WO2004106925A3 - Procedes et appareil utilises pour la detection et la quantification de divers types de cellules et utilisation d'un bio-disque optique pour leur mise en oeuvre - Google Patents

Procedes et appareil utilises pour la detection et la quantification de divers types de cellules et utilisation d'un bio-disque optique pour leur mise en oeuvre Download PDF

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Publication number
WO2004106925A3
WO2004106925A3 PCT/IB2004/002780 IB2004002780W WO2004106925A3 WO 2004106925 A3 WO2004106925 A3 WO 2004106925A3 IB 2004002780 W IB2004002780 W IB 2004002780W WO 2004106925 A3 WO2004106925 A3 WO 2004106925A3
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Prior art keywords
methods
disc
quantitation
detection
cell types
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Ceased
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PCT/IB2004/002780
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English (en)
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WO2004106925A2 (fr
Inventor
James Howard Coombs
John Francis Gordon
Brigitte Chau Phan
Joseph Roby Iringan Urcia
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Priority to EP04769197A priority Critical patent/EP1599730A2/fr
Priority to AU2004243690A priority patent/AU2004243690A1/en
Priority to JP2006530721A priority patent/JP2007501407A/ja
Priority to CA002518677A priority patent/CA2518677A1/fr
Publication of WO2004106925A2 publication Critical patent/WO2004106925A2/fr
Publication of WO2004106925A3 publication Critical patent/WO2004106925A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Signal Processing (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention se rapporte à des procédés et un appareil permettant d'effectuer des numérations différentielles de cellules, y compris des leucocytes, et à l'utilisation de bio-disques optiques pour réaliser de telles numérations de cellules. Le bio-disque comprend un substrat sensiblement circulaire présentant un centre et un bord périphérique, une couche active associée au substrat, une zone cible disposée entre le centre et le bord périphérique et une pluralité d'anticorps de capture liés à la couche active de sorte que les anticorps sont immobilisés sur la couche active dans la zone cible.
PCT/IB2004/002780 2003-03-03 2004-03-02 Procedes et appareil utilises pour la detection et la quantification de divers types de cellules et utilisation d'un bio-disque optique pour leur mise en oeuvre Ceased WO2004106925A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04769197A EP1599730A2 (fr) 2003-03-03 2004-03-02 Procedes et appareil utilises pour la detection et la quantification de divers types de cellules et utilisation d'un bio-disque optique pour leur mise en oeuvre
AU2004243690A AU2004243690A1 (en) 2003-03-03 2004-03-02 Methods and apparatus for use in detection and quantitation of various cell types and use of optical bio-disc for performing same
JP2006530721A JP2007501407A (ja) 2003-03-03 2004-03-02 多様な細胞タイプの検出および定量に使用される方法および装置並びにこれを行うための光バイオディスクの使用
CA002518677A CA2518677A1 (fr) 2003-03-03 2004-03-02 Procedes et appareil utilises pour la detection et la quantification de divers types de cellules et utilisation d'un bio-disque optique pour leur mise en oeuvre

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45158703P 2003-03-03 2003-03-03
US60/451,587 2003-03-03

Publications (2)

Publication Number Publication Date
WO2004106925A2 WO2004106925A2 (fr) 2004-12-09
WO2004106925A3 true WO2004106925A3 (fr) 2005-06-16

Family

ID=33489410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002780 Ceased WO2004106925A2 (fr) 2003-03-03 2004-03-02 Procedes et appareil utilises pour la detection et la quantification de divers types de cellules et utilisation d'un bio-disque optique pour leur mise en oeuvre

Country Status (7)

Country Link
US (1) US20050032126A1 (fr)
EP (1) EP1599730A2 (fr)
JP (1) JP2007501407A (fr)
CN (1) CN101044404A (fr)
AU (1) AU2004243690A1 (fr)
CA (1) CA2518677A1 (fr)
WO (1) WO2004106925A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7271913B2 (en) * 2003-11-24 2007-09-18 General Electric Company Sensor systems and methods for remote quantification of compounds
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
JP2007522131A (ja) 2004-01-23 2007-08-09 アドバンスド セル テクノロジー、インコーポレイテッド 網膜変性疾患治療のための改良された様式
US20080261297A1 (en) * 2005-05-20 2008-10-23 Rmit University Assay Device
GB0614297D0 (en) * 2006-07-19 2006-08-30 Shaw Water Engineering Ltd Apparatus, system and method for detecting particles
US7521200B2 (en) * 2006-10-05 2009-04-21 Michael Glogauer Method for non-invasive rinse diagnosis and monitoring of periodontal diseases using colourimetric reagents
WO2009051671A1 (fr) 2007-10-12 2009-04-23 Advanced Cell Technology, Inc. Procédés améliorés pour la production de cellules rpe et de compositions de cellules rpe
CN102414562B (zh) * 2009-03-24 2019-05-07 生物概念股份有限公司 细胞捕获和分析的装置和方法
US20120100538A1 (en) 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
IL301479B1 (en) 2009-11-17 2025-12-01 Astellas Inst For Regenerative Medicine Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells
WO2011063416A2 (fr) * 2009-11-23 2011-05-26 The General Hospital Corporation Dispositifs microfluidiques destinés à capturer des composants d'un échantillon biologique
JP6184865B2 (ja) 2010-07-23 2017-08-23 アステラス インスティテュート フォー リジェネレイティブ メディシン 細胞の稀少なサブ集団を検出するための方法及び細胞の高度に精製された組成物
US9976973B2 (en) 2010-11-09 2018-05-22 The General Hospital Corporation Counting particles using an electrical differential counter
JP5958066B2 (ja) * 2011-05-13 2016-07-27 株式会社Ｊｖｃケンウッド 試料分析用ディスク
CN103185803A (zh) 2011-12-31 2013-07-03 深圳迈瑞生物医疗电子股份有限公司 一种鉴定抗体敏感性和克隆细胞株的方法及试剂盒
CN103323448B (zh) * 2013-01-20 2018-01-16 温州医科大学 一种辣根过氧化物酶黑色显色剂及其制备方法与应用
JP7001475B2 (ja) 2015-02-10 2022-01-19 イラミーナ インコーポレーテッド 細胞の構成成分を分析するための方法及び組成物
MA41883B1 (fr) * 2015-07-23 2019-03-29 Gentian Diagnostics As Procédé pour évaluer les récepteurs de surface cellulaire des cellules sanguines
WO2017055327A1 (fr) * 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de cellules endothéliales dans un échantillon de tissu
WO2017055321A1 (fr) * 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de fibroblastes dans un prélèvement de tissu
WO2017055324A1 (fr) * 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de quantification de la population de cellules d'origine monocytaire dans un prélèvement de tissu
CN106769800B (zh) * 2016-11-14 2019-03-22 天津市康婷生物工程有限公司 一种高通量测量间充质干细胞数量的方法
CN108918500B (zh) * 2018-07-14 2020-10-23 北京航空航天大学青岛研究院 基于免疫磁珠标记的sers分选方法
KR102543482B1 (ko) * 2023-03-20 2023-06-19 주식회사 디앤샤인 미세조류 유세포분석을 위한 턴테이블 시스템 및 이를 이용한 미세조류 유세포분석 방법

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311492A2 (fr) * 1987-09-30 1989-04-12 Elf Sanofi Trousse et méthode de dosage immunométrique applicables à des cellules entières
US5348859A (en) * 1990-11-23 1994-09-20 Coulter Corporation Method and apparatus for obtaining an absolute white blood cell subset count and white blood cell multipart differential
WO2000005582A2 (fr) * 1998-07-21 2000-02-03 Burstein Laboratories, Inc. Dispositifs de dosage utilisant des disques optiques et methodes correspondantes
WO2002044695A1 (fr) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methodes et appareils destines a la detection et au denombrement de lymphocytes utilisant des biodisques optiques
US20020072078A1 (en) * 1999-04-28 2002-06-13 Development Center For Biotechnology, A Taiwan Corporation Rapid test for cell surface antigen
US20020076804A1 (en) * 1996-12-20 2002-06-20 Sheppard Norman F. Affinity binding-based system for detecting particulates in a fluid
WO2003006956A2 (fr) * 2001-07-11 2003-01-23 National Health Laboratory Service Enumeration cellulaire

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
NL154600B (nl) * 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4181650A (en) * 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
DE2930706A1 (de) * 1979-07-28 1981-02-05 Medac Klinische Spezialpraep Verfahren zum nachweis von erregerspezifischen antikoerpern
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4778767A (en) * 1984-12-17 1988-10-18 Akzo N.V. Solid phase immunoassay using immunoreagents immobilized on inert synthetic resin surfaces
US5262302A (en) * 1987-03-13 1993-11-16 Coulter Corporation Method for screening white blood cells
US4847205A (en) * 1987-04-08 1989-07-11 Martin Marietta Energy Systems, Inc. Device and method for automated separation of a sample of whole blood into aliquots
FR2645534B1 (fr) * 1989-04-06 1991-07-12 Centre Nat Rech Scient Procede de preparation de sulfonylmethanes et de leurs derives
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5087556A (en) * 1989-05-17 1992-02-11 Actimed Laboratories, Inc. Method for quantitative analysis of body fluid constituents
DE69431023T2 (de) * 1993-09-01 2003-02-06 Kabushiki Kaisha Toshiba, Kawasaki Halbleiteraufbau und Verfahren zur Herstellung
US6327031B1 (en) * 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
GB9418981D0 (en) * 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5631166A (en) * 1995-03-21 1997-05-20 Jewell; Charles R. Specimen disk for blood analyses
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6709869B2 (en) * 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US20030054376A1 (en) * 1997-07-07 2003-03-20 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
JP3469585B2 (ja) * 1997-05-23 2003-11-25 ガメラ バイオサイエンス コーポレイション ミクロ流体工学システムでの流動運動を駆動するために向心的加速を使用するための装置および方法
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
EP1051259B1 (fr) * 1998-01-12 2006-04-05 Massachusetts Institute Of Technology Procede pour effectuer des dosages microscopiques
US6395562B1 (en) * 1998-04-22 2002-05-28 The Regents Of The University Of California Diagnostic microarray apparatus
US6342395B1 (en) * 1998-04-22 2002-01-29 The Regents Of The University Of California Compact assay system with digital information
ES2344180T3 (es) * 1998-12-23 2010-08-19 Medsaic Pty Limited Ensayo para la deteccion de una pareja de union.
US6888951B1 (en) * 1999-08-23 2005-05-03 Nagaoka & Co., Ltd. Methods and apparatus for analyzing operational and analyte data acquired from optical disc
US7061594B2 (en) * 2000-11-09 2006-06-13 Burstein Technologies, Inc. Disc drive system and methods for use with bio-discs
WO2002041004A2 (fr) * 2000-11-16 2002-05-23 Burstein Technologies, Inc. Biodisques optiques dotes de couches reflechissantes
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US20020196435A1 (en) * 2000-11-22 2002-12-26 Cohen David Samuel Apparatus and methods for separating agglutinants and disperse particles
US20020172980A1 (en) * 2000-11-27 2002-11-21 Phan Brigitte Chau Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
US20030003464A1 (en) * 2000-11-27 2003-01-02 Phan Brigitte C. Dual bead assays including optical biodiscs and methods relating thereto
US20030082568A1 (en) * 2000-11-27 2003-05-01 Phan Brigitte Chau Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
WO2002043866A2 (fr) * 2000-12-01 2002-06-06 Burstein Technologies, Inc. Appareil et procedes de separation des composants d'une suspension particulaire
US7054258B2 (en) * 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
AU2002239553A1 (en) * 2000-12-08 2002-06-18 Burstein Technologies, Inc. Methods for detecting analytes using optical discs and optical disc readers
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
WO2002046721A2 (fr) * 2000-12-08 2002-06-13 Burstein Technologies, Inc. Disques optiques permettant de mesurer des analytes
US7091034B2 (en) * 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
AU2002231189A1 (en) * 2000-12-22 2002-07-08 Burstein Technologies, Inc. Optical bio-discs and methods relating thereto
AU2002241851A1 (en) * 2001-01-11 2002-07-24 Burstein Technologies, Inc. Optical disc analysis system including related methods for biological and medical imaging
US20020168663A1 (en) * 2001-02-27 2002-11-14 Phan Brigitte Chau Methods for DNA conjugation onto solid phase including related optical biodiscs and disc drive systems
US7033747B2 (en) * 2001-04-11 2006-04-25 Nagaoka & Co., Ltd Multi-parameter assays including analysis discs and methods relating thereto
WO2004010099A2 (fr) * 2001-05-16 2004-01-29 Burstein Technologies, Inc. Commande d'echantillonnage variable pour la pixelisation de resultats d'analyse dans un ensemble biodisque, et appareil correspondant
EP1409996B1 (fr) * 2001-07-19 2006-10-11 Burstein Technologies, Inc. Ensembles disques optiques transparents permettant de realiser des mesures physiques
AU2002326441A1 (en) * 2001-07-20 2003-03-03 Burstein Technologies, Inc. Optical analysis disc and related drive assembly for performing interactive centrifugation
US20040226348A1 (en) * 2001-07-24 2004-11-18 Phillip Bruce Magnetic assisted detection of magnetic beads using optical disc drives
WO2003027723A2 (fr) * 2001-07-24 2003-04-03 Burstein Technologies, Inc. Procede et dispositif de fabrication d'un disque biologique optique equipe d'un circuit fluidique, forme a partir de deux disques colles l'un contre l'autre
US20030096324A1 (en) * 2001-09-12 2003-05-22 Mikhail Matveev Methods for differential cell counts including related apparatus and software for performing same
WO2003036337A2 (fr) * 2001-10-24 2003-05-01 Burstein Technologies, Inc. Detecteur segmente de surface pour bio-lecteur et procedes associes
WO2003060668A2 (fr) * 2002-01-14 2003-07-24 Burstein Technologies, Inc. Procede et appareil permettant de visionner des donnees
CN1625779A (zh) * 2002-01-28 2005-06-08 长冈实业株式会社 逻辑触发光生物盘的方法和设备
US20050002827A1 (en) * 2002-01-29 2005-01-06 Mcintyre Kevin Robert Optical discs including equi-radial and/or spiral analysis zones and related disc drive systems and methods
US20050003459A1 (en) * 2002-01-30 2005-01-06 Krutzik Siegfried Richard Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents
US20050019901A1 (en) * 2002-01-31 2005-01-27 Evgenia Matveeva Methods for synthesis of bio-active nanoparticles and nanocapsules for use in optical bio-disc assays and disc assembly including same
US20040241381A1 (en) * 2002-01-31 2004-12-02 Chen Yihfar Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs
WO2003065355A2 (fr) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Elements de securite biologique pour disque d'analyse optique et systeme de disques les contenant
US8321236B2 (en) * 2002-02-01 2012-11-27 Walgreen Co. Method and apparatus for prescription processing
WO2004113871A2 (fr) * 2003-06-19 2004-12-29 Nagaoka & Co., Ltd. Circuits fluidiques pour preparation d'echantillons comprenant des disques biologiques et procedes correspondants

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311492A2 (fr) * 1987-09-30 1989-04-12 Elf Sanofi Trousse et méthode de dosage immunométrique applicables à des cellules entières
US5348859A (en) * 1990-11-23 1994-09-20 Coulter Corporation Method and apparatus for obtaining an absolute white blood cell subset count and white blood cell multipart differential
US20020076804A1 (en) * 1996-12-20 2002-06-20 Sheppard Norman F. Affinity binding-based system for detecting particulates in a fluid
WO2000005582A2 (fr) * 1998-07-21 2000-02-03 Burstein Laboratories, Inc. Dispositifs de dosage utilisant des disques optiques et methodes correspondantes
US20020072078A1 (en) * 1999-04-28 2002-06-13 Development Center For Biotechnology, A Taiwan Corporation Rapid test for cell surface antigen
WO2002044695A1 (fr) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methodes et appareils destines a la detection et au denombrement de lymphocytes utilisant des biodisques optiques
WO2003006956A2 (fr) * 2001-07-11 2003-01-23 National Health Laboratory Service Enumeration cellulaire

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US20050032126A1 (en) 2005-02-10
CN101044404A (zh) 2007-09-26
CA2518677A1 (fr) 2004-12-09
JP2007501407A (ja) 2007-01-25
WO2004106925A2 (fr) 2004-12-09
EP1599730A2 (fr) 2005-11-30
AU2004243690A1 (en) 2004-12-09

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