WO2004014357A3 - Utilisation therapeutique de derives d'acide amine d'aryle - Google Patents

Utilisation therapeutique de derives d'acide amine d'aryle Download PDF

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Publication number
WO2004014357A3
WO2004014357A3 PCT/IB2003/003193 IB0303193W WO2004014357A3 WO 2004014357 A3 WO2004014357 A3 WO 2004014357A3 IB 0303193 W IB0303193 W IB 0303193W WO 2004014357 A3 WO2004014357 A3 WO 2004014357A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
acid derivatives
therapeutic use
disorders
aryl amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2003/003193
Other languages
English (en)
Other versions
WO2004014357A2 (fr
Inventor
Graham Nigel Maw
David James Rawson
Lisa Rosemary Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Pfizer Inc
Original Assignee
Pfizer Ltd
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd, Pfizer Inc filed Critical Pfizer Ltd
Priority to JP2004527144A priority Critical patent/JP2006507238A/ja
Priority to BR0313284-6A priority patent/BR0313284A/pt
Priority to AU2003247056A priority patent/AU2003247056A1/en
Priority to EP03784335A priority patent/EP1528919A2/fr
Priority to MXPA05001534A priority patent/MXPA05001534A/es
Priority to CA002495108A priority patent/CA2495108A1/fr
Publication of WO2004014357A2 publication Critical patent/WO2004014357A2/fr
Publication of WO2004014357A3 publication Critical patent/WO2004014357A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

Selon cette invention, les composés de formule (I) sont utilisés dans le traitement d'attaques de lipothymie, d'hypocinésie, de troubles crâniens, de troubles neurodégénératifs, de dépression, d'anxiété, de panique, de douleurs neuropathiques, de troubles neuropathologiques et de troubles du sommeil. Ladite invention a aussi trait à des processus de préparation des produits finaux et d'intermédiaires utilisés dans le traitement, ainsi que des compositions pharmaceutiques renfermant au moins un desdits composés.
PCT/IB2003/003193 2002-08-09 2003-07-29 Utilisation therapeutique de derives d'acide amine d'aryle Ceased WO2004014357A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2004527144A JP2006507238A (ja) 2002-08-09 2003-07-29 アリールアミノ酸誘導体の治療的使用
BR0313284-6A BR0313284A (pt) 2002-08-09 2003-07-29 Utilização terapêutica de derivados de aril-aminoácidos
AU2003247056A AU2003247056A1 (en) 2002-08-09 2003-07-29 Therapeutic use of aryl amino acid derivatives
EP03784335A EP1528919A2 (fr) 2002-08-09 2003-07-29 Utilisation therapeutique de derives d'acide amine d'aryle
MXPA05001534A MXPA05001534A (es) 2002-08-09 2003-07-29 Uso terapeutico de derivados arilo de aminoacidos.
CA002495108A CA2495108A1 (fr) 2002-08-09 2003-07-29 Utilisation therapeutique de derives d'acide amine d'aryle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0218590.8 2002-08-09
GBGB0218590.8A GB0218590D0 (en) 2002-08-09 2002-08-09 Therapeutic use of aryl amino acid derivatives

Publications (2)

Publication Number Publication Date
WO2004014357A2 WO2004014357A2 (fr) 2004-02-19
WO2004014357A3 true WO2004014357A3 (fr) 2004-07-01

Family

ID=9942061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/003193 Ceased WO2004014357A2 (fr) 2002-08-09 2003-07-29 Utilisation therapeutique de derives d'acide amine d'aryle

Country Status (8)

Country Link
EP (1) EP1528919A2 (fr)
JP (1) JP2006507238A (fr)
AU (1) AU2003247056A1 (fr)
BR (1) BR0313284A (fr)
CA (1) CA2495108A1 (fr)
GB (1) GB0218590D0 (fr)
MX (1) MXPA05001534A (fr)
WO (1) WO2004014357A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031194A1 (fr) * 1994-05-11 1995-11-23 Shapiro Howard K Compositions pour le traitement de maladies inflammatoires chroniques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031194A1 (fr) * 1994-05-11 1995-11-23 Shapiro Howard K Compositions pour le traitement de maladies inflammatoires chroniques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GEE N S ET AL: "The novel anti-convulsant drug, Gabapentin (NEURONTIN), BINDS TO THE ALPHA.2.DELTA SUBUNIT OF A CALCIUM CHANNEL", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 10, 8 March 1996 (1996-03-08), pages 5768 - 5776, XP002240620, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2495108A1 (fr) 2004-02-19
MXPA05001534A (es) 2005-04-19
JP2006507238A (ja) 2006-03-02
BR0313284A (pt) 2005-07-12
WO2004014357A2 (fr) 2004-02-19
AU2003247056A1 (en) 2004-02-25
EP1528919A2 (fr) 2005-05-11
GB0218590D0 (en) 2002-09-18

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