WO2005020848A2 - Dispositif d'assistance cavopulmonaire et procede associe - Google Patents

Dispositif d'assistance cavopulmonaire et procede associe Download PDF

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Publication number
WO2005020848A2
WO2005020848A2 PCT/US2004/027765 US2004027765W WO2005020848A2 WO 2005020848 A2 WO2005020848 A2 WO 2005020848A2 US 2004027765 W US2004027765 W US 2004027765W WO 2005020848 A2 WO2005020848 A2 WO 2005020848A2
Authority
WO
WIPO (PCT)
Prior art keywords
blood pump
vena cava
patient
inlet
positioning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/027765
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English (en)
Other versions
WO2005020848A3 (fr
Inventor
Mark D. Rodefeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of WO2005020848A2 publication Critical patent/WO2005020848A2/fr
Anticipated expiration legal-status Critical
Publication of WO2005020848A3 publication Critical patent/WO2005020848A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A61M60/414—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/237—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/35—Medical purposes thereof other than the enhancement of the cardiac output for specific surgeries, e.g. for Fontan procedure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/804—Impellers
    • A61M60/806—Vanes or blades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/81—Pump housings
    • A61M60/812—Vanes or blades, e.g. static flow guides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/833—Occluders for preventing backflow

Definitions

  • the present disclosure relates generally to intravascular implantable devices and methods for assisting blood flow of a patient.
  • the ventricle is the muscular heart chamber that performs the work of pumping blood to the body (left ventricle) or to the lungs (right ventricle). If left untreated, infants born with only one functional ventricle will die. Conventionally, infants born with such a condition are treated surgically with a series of three surgical procedures. The first procedure is typically performed on newborn patients within two weeks from birth, the second procedure is performed at six to twelve months from birth, and the third procedure is performed at two to six years of age. The first surgical procedure has a survival rate of approximately 50-70%. The second and third procedures have generally higher survival rates.
  • the second and third procedures cannot be performed in the newborn because these procedures divert the blood from the superior or inferior venae cavae directly into the arteries of the lungs, and thus passive blood flow must occur from the venae cavae through the lungs.
  • the resistance of the arteries leading to the lungs is high.
  • blood flow will not passively advance through the lungs.
  • the first procedure utilizes a shunt to divert blood from the aorta, where pressure is high, to the pulmonary arteries.
  • the pressure from the aorta is high enough to push blood through the lungs.
  • the use of the shunt directly contributes the relatively high morbidity rate of the first procedure.
  • the shunt creates a physiologic situation in which the blood flow to the body and the lungs must be delicately "balanced.”
  • a method of performing a cavopulmonary diversion procedure in a newborn patient includes the steps of positioning an inlet of a blood pump in a vena cava of the newborn patient, and anastomosing the vena cava to a pulmonary artery of the newborn patient.
  • the inlet of the blood pump is positioned in the superior vena cava.
  • the inlet of the blood pump is positioned in the inferior vena cava.
  • the blood pump is embodied with two inlets, one of which is positioned in the superior vena cava, the other of which is positioned in the inferior vena cava.
  • an intravascular blood pump includes a housing, an impeller positioned in the housing, and an inflatable bladder positioned around a portion of the periphery of the housing.
  • the housing is cylindrically shaped, and the inflatable bladder extends around a portion of an outer circumferential surface of the cylindrically shaped housing. In other implementations, the inflatable bladder extends completely around the outer circumferential surface of the cylindrically shaped housing.
  • an intravascular axial blood pump is configured to draw blood from both opposite axial ends thereof.
  • a flow deflector is positioned between the opposite axial ends of the pump and deflects blood radially outwardly therefrom.
  • the pump is configured with (i) a first pump housing having a first inlet and a first outlet, and (ii) a second pump housing having a second inlet and a second outlet.
  • the flow deflector is positioned between the first outlet and the second outlet.
  • An impeller may be positioned in each pump housing.
  • One or both of the pump housings may have an inflatable bladder positioned around a portion of the periphery thereof.
  • the axial pump may include
  • a first impeller configured to advance blood in a first direction
  • a second impeller configured to advance blood in a second direction.
  • the second direction is opposite the first direction.
  • the flow deflector is positioned between the first impeller and the second impeller.
  • FIG. 1 is a diagrammatic view showing an intravascular blood pump operating to pump blood from the superior vena cava to the right pulmonary artery of a newborn patient
  • FIG. 2 is a simplified cross sectional view of an intravascular axial blood pump
  • FIG. 3 is a diagrammatic view showing an intravascular blood pump operating to direct blood flow from both the superior vena cava and the inferior vena cava to the right pulmonary artery of a newborn patient
  • FIG. 4 is a simplified cross sectional view of an intravascular axial blood pump, note that the angle and helical orientation of the blades of the pump are not shown for clarity of description.
  • FIGS. 1 and 2 there is shown a heart 10 of a newborn patient which has been treated with the concepts of the present disclosure.
  • the concepts demonstrated in FIG. 1 are shown in the context of the treatment of a non-functional left heart ventricle such as in the case of, for example, hypoplastic left heart syndrome.
  • FIG. 1 the concepts demonstrated in FIG. 1 may also be used in the treatment of other ailments as well.
  • the superior vena cava 12 of the newborn patient is anastomosed to the right pulmonary artery 14.
  • blood is advanced from the superior vena cava 12 to the right pulmonary artery 14.
  • a cavopulmonary assist device is implanted into the newborn patient.
  • an intravascular blood pump 16 is implanted into the superior vena cava 12 of the newborn patient.
  • the blood pump 16 includes an inlet 18 that draws blood from the superior vena cava 12 and an outlet 20 which expels blood into the right pulmonary artery 14.
  • the blood pump 16 may be embodied as any type of intravascular blood pump.
  • One type of intravascular blood pump that may be used is an axial blood pump such as the axial blood pumps described in U.S. Patent No. 4,846,152 (with some modification thereof). The entirety of U.S. Patent No. 4,846,152 is hereby incorporated by reference.
  • An exemplary embodiment of a blood pump that may be utilized as the blood pump 16 is shown in FIG. 2.
  • the blood pump 16 includes a pump body in the form of a cylindrically-shaped housing 22.
  • An impeller 24 is positioned in the housing 22.
  • the impeller 24 is embodied as a rotor 26 having a number of helically-arranged blades 28 extending therefrom.
  • the rotor 26 rotates relative to a stator 30 which also has a number of helically-arranged blades 32 extending therefrom.
  • the number, size, and orientation of the blades 28, 32 may be varied to fit the needs of a given pump design.
  • the pump 16 is driven by a cable 36 which rotates within a sheath 38 that extends from the outside of the newborn patient's body.
  • the cable 36 is driven by an external drive mechanism (not shown).
  • the blood pump 16 has an inflatable bladder, such as a balloon 34, secured to an outer periphery of the housing 22.
  • the balloon 34 may extend along only a portion of the axial length of the housing 22, as shown in FIG. 2. Alternatively, the balloon 34 may extend along the entire axial length of the housing 22. The balloon 34 may be configured to wrap around the entire outer circumferential surface of the housing 22. Alternatively, the balloon may wrap around only a portion of the outer circumferential surface of the housing 22. As shown in FIG. 1, the balloon 34 may be inflated or otherwise expanded into contact with the walls of the superior vena cava 12. This prevents blood recirculation around the implanted blood pump 16. It should be appreciated that the inflatable bladder described herein (e.g., the balloon 34) is but one exemplary device for preventing blood recirculation around the implanted blood pump 16.
  • FIGS. 3 and 4 there is shown the heart 10 of the newborn patient having been treated with additional concepts of the present disclosure. Similar to as described above in regard to FIG. 1, the concepts demonstrated in FIG. 3 are shown in the context of the treatment of a non-functional left heart ventricle such as in the case of, for example, hypoplastic left heart syndrome. However, the concepts demonstrated in FIG. 3 may also be used in the treatment of other ailments as well. As shown in FIG. 3, both the superior vena cava 12 and the inferior vena cava 42 of the newborn patient are anastomosed to the right pulmonary artery 14.
  • a cavopulmonary assist device is implanted into the newborn patient.
  • an intravascular blood pump 46 is implanted into the newborn patient.
  • the blood pump 46 includes a first inlet 48 that draws blood from the superior vena cava 12 and a second inlet 58 that draws blood from the inferior vena cava 42.
  • the inlets 48, 58 are on axial opposite ends of the pump 46 from one another.
  • the blood pump 46 also includes a first outlet 50 and a second outlet 60, both of which expel blood into the right pulmonary artery 14.
  • a flow deflector 62 directs pumped blood radially outwardly therefrom and into the right pulmonary artery 14.
  • the blood pump 46 may be embodied as any type of intravascular blood pump.
  • One type of intravascular blood pump that may be used is an axial blood pump such as the axial blood pumps described in U.S. Patent No. 4,846,152 (with some modification thereof).
  • An exemplary embodiment of a blood pump that may be utilized as the blood pump 46 is shown in FIG. 4.
  • the blood pump 16 includes a pump body in the form of a pair of cylindrically-shaped housings 72, 74. The axially outer ends of the housings 72, 74 define the inlets 48, 58, respectively, of the blood pump 46.
  • the axially inner ends of the housings 72, 74 define the outlets 50, 60, respectively, of the blood pump 46.
  • An impeller 76, 78 is positioned in each of the housings 72, 74, respectively.
  • the impellers 76, 78 are each embodied as a rotor 80 having a number of helically-arranged blades 82 extending therefrom.
  • the rotor 80 rotates relative to a stator 88 which also has a number of helically-arranged blades 84 extending therefrom.
  • the number, size, and orientation of the blades 82, 84 of the impellers 76, 78 may be varied to fit the needs of a given pump design.
  • the rotor blades 82 and the stator blades 84 associated with the impeller 76 are oppositely angled relative to the rotor blades 82 and the stator blades 84 associated with the impeller 78.
  • the impellers 76, 78 direct blood in axial opposite directions from the pump inlets 48, 58 to the outlets 50, 60 of the blood pump 46, as shown by the arrows of FIG. 3.
  • This common cable 36 rotates within a sheath 38 that extends from the outside of the newborn patient's body.
  • the cable 36 is driven by an external drive mechanism (not shown). As shown in FIG.
  • the flow deflector 62 has a pair of oppositely facing annular surfaces 86.
  • the diameter of each of the annular surfaces 86 increases gradually in a direction away from the stators 88.
  • blood exiting the outlets 50, 60 of the housings 72, 74 is directed radially outwardly into the right pulmonary artery 14.
  • the blood pump 46 has an inflatable bladder, such as the balloon 34, secured to the outer periphery of the housings 72, 74.
  • the balloons 34 may extend along only a portion of the axial length of the housings 72, 74, as shown in FIG. 4. Alternatively, the balloon 34 may extend along the entire axial length of one or both of the housings 72, 74.
  • the balloon 34 may be configured to wrap around the entire outer circumferential surface of the housings 72, 74. Alternatively, the balloon may wrap around only a portion of the outer circumferential surface of the housings 72, 74. As shown in FIG. 3, the balloons 34 may be inflated or otherwise expanded into contact with the walls of the superior vena cava 12 (in the case of the balloon 34 associated with the housing 72) and the walls of the inferior vena cava 42 (in the case of the balloon associated with the housing 74). This prevents blood recirculation around the implanted blood pump 46. It should be appreciated that the inflatable bladder described herein (e.g., the balloon 34) is but one exemplary device for preventing blood recirculation around the implanted blood pump 46.
  • a blood pump similar to the blood pump 16 may be implanted in the inferior vena cava 42 to support cavopulmonary blood flow.
  • the drainage from the inferior vena cava 42 is a potential source of problems, thus, a unidirectional pump positioned in the inferior vena cava 42 may be utilized to provide mechanical flow support.
  • Such a configuration would be similar to as shown in FIG. 1, except that the pump 16 would be positioned in the inferior vena cava 42 only. It should be appreciated that such an arrangement (i.e., a blood pump positioned in the inferior vena cava 42 only) is also contemplated for use in the treatment of newborns.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention porte sur une pompe à sang (16) comportant un orifice d'aspiration (18) du sang de la veine cave (12) d'un nouveau né et une orifice de transfert (20) du sang dans son artère pulmonaire (14)L'invention porte également sur un procédé de réalisation d'une procédure de diversion cavopulmonaire chez un nouveau né.
PCT/US2004/027765 2003-08-28 2004-08-26 Dispositif d'assistance cavopulmonaire et procede associe Ceased WO2005020848A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49862503P 2003-08-28 2003-08-28
US60/498,625 2003-08-28

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Publication Number Publication Date
WO2005020848A2 true WO2005020848A2 (fr) 2005-03-10
WO2005020848A3 WO2005020848A3 (fr) 2006-04-06

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Cited By (64)

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WO2010042546A1 (fr) * 2008-10-06 2010-04-15 Indiana University Research And Technology Corporation Procédés et appareil destinés à une assistance active ou passive dans le système circulatoire
WO2013148697A1 (fr) * 2012-03-26 2013-10-03 Procyrion, Inc. Systèmes et procédés de circulation et de perfusion permettant d'améliorer l'écoulement et/ou la pression des liquides organiques
EP2785392A4 (fr) * 2011-12-03 2015-08-12 Univ Indiana Res & Tech Corp Dispositif et procédé d'assistance de propulseur de liquide visqueux cavopulmonaire
WO2015177793A3 (fr) * 2014-05-19 2016-03-17 Magenta Medical Ltd. Pompe à sang
US9597205B2 (en) 2012-06-06 2017-03-21 Magenta Medical Ltd. Prosthetic renal valve
US9764113B2 (en) 2013-12-11 2017-09-19 Magenta Medical Ltd Curved catheter
US9913937B2 (en) 2013-03-13 2018-03-13 Magenta Medical Ltd. Renal pump
AU2016253685B2 (en) * 2008-10-06 2018-08-30 Indiana University Research And Technology Corporation Methods and apparatus for active or passive assistance in the circulatory system
WO2018226991A1 (fr) * 2017-06-07 2018-12-13 Shifamed Holdings, Llc Dispositifs de déplacement de fluide intravasculaire, systèmes et procédés d'utilisation
EP3581216A1 (fr) * 2018-06-11 2019-12-18 Universität Zürich Pompe sanguine pour l'assistance circulatoire mécanique des patients opérés d'un fontan
US10583231B2 (en) 2013-03-13 2020-03-10 Magenta Medical Ltd. Blood pump
WO2020061379A1 (fr) * 2018-09-19 2020-03-26 NXT Biomedical Procédés et technologie pour créer des connexions et des dérivations entre des vaisseaux et des chambres de structures biologiques
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US10881770B2 (en) 2018-01-10 2021-01-05 Magenta Medical Ltd. Impeller for blood pump
US10893927B2 (en) 2018-03-29 2021-01-19 Magenta Medical Ltd. Inferior vena cava blood-flow implant
WO2021026469A1 (fr) * 2019-08-07 2021-02-11 Daniel Hildebrand Pompes à sang de cathéter et turbines
US11033727B2 (en) 2016-11-23 2021-06-15 Magenta Medical Ltd. Blood pumps
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WO2021138233A1 (fr) * 2019-12-31 2021-07-08 Children's National Medical Center Dispositif non obstructif implantable durable d'assistance veineuse pour le support de la circulation de fontan cavopulmonaire
US20210338409A1 (en) * 2019-06-14 2021-11-04 Chandramouli HONNAVALLI CHANDRASHEKAR Prosthetic cardiac implant
WO2021243263A1 (fr) * 2020-05-29 2021-12-02 Shifamed Holdings, Llc Pompes à sang intravasculaires
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US11752314B2 (en) 2019-02-07 2023-09-12 Nxt Biomedical, Llc Rivet shunt and method of deployment
US11754075B2 (en) 2018-07-10 2023-09-12 Kardion Gmbh Impeller for an implantable, vascular support system
US11944805B2 (en) 2020-01-31 2024-04-02 Kardion Gmbh Pump for delivering a fluid and method of manufacturing a pump
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
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US12107474B2 (en) 2018-05-16 2024-10-01 Kardion Gmbh End-face rotating joint for transmitting torques
US12102815B2 (en) 2019-09-25 2024-10-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible pump housings
US12121713B2 (en) 2019-09-25 2024-10-22 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits
US12128228B2 (en) 2019-05-23 2024-10-29 Magenta Medical Ltd Blood pumps
US12128227B2 (en) 2020-04-07 2024-10-29 Magenta Medical Ltd. Manufacture of an impeller
US12144976B2 (en) 2018-06-21 2024-11-19 Kardion Gmbh Method and device for detecting a wear condition of a ventricular assist device and for operating same, and ventricular assist device
US12161857B2 (en) 2018-07-31 2024-12-10 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
US12194287B2 (en) 2018-05-30 2025-01-14 Kardion Gmbh Method of manufacturing electrical conductor tracks in a region of an intravascular blood pump
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US12220570B2 (en) 2018-10-05 2025-02-11 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
US12263333B2 (en) 2018-06-21 2025-04-01 Kardion Gmbh Stator vane device for guiding the flow of a fluid flowing out of an outlet opening of a ventricular assist device, ventricular assist device with stator vane device, method for operating a stator vane device and manufacturing method
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