WO2004065546A3 - Compositions et procedes destines a l'inhibition du gene icam-1 par arn a faible inhibition - Google Patents

Compositions et procedes destines a l'inhibition du gene icam-1 par arn a faible inhibition Download PDF

Info

Publication number
WO2004065546A3
WO2004065546A3 PCT/US2004/001166 US2004001166W WO2004065546A3 WO 2004065546 A3 WO2004065546 A3 WO 2004065546A3 US 2004001166 W US2004001166 W US 2004001166W WO 2004065546 A3 WO2004065546 A3 WO 2004065546A3
Authority
WO
WIPO (PCT)
Prior art keywords
icam
compositions
methods
small interfering
interfering rnas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/001166
Other languages
English (en)
Other versions
WO2004065546A2 (fr
Inventor
Samuel Jotham Reich
Michael J Tolentino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Priority to AU2004205895A priority Critical patent/AU2004205895B2/en
Priority to EP04702982A priority patent/EP1604010B1/fr
Priority to AT04702982T priority patent/ATE477337T1/de
Priority to JP2006500988A priority patent/JP2007524349A/ja
Priority to MXPA05007651A priority patent/MXPA05007651A/es
Priority to DE602004028587T priority patent/DE602004028587D1/de
Priority to CA002513623A priority patent/CA2513623A1/fr
Publication of WO2004065546A2 publication Critical patent/WO2004065546A2/fr
Anticipated expiration legal-status Critical
Publication of WO2004065546A3 publication Critical patent/WO2004065546A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)

Abstract

L'invention concerne l'utilisation d'ARN, notamment des ARN à faible intervention spécifiques au gène ICAM-1, qui permet d'inhiber l'expression de ce gène. Des maladies qui sont liées à l'adhérence cellulaire à médiation par ICAM-1 telles que les maladies inflammatoires ou auto-immunes, la rétinopathie diabétique et d'autres complications provoquées par le diabète de type I, la dégénérescence maculaire liée à l'âge et plusieurs types de cancer, peuvent être traités par l'administration d'ARN à faible intervention.
PCT/US2004/001166 2003-01-16 2004-01-16 Compositions et procedes destines a l'inhibition du gene icam-1 par arn a faible inhibition Ceased WO2004065546A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2004205895A AU2004205895B2 (en) 2003-01-16 2004-01-16 Compositions and methods for siRNA inhibition of ICAM-1
EP04702982A EP1604010B1 (fr) 2003-01-16 2004-01-16 Compositions et procedes destines a l'inhibition du gene icam-1 par arn a faible inhibition
AT04702982T ATE477337T1 (de) 2003-01-16 2004-01-16 Zusammensetzungen und verfahren zur sirna-hemmung von icam-1
JP2006500988A JP2007524349A (ja) 2003-01-16 2004-01-16 ＩＣＡＭ−１のｓｉＲＮＡ阻害のための組成物及び方法
MXPA05007651A MXPA05007651A (es) 2003-01-16 2004-01-16 Composiciones y metodos para la inhibicion por arnsi de la molecula de adhesion intercelular-1.
DE602004028587T DE602004028587D1 (de) 2003-01-16 2004-01-16 ZUSAMMENSETZUNGEN UND VERFAHREN ZUR siRNA-HEMMUNG VON ICAM-1
CA002513623A CA2513623A1 (fr) 2003-01-16 2004-01-16 Compositions et procedes destines a l'inhibition du gene icam-1 par arn a faible inhibition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44057903P 2003-01-16 2003-01-16
US60/440,579 2003-01-16

Publications (2)

Publication Number Publication Date
WO2004065546A2 WO2004065546A2 (fr) 2004-08-05
WO2004065546A3 true WO2004065546A3 (fr) 2006-03-23

Family

ID=32771836

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001166 Ceased WO2004065546A2 (fr) 2003-01-16 2004-01-16 Compositions et procedes destines a l'inhibition du gene icam-1 par arn a faible inhibition

Country Status (9)

Country Link
US (4) US20040220129A1 (fr)
EP (2) EP2251434B1 (fr)
JP (1) JP2007524349A (fr)
AT (1) ATE477337T1 (fr)
AU (1) AU2004205895B2 (fr)
CA (1) CA2513623A1 (fr)
DE (1) DE602004028587D1 (fr)
MX (1) MXPA05007651A (fr)
WO (1) WO2004065546A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US9139554B2 (en) 2008-10-09 2015-09-22 Tekmira Pharmaceuticals Corporation Amino lipids and methods for the delivery of nucleic acids

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001264317A1 (en) * 2000-06-20 2002-01-02 Koken Co., Ltd. Preparations for oligonucleotide transfer
US20050203040A1 (en) * 2001-05-18 2005-09-15 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
US20050187174A1 (en) * 2001-05-18 2005-08-25 Sirna Therapeutics, Inc. RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
US20050048529A1 (en) * 2002-02-20 2005-03-03 Sirna Therapeutics, Inc. RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
EP1407787B1 (fr) * 2001-06-20 2009-04-29 Dainippon Sumitomo Pharma Co., Ltd. Procede facilitant le transfert d'acides nucleiques
IL163547A0 (en) * 2002-02-12 2005-12-18 Quark Biotech Inc Use of the axl receptor for diagnosis and treatment of renal disease
US20090192105A1 (en) * 2002-02-20 2009-07-30 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA)
EP1495120B1 (fr) * 2002-04-18 2012-10-10 Acuity Pharmaceuticals, Inc Moyens et procedes pour la modulation specifique de genes cibles dans l'oeil
EP1519714B1 (fr) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Appareil liposomal et procedes de fabrication
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
US20050048641A1 (en) * 2002-11-26 2005-03-03 Medtronic, Inc. System and method for delivering polynucleotides to the central nervous system
JP2007524349A (ja) * 2003-01-16 2007-08-30 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア ＩＣＡＭ−１のｓｉＲＮＡ阻害のための組成物及び方法
AU2004233043A1 (en) * 2003-04-18 2004-11-04 The Trustees Of The University Of Pennsylvania Compositions and methods for siRNA inhibition of angiopoietin 1 and 2 and their receptor Tie2
CA2532228C (fr) * 2003-07-16 2017-02-14 Protiva Biotherapeutics, Inc. Arn interferant encapsule dans un lipide
WO2005045039A2 (fr) * 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. Inhibition mediee par un arn a interference de l'expression genique d'une molecule d'adhesion intercellulaire (icam) a l'aide d'un acide nucleique court a interference (sina)
JP4764426B2 (ja) 2004-06-07 2011-09-07 プロチバ バイオセラピューティクス インコーポレイティッド カチオン性脂質および使用方法
CA2569664C (fr) 2004-06-07 2013-07-16 Protiva Biotherapeutics, Inc. Arn interferant encapsule dans des lipides
EP1773857A4 (fr) 2004-07-02 2009-05-13 Protiva Biotherapeutics Inc Molecules sirna immunostimulatrices et utilisations de celles-ci
EP1789447B1 (fr) 2004-08-16 2012-04-25 Immune Disease Institute, Inc. Méthode d'interférence arn et utilisations
WO2006039656A2 (fr) 2004-10-01 2006-04-13 Novartis Vaccines And Diagnostics Inc. Molecules de petits arn interferants modifiees et methodes d'utilisation de celles-ci
US8765704B1 (en) 2008-02-28 2014-07-01 Novartis Ag Modified small interfering RNA molecules and methods of use
US20060089324A1 (en) * 2004-10-22 2006-04-27 Sailen Barik RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
US7790878B2 (en) 2004-10-22 2010-09-07 Alnylam Pharmaceuticals, Inc. RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
TWI386225B (zh) 2004-12-23 2013-02-21 Alcon Inc 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術
DE102005003788A1 (de) 2005-01-19 2006-07-20 Eberhard-Karls-Universität Tübingen Universitätsklinikum siRNA-Moleküle zur Behandlung von Blutgefäßen
WO2007048046A2 (fr) 2005-10-20 2007-04-26 Protiva Biotherapeutics, Inc. Extinction par arnsi de l'expression du gene de filovirus
CN101346393B (zh) 2005-11-02 2015-07-22 普洛体维生物治疗公司 修饰的siRNA分子及其应用
US20090130212A1 (en) * 2006-05-15 2009-05-21 Physical Pharmaceutica, Llc Composition and improved method for preparation of small particles
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
DK2029746T3 (da) * 2006-06-12 2012-10-08 Exegenics Inc D B A Opko Health Inc Sammensætninger og fremgangsmåder til siRNA-hæmning af angiogenese
US7872118B2 (en) * 2006-09-08 2011-01-18 Opko Ophthalmics, Llc siRNA and methods of manufacture
WO2008097926A2 (fr) 2007-02-02 2008-08-14 Yale University Transfection transitoire avec de l'arn
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
WO2009026328A2 (fr) * 2007-08-21 2009-02-26 Immune Disease Institute, Inc. Procédés d'administration d'agents à des leucocytes et des cellules endothéliales
ES2830024T3 (es) * 2007-10-19 2021-06-02 Novartis Ag Composiciones y métodos para el tratamiento del edema macular
CA2721333C (fr) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Nouvelles formulations lipidiques pour l'administration d'acides nucleiques
AU2009322279A1 (en) 2008-12-04 2011-07-14 Opko Pharmaceuticals, Llc Compositions and methods for selective inhibition of pro-angiogenic VEGF isoforms
WO2010111497A2 (fr) * 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. Inhibition à médiation par l'interférence arn de l'expression du gène de la molécule d'adhésion intercellulaire 1 (icam-1) faisant appel à de courts acides nucléiques interférents (ansi)
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011000107A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Formulations lipidiques inédites permettant l'administration d'agents thérapeutiques en direction de tumeurs solides
US8716464B2 (en) 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
US8833942B2 (en) * 2009-11-12 2014-09-16 Agency For Science, Technology And Research Method and device for monitoring retinopathy
WO2011115810A2 (fr) * 2010-03-16 2011-09-22 Massachusetts Institute Of Technology Arni spécifique d'une isoforme basé sur une redondance ou une dégénérescence de codons
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
US20120310140A1 (en) 2010-12-01 2012-12-06 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
WO2013123996A1 (fr) * 2012-02-24 2013-08-29 Astrazeneca Uk Limited Nouveaux inhibiteurs d'arnsi de icam-1 humain
US9833523B2 (en) 2012-04-24 2017-12-05 The Ohio State University Pharmacokinetic determination of intravitreal agents
JP2015003902A (ja) 2013-05-20 2015-01-08 杏林製薬株式会社 血管新生阻害剤
WO2015006501A2 (fr) 2013-07-09 2015-01-15 President And Fellows Of Harvard College Marqueurs de surface de cellules endothéliales de microvaisseaux et utilisations de ceux-ci
EP3019203A4 (fr) * 2013-07-09 2017-04-26 President and Fellows of Harvard College Gènes de cellules endothéliales et leurs utilisations
AU2014296278C1 (en) * 2013-07-30 2023-02-02 Genevant Sciences Gmbh Block copolymers and their conjugates or complexes with oligonucleotides
EP3052189A4 (fr) * 2013-10-03 2017-11-01 Leuvas Therapeutics Modulation de l'activité leucocytaire dans le traitement d'une maladie dégénérative neuro-inflammatoire
US10900039B2 (en) 2014-09-05 2021-01-26 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
US12544344B2 (en) 2017-04-19 2026-02-10 Phio Pharmaceuticals Corp. Topical delivery of nucleic acid compounds
WO2019071007A1 (fr) * 2017-10-05 2019-04-11 New York Genome Center, Inc. Procédés et compositions pour le ciblage du mimétisme vasculaire
US11274303B2 (en) 2017-10-06 2022-03-15 The Regents Of The University Of California Olmalinc as a diagnostic and therapeutic target for NAFLD, NASH, metabolic syndrome, and hepatic fibrosis
JP2023524679A (ja) 2020-04-30 2023-06-13 フィジーン、エルエルシー 癌線維芽細胞を標的化するための免疫療法の方法および組成物
WO2022115645A1 (fr) 2020-11-25 2022-06-02 Akagera Medicines, Inc. Nanoparticules lipidiques utilisées pour l'administration d'acides nucléiques, et méthodes d'utilisation associées
CA3256897A1 (fr) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Nanoparticules lipidiques pour l'administration d'acides nucléiques et leurs procédés d'utilisation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015894A (en) * 1990-08-14 2000-01-18 Isis Pharmaceuticals Inc. Oligonucleotide modulation of cell adhesion

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US6096722A (en) * 1990-08-14 2000-08-01 Isis Pharmaceuticals Inc. Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases
US6111094A (en) 1990-08-14 2000-08-29 Isis Pharmaceuticals Inc. Enhanced antisense modulation of ICAM-1
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
US6177401B1 (en) * 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
FR2786102B1 (fr) 1998-11-20 2001-02-16 Monique Vincens Utilisation de sulfate de dehydroepiandrosterone pour augmenter le nombre de recepteurs nmda chez un mammifere
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
WO2000046147A2 (fr) 1999-02-03 2000-08-10 Biosante Pharmaceuticals, Inc. Particules therapeutiques de phosphate de calcium et procedes de fabrication et d'utilisation associes
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
EP1272630A2 (fr) * 2000-03-16 2003-01-08 Genetica, Inc. Procedes et compositions d'interference d'arn
ES2336887T5 (es) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediadores de interferencia por ARN específicos de secuencias de ARN
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20020132788A1 (en) * 2000-11-06 2002-09-19 David Lewis Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo
US20020173478A1 (en) * 2000-11-14 2002-11-21 The Trustees Of The University Of Pennsylvania Post-transcriptional gene silencing by RNAi in mammalian cells
CA2429814C (fr) * 2000-12-01 2014-02-18 Thomas Tuschl Petites molecules d'arn mediant l'interference arn
US20050048529A1 (en) * 2002-02-20 2005-03-03 Sirna Therapeutics, Inc. RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
US20050187174A1 (en) * 2001-05-18 2005-08-25 Sirna Therapeutics, Inc. RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
US20030108958A1 (en) * 2001-06-28 2003-06-12 Rene De Waal Malefyt Biological activity of AK155
US7195916B2 (en) * 2001-09-13 2007-03-27 California Institute Of Technology Method for expression of small antiviral RNA molecules within a cell
AU2003237686A1 (en) 2002-05-24 2003-12-12 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. Rna interference mediating small rna molecules
JP2007524349A (ja) * 2003-01-16 2007-08-30 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア ＩＣＡＭ−１のｓｉＲＮＡ阻害のための組成物及び方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015894A (en) * 1990-08-14 2000-01-18 Isis Pharmaceuticals Inc. Oligonucleotide modulation of cell adhesion

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
AGAMI R ET AL: "RNAi and related mechanisms and their potential use for therapy.", CURR OPIN CHEM BIOL., vol. 6, 2002, pages 829 - 834, XP002239988 *
AGRAWAL S ET AL: "Antisense therapeutics: is it as simple as complementary base recognition?", MOLECULAR MEDICINE TODAY., vol. 6, 2000, pages 72 - 81, XP002952062 *
CAPLEN N J ET AL: "Gene therapy: RNAi as a gene therapy approach.", EXPERT OPIN BIOL THER., vol. 3, 2003, pages 575 - 586, XP008055014 *
COBURN G A ET AL: "siRNAs: a new wave of RNA-based therapeutics.", J ANTIMICROB CHEMOTHER., vol. 51, 2003, pages 753 - 756, XP002992788 *
DRAGUN D ET AL: "ICAM-1 antisense oligodeoxynucleotide prevent reperfusion injury and enhance immediate graft function in renal transplantation.", KIDNEY INTERNATIONAL., vol. 54, 1998, pages 590 - 602, XP002996069 *
ELBASHIR S M ET AL: "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.", NATURE., vol. 411, 2001, pages 494 - 498, XP002206451 *
JEN K Y ET AL: "Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies.", STEM CELLS., vol. 18, 2000, pages 307 - 319, XP002181426 *
KATZ S M ET AL: "ICAM-1 antisense oligodeoxynucleotide improves islet allograft survival and function.", CELL TRANSPLANTATION., vol. 9, 2000, pages 817 - 828, XP008062495 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139554B2 (en) 2008-10-09 2015-09-22 Tekmira Pharmaceuticals Corporation Amino lipids and methods for the delivery of nucleic acids
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents

Also Published As

Publication number Publication date
EP2251434A1 (fr) 2010-11-17
JP2007524349A (ja) 2007-08-30
EP1604010B1 (fr) 2010-08-11
US20090104260A1 (en) 2009-04-23
CA2513623A1 (fr) 2004-08-05
US20110092571A1 (en) 2011-04-21
DE602004028587D1 (de) 2010-09-23
US7847090B2 (en) 2010-12-07
EP1604010A2 (fr) 2005-12-14
AU2004205895B2 (en) 2009-02-26
US20120276192A1 (en) 2012-11-01
EP1604010A4 (fr) 2006-10-25
WO2004065546A2 (fr) 2004-08-05
US20040220129A1 (en) 2004-11-04
AU2004205895A1 (en) 2004-08-05
MXPA05007651A (es) 2005-10-26
ATE477337T1 (de) 2010-08-15
EP2251434B1 (fr) 2014-07-30
US8193163B2 (en) 2012-06-05

Similar Documents

Publication Publication Date Title
WO2004065546A3 (fr) Compositions et procedes destines a l'inhibition du gene icam-1 par arn a faible inhibition
WO2004009769A3 (fr) Compositions et procede d'inhibition de l'angiogenese par arn-si
WO2004042024A3 (fr) Compositions et procedes destines a l'inhibition par arnsi des hif-1 alpha
WO2007067981A3 (fr) INHIBITION PRODUITE PAR UNE INTERFÉRENCE AVEC UN ARN DE L'EXPRESSION DES GÈNES DU FACTEUR DE CROISSANCE DE L'ENDOTHÉLIUM VASCULAIRE ET DU RÉCEPTEUR DU FACTEUR DE CROISSANCE DE L'ENDOTHÉLIUM VASCULAIRE EN UTILISANT UN PETIT ACIDE NUCLÉIQUE INTERFÉRENT (ANsi)
WO2007115168A8 (fr) Compositions et méthodes destinées à inhiber l'expression du gène eg5
WO2007134161A3 (fr) Compositions et procédés d'inhibition de l'expression du gène pcsk9
WO2004094606A3 (fr) Compositions et methodes d'inhibition par arnic de l'angiopoietine 1 et 2 et de leur recepteur tie2
WO2011008730A3 (fr) Modification chimique de petits arn en épingle à cheveux pour l'inhibition d'une expression de gène
WO2008131419A3 (fr) Glycoconjugués d'agents d'interférence arn
WO2007051045A3 (fr) Compositions et methodes destinees a inhiber l'expression du gene huntingtine
WO2003064621A3 (fr) Courts fragments d'arn interferant haute activite visant a reduire l'expression de genes cibles
WO2008036638A3 (fr) MODULATION PAR L'ARNi DE GÈNE SCAP ET UTILISATIONS THÉRAPEUTIQUES
WO2008008719A3 (fr) Compositions et procédés permettant d'inhiber l'expression du gène myc
WO2010080129A3 (fr) Agents allongés servant de substrats de dicer et procédés d'inhibition spécifique de l'expression d'un gène
WO2005007623A8 (fr) Inhibition de l'expression d'une syk kinase
WO2007137156A3 (fr) Modulation d'aha par l'arn et utilisateurs thérapeutiques de celle-ci
WO2011116152A3 (fr) Administration d'agents par le biais de l'utilisation de nanoparticules interférentes
WO2005018534A3 (fr) Procedes et compositions d'interference d'arn
WO2007137220A3 (fr) Compositions et méthodes inhibant l'expression du gène ikk-b
WO2007117121A3 (fr) Thérapie génique pour le traitement du cancer utilisant un petit arn interférent spécifique de ant2 et méthode permettant de surmonter la tolérance aux agents antitumoraux
WO2005112636A3 (fr) Compositions et procedes d'inhibition par arnic de genes du virus du polyome primate
WO2004022782A3 (fr) Compositions et methodes d'inhibition a specificite ou declenchement tissulaire de l'expression de genes
WO2005062957A3 (fr) Compositions et procedes pour la therapie combinee de maladie
WO2007032794A3 (fr) Inhibition de l'expression genique virale a l'aide d'un petit arn interferent
WO2006045591A3 (fr) Procede et produits de synthese permettant d'administrer un arn en double brin a des organismes de parasites

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004205895

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: PA/a/2005/007651

Country of ref document: MX

Ref document number: 2513623

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004702982

Country of ref document: EP

Ref document number: 2006500988

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2004205895

Country of ref document: AU

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWP Wipo information: published in national office

Ref document number: 2004702982

Country of ref document: EP