 Nipro Corp Récipient d échantillonnage de liquide
WO2006132041A1 (fr) * 2005-06-08 2006-12-14 Nipro Corporation Recipient pour prelevement d’echantillons en phase liquide
CN102782472A (zh) * 2009-10-02 2012-11-14 生命科技公司 样品制备装置和方法
CN102782472B (zh) * 2009-10-02 2016-04-06 生命科技公司 样品制备装置和方法
CN105973686A (zh) * 2009-10-02 2016-09-28 生命科技公司 样品制备装置和方法
CZ307454B6 (cs) * 2016-12-22 2018-09-05 Univerzita PalackĂ©ho v Olomouci Zařízení pro usnadnění manipulace s rozpouštědly, směsmi a vzorky na nosičích, sada pro manipulaci s nimi a použití zařízení a/nebo sady

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AU2003245776B2 (en) 2009-03-05
ATE456969T1 (de) 2010-02-15
CA2433235C (fr) 2010-08-17
ES2340477T3 (es) 2010-06-04
DE60331188D1 (de) 2010-03-25
CA2433235A1 (fr) 2004-01-03
US20040005246A1 (en) 2004-01-08
ZA200410405B (en) 2005-12-28
NZ537438A (en) 2008-02-29
US7176034B2 (en) 2007-02-13
JP4423351B2 (ja) 2010-03-03
EP1517735A1 (fr) 2005-03-30
JP2005531774A (ja) 2005-10-20
EP1517735B1 (fr) 2010-02-03

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