WO2004106936A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled p2y purinoreceptor 9 (p2y9) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled p2y purinoreceptor 9 (p2y9) Download PDF

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Publication number
WO2004106936A3
WO2004106936A3 PCT/EP2004/005554 EP2004005554W WO2004106936A3 WO 2004106936 A3 WO2004106936 A3 WO 2004106936A3 EP 2004005554 W EP2004005554 W EP 2004005554W WO 2004106936 A3 WO2004106936 A3 WO 2004106936A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
purinoreceptor
therapeutics
diagnostics
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/005554
Other languages
French (fr)
Other versions
WO2004106936A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Ralf Thiele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of WO2004106936A2 publication Critical patent/WO2004106936A2/en
Publication of WO2004106936A3 publication Critical patent/WO2004106936A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human P2Y9 which is associated with the cancer disorders, hematological disorders, inflammatory diseases, neurological diseases, cardiovascular diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cancer disorders, hematological disorders, inflammatory diseases, neurological diseases, cardiovascular diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of P2Y9 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/005554 2003-06-02 2004-05-24 Diagnostics and therapeutics for diseases associated with g protein-coupled p2y purinoreceptor 9 (p2y9) Ceased WO2004106936A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03012496.0 2003-06-02
EP03012496 2003-06-02

Publications (2)

Publication Number Publication Date
WO2004106936A2 WO2004106936A2 (en) 2004-12-09
WO2004106936A3 true WO2004106936A3 (en) 2005-06-16

Family

ID=33483902

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/005554 Ceased WO2004106936A2 (en) 2003-06-02 2004-05-24 Diagnostics and therapeutics for diseases associated with g protein-coupled p2y purinoreceptor 9 (p2y9)

Country Status (1)

Country Link
WO (1) WO2004106936A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0520405D0 (en) * 2005-10-07 2005-11-16 Imp College Innovations Ltd Biological agents and method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0853126A2 (en) * 1997-01-10 1998-07-15 Smithkline Beecham Corporation cDNA clone HE8CS41 that encodes a human 7-transmembrane receptor
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
WO2002068591A2 (en) * 2001-02-23 2002-09-06 Bristol-Myers Squibb Company G-protein coupled receptor nucleic acids, polypeptides, antibodies and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0853126A2 (en) * 1997-01-10 1998-07-15 Smithkline Beecham Corporation cDNA clone HE8CS41 that encodes a human 7-transmembrane receptor
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
WO2002068591A2 (en) * 2001-02-23 2002-09-06 Bristol-Myers Squibb Company G-protein coupled receptor nucleic acids, polypeptides, antibodies and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JANSSENS R ET AL: "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 236, 9 July 1997 (1997-07-09), pages 106 - 112, XP002124833, ISSN: 0006-291X *
O'DOWD B F ET AL: "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 187, no. 1, 10 March 1997 (1997-03-10), pages 75 - 81, XP004093242, ISSN: 0378-1119 *

Also Published As

Publication number Publication date
WO2004106936A2 (en) 2004-12-09

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