WO2004007770A3 - Procede de diagnostic de tumeurs gastriques de type intestinal - Google Patents

Procede de diagnostic de tumeurs gastriques de type intestinal Download PDF

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Publication number
WO2004007770A3
WO2004007770A3 PCT/JP2003/008651 JP0308651W WO2004007770A3 WO 2004007770 A3 WO2004007770 A3 WO 2004007770A3 JP 0308651 W JP0308651 W JP 0308651W WO 2004007770 A3 WO2004007770 A3 WO 2004007770A3
Authority
WO
WIPO (PCT)
Prior art keywords
intestinal
type gastric
gastric cancer
methods
lymph node
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/008651
Other languages
English (en)
Other versions
WO2004007770A2 (fr
Inventor
Yusuke Nakamura
Yoichi Furukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncotherapy Science Inc
University of Tokyo NUC
Original Assignee
Oncotherapy Science Inc
University of Tokyo NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc, University of Tokyo NUC filed Critical Oncotherapy Science Inc
Priority to CA002492355A priority Critical patent/CA2492355A1/fr
Priority to US10/520,881 priority patent/US20060105333A1/en
Priority to EP03741269A priority patent/EP1523577A2/fr
Priority to JP2004521153A priority patent/JP2005532077A/ja
Priority to AU2003280991A priority patent/AU2003280991A1/en
Publication of WO2004007770A2 publication Critical patent/WO2004007770A2/fr
Publication of WO2004007770A3 publication Critical patent/WO2004007770A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5753—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the stomach or small intestine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/828—Stomach
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention porte sur des procédés de détection et de diagnostic de tumeurs gastriques de type intestinal. Elle concerne aussi un procédé de prédiction de présence ou d'absence de métastase du noeud lymphatique (c'est-à-dire l'identification du phénotype métastatique). Dans un mode de réalisation, le procédé de diagnostic consiste à évaluer des profiles d'expression génique qui différencient les tumeurs positives du noeud lymphatique des tumeurs négatives du noeud lymphatique. L'évaluation prédictive calculée sert d'indicateur de diagnostic pouvant objectivement indiquer si un tissu échantillon possède le phénotype métastatique. L'invention concerne aussi des procédés de diagnostic du cancer gastrique de type intestinal chez un sujet, des procédés de criblage d'agents thérapeutiques utiles dans le traitement du cancer gastrique de type intestinal, des procédés de traitement du cancer gastrique de type intestinal et un procédé de vaccination d'un sujet contre un cancer gastrique de type intestinal.
PCT/JP2003/008651 2002-07-10 2003-07-08 Procede de diagnostic de tumeurs gastriques de type intestinal Ceased WO2004007770A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002492355A CA2492355A1 (fr) 2002-07-10 2003-07-08 Procede de diagnostic de tumeurs gastriques de type intestinal
US10/520,881 US20060105333A1 (en) 2002-07-10 2003-07-08 Method for diagnosis of intestinal-type gastric tumors
EP03741269A EP1523577A2 (fr) 2002-07-10 2003-07-08 Procede de diagnostic de tumeurs gastriques de type intestinal
JP2004521153A JP2005532077A (ja) 2002-07-10 2003-07-08 腸型胃腫瘍の診断法
AU2003280991A AU2003280991A1 (en) 2002-07-10 2003-07-08 Method for diagnosis of intestinal-type gastric tumors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39494102P 2002-07-10 2002-07-10
US60/394,941 2002-07-10

Publications (2)

Publication Number Publication Date
WO2004007770A2 WO2004007770A2 (fr) 2004-01-22
WO2004007770A3 true WO2004007770A3 (fr) 2004-04-29

Family

ID=30115790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/008651 Ceased WO2004007770A2 (fr) 2002-07-10 2003-07-08 Procede de diagnostic de tumeurs gastriques de type intestinal

Country Status (6)

Country Link
US (1) US20060105333A1 (fr)
EP (1) EP1523577A2 (fr)
JP (1) JP2005532077A (fr)
AU (1) AU2003280991A1 (fr)
CA (1) CA2492355A1 (fr)
WO (1) WO2004007770A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005001126A1 (fr) * 2003-06-12 2005-01-06 Korea Research Institute Of Bioscience And Biotechnology Necessaire de detection du cancer gastrique et cancer gastrique metastatique
JP2006006155A (ja) * 2004-06-24 2006-01-12 National Institute Of Advanced Industrial & Technology 新規硫酸転移酵素及びその遺伝子
DE102006031937A1 (de) * 2006-07-06 2008-01-10 Friedrich-Schiller-Universität Jena Verfahren und Vorrichtung zur Bewertung eines Bildes und/oder einer zeitlichen Bildsequenz von Gewebe oder Gewebeproben
US7811778B2 (en) * 2006-09-06 2010-10-12 Vanderbilt University Methods of screening for gastrointestinal cancer
WO2008032323A2 (fr) * 2006-09-11 2008-03-20 Seng Enterprises Ltd. Procédé de détermination d'une métastase de ganglion lymphatique
KR100863440B1 (ko) 2007-02-07 2008-10-16 주식회사 마크로젠 위암의 전이 또는 전염 진단용 키트 및 판단 방법
CN101827936B (zh) 2007-08-20 2014-12-10 肿瘤疗法科学股份有限公司 Cdh3肽以及含有cdh3肽的药剂
US8435749B2 (en) 2008-06-30 2013-05-07 Oncotherapy Science, Inc. Anti-CDH3 antibodies labeled with radioisotope label and uses thereof
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
US9017669B2 (en) 2009-12-28 2015-04-28 Oncotherapy Science, Inc. Anti-CDH3 antibodies and uses thereof
GB201201766D0 (en) * 2012-02-01 2012-03-14 Imp Innovations Ltd Method
US20160039877A1 (en) 2013-03-15 2016-02-11 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
JP6168625B2 (ja) * 2016-01-12 2017-07-26 国立研究開発法人産業技術総合研究所 上皮性卵巣癌鑑別マーカー
LT3483164T (lt) 2017-03-20 2020-05-11 Forma Therapeutics, Inc. Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
EP4197552A1 (fr) 2018-03-12 2023-06-21 The Children's Hospital of Philadelphia Procédés et compositions pour l'utilisation d'auto-antigènes tumoraux en immunothérapie adoptive
EP3852791B1 (fr) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activation de la pyruvate kinase r
EP3853206B1 (fr) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Traitement de la drépanocytose avec un composé activant la pyruvate kinase r
HRP20251148T1 (hr) 2019-09-19 2025-11-21 Novo Nordisk Health Care Ag Pripravci koji aktiviraju piruvat-kinazu r (pkr)
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN115961042A (zh) * 2022-12-09 2023-04-14 广东医科大学 Igfbp1基因或chaf1a基因在作为胃腺癌预后分子标志物中的应用
CN120514861B (zh) * 2025-05-29 2026-04-24 中国人民解放军军事科学院军事医学研究院 Nedd8抑制剂在制备抗焦虑药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041864A1 (fr) * 1997-03-18 1998-09-24 Locus Genex Oy Diagnostic precoce du cancer gastrique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041864A1 (fr) * 1997-03-18 1998-09-24 Locus Genex Oy Diagnostic precoce du cancer gastrique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HASEGAWA SUGURU ET AL: "Genome-wide analysis of gene expression in intestinal-type gastric cancers using a complementary DNA microarray representing 23,040 genes.", CANCER RESEARCH. UNITED STATES 1 DEC 2002, vol. 62, no. 23, 1 December 2002 (2002-12-01), pages 7012 - 7017, XP002254863, ISSN: 0008-5472 *
HIPPO YOSHITAKA ET AL: "Global gene expression analysis of gastric cancer by oligonucleotide microarrays.", CANCER RESEARCH, vol. 62, no. 1, 1 January 2002 (2002-01-01), January 1, 2002, pages 233 - 240, XP002254861, ISSN: 0008-5472 *
MORI MASAKI ET AL: "Analysis of the gene-expression profile regarding the progression of human gastric carcinoma.", SURGERY (ST LOUIS), vol. 131, no. 1 Supplement, January 2002 (2002-01-01), pages S39 - S47, XP008022195, ISSN: 0039-6060 *

Also Published As

Publication number Publication date
US20060105333A1 (en) 2006-05-18
CA2492355A1 (fr) 2004-01-22
WO2004007770A2 (fr) 2004-01-22
AU2003280991A1 (en) 2004-02-02
JP2005532077A (ja) 2005-10-27
AU2003280991A8 (en) 2004-02-02
EP1523577A2 (fr) 2005-04-20

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