WO2004033728A3 - Nucleic acid amplification primers for pcr-based clonality studies - Google Patents

Nucleic acid amplification primers for pcr-based clonality studies Download PDF

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Publication number
WO2004033728A3
WO2004033728A3 PCT/NL2003/000690 NL0300690W WO2004033728A3 WO 2004033728 A3 WO2004033728 A3 WO 2004033728A3 NL 0300690 W NL0300690 W NL 0300690W WO 2004033728 A3 WO2004033728 A3 WO 2004033728A3
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WO
WIPO (PCT)
Prior art keywords
rearrangement
pcr
igh
tcrd
nucleic acid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/NL2003/000690
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French (fr)
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WO2004033728A2 (en
Inventor
Dongen Jacobus Johannes Ma Van
Anthonie Willem Langerak
Eduardus Maria Domin Schuuring
Miquel Jesus Fernando San
Sanz Ramon Garzia
Antonio Parreira
John Lewis Smith
Frances Louise Lavender
Gareth John Morgan
Paul Anthony Stuart Evans
Michael Kneba
Michael Hummel
Elizabeth Anne Macintyre
Christian Bastard
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Erasmus Universiteit Rotterdam
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Erasmus Universiteit Rotterdam
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Priority to US10/531,106 priority Critical patent/US8859748B2/en
Application filed by Erasmus Universiteit Rotterdam filed Critical Erasmus Universiteit Rotterdam
Priority to JP2004542919A priority patent/JP4708029B2/en
Priority to AT03756746T priority patent/ATE483822T1/en
Priority to AU2003300565A priority patent/AU2003300565A1/en
Priority to DE60334471T priority patent/DE60334471D1/en
Priority to DK03756746.8T priority patent/DK1549764T3/en
Priority to EP03756746A priority patent/EP1549764B1/en
Priority to CA002501863A priority patent/CA2501863A1/en
Publication of WO2004033728A2 publication Critical patent/WO2004033728A2/en
Publication of WO2004033728A3 publication Critical patent/WO2004033728A3/en
Anticipated expiration legal-status Critical
Priority to US14/312,583 priority patent/US10280462B2/en
Priority to US16/404,583 priority patent/US20200172973A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a Vλ-Jλ IGL rearrangement, a Vß-Jß TCRB rearrangement, a Dß-Jß TCRB rearrangement, a VϜ-JϜ TCRG rearrangement, a Vδ-Jδ TCRD rearrangement, a Dδ-Dδ TCRD rearrangement, a Dδ-Jδ TCRD rearrangement, a Vδ-Dδ TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.
PCT/NL2003/000690 2002-10-11 2003-10-13 Nucleic acid amplification primers for pcr-based clonality studies Ceased WO2004033728A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP03756746A EP1549764B1 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for pcr-based clonality studies
DK03756746.8T DK1549764T3 (en) 2002-10-11 2003-10-13 Primers for nucleic acid amplification in PCR-based clonality studies
JP2004542919A JP4708029B2 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for PCR-based clonality studies
AT03756746T ATE483822T1 (en) 2002-10-11 2003-10-13 PRIMERS FOR NUCLEIC ACID AMPLIFICATION IN PCR-BASED CLONALITY STUDIES
AU2003300565A AU2003300565A1 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for pcr-based clonality studies
DE60334471T DE60334471D1 (en) 2002-10-11 2003-10-13 NUCLEIC ACID AMPLIFICATION PRIMERS IN PCR-BASED CLONALITY STUDIES
CA002501863A CA2501863A1 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for pcr-based clonality studies
US10/531,106 US8859748B2 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for PCR-based clonality studies
US14/312,583 US10280462B2 (en) 2002-10-11 2014-06-23 Nucleic acid amplification primers for PCR-based clonality studies
US16/404,583 US20200172973A1 (en) 2002-10-11 2019-05-06 Nucleic acid amplification primers for pcr-based clonality studies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41777902P 2002-10-11 2002-10-11
US60/417,779 2002-10-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/531,106 A-371-Of-International US8859748B2 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for PCR-based clonality studies
US14/312,583 Continuation US10280462B2 (en) 2002-10-11 2014-06-23 Nucleic acid amplification primers for PCR-based clonality studies

Publications (2)

Publication Number Publication Date
WO2004033728A2 WO2004033728A2 (en) 2004-04-22
WO2004033728A3 true WO2004033728A3 (en) 2004-08-12

Family

ID=32094087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2003/000690 Ceased WO2004033728A2 (en) 2002-10-11 2003-10-13 Nucleic acid amplification primers for pcr-based clonality studies

Country Status (11)

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US (3) US8859748B2 (en)
EP (3) EP2418287B1 (en)
JP (1) JP4708029B2 (en)
CN (1) CN1965089A (en)
AT (1) ATE483822T1 (en)
AU (1) AU2003300565A1 (en)
CA (1) CA2501863A1 (en)
DE (1) DE60334471D1 (en)
DK (2) DK2418287T3 (en)
ES (3) ES2442791T3 (en)
WO (1) WO2004033728A2 (en)

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US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US10077478B2 (en) 2012-03-05 2018-09-18 Adaptive Biotechnologies Corp. Determining paired immune receptor chains from frequency matched subunits
CN110656161B (en) * 2018-06-28 2022-12-13 苏州云泰生物医药科技有限公司 Capillary electrophoresis kit for detecting human immunoglobulin gene rearrangement and use method thereof

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