WO2004108906A3 - Bakterielle träger für nukleotidsequenzen kodierend für wirkstoffe - Google Patents

Bakterielle träger für nukleotidsequenzen kodierend für wirkstoffe Download PDF

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Publication number
WO2004108906A3
WO2004108906A3 PCT/DE2004/001180 DE2004001180W WO2004108906A3 WO 2004108906 A3 WO2004108906 A3 WO 2004108906A3 DE 2004001180 W DE2004001180 W DE 2004001180W WO 2004108906 A3 WO2004108906 A3 WO 2004108906A3
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WO
WIPO (PCT)
Prior art keywords
nucleotide sequences
active substances
sequences coding
bacterial
bacterial carriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2004/001180
Other languages
English (en)
French (fr)
Other versions
WO2004108906A2 (de
Inventor
Werner Goebel
Sabine Pilgrim
Jochen Strizker
Ivaylo Gentschev
Christoph Schoen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medinnova Gesellschaft fuer Medizinische Innovationen aus Akademischer Forschung mbH,
Original Assignee
Medinnova Gesellschaft fuer Medizinische Innovationen aus Akademischer Forschung mbH,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medinnova Gesellschaft fuer Medizinische Innovationen aus Akademischer Forschung mbH, filed Critical Medinnova Gesellschaft fuer Medizinische Innovationen aus Akademischer Forschung mbH,
Priority to DE112004001496T priority Critical patent/DE112004001496D2/de
Publication of WO2004108906A2 publication Critical patent/WO2004108906A2/de
Publication of WO2004108906A3 publication Critical patent/WO2004108906A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1092—3-Phosphoshikimate 1-carboxyvinyltransferase (2.5.1.19), i.e. 5-enolpyruvylshikimate-3-phosphate synthase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Die Erfindung betrifft einen bakteriellen Mikroorganismus, enthaltend eine fremde Nukleinsäuresequenz, welche für einen Wirkstoff codiert, wobei in der chromosomalen DNA des Mikroorganismus eine natürliche und für die Expression eines bakteriellen Enzyms codierende Nukleinsäuresequenz des Bakteriums entweder deletiert oder mit der Maßgabe mu­tiert ist, dass ein hieraus entstehendes Translationspro­dukt nicht-funktionell ist. Die Erfindung betrifft des Weiteren Zellen, die mit solchen Mikroorganismen infiziert sind, Verfahren zur Herstellung solcher Organismen sowie deren Verwendung, insbesondere zur Herstellung von phar­mazeutischen Zusammensetzungen.
PCT/DE2004/001180 2003-06-06 2004-06-07 Bakterielle träger für nukleotidsequenzen kodierend für wirkstoffe Ceased WO2004108906A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112004001496T DE112004001496D2 (de) 2003-06-06 2004-06-07 Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10326189.3 2003-06-06
DE10326189A DE10326189A1 (de) 2003-06-06 2003-06-06 Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe

Publications (2)

Publication Number Publication Date
WO2004108906A2 WO2004108906A2 (de) 2004-12-16
WO2004108906A3 true WO2004108906A3 (de) 2005-02-10

Family

ID=33494938

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/001180 Ceased WO2004108906A2 (de) 2003-06-06 2004-06-07 Bakterielle träger für nukleotidsequenzen kodierend für wirkstoffe

Country Status (2)

Country Link
DE (2) DE10326189A1 (de)
WO (1) WO2004108906A2 (de)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048026A1 (en) * 1997-04-18 1998-10-29 Gesellschaft für Biotechnologische Forschung mbH Attenuated salmonella strain used as a vehicle for oral immunization
US5877159A (en) * 1995-05-03 1999-03-02 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same
WO1999034007A1 (en) * 1997-12-29 1999-07-08 Schering Aktiengesellschaft Delivery of polypeptide-encoding plasmid dna into the cytosol of macrophages by attenuated suicide bacteria

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877159A (en) * 1995-05-03 1999-03-02 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same
WO1998048026A1 (en) * 1997-04-18 1998-10-29 Gesellschaft für Biotechnologische Forschung mbH Attenuated salmonella strain used as a vehicle for oral immunization
WO1999034007A1 (en) * 1997-12-29 1999-07-08 Schering Aktiengesellschaft Delivery of polypeptide-encoding plasmid dna into the cytosol of macrophages by attenuated suicide bacteria

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THOMPSON R J ET AL: "Pathogenicity and Immunogenicity of a Listeria monocytogenes Strain That Requires D-Alanine for Growth", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 66, no. 8, 1998, pages 3552 - 3561, XP002170925, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
DE112004001496D2 (de) 2006-04-20
WO2004108906A2 (de) 2004-12-16
DE10326189A1 (de) 2005-01-05

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