WO2004016731A3 - Expansion ex vivo de populations de cellules souches hematopoietiques dans des cultures de cellules mononucleaires - Google Patents

Expansion ex vivo de populations de cellules souches hematopoietiques dans des cultures de cellules mononucleaires Download PDF

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Publication number
WO2004016731A3
WO2004016731A3 PCT/IL2003/000681 IL0300681W WO2004016731A3 WO 2004016731 A3 WO2004016731 A3 WO 2004016731A3 IL 0300681 W IL0300681 W IL 0300681W WO 2004016731 A3 WO2004016731 A3 WO 2004016731A3
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WO
WIPO (PCT)
Prior art keywords
hematopoietic stem
vivo expansion
stem cell
mononuclear
cell cultures
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Ceased
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PCT/IL2003/000681
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English (en)
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WO2004016731A2 (fr
Inventor
Tony Peled
Avi Treves
Oren Rosen
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Gamida Cell Ltd
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Gamida Cell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL15290402A external-priority patent/IL152904A0/xx
Priority claimed from PCT/IL2003/000062 external-priority patent/WO2003062404A1/fr
Priority to EP03787995A priority Critical patent/EP1534820A4/fr
Priority to BR0314402-0A priority patent/BR0314402A/pt
Priority to JP2005502022A priority patent/JP2006508692A/ja
Priority to CA002495824A priority patent/CA2495824A1/fr
Priority to AU2003250519A priority patent/AU2003250519A1/en
Priority to MXPA05001992A priority patent/MXPA05001992A/es
Application filed by Gamida Cell Ltd filed Critical Gamida Cell Ltd
Publication of WO2004016731A2 publication Critical patent/WO2004016731A2/fr
Priority to EP04717214A priority patent/EP1601759A4/fr
Priority to CA002517959A priority patent/CA2517959A1/fr
Priority to AU2004217699A priority patent/AU2004217699B2/en
Priority to US10/795,215 priority patent/US20050054103A1/en
Priority to PCT/IL2004/000215 priority patent/WO2004078917A2/fr
Priority to JP2006507579A priority patent/JP2006521813A/ja
Publication of WO2004016731A3 publication Critical patent/WO2004016731A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2503/00—Use of cells in diagnostics
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    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés ex vivo d'expansion de cellules souches hématopoïétiques de cellules mononucléaires hématopoïétiques qui comprennent une fraction majeure de cellules hématopoïétiques engagées et une fraction mineure de cellules souches hématopoïétiques et de cellules progénitrices hématopoïétiques, et des populations développées de cellules souches hématopoïétiques obtenues à partir de ces procédés ainsi que leurs utilisations.
PCT/IL2003/000681 2002-08-19 2003-08-17 Expansion ex vivo de populations de cellules souches hematopoietiques dans des cultures de cellules mononucleaires Ceased WO2004016731A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP03787995A EP1534820A4 (fr) 2002-08-19 2003-08-17 Expansion ex vivo de populations de cellules souches hematopoietiques dans des cultures de cellules mononucleaires
BR0314402-0A BR0314402A (pt) 2002-08-19 2003-08-17 Expansão ex-vivo de populações de células raìzes em culturas celulares mononucleares
JP2005502022A JP2006508692A (ja) 2002-08-19 2003-08-17 単核細胞培養物における造血幹細胞集団のエクスビボ拡大
CA002495824A CA2495824A1 (fr) 2002-08-19 2003-08-17 Expansion ex vivo de populations de cellules souches hematopoieti ques dans des cultures de cellules mononucleaires
AU2003250519A AU2003250519A1 (en) 2002-08-19 2003-08-17 Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures
MXPA05001992A MXPA05001992A (es) 2002-08-19 2003-08-17 Expansion ex-vivo de poblaciones de celulas de tallo, hematopoyeticas, en cultivos de celulas mononucleares.
JP2006507579A JP2006521813A (ja) 2003-03-07 2004-03-04 Ｐｉ３−キナーゼの調節剤を用いた再生可能な幹細胞集団の拡大
EP04717214A EP1601759A4 (fr) 2003-03-07 2004-03-04 Extension de populations de cellules souches renouvelables au moyen de modulateurs de kinase pi 3
PCT/IL2004/000215 WO2004078917A2 (fr) 2003-03-07 2004-03-04 Extension de populations de cellules souches renouvelables au moyen de modulateurs de kinase pi 3
US10/795,215 US20050054103A1 (en) 2003-03-07 2004-03-04 Expansion of renewable stem cell populations using modulators of PI 3-kinase
CA002517959A CA2517959A1 (fr) 2003-03-07 2004-03-04 Extension de populations de cellules souches renouvelables au moyen de modulateurs de kinase pi 3
AU2004217699A AU2004217699B2 (en) 2003-03-07 2004-03-04 Expansion of renewable stem cell populations using modulators of PI 3-kinase

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US40413702P 2002-08-19 2002-08-19
US40414502P 2002-08-19 2002-08-19
US60/404,145 2002-08-19
US60/404,137 2002-08-19
IL152904 2002-11-17
IL15290402A IL152904A0 (en) 2002-01-24 2002-11-17 Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
ILPCT/IL03/00062 2003-01-23
PCT/IL2003/000062 WO2003062404A1 (fr) 2002-01-25 2003-01-23 Methodes de developpement de cellules souches et de cellules precurseurs, populations de cellules multipliees obtenues a l'aide de ces methodes
PCT/IL2003/000064 WO2003062369A2 (fr) 2002-01-24 2003-01-26 Developpement de populations de cellules souches renouvelables
ILPCT/IL03/00064 2003-01-26
US45254503P 2003-03-07 2003-03-07
US60/452,545 2003-03-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/795,215 Continuation-In-Part US20050054103A1 (en) 2003-03-07 2004-03-04 Expansion of renewable stem cell populations using modulators of PI 3-kinase

Publications (2)

Publication Number Publication Date
WO2004016731A2 WO2004016731A2 (fr) 2004-02-26
WO2004016731A3 true WO2004016731A3 (fr) 2004-09-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000681 Ceased WO2004016731A2 (fr) 2002-08-19 2003-08-17 Expansion ex vivo de populations de cellules souches hematopoietiques dans des cultures de cellules mononucleaires

Country Status (7)

Country Link
EP (1) EP1534820A4 (fr)
JP (1) JP2006508692A (fr)
AU (1) AU2003250519A1 (fr)
BR (1) BR0314402A (fr)
CA (1) CA2495824A1 (fr)
MX (1) MXPA05001992A (fr)
WO (1) WO2004016731A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018885A1 (fr) 1998-09-29 2000-04-06 Gamida Cell Ltd. Procedes de regulation de la proliferation et de la differentiation de cellules souches et precurseurs
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (fr) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methodes de developpement de cellules souches et de cellules precurseurs, populations de cellules multipliees obtenues a l'aide de ces methodes
US20050054103A1 (en) * 2003-03-07 2005-03-10 Tony Peled Expansion of renewable stem cell populations using modulators of PI 3-kinase
US8361976B2 (en) 2004-07-09 2013-01-29 University Of Massachusetts Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
KR20080072748A (ko) * 2005-11-29 2008-08-06 가미다-셀 리미티드 줄기세포 귀소 및 생착을 향상시키는 방법
EP2798956A1 (fr) 2007-04-23 2014-11-05 Stowers Institute for Medical Research Procedes et compositions pour auto-renouvellement de cellules souches hematopoeitiques
KR101594046B1 (ko) 2008-01-09 2016-02-15 첼카 게엠베하 개선된 배양 배지 첨가제 및 이를 이용한 방법
HK1202581A1 (en) 2012-02-13 2015-10-02 Gamida-Cell Ltd. Mesenchymal stem cells conditioned medium and methods of generating and using the same
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
CA3036926C (fr) * 2016-09-30 2022-05-31 Poseida Therapeutics, Inc. Cellules t de memoire de cellules souches modifiees, procedes de fabrication et procedes d'utilisation correspondants
US20190119636A1 (en) 2017-10-23 2019-04-25 Poseida Therapeutics, Inc. Modified stem cell memory t cells, methods of making and methods of using same

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WO2003078567A2 (fr) * 2002-03-18 2003-09-25 Gamida-Cell Ltd. Procedes permettant d'induire la differenciation dans des cellules souches expansees ex vivo

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PELED T. ET AL: "Regulation of long-term expansion of hemopoietic stem/progenitor cells (HPC) by intracellular copper content", BLOOD, vol. 96, no. 1, 16 November 2000 (2000-11-16), pages 776A - 777A, XP002978694 *
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SCHMETZER H.M. ET AL: "Effect of GMCSF 1,25 Dihydroxycholecalciferol (Vit.D) and all-trans-retinoic acid (ATRA) on the proliferation and differentiation of MDS-bone marrow (BM)-cells in vitro", HEMATOLOGY, vol. 2, 1997, pages 11 - 19, XP002978933 *
See also references of EP1534820A4 *
SHIMAKURA Y. ET AL: "Murine stromal cell line HESS-5 maintains reconstituting ability of ex vivo-generated hematopoietic stem cells from human bone marrow and cytokine-mobilized peripheral blood", STEM CELLS, vol. 18, 2000, pages 183 - 189, XP002978668 *
VERLINDEN L. ET AL: "Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements", JOURNAL OF BONE AND MINERAL RESEARCH, vol. 16, no. 4, 2001, pages 625 - 638, XP002978669 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment

Also Published As

Publication number Publication date
MXPA05001992A (es) 2005-08-03
EP1534820A2 (fr) 2005-06-01
CA2495824A1 (fr) 2004-02-26
JP2006508692A (ja) 2006-03-16
AU2003250519A8 (en) 2004-03-03
WO2004016731A2 (fr) 2004-02-26
AU2003250519A1 (en) 2004-03-03
EP1534820A4 (fr) 2006-04-26
BR0314402A (pt) 2005-07-19

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